The following team members have made invaluable, direct contributions to the effort to build Skyline:

Brendan MacLean Brendan MacLean - principal developer
Brendan worked at Microsoft for 8 years in the 1990s where he was a lead developer and development manager for the Visual C++/Developer Studio Project. Since leaving Microsoft, Brendan has been the Vice President of Engineering for Westside Corporation, Director of Engineering for BEA Systems, Inc., Sr. Software Engineer at the Fred Hutchinson Cancer Research Center, and a founding partner of LabKey Software. In this last position he was one of the key programmers responsible for the Computational Proteomics Analysis System (CPAS), made significant contributions to the development of X!Tandem and the Trans Proteomic Pipeline, and created the LabKey Enterprise Pipeline. Since August, 2008 he has worked as a Sr. Software Engineer within the MacCoss lab and been responsible for all aspects of design, development and support in creating the Skyline Targeted Mass Spec Environment and its growing worldwide user community.
Nat Brace 

Nat Brace - project manager - outreach & user education
Nat worked full-time for Microsoft from 1991 through 2000 where he led a team of system engineers who were helping organizations plan for and integrate Microsoft’s advanced server solutions including network and database products, as well as software development tools. He continued at Microsoft as a consultant from 2000 to 2011, with several internal teams as a technical project owner, customer outreach lead and marketing manager. More recently, Nat joined a social innovation start-up piloting a global educational reform initiative where he served as the lead project manager in delivering a collaboration platform for use by the initiative’s participating educators, researchers and sponsors. As project manager for the Skyline team, Nat is responsible for outreach programs, like webinars, courses and user meetings, foreign language translation, and instrument vendor interactions.

Matthew Chambers Matthew Chambers - development (ProteoWizard)
Matt has worked in mass spectrometry informatics (mostly proteomics) since 2005; the first ten years he worked for David Tabb and Bing Zhang at Vanderbilt University Medical Center, and since then he has continued working as an independent consultant. He has worked in many subfields within MS, including shotgun proteomics database search, sequence tagging, spectral library search, and protein assembly. Along with Darren Kessner (director: Parag Mallick), Matt developed ProteoWizard, a free open-source library for mass spectrometry data processing. Since 2009, he has been its principal developer. The ProteoWizard tool msconvert is widely used for converting mass spectrometry data by users all over the world. For Skyline, he has focused on being able to read data directly from vendor proprietary data formats.
Rita Chupalov Rita Chupalov development
Rita’s experience with software and computers goes back to a Russian clone of DEC’s PDP-11 in 1991. She finished her degree in Organic Chemistry from Saint-Petersburg State University in 1996 where she wrote her first mass-spectrometry software: identification of halogen isotopic multiplets in low-resolution mass-spectra. Since then she worked for multiple software development companies specializing on database-centric applications, analytics and data warehousing. Her most recent job was with Amazon where she learned big data and cloud technologies.

Brian Connolly Brian Connolly - IT
Over the years Brian has worked for a number of companies in the Seattle area including Microsoft, BEA Systems and Cray. In 2007 Brian joined LabKey where he wore a number of hats. He helped LabKey's customers design and operate their LabKey Servers and pipelines. He architected and operated all of LabKey's Servers running in the public cloud (AWS and other cloud vendors) and became an expert in FISMA and HIPAA regulations. As part of the Skyline Team, Brian is responsible for managing growth of the and servers and helping the team grow its use of the AWS cloud.
Brian Pratt Brian Pratt - development, support
Brian's love affair with computing started the day he and his dad unboxed that brand new Apple II. Since then he's been involved with software development for, and started a couple of companies around, such varied applications as robot-assisted surgery, circuit board manufacturing and test, internet firewalls, and proteomics. Brian's proteomics work prior to joining the Skyline team included contributions to TPP, X!Tandem, LabKey's CPAS, and ProteoWizard. He's excited to be on a team of software professionals that value performance, reliability, and usability in the support of science.
Vagisha Sharma Vagisha Sharma - development, support, documentation (Panorama)
Vagisha got involved with proteomics at UC San Diego where she worked with Prof. Vineet Bafna. During that time she built her first tools for visualizing Mass Spectrometry data while working at ActivX Biosciences. Since moving to Seattle Vagisha has worked on Mass Spectrometry pipelines for the Aebersold group at the Institute for Systems Biology, and developed a data management system while at the University of Washington Proteomics Resource and the Yeast Resource Center. She joined the Skyline team in October, 2011. Vagisha enjoys developing tools that help researchers get stuff done.

Nicholas Shulman Nicholas Shulman - development
Nick worked from 1995-2000 at Microsoft on the Microsoft Access team, leaving to join Westside Corporation with Brendan to create browser-based database design tools. After Westside was acquired by BEA Systems, Nick created a new graphical JSP designer for Weblogic Workshop, an award winning Integrated Development Environment for enterprise Java applications. At LabKey Corporation, Nick created the flow cytometry module and the graphical query designer. Since March, 2009 he has worked in the Maccoss lab on Skyline and Topograph, a quantitative analysis tool for protein turnover experiments.
Kaipo Tamura Kaipo Tamura - development, support
Kaipo completed a CS degree at Washington State University in 2012, where he was introduced to proteomics as part of a senior project. He developed lipid identification software at the Pacific Northwest National Laboratory in 2012 before joining the Department of Genome Sciences at the University of Washington. Kaipo helps develop Crux in the Noble Lab, and BiblioSpec in the MacCoss Lab. He also implemented the Skyline Tool Store and is responsible for the Import Peptide Search wizard.


Previous contributors:

  • Susan E. Abbatiello, Ph.D. - software design, data acquisition, scientific consulting (Broad Institute, now Northeastern University)
  • Dario Amodei - development - Stanford (Baidu, Google, now OpenAI, SF)
  • Eva Baker - development (now UW Med. School)
  • Jarrett Egertson - develpment - UW (MSX and overlapped demux)
  • Gregory Finney, Ph.D. - development - UW (Crawdad)
  • Barbara Frewen - development - UW (BiblioSpec, Thermo BRIMS, now Zymergen)
  • Randall Kern - development architecture consulting (Microsoft, now
  • Don Marsh - development (now Whitemarsh Forests)
  • Birgit Schilling, Ph.D. - software design, data acquisition, scientific consulting, documentation (Buck Institute)
  • Daniela Tomazela, Ph.D. - software design, data acquisition, scientific consulting (now Merck)

Previous interns:

  • Yuval Boss - development intern - UW (now NOAA)
  • Daniel Broudy - development intern - Harvard (now Google, Seattle)
  • John Chilton - development intern - UW
  • Henry Estberg - development intern - UC Santa Cruz
  • Mimi Fung - development intern - UW (now Microsoft)
  • Max Horowitz-Gelb - development intern - U. Wisconsin (now Google, Seattle)
  • Shannon Joyner - development intern - CMU (Cisco Meraki, Cornell, now Afresh)
  • Hanna Kidanemariam - development intern - Dartmouth College (accepted Microsoft position)
  • Alana Killeen - development intern - UW (Microsoft, Dropbox, now Nautilus Biotech)
  • Trevor Killeen - development intern - UW (Facebook, now Stripe)
  • Alex MacLean - development intern - Roosevelt High School (Cal Poly CS, Dropbox intern, accepted NVIDIA)
  • Surya Mani - development intern - Hamilton College
  • Ali Marsh - development intern - MIT
  • Rohith Mondavilli - web development intern - Dartmouth College (now intern at Apple)
  • Tobias Rohde - development intern - UW (intern at AI2 Incubator, accepted Amazon)
  • Henry Sanford - development intern - UW (accepted Regeneron internship)
  • Pradyoth Vemulapati - development intern - UW (now OpenMarket)

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