|Buyun Chen, Ph.D., received her B.S. from Fudan University and PhD from University of Georgia. She has worked in Abbvie and Genentech after graduation. She is currently the leader of DMPK biomarker and proteomics Working Group of Genentech and serves on the steering committee of the Bioanalytical Focus Group of AAPS. Read More
However, significant variation (up to 100 fold) between different assays leaves transporter related PBPK modeling remained to be difficult. In our study we used MDR1 as an example to show how different surrogate peptide could impact the quantitation result and why.