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Senior Scientist - Computational Biologist
liang xue 2024-04-12 14:07

Application link:

Job Summary: The Senior Scientist Computational Biologist will be a key member of the Machine Learning and Computational Sciences Team, focusing on the analysis and interpretation of complex datasets generated from omics experiments to drive drug discovery and development. The role will require applying a deep understanding of biology together with advanced computational methods to solve complex biological problems and contribute to the understanding of disease mechanisms at the molecular level. The successful candidate will demonstrate an enthusiasm to work, collaborate, and communicate with both computational and experimental colleagues.

Key Responsibilities:
Develop and apply computational tools and algorithms for the analysis of large-scale proteomics datasets.
Collaborate with cross-functional teams to design, guide, conduct statistical analysis, and interpret multi-omics datasets including proteomics, NGS, and chemical biology data in the context of drug discovery projects.
Contribute to the development of machine learning models for predicting protein function and interactions.
Stay abreast of the latest developments in proteomics and computational biology. Integrate new technologies and methodologies into research practices.
Communicate findings effectively to both technical and non-technical audiences through presentations and scientific publications.

Ph.D. in computational biology, bioinformatics, statistics, computer science, or a related technical field.
Strong background in omics type data analysis and interpretation, such as proteomics, metabolomics, genomics, transcriptomics, etc.
Proficiency in programming languages such as Python or R and experience with bioinformatics tools and databases.
Deep understanding of biological systems, including post-translational modification, molecular and cell biology, pathway regulation, etc.
Familiarity with machine learning techniques and their application to biological data.
Experience with mass spectrometry-based proteomics/metabolomics, chemical biology, Olink proteomics, and next-generation sequencing is preferred.
Excellent problem-solving skills and the ability to work independently and as part of a team.
Strong communication skills and a track record of scientific publications in peer-reviewed journals.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Relocation support available

Work Location Assignment: Cambridge, MA, USA On Premise/Hybrid

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PhD student (f/m/d) in the group “Translational Mass Spectrometry and Biomarker Research (Oeckl lab)” at the German Center for Neurodegenerative Dieseases (DZNE) in Ulm, Germany
patrick oeckl 2023-10-30 06:04

The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine ( For the DZNE site in Ulm, we are inviting applications for a

PhD student (f/m/d) in the group “Translational Mass Spectrometry and Biomarker Research (Oeckl lab)” Code – 6033/2023/10

The Oeckl lab ( uses state-of-the-art mass spectrometry for the discovery, characterization and implementation of fluid biomarkers (blood, cerebrospinal fluid) for neurodegenerative diseases such as Alzheimer´s disease, amyotrophic lateral sclerosis (ALS) or frontotemporal dementia. We use proteomic/peptidomic approaches in patient samples to discover novel biomarker candidates which might improve (early/differential) diagnosis, disease monitoring or drug development (e.g. Oeckl et al., Acta Neuropathol 2020). To characterize specific biomarker candidates and the related pathomechanisms in detail (e.g. synaptic marker beta-synuclein in blood), we develop highly sensitive and accurate methods using targeted mass spectrometry (MRM, PRM, IP-MS) to study samples from large patient cohorts and evaluate their value for use in the clinic or drug development (e.g. Oeckl et al., Alzheimers Dement 2023). These assays are also intended to be used as reference measurement procedures in round robins and biomarker implementation. For promising biomarker candidates, we also develop highly sensitive immunoassays (ELISA, Simoa, Ella) for routine clinical application. The association of the Oeckl lab to the Neurology Department of the Ulm University Hospital provides excellent interaction with neurologists and psychologists and access to well-characterized patient samples enabling highly clinically-oriented research. We have our own equipment for highly competitive biomarker research including state-of-the-art mass spectrometry (Exploris 480 with FAIMS, QTRAP6500), immunoassay instruments (Simoa, Ella) and devices for sample handling (e.g. KingFisher Apex, Viaflo96).

Your tasks
• Development of new and use of established targeted mass spectrometry (MRM, PRM, IP-MS) methods for key biomarkers in CSF and blood (e.g. beta-synuclein, NfL, Tau, FUS)
• Investigation of samples (CSF, blood) from patients with neurodegenerative diseases using targeted MS and proteomic/peptidomic approaches (i.e. active participation in experimental work, experimental design, data generation, data analysis and interpretation)
• Supervision and maintenance of mass spectrometers and related devices (LC, autosampler)
• Prepare and write manuscripts for publication in international scientific journals
• Oral presentation of results on local, national, and international conferences

• Master degree in analytical chemistry, biochemistry, neuroscience, molecular medicine or a related field
• Good knowledge of protein biochemistry and good technical skills
• Prior experience with mass spectrometry and neuroscience is advantageous
• A keen interest in neurodegenerative diseases, handling of mass spectrometers and in moving the borders of what is possible
• English language is a prerequisite
• We are looking for candidates who are open-minded, creative team-player, enthusiastic, have strong analytical skills, think critically, and with good social skills
• Employment, payment and social benefits are consistent with those at other research institutes

The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and
especially encourages them to apply.

Please apply via:

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Senior Research Support Specialist with a focus on Metabolomics | Proteomics Resource Center Organization Overview
henrik molina 2023-09-18 07:19

The Proteomics Resource Center (PRC) at The Rockefeller University masters many aspects of liquid chromatography/mass spectrometry applied to metabolomics and proteomics. Examples include de novo sequencing, and quantitative analysis based on label-free quantitation as well as heavy isotope labeled samples. The PRC is equipped with Orbitrap-type mass spectrometers (high resolution/high mass accuracy) and can separate analytes using both nano and high-flow liquid chromatography. The Center is a source for help with planning of mass spectrometry-based experiments, and it has the capability to offer in-depth collaborative analysis. Also, the PRC is operated in a boutique style, encouraging the scientists of the Center to work closely with users to create a tailored approach to fit the many unique questions that can be answered by analytical mass spectrometry. The Center is equipped with multiple high-performance servers for data analysis.

The Proteomics Resource Center is looking for a Senior Research Support Specialist to lead PRC staff for metabolomics services. Metabolomics platform services include, but are not limited to, polar metabolite and lipid profiling (targeted and untargeted), absolute quantification of small molecules and flux analysis. Under very limited supervision, the Senior Research Support Specialist will demonstrate and deliver expertise in metabolomics tools and strategies. The Senior Research Support Specialist will provide excellent guidance in experimental design and data interpretation for metabolomics, and informational and technical support to center users, including assistance in experimental design and analysis.

Responsibilities include:
• Maintain, operate and manage LC-MS and related equipment
• Interact directly with and advise investigators on technical questions related to metabolomics
• Develop, improve and implement metabolomics technologies and methods
• Process, analyze, and interpret metabolomics data and report findings to the Director and investigators
• Maintain and document standard operating procedures; revise as needed.
• Track and maintain relevant Center documentation, including metabolomics service billing and requisitioning information
• Monitor and maintain laboratory appearance
• Mentor and train junior PRC staff members in metabolomics techniques and analysis
• Day to day supervision of junior PRC staff members’ performance of metabolomics related activities
• Participate in relevant meetings/conferences

• Ph.D. in metabolomics or other related field with at least two years relevant laboratory experience
• Proven competency with liquid chromatography and mass spectrometry
• Experience and competency in relevant instrumentation and supporting software
• Demonstrate ability to stay current with relevant techniques and technologies
• Strong communication, organizational, and interpersonal skills

• Skyline and LipidSearch analysis software experience
• Experience with Orbitrap IQ-X and Q-Exactive Plus Mass Spectrometers
• Experience with Vanquish LC system
• HILIC experience

Rockefeller University does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy, gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service or other non-merit factor. All qualified applicants will receive consideration for employment without regard to the characteristics listed above.

Compensation Range: USD $90,000.00/Yr. to USD $120,000.00/Yr.

Apply via:|-proteomics-resource-center/job?mode=view&mobile=false&width=785&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240

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Junior Group leader for mass spectrometry at the Institute of Biochemistry, Faculty of Medicine, JLU Giessen
lienhard schmitz 2023-08-10 06:14

Commencing in 2024, a position is available at the Department of Biochemistry within the Faculty of Medicine, offering the possibility to establish an independent research group. The position is initially limited to 6 years, but it can be made permanent upon fulfilling the corresponding requirements. The junior group leader will conduct own research projects and develop new applications in protein mass spectrometry. In addition the scientist will provide technical mass spectrometry support for other researchers. The position will be supported by a technician. Active participation in teaching, as well as acquiring third-party funding, is expected. The opportunity for habilitation is provided upon fulfilling the necessary requirements. The salary is in accordance with the collective labour agreement of the State of Hessen.

For more information, please contact Prof. Lienhard Schmitz

 Job description mass spectrometry.pdf  00_Ausschreibungstext E.pdf 
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