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Scientist LCMS (
AdimabHR 2019-10-13


Adimab is seeking a skilled biochemist to join our Protein Analytics team. This person will work in a small team setting to support Adimab’s novel antibody discovery, maturation, and production platform.


-Develop and execute LCMS-related assays to characterize therapeutic antibodies, investigate PTMs, identify epitopes, and survey chemical liabilities
-Critically interpret data, troubleshoot experiments, and communicate the results to internal customers
-Operate and maintain multiple LCs & mass spectrometers
-Other responsibilities include, but are not limited to, characterization of antibody samples using other analytical technologies such as ForteBio kinetics, chromatographic assays, CZE, etc.

Needed upon hire

-M.S. in biochemistry, analytical chemistry or a related field; industry experience preferred
-Strong biochemistry background with an in-depth technical knowledge of MS
-Strong attention to detail
-Ability to proactively identify and troubleshoot problems
-Adaptable and productive in a fast-paced environment
-Communicates effectively and openly with colleagues and supervisors
-Prior experience with epitope mapping, HDX, or nanospray MS is desired
-Familiarity of scripting workflows and analyses is a plus

Come join us!

As a profitable privately-held biotech company, we take a long-term view on value creation and make substantial investments in technology development, research, and our people. We proudly promote meritocracy and reward employees who are productive, use their resources wisely, and make meaningful contributions to the team. We offer individually tailored compensation packages comprised of a competitive salary, meaningful equity, a 2:1 401(k) match, and comprehensive health care benefits.

Located in New Hampshire’s beautiful Upper Connecticut River Valley, we are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated in an area that is renowned for its premier skiing, hiking, and biking.

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Post-doctoral research position in functional cancer proteomics
kentsisresearchgroup 2019-09-30

Functional Cancer Proteomics

We are a group of biochemists, biologists and physicians in the Molecular Pharmacology Program at the Sloan Kettering Institute in New York City, USA. We carry out research in cancer biology, and our current work is focused on the phenomenon of cellular plasticity, as it relates both to the fundamental mechanisms of cancer pathogenesis and emerging rational therapies.

In particular, we are studying the biology of refractory leukemias and solid tumors, and we are interested in understanding the principles of disorganization of their genomes and proteomes, and determining the molecular mechanisms of response and adaptation of tumor cells to targeted therapies.

To answer these questions, we are developing new approaches, based on quantitative mass spectrometry and functional proteomics, to decipher the mechanisms of cancer cell signaling and develop new therapeutics.

Forward Proteomic Screens for Cancer Therapeutics and Macromolecular Delivery. Using recently developed methods for quantitative proteomics and peptide barcoding (Egloff et al, Nature Methods 2019, PMID: 31113958), we’ve developed a new platform for high-throughput design and screening of macromolecular cell penetration and delivery reagents. This is a transformative technology that enables the generation of new classes of drugs to modulate specific protein-protein interactions, which we’ve recently applied for targeted leukemia therapy (Ramaswamy et al, Nature Communications 2018, PMID 29317678). Current efforts are focused on applying this technology for protein engineering and development of new peptide conjugates for cancer and gene therapy.

Quantitative Cell Proteomics Atlas ( Using developed methods for ultra-sensitive quantitative proteomics (Cifani & Kentsis, MCP 2017, PMID 28821601), we’ve developed an atlas of targeted mass spectrometry assays to profile biochemical signaling at the pathway scale in normal and cancer cells. Current efforts are focused on developing high-throughput and genome-scale methods. This work aims to define systems-level mechanisms of aberrant signaling in cancer cells, as well as fundamental cell biological processes of signaling adaptation, feedback and integration.

If you are a recent PhD graduate with interest in the above areas and experience with nanoscale liquid chromatography, electrospray ionization, high-resolution mass spectrometry or protein engineering and chemistry, please contact Alex Kentsis at or

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Postdoc in Targeted Proteomics, Aarhus University, Aarhus
bh 2019-09-29

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a three-year position as Postdoc in the field of Targeted Proteomics as per 1 December 2019 or as soon as possible thereafter. The position is a fixed-term full-time position.

We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work either in the brand new ‘Skou Building’ or similar as we are in the process of modernizing our old facilities. You can read more about the department here ( and about the faculty here (

About the research project
The position is part of a newly established national research group that investigates the eye disease age-related macular degeneration (AMD). The position is funded by the Velux Foundation. The research work will mainly be to perform LC-MS analyses (targeted proteomics using SRM) and other relevant protein analyses on samples obtained from the other participating laboratories. The samples consist of biological material from patients, research animals and cultured cells.

Your job responsibilities
As Postdoc in Targeted Proteomics your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of:

Independent research of high international quality, including publication.

You will report to Professor Bent Honoré and be supervised by him.

Your competences
The ideal candidate has the following profile:

MSc/PhD in human biology, molecular biology, molecular medicine or similar.
Hands-on experience using liquid chromatography and tandem mass spectrometry (LC-MS/MS) on Thermo Scientific instruments with standard software for instrument control (Xcalibur).
Knowledge concerning preparation of biological samples (e.g., tissue, cells, plasma, serum).
Experience with quantitative analyses of peptides/proteins from biological material using nanoLC and MS-techniques (SRM, MRM on triple quadrupole MS, e.g. TSQ Quantiva).
Ability to pursue and evaluate quantitative analyses and skills to analyze complex data sets using, e.g., Skyline and other types of software for bioinformatics analyses.
Excellent communication and presentation skills. Ability to work as part of a group as well as independently.
Willingness to implement new relevant methods for proteomics analyses of tissue.

For further information please see:

If you have any questions about the position, please contact Professor Bent Honoré at The application must be submitted via Aarhus University’s recruitment system at the latest on the 10th of October 2019, which can be accessed under the job advertisement on Aarhus University's website.

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Translational Research Scientist (with Proteomic Mass Spec expertise)
nancy.finkel 2019-09-12

#1! That’s the ranking that Fast Company gave Novartis in their 2018 list of ‘The World’s Most Innovative Companies’. The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. We collaborate across scientific and organization boundaries, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs from patients.

We seek a creative and collaborative scientist to join the Exploratory Translational Profiling group in Disease Area X and contribute to advancing novel therapeutics by enabling the discovery and validation of novel biomarkers. In this role, you will focus on discovery and targeted proteomics of clinical samples from well-designed disease cohorts, applying competitive edge mass spectrometry and aptamer/antibody-based approaches.

Your responsibilities will include:

• Developing and employing novel approaches to identify, profile and quantify biomarkers in clinical samples to support translational research across multiple therapeutic areas of unmet medical need, including hepatology, nephrology and benign hematology
• Establishing quantitative mass spectrometry and antibody/aptamer assays for measuring proteins in complex biological matrices (plasma, serum, urine, CSF), including data processing and analyses in support of translation to clinical validation /qualification
• Playing a key role in an interdisciplinary team of translational research/medical scientists, biologist and computational scientists
• Participating in alliances with external partners at top healthcare institutions, with the opportunity to publish your work

EEO Statement
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements
What you will bring to the role:

• BS with +7 years experience or MS with +3 years experience in relevant scientific area.
• Proven experience with instrumentation and techniques in mass spectrometry and nano-HPLC is required with experience in targeted and global proteomic profiling.
• Excellent communication, good organizational skills, capacity to multi-task and the ability to work in a fast-paced, team-oriented environment are essential.

Additional desirable attributes include, but are not limited to:

• Translational research and industry working experience, including the handling of clinical samples and data
• Familiarity with developing quantitative antibody/aptamer-based assays with orthogonal detection methods

Why consider Novartis?

750 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

You can apply using the following link: Job ID 276154BR

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Postdoctoral Scholar - Proteomics
aulke 2019-03-29

The Lewis Research Group at the Department of Biological Sciences in the Faculty of Science at the University of Calgary is accepting applications for a Postdoctoral Fellow in Proteomics.

Dr. Lewis‘ team employs state-of-the-art mass spectrometry to investigate the metabolic dynamics of opportunistic pathogens, including Pseudomonas aeruginosa and Staphylococcus aureus, and is working to develop new approaches to detect and control human infections.

Job Description:

The Lewis laboratory is looking for a postdoctoral fellow to aid in developing a large precision medicine project related to microbial proteomics. This position will be a critical part of an interdisciplinary team working to integrate genomics, proteomics, metabolomics, and clinical data to help develop a new approach to infection management.

We are a large, interdisciplinary research group including proteomics, metabolomics, engineering and computer science as well as several Mass Specs for your need.

Check out our posting at
and some more information here: and here:

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Assoc.Scientist - Proteomics/Immunopeptidomics
robert salzler 2019-03-18

Regeneron is looking for a highly motivated Associate Scientist who will leverage our state-of-the-art facilities and technology to perform qualitative and quantitative mass spectrometry experiments focusing on autoimmune, infectious disease and oncology targets. The successful candidate’s primary responsibility will be to utilize the latest mass spectrometry techniques for the discovery and validation of novel viral- and cancer-specific antigens from human tissues and cell lines as well as to develop innovative techniques and investigate new technologies to enhance our target discovery efforts.
The successful candidate will operate state-of-the-art mass spectrometry to analyze patient derived samples. Daily activities will include of tissue preparations, affinity purification, peptide purification, and the analysis of mass spectrometry data. Further responsibilities will be the integration of whole exome sequencing and RNA seq data with mass spectrometry results, developing proteomic databases for the target discovery efforts, and validation of results. Previous experience with mass spectrometry is a highly desirable prerequisite.

Job Duties:
• Participation in the day-to-day operation of Orbitrap Fusion Lumos mass spectrometers
• Engage in method development and optimization
• Preparation of MS samples from a variety of sample types including sample pre-fractionation and proteolytic digestion
• Affinity purification of endogenous peptides from a variety of different samples (i.e. patient tissue biopsies, animal specimens, and cell culture)
• Sample analysis and fractionation using HPLC techniques
• Work closely within and across scientific disciplines to design and perform analyses
• Present data packages and conclusions to internal and external collaborators

• PhD in biology, biotechnology or medicine.
• Basic knowledge of operating an HPLC and mass spectrometer (LC-MS)
• Knowledge in immunology and cancer research
• Experience in basic MS sample preparation and analysis
• Experience with immunoprecipitation sample preparation techniques
• Mass Spectrometric data analysis using Xcalibur, PEAKS, Skyline and general DB search engine tools
• Expertise in large-scale data analysis of NGS (Whole Exome sequencing, RNA-seq, and MS proteomics) is a plus.
• The position requires the ability to work in interdisciplinary projects, independently take responsibility of your project, strong teamwork and communication skills, reliability, attention to detail and effective time management.

Please apply using the link below

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