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Showing: all postings
Lab Research Analyst II, Duke Proteomics and Metabolomics Core Facility
Will Thompson 2021-02-22

LAB RESEARCH ANALYST II , Duke University School of Medicine
Duke Proteomics and Metabolomics Core Facility
Durham, North Carolina

Position Description:
Seeking a self-starting scientist with good problem-solving skills and strengths in quantitative analysis, particularly by LC-MS/MS. Job duties will be to work in a fast-paced, team-based environment to conduct a variety of complex and independent investigations addressing physical, chemical, and other research laboratory experiments to obtain and interpret data for research projects at Duke, specifically addressing metabolomics and proteomics in cancer, neurodegenerative diseases, and infectious diseases. Scientific integrity, curiosity, and determination are key qualities of a successful candidate.

In particular, under the guidance of the Director or Assistant Director, the Lab Analyst II will conduct a variety of complex laboratory procedures and specialized laboratory techniques for the analysis of endogenous metabolites, drug molecules, peptides and proteins in the Proteomics and Metabolomics Core Facility for the School of Medicine. Note that both SOP-driven and independent analyses will be required, and proven analytical thinking and problem-solving skills are critical. The ability to effectively work in a multidisciplinary team environment and move easily from one task to another is essential.

Position requires a bachelor’s degree in Chemistry, Biology, or related field and a minimum of 4 years experience. Master’s degree or Ph.D. can substitute for appropriate years’ experience.

Tasks may include:

  1. 40% - Preparation of biological samples for metabolomic, proteomic, and pharmacokinetic analyses.

  2. 40% - Quantification of metabolites using triple quadrupole mass spectrometry, and contribution to the development of new LC-MS/MS assays. Validation of figures of merit for quantitative LC-MS/MS assay.

  3. 10% - Protein identification and quantitation using nanoscale capillary liquid chromatography and analytical scale liquid chromatography coupled with either high resolution, accurate mass tandem mass spectrometers (LC/MS/MS) or triple quadrupole mass spectrometers operated in MRM mode.

  4. 5% - Contribution to written reports and publications of results in collaboration with investigators inside and outside of Duke. Review journals, abstracts and scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.

  5. 5% - Presentation of their ongoing work at group meetings, and critical evaluation of new approaches for metabolomics and proteomics presented in the literature or by others.

Interested applicants can find more information and apply for the position at the link below:
https://careers.duke.edu/job/Durham-LAB-RESEARCH-ANALYST-II-NC-27710/713080600/?locale=en_US

Interested individuals may contact Will Thompson (will.thompson at duke.edu) for more information, however applications must be processed through the Duke Careers web site.

view posting
Staff Scientist, Analytical Chemistry
diana saggese 2021-02-21

Regeneron’s Analytical Chemistry Group, Inc. located at Tarrytown, NY is looking for a Staff Scientist, Analytical Chemistry. The Staff Scientist will work in a state-of-the-art analytical lab and lead characterization of therapeutic protein drug candidates to enhance all stages of drug development, from early-stage candidate selections to late-stage regulatory submissions. As a group, our Analytical Chemistry team develops innovative mass spectrometry-related technologies to support Regeneron R&D programs in the context of multidisciplinary project teams.

A Typical Day in the Role Might Look Like:
•Lead analytical and biochemical characterization of therapeutics, including monoclonal antibodies, bispecifics, adeno-associated virus and other therapeutic drug candidates to support different drug development activities;
•Accountable for the development of analytical strategies and methods to elucidate and ascertain quality attributes, risk assessment and control strategies, including PTMs, product and process related impurities, especially for host cell proteins (HCPs), charge variants, LMW/HMW species, sequence variants, etc., to address emerging challenges
•Provide analytical mentorship and support for formulation development, upstream and downstream functional groups manufacturing to tackle real-time development issues in the process development and OOT/OOS investigations
•Identify and drive technical innovations that will supply future developmental needs and improvements
•Present work at the internal and external meetings; prepares and reviews development reports, memos, and regulatory submission documents in CMC (e.g., IND, IMPD, BLA, MAA, comparability and other study reports.) and peer-reviewed articles for publications
•Serve as a team representative and provides the knowledge and expertise of analytics to cross-function teams;
•Supervise and improve staff performance and build a scientific climate of excellence to achieve business goals.

This Role Might Be For You If:•Developing innovative mass spectrometry related technologies and an in-depth understanding of analytical chemistry is a passion of yours
•You have strong initiative to complete results-oriented tasks and drive new technologies related to Formulation Development.
•You are capable of multi-tasking, working both independently and with a collaborative demeanor.

This role requires PhD in chemistry, or biochemistry with 5-10 years of shown experience, and consistent track record of publications in the field of endeavor. Experience in liquid chromatography and mass spectrometry with biopharma experience especially in host cell proteins (HCPs) analysis is highly desired. Knowledge of both upstream and downstream process development is a plus. Expertise in mass spectrometry principles and applications for protein characterization, with keen analytical and problem-solving skills, especially for Orbitraps, Q-Exactive, Q-TOF and/or Triple-quadruple MS systems desired. Knowledge of and trouble-shooting skills in separation science (e.g. U/HPLC, nanoLC, SEC, IEX, HIC, HILIC, 2D-LC, CE, iCIEF, etc.) needed. Proficiency in LC and MS-related software, such as Xcalibur, MassLynx, MassHunter, Proteome Discoverer, Byonics, Skyline, Panorama, Empower desired. Abilities in computer programming and bioinformatics a plus. Experience with liquid handling and automation systems is a plus. Excellent oral and written communication skills and interpersonal skills a plus. Experiences in composing regulatory submission documents and knowledge in the industry practice and regulatory guidance on analytics development desired. Passion for science with strong leadership and motivation of making contributions in a team environment is a must.

To Apply: https://careers.regeneron.com/job/23276BR/Staff-Scientist-Analytical-Chemistry

Contact: Haibo Qiu/ Diana Saggese
diana.saggese@regeneron.com

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Scientist/Senior Scientist, Analytical Development (Mass Spectrometry)
echan 2021-02-17

AbSci is a growth stage synthetic biology company located in a new, state-of-the art laboratory in downtown Vancouver, WA, just across the river from Portland, OR. AbSci is a global leader and innovator of revolutionary biomanufacturing technologies, designing and programming cells for next-generation biopharmaceuticals. Our Protein Printing™ technology results in dramatic reductions in the cost of producing biologics, acceleration of drug discovery timelines, and enables the production of previously difficult or impossible-to-produce molecules. Our technology is a new paradigm in protein production, as it increases discovery throughput, accelerates development, reduces manufacturing costs, and increases plant capacity for the biopharmaceutical industry.

Job Description:
We are currently seeking a self-motivated, passionate, and accomplished Scientist to join our Analytical Development team. Using your strong attention to detail, you will play a significant role in analytical method development and characterization of therapeutic proteins expressed using SoluPro™, AbSci’s proprietary E. coli expression platform. You will utilize your successful background in the development and analytical characterization of complex biologics by LC-MS and proteomics approaches while exploring new and innovative technologies. This position will utilize your interpersonal and strong written and verbal communication skills for multi-disciplinary collaboration with the other teams within AbSci, including Molecular Sciences, Fermentation, Purification, and Bioinformatics. You bring a passion for scientific innovation, excellent technical skills, and you execute your responsibilities with high attention to detail. You work with a sense of urgency, and thrive in a team dynamic in a high-performance culture.

Responsibilities:
Develop and execute laboratory tasks to support the development and optimization of various mass spectrometry-based methods for the characterization of complex biotherapeutics by LC-MS, including intact mass, disulfide mapping (including PTMs), and targeted mass spectrometry (PRM/MRM)
Perform multi-step sample preparations including enzymatic digestion (solution and in-gel), reduction/alkylation, buffer exchange, deglycosylation, sample concentration, etc.
Method development and optimization for transfer to non-mass spectrometry, stand-alone LC-UV-based techniques for analyses of protein biologics
Operation, maintenance, and installation of LC-MS instrumentation
Write and review formal reports, including method SOPs, reports, and other technical documents
Evaluate data for trends indicative of product performance, method performance, and/or analyst performance and present internally to team members and senior management
Oversee routine instrument operation and maintenance
Lead, mentor, and inspire junior team members
Evaluate new technologies and platforms
Support internal technical teams, including R&D, fermentation and purification process development teams
Maintain accurate documentation of all work in laboratory notebooks

Qualifications:
PhD in Analytical Chemistry, Biochemistry, or related scientific disciplines
Experience in protein engineering, expression, purification, and biochemical characterization (e.g. antibodies, cytokines, and antigens).
Hands-on knowledge of protein analytics and characterization by LC-MS, including intact mass, disulfide mapping, PTMs, and targeted mass spectrometry (MRM/SRM)
Hands-on experience with SDS-PAGE, Western blot, and capillary electrophoresis
Experience in the operation, maintenance, and troubleshooting of associated instrumentation
Strong capabilities in experimental design, execution and data interpretation
Ability to communicate with colleagues and business partners who do not share candidate’s core area of expertise is required
Huge plus (but not required):
Post-doctoral and/or industry experience preferred; 2+ years industry experience is a plus
Experience with Sciex and Thermo MS and Agilent LCs is preferred
Experience with proteomics is preferred
Experience in LC-MS sample preparation for implementation on automated liquid handlers is preferred
Experience with JMP or comparable statistical software packages is preferred
Proficiency in Python or R is a plus
Experience with ELISA, BLI, and SPR is a plus
Experience working with CMO’s and CRO’s for methods transfer, method optimization, and data and report review is a plus
Knowledge of cGLP/cGMP, FDA, EMA, ICH guidance and industry standards for analytical development and characterization of proteins is a plus

We seek candidates with a passion for building a creative company culture that is collaborative, multidisciplinary, and committed to making a transformative impact on our industry. To be successful in this role, we look for passion in technology innovation, adept technical skills, and excitement about working in a dynamic startup environment. A demonstrable track record of success in functioning as part of a project team is essential.

Apply here:
https://grnh.se/ed9d1f623us

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Senior Scientist - Proteomics
afederat 2021-02-16

Talus Bio is an early-stage drug discovery company located in Seattle, WA that partners with pharmaceutical companies to discover and develop cutting-edge therapeutics for gene regulation.

Role Description

We are seeking a Senior Scientist to join our team in a full-time role. The scientist will work in a small team setting to develop and improve our platform for drug discovery of gene regulators. We are looking for a technology leader interested in developing and applying new proteomics technologies to solve complex biological problems who are interested in working in a fast-paced, innovative, early-stage biotech environment.

Responsibilities

  • Experimental design and laboratory execution of biochemical and mass spectrometry-based assays including proteomics data processing, visualization, and biological interpretation
  • Protein isolation from mammalian cells and peptide preparation for mass spectrometry
  • Routine usage of Thermo Orbitrap mass spectrometers with HPLC separation and high-throughput quantitative proteomics methodologies-
  • Mass spectrometry data analysis using bioinformatics software including R and/or Python
  • Conduct independent research and demonstrate scientific leadership within the project team and across departments; Collaborate with all the functions within the Company to advance our science
  • Accurately document experiments and results in electronic laboratory notebooks in a timely fashion
  • Maintain a safe and productive laboratory environment
  • Prepare and present experimental results, analysis, and plans in R&D meetings

Qualifications

Required

  • The successful candidate will have a PhD with 0-3 or BS/MS degree with 5-7 years of industry experience developing and analyzing quantitative mass spectrometry proteomics assays
  • Familiarity with proteomics raw data processing, interpretation, and visualization
  • Familiarity with Thermo instrument software (XCalibur, Tune) as well as Skyline
  • Experience with LCMS method development, maintenance, and troubleshooting
  • Understanding of best-practices for proteomic sample handling and preparation
  • Ability to deliver complex results to teams of diverse scientific backgrounds
  • Ability to work effectively and collaboratively on cross-functional projects teams
  • Excellent oral, presentation, and written communication skills

Preferred

  • Experience working with Data-Independent Acquisition (DIA) proteomics data
  • Familiarity with AWS cloud data processing pipelines and/or the WDL or NextrFlow computational biology pipeline languages
  • Familiarity with cancer biology and/or drug discovery
view posting
Marine Metabolomics Research Technician, University of Florida
bryndandurham 2021-02-13

The Durham Lab at the University of Florida is currently recruiting a laboratory Research Technician. The start date is flexible, but ideally the successful candidate would begin between April 2021 and June 2021. Research in the Durham Lab (https://www.durham-lab.com) focuses on the molecular ecology and chemistry of environmental microbes. Current projects include exploration of metabolite exchange in marine phytoplankton-bacterial interactions and terrestrial moss-cyanobacterial interactions. The technician will be primarily responsible for processing and analyzing microbial and plant samples using liquid chromatography-mass spectrometry (LC-MS)-metabolomics techniques. In particular, the technician will analyze samples using high-resolution LC-MS system(s) located in the UF’s Interdisciplinary Center for Biotechnology Research (www.biotech.ufl.edu) mass spectrometry core facility. Other responsibilities may include microbial cell culture, administration of the lab (e.g., lab safety, chemical inventory, ordering supplies), and LC-MS data analysis. This is a one-year term position with the potential for renewal. We will consider candidates who seek part-time or full-time work, with a minimum commitment of 20 hours per week.

Fundamental requirements and qualifications include the following:
• A Bachelor’s degree in Chemistry or related field
• Demonstrated knowledge of chromatography and/or mass spectrometry methods
• Strong work ethic and independence
• Excellent communication and teamwork skills
• Excellent English writing and speaking ability
• Ability to manage multiple projects
• Excellent organizational skills and attention to detail

Additional, preferred qualifications include the following:
• A Master’s degree or work experience in environmental or analytical chemistry or related field
• Demonstrated scientific writing skills (preferably through publication record)
• Data analysis experience (R or Python)

 Technician_Job_Posting.docx.pdf 
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Postdoctoral Fellow
pandafj 2021-02-10

Tulane University: School of Medicine: Basic Science Departments: Biochemistry & Molecular Biology
Location
New Orleans, LA
Open Date
Jan 19, 2021

Description
The Postdoctoral Fellow for the Department of Biochemistry and Molecular Biology will be responsible for developing mass spectrometry-based new technologies and approaches to detect and measure biomarkers associated with cancer and infectious disease, and to employ these methods to analyze samples from animal models of human disease and human subjects to test and validate their performance.

We are a multi-disciplinary team across biology, chemistry and bioinformatics. You will join a team that focuses on developing non-invasive approaches for early disease diagnosis and disease prognosis, the use of advanced mass spectrometry approaches for proteomics and protein/peptide characterization, and analysis of extracellular vesicles as biomarkers in the progression of cancer and infectious disease.

Qualifications

  1. Recent Ph.D. in in protein mass spectrometry, proteomics or related field, with demonstrated skills in analytical chemistry, MALDI, LC-MS/MS
  2. Research experience in nano/micro scale liquid chromatography, electrospray ionization, high resolution mass spectrometry, protein biochemistry, top-down and bottom-up proteomics including project design, sample preparation and data analysis, PTM identification.

Equal Employment Opportunity Statement
Tulane University is an Equal Employment Opportunity/Affirmative Action institution committed to excellence through diversity. Tulane University will not discriminate based upon race, ethnicity, color, sex, religion, national origin, age, disability, genetic information, sexual orientation, gender identity or expression, pregnancy, marital status, military or veteran status, or any other status or classification protected by federal, state, or local law. All eligible candidates are encouraged to apply.

Application link: https://apply.interfolio.com/83136

 Apply - Interfolio.pdf 
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Post-doctoral fellowship in data independent acquisition method development using 21 Tesla FT-ICR MS
Mike MacCoss 2021-02-10

The National High Magnetic Field Laboratory (NHMFL) is searching for a postdoctoral fellow to assist the Ion Cyclotron Resonance (ICR) Program instrumentation group. The ideal candidate for this postdoctoral position will be a scientist with experience in the field of mass spectrometry with a record of significant scholarly activity. Experience in mass spectrometry applications and/or software development for mass spectrometry data analysis is desired.

The postdoctoral fellow will work with the FT-ICR Facility permanent staff to implement a novel data-independent analysis pipeline for the flagship 21 Tesla FT-ICR MS and help develop downstream software to analyze the data in collaboration with the MacCoss Laboratory at the University of Washington. The candidate will collaborate with NHMFL and MacCoss laboratory staff. Travel funds have been allocated for an extended learning/collaboration opportunity to perform research at the University of Washington within the MacCoss Laboratory. Candidates are expected to have a Ph.D. in a relevant field.

The NHMFL is the world’s premier magnet laboratory with state-of-the-art high magnetic field facilities (up to 21T in superconducting magnets, 36T in resistive DC magnets, 45T in hybrid DC magnets, and 100T in pulsed magnets) for research in physics, materials science, engineering, chemistry geochemistry, biochemistry, and biology.

Interested candidates can apply to Florida State University at https://jobs.fsu.edu and reference Job Requisition #48464. Please attach your curriculum vitae, cover letter describing your research experience, and names and contact information of at least three references. For additional information, please contact Ms. Bettina Roberson, National High Magnetic Field Laboratory, Florida State University, 1800 E. Paul Dirac Drive, Tallahassee, FL 32310-2740, 850-644-0855. Additional information may be attached and emailed to roberson@magnet.fsu.edu. The NHMFL is operated for the National Science Foundation by a collaboration of institutions comprising Florida State University, the University of Florida, and Los Alamos National Laboratory. The Florida State University is an Equal Opportunity, Affirmative Action employer, committed to diversity in hiring, and a Public Records Agency.
If you have any questions, or want to check directly about the position, please do not hesitate to contact Chad Weisbrod at weisbrod@magnet.fsu.edu or Mike MacCoss at maccoss@uw.edu for further information.

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Scientist/Senior Research Associate
fiona 2021-02-08

Who we are:
Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.
Position description:
Calico is seeking an experienced Senior Research Associate/Scientist to join the mass spectrometry proteomics group. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. We are looking for someone with detailed knowledge of proteomics and biochemistry techniques, and with demonstrated hands-on application. This is a hands-on bench position, focused on sample preparation, instrument maintenance, troubleshooting and data analysis. The successful candidate will work with a large numbers of samples for collaborative projects, optimize and develop methods as well as be responsible for smaller research projects. The Proteomics group collaborates with multiple labs within Calico, and as such is involved in many areas of research from oncology to immunology, as well as technology and assay development.
Responsibilities:
• Prepare samples from tissues, cells, and biofluids.
• Optimize and develop new sample preparation methods
• Maintain and troubleshoot instruments including HPLCs, mass spectrometers and other bioanalytical equipment.
• Analyze data to share will collaborators
Position requirements:
• Recent PhD graduates are encouraged to apply. Or thesis-based MS in biochemistry or related discipline required, plus 5 years of research experience in an academic or industry.
• Experience in method development for HPLC and/or mass spectrometers
• Experience in maintaining and troubleshooting HPLCs and mass spectrometers
• Experience in sample preparation for proteomics (e.g. isobaric labels)
• Experience in proteomics data analysis and basic coding (e.g. R, Matlab, Python)
• Detail-oriented and organized
• Strong teamwork and communication skills
• Self-motivated with a “can-do” attitude is required for success
• Flexible, able to respond quickly to shifting priorities and able to multitask
• Demonstrated ability to design, execute and draw conclusions from scientific projects

Nice to have:
• Experience maintaining Thermo mass spectrometers (e.g. Eclipse/Lumos) and HPLC
• Experience in automation and liquid handling platforms
• Experience in affinity/immunoprecipitation of proteins and post translational modification
• Experience in native fractionation FPLC/HPLC.

Link to apply: https://www.linkedin.com/jobs/view/2384574356/?capColoOverride=true

 Scientist_SRA_Contractor_JD.pdf 
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AI software engineer/developer at EpiQMAx GmbH
solis 2021-02-06

At EpiQMAx, we offer a service to pharmaceutical companies and research institutes, based on mass spectrometry, for the measurement of epigenetic and post-translational modifications on histones and other proteins. An essential challenge in our domain is the discovery and identification of markers associated with a disease or a biological condition.

We are looking for an AI developer/engineer, whose role will be to use classical ML algorithms as well as develop CNN models for the discrimination of distinctive proteins and PTMs associated with a condition. As input data, she/he will count with matrix-like files and images.

Candidate requirements: Master Sc. or Ph.D. title in Computer Science or Statistics/Data Analysis, Bioinformatics or alike. Good to very good knowledge of ML/AI models, architectures, and model training. Good to vast expertise on image classification and object recognition.

Apply by sending your CV and a cover letter to info@epiqmax.de

More information about the position can be found on our careers site: https://epiqmax.com/career

view posting
Senior Associate Scientist, Platform Biology
kelli nolan 2021-02-05

This key position in our platform biology group will develop and perform mass spectrometry (MS) assays in support of proteomics applications for our therapeutic areas. The candidate will be expected to work with key stakeholders and under direction of senior members of the group to perform analyses to support our understanding of the mechanism of action, cell-based activity and biophysical properties of our small molecule protein degraders. This position reports to Principal Research Investigator, under the supervision of Senior Research Scientist in the Platform Biology department and will be located at our headquarters in New Haven, CT.
Qualifications
• Extensive hands-on experience with Orbitrap MS platforms
• Experience with liquid chromatography systems (nanoLC experience is preferred)
• Proficiency in MS acquisition methods such as data-dependent acquisition (DDA), data-independent acquisition (DIA), parallel reaction monitoring (PRM), etc.
• Experience with labeled MS quantitation methods such as TMT and iTRAQ
• Hands-on experience with MS proteomics sample preparation methods including BCA quantitation, tryptic digestion, peptide desalting, phosphopeptide enrichment, peptide labeling
• Experience with targeted MS protein quantitation using heavy isotope labeled standards
• Experience with top-down MS methods for intact protein analysis
• Proficiency in mass spectrometry analysis software packages including Proteome Discoverer, Scaffold, and Skyline.
• Ability to trouble-shoot and problem-solve independently while under general supervision by the project leader
• Ability to organize and work on multiple projects simultaneously
• Excellent data handling and recording skills as well as oral and written communication skills is required.

 Arvinas Senior Associate Scientist Platform Biology Proteomics-Final-2.docx 
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PD at the Laboratory of Biochemistry of Oxidants and Radicals at the Chemistry Institute USP, São Paulo
oaugusto 2021-02-05

Description: A full-time, FAPESP-funded postdoctoral position is available at the laboratory of Biochemistry of Oxidants and Radicals at the Chemistry Institute USP, São Paulo, Brazil. The project aims to characterize protein cross-links produced by oxidative processes in vitro and in biological samples, investigating the role of these modifications in protein dysfunction, oligomerization and aggregation. The project will take place in the highly collaborative environment of the RIDC Redoxoma (http://redoxoma.iq.usp.br/). This opportunity is open to candidates of any nationality for 30 days after publication.

Eligibility: Candidates have a PhD degree (for less than six years) in Chemistry, Biochemistry, or related fields. Previous experience with LS-MS/MS of oxidized proteins (including bioinformatics tools) and/or free radical chemistry and NMR analysis are desirable. Candidates should send a letter of motivation of up to one page and the curriculum vitae to Professor Ohara Augusto´s email (oaugusto@iq.usp.br).

Salary: The selected candidate will receive a Post-Doctoral fellowship from the São Paulo Research Foundation (FAPESP) and a research contingency fund 10% of the annual value of the fellowship to spend in items related to the research activity.
Contact: Ohara Augusto (oaugusto@iq.usp.br)

 Augusto_O_publications.doc 
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Proteomics Specialist I/II/Post-doctoral fellow
young goo 2021-02-04

Summary of Open Positions:
The Proteomics Core Facility at Northwestern University, has an opening available for highly qualified, highly motivated applicants for the position of Proteomics Specialist. The Proteomics Core is a recharge facility within the Proteomics Center of Excellence (PCE) serving regional, national and worldwide researchers for their proteomics needs. The position is available for immediate start.

Research Environment:
Successful applicants for these positions will be expected to work well as both a leader and a follower in a team environment and demonstrate the ability to work diligently and independently toward tangible, hypothesis-driven or discovery research goals on multiple biomedical projects that users and collaborators wish to achieve. The Proteomics Specialist will participate in the design and execution of research plans under the direction of the Proteomics Core director. We are currently looking for staff with experience in quantitative proteomics, phosphoproteomics, targeted proteomics (SRM/MRM), X-linking MS, Ion Mobility MS, HDX-MS, and/or Top-Down proteomics. Prior experience in one or more of these techniques is strongly preferred, but not required for highly qualified applicants. If selected for this position, you will immediately be immersed into a dynamic research environment with >6 high-end mass spectrometers and all of the support equipment that one would need to be successful. In addition to mass spectrometers, successful applicants will be familiar with multidimensional liquid chromatography, bioinformatics, and data processing pipeline. Prior knowledge in Mascot, Scaffold, MaxQuant, Perseus, Skyline, and/or statistical analysis is strongly preferred. The Proteomics Specialist will analyze data and present interpretations to users/collaborators as well as prepare manuscripts for collaborative publications in peer-reviewed journals. The Proteomics Specialist will be expected to contribute to report writing within the research center.

Minimum Preferred Qualifications:
Ph.D. or equivalent doctorate with 0-5+ years’ experience;
Demonstrated independent problem-solving skills;
Strong written and verbal communication skills

Apply:
Send your updated C.V. or resume to:
young.goo@northwestern.edu
http://proteomics.northwestern.edu/

view posting
Senior Research Associate on Proteomics - Impossible Foods, Redwood City, CA
Yiming Chen 2021-02-04

Play here: https://jobs.lever.co/impossiblefoods/401f5851-7291-4294-afec-704d7f8ad2b5

Impossible Foods is addressing the most catastrophic threats facing humanity: climate change and biodiversity collapse. A global transition to a plant-based food system will turn back the clock on atmospheric CO2 levels, restore natural ecosystems and reverse meltdown in wildlife biomass.

The easiest -- if not only -- way to make our civilization sustainable is to eliminate livestock, the most dangerous technology on Earth. But humans won’t give up meat. So we need to make meat better -- more delicious and more nutritious, without animals as the underlying production technology. That means that making meat sustainably is the most important and urgent problem for the global scientific community.

Impossible Foods' mission is to completely replace the use of animals as a food-production technology by offering consumers everything they currently value about animal products -- and making products that are vastly superior to their animal analogues.

To do this, we are taking a revolutionary scientific and market-based approach. We are inventing efficient, sustainable ways to transform ingredients from plants into meat, fish and dairy foods that deliver all the pleasures and nutritional benefits consumers demand, without the destructive environmental or public health impact.

Our world-class R&D team has been building the know-how and technology platform to produce meat, fish and dairy foods from plants. Impossible Foods is experiencing rapid growth and is resolutely committed to leading all aspects of the plant-based food revolution—from discovery to commercial production. The only thing that will separate Impossible Foods from success and failure is our ability to recruit more world-class experts.

Want to join? Check out the job opening and requirements below:

We are inviting an experienced researcher with broad knowledge of proteomics and mass spectrometry to join the Discovery Team at Impossible Foods at Redwood City, CA. We are looking for a top-tier scientist to design and perform high-throughput proteomics experiments, and to develop in-house protein analysis platforms. Alongside your R&D team members you will collaboratively tackle some of the hardest challenges at the frontier of food science and biotechnology.

You Will:

  • Use your knowledge in analytical chemistry and biology to design and perform high-throughput quantitative proteomics experiments.
  • Develop new analytical methods for mass spectrometry-based protein analysis, including but not limited to bottom-up proteomics, top-down proteomics, targeted proteomics, PTM characterization, peptide mapping, intact protein MS, native MS.
  • Collaborate with other researchers on the projects in different fields including microbiology, downstream processing, materials and texture, nutrition, food science, legal and regulation.
  • Performing MS data processing and statistical analysis with various software packages.

You Have:

  • Ph. D./M. S., or equivalent, in chemistry, biology, or related fields.
  • Strong oral and written communications skills.
  • Abilities to work efficiently with diverse and dynamic teams.
  • A self-motivated personality and an “can-do” attitude are required for success.
  • Good hands-on abilities. Good observer and recorder.
  • Avid data analyst.
  • Extensive hands-on experience on proteomics sample preparation, including but not limited to: sample homogenization, protein extraction, proteolytic digestion, peptide fractionation.
  • Extensive experience and knowledge on using LC-MS systems, preferably Thermo Orbitrap series instruments.
  • Experiences in data processing with programming languages such as Python or R are strongly preferred, especially on pipeline & workflow development and web frameworks.

Impossible Foods Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

view posting
Mass Spectrometry Senior Scientist- InterVenn Biosciences
xcong 2021-02-04

SUMMARY

InterVenn Biosciences is seeking mass spectrometry scientists to join our highly collaborative and supportive mass spectrometry team. Candidates will have substantive experience in the field of mass spectrometry-based proteomics/glycoproteomics, and will be highly motivated and resourceful. Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
● Lead projects in analytical method development and optimization. Develop LC-MS based targeted biomarker assay (SRM/MRM) and facilitate method validation activities.
● Be responsible for mass spectrometry instrumentation operation, troubleshooting and maintenance.
● Train and supervise new analysts in glycoproteomics mass spectrometry workflows.
● Manage multiple projects within timelines according to high scientific and ethical standards.
● Align and collaborate with project managers, data science team and clinical laboratory personnel across the biomarker assay product portfolio.
● Promote a culture of transparency and traceability across all aspects of laboratory operations.

SKILLS AND QUALIFICATION REQUIREMENTS
● Ph.D. in biological sciences, chemistry, or analytical chemistry.
● Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially triple-quadrupole MS (QQQ).
● Extensive experience in targeted mass spectrometry-based proteomics/glycoproteomics.
● Extensive knowledge of application of complex sample preparation methodologies for protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies, in particular SRM/MRM methods.
● Proven track record of LC-MS based method development and validation for proteomics biomarker assays.
● Applied knowledge of/experience with MS software analysis pipelines.
● Experience in the pharmaceutical/biotech, diagnostic, or life-science-tools industry is preferred.
● Experience in developing computational algorithms proteomics data processing and skills in computational programming languages (e.g. Python) is a plus.
● Working experience in regulatory-compliant environments (GxP) and familiarity with regulatory guidelines on bioanalysis (FDA, CLSI etc.) is a plus.
● Proven record of being a fast learner, flexible, and mindful team member.
● Excellent verbal and written communication skills.

view posting
Postdoctoral position in translational proteomics in Freiburg, Germany
mcfoell 2021-02-04

The laboratory for Functional and Translational Proteomics, led by Prof. Oliver Schilling, is part of the Institute for Surgical Pathology, at the University Medical Center Freiburg, Germany. We are soliciting applications for a postdoctoral researcher to join our friendly and open-minded team of about 15 scientists with backgrounds in biology, chemistry, medicine, pharmacy and bioinformatics.

The project enables the unique opportunity to shape the next generation of translational proteomics by integrating state of the art approaches for sample preparation, data acquisition and data analysis to unravel proteomic characteristics of diverse solid tumors.

Selected tasks include:

  • Improvement of existing and development of new methods, especially for shotgun proteomics to allow additional analysis such as regulatory modifications and proteogenomics
  • Establishing targeted proteomic assays
  • Contribute to the supervision and maintenance of our diverse mass spectrometers
  • Active collaboration with medical doctors and life scientists on local, national and international level

We offer

  • Full-time postdoctoral position (TV-L E13, 100%) for initially two years (extension possible); starting date is flexible but early in 2021 is preferred
  • Highly translational projects with clinical relevance in a productive and friendly work environment with international and industry collaborations
  • Well funded and equipped lab
  • Ample opportunities for scientific publishing, conference presentations, grant applications and student supervision
  • Plenty opportunities for scientific and professional development

Required qualifications include a PhD in a life sciences discipline (e.g. biology, molecular medicine,
chemistry, pharmacy); strong scientific background and experience in mass spectrometry based
proteomics including sample preparation, LC-MS/MS instrument handling and ideally also data
analysis. Experience with cell culture techniques, protein biochemistry, molecular biology, and / or
microscopy is an asset. We also ask for a proactive and cooperative work attitude with excellent
problem-solving and organizational skills, very good communication skills in English (written and
spoken), and an interest in supervising (PhD) students.

For further inquiries please contact
oliver.schilling@uniklinik-freiburg.de

To apply, please send CV, motivation letter and contact details of two references to melanie.foell@uniklinik-freiburg.de.

Please find further information in the attachment.

 postdoc_Schilling_lab.pdf 
view posting
Sr. Data Scientist for Proteomics and Metabolomics
wen yu 2021-02-04

We're currently looking for a highly motivated bioinformatic/data scientist to join our team in the department of Data Science & AI. The candidate will primarily work with the proteomics and metabolomics labs in Astrazeneca on novel analytics, and workflow automation to derive more values from the MS data. Additionally, the candidate will contribute to multiomics analysis, mining of large complex datasets to advance our understanding of diseases for biomarker identification and/or target validation. The position will be based in Gaithersburg, MD.

Please submit your application at the link below.
https://astrazeneca.wd3.myworkdayjobs.com/Careers/job/US---Gaithersburg---MD/Senior-Data-Scientist_R-098286

view posting
Protein Structural Mass Spectrometry Position
ray blind 2021-02-04

Greetings!

My lab at Vanderbilt University in Nashville, TN, USA is looking for a biochemistry-minded research scientist, research associate or postdoctoral fellow interested in applying mass spectrometry-based approaches to protein structural biology. We recently published the first full-length integrated structural model of a monomeric nuclear receptor. The model of this transcription factor bound to a DNA oligo was derived largely from mass spectrometry-based data:

https://www.cell.com/structure/fulltext/S0969-2126(20)30166-0

The target protein is the nuclear receptor LRH-1 (NR5A2), a ligand activated transcription factor and target for antidiabetic drug design. The above paper establishes the unperturbed ground state structure. Your project will be to determine how known small molecule ligands, drugs, hormones, peptides and DNA sequences regulate this structure.

The techniques we applied to determine the above structure included BS3 chemical crosslinking, benzophenone artificial amino acid crosslinking, engineered disulphide crosslinking and hydrogen-deuterium exchange (HDX). We used these techniques as amino acid proximity sensors in this multi-domain protein target to model how the individual domains interact with each other. For more details please visit my lab site:

http://www.blindlab.org

Although scientist-level candidates should have extensive proteomic data analysis, protein expression, purification and characterization experience, postdoc or research associates need only basic protein biochemistry skills, an eagerness to learn and a strong sense of scientific bravery.

Send your CV to the PI (Ray Blind) at ray.blind@vanderbilt.edu, soon-to-be PhD graduates are specifically encouraged to apply.

view posting
Protein/Peptide Mass Spectrometry Post-Doctoral Research Fellow
cbroeckl 2021-02-04

This position will be dedicated to supporting and advancing services in the areas of quantitative, qualitative, and structure protein and proteomics analysis using mass spectrometry. This position will have opportunities in both collaborative and independent research supporting analytical knowledge and assay development within our facility.

The Bioanalysis and Omics Center of the Analytical Resource Core (ARC-BIO), formerly the Proteomics and Metabolomics Facility, PMF) is a Center within the Analytical Resources Core (ARC), operated under the office of the Vice President for Research and is located on the CSU main campus in the Microbiology building. The mission of ARC-BIO is to serve as an enabling resource for research and development programs at Colorado State University. We strive to build mass spectrometry instrument capabilities that exceed the normal resources of individual research programs, and make those technologies available as a shared resource. We also aim to provide an environment rich in expertise and educational resources, and to foster collaboration across the CSU community and beyond. ARC-BIO works closely with other ARC Centers, including Imaging and Surface Science (ISS) and Materials and Molecular Analysis (MMA). ARC-BIO works closely with researchers at CSU, from other academic institutions, with governmental and non-profits, as well as with corporate researchers.

https://jobs.colostate.edu/hr/postings/82144

Applications must be submitted through the CSU jobs portal.

view posting
Postdoctoral Research Fellow – Pharmacokinetics and Metabolomics: Merck Research Laboratories: West Point, PA
shivangi awasthi15418 2021-02-04

West Point, Pennsylvania, United States of America Job Type : Full time

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Merck Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

What You'll Be Doing:

You'll be helping us build metabolomics capabilities for improving drug metabolism and pharmacokinetics. You will join a dynamic bioanalytical group, also work closely with drug absorption, distribution, metabolism and excretion (ADME) experts and big data modeling scientists in PPDM to study the roles of endogenous molecules (including metabolites, lipids and peptides) in our drug discovery models. The goal is to develop novel predictive approaches based on the flux of endogenous molecules to enable early detection of drug-drug interactions and drug clearance pathways.

Responsibilities include but are not limited to:
Interact frequently with key collaborators and solicit input from bioanalytical and ADME experts to shape study plans. This includes but not limited to:
Design in vitro and in vivo studies on preclinical species using probe drugs to generate hypotheses driven samples.
Generate metabolomics data. Analyze samples using state of the art LC/MS instruments and coordinate with other capability groups within our company or CROs.
Metabolomic data analysis and model building to link endogenous molecules changes responding to probe drugs.
Drive novel hypotheses based on data; conduct new experiments to progress continuously and achieve predictability.
Prepare manuscripts for novel findings

What You Need:
Candidates must currently hold a PhD OR receive a PhD by fall of 2021.
A record of establishments in advancing metabolomics workflow and applications including analytical platform development and biological sample analysis
Excellent big data processing, visualization (including graphical model) skills with proficiency of metabolomics bioinformatic software packages including pathway analysis
Excellent verbal and written communication skills; ability to excel in a team-interactive environment.
Proven record of innovation with publications in peer-reviewed journals and presentations in leading scientific conferences (ASMS, Metabolomics, etc.).

It's Great If You Have:
Experiences working with endogenous molecules flux for enzymatic systems
Ability to create novel data visualization methods when existing software doesn’t suffice.
Proven understanding of drug metabolism and pharmacokinetics of xenobiotics

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.
IMPACT.
INSPIRE.

mrlpostdoc
US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement​
OFCCP EEO Supplement
OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:
1
Requisition ID:R91315

Apply at: https://jobs.merck.com/us/en/job/R91315/Postdoctoral-Research-Fellow-Pharmacokinetics-and-Metabolomics

view posting
Translational Mass Spectrometry Research Associate, Genentech, Inc. (South San Francisco, CA)
hechte4 2021-02-03

A position is available in Genentech's Translational Mass Spectrometry group, within the department of Microchemistry, Proteomics, Lipidomics and NGS. Our group utilizes state of the art mass spectrometric techniques as well as traditional chemistries to characterize proteins, lipids, protein interactions and post translational modifications. The successful candidate will have a working knowledge of mass spectrometry and chromatography, with particular emphasis on molecular characterization and data analysis.

The ideal candidate will have strong informatics skills and be proficient in a variety of mass spectrometry based methodologies including targeted analysis, proteolytic digestion, intact MS (native MS a bonus!), quantitative approaches and proteomic data analysis.

The candidate must be knowledgeable with HPLC and MS instrumentation and have strong troubleshooting capabilities, good communication, presentation and interpersonal skills, be able to work in a team environment and willing and eager to learn new technologies.

Requirements: Bachelors degree or MS in chemistry, biochemistry, biotechnology or a related field plus at least three years work experience or a PhD in chemistry, biochemistry, biotechnology or a related field.

Location: South San Francisco, CA. This is a lab based position and remote work is not an option.

Contact: Please contact hecht.elizabeth@gene.com. Please write "Skyline TMS-RA position inquiry" in the subject line.

view posting
Metabolomics/Lipidomics Internship
davis 2021-02-01

The Opportunity

Denali Therapeutics has an exciting opportunity for a summer intern in the Metabolomics/Lipidomics group within Developmental Sciences. During the 10 – 12 week internship, the individual will assist in optimization of mass spectrometric techniques to assess 13C stable isotope metabolic labelling experiments. This is a hands-on laboratory position with an exciting opportunity to learn novel analytical techniques and computational skills to assess CNS cellular metabolism in a dynamic start-up environment.

Responsibilities:

Work under supervision of Denali scientists to optimize LC-MS/MS-based metabolic flux assays
Execute LCMS-Flux analytical workflows, analyze and interpret 13C metabolite labelling patterns for flux quantitation
Prepare presentations and communicate results to internal collaborators

Position requirements:

Enrolled in a PhD program in Analytical Chemistry, Biochemistry or related field
Proficient in basic laboratory skills, and record keeping
Previous hands-on laboratory experience with LC-HRMS, & QQQ MS instrumentation, metabolite/lipid extraction is preferred
Strong computational and statistical skills, a plus
Energetic, self-motivated with ability to work in a highly collaborative environment
Demonstrated ability to organize, analyze and interpret experimental data
Excellent oral and written communication skills

Interested scientists are encouraged to apply here: https://www.denalitherapeutics.com/job?id=2619093

view posting
Scientist II: Mass Spectrometry Proteomics
faizanzubair2 2021-01-29

Apply Here: https://takeda.wd3.myworkdayjobs.com/External/job/San-Diego-CA/Scientist-II--DMPK_R0026102-1

OBJECTIVES:
Develop targeted biomarker assays for target engagement and pathway modulation biomarkers using mass spectrometry approaches
Quantify peptides, proteins, post-translational modifications, lipids, and metabolites to inform go- no-go decisions on assets and targets
Support discovery proteomics efforts using DIA, TMT, and label-free proteomics approaches
Lead scientific advances in specialized sample processing techniques, nano-LCMS, and software packages related to biomarker analyses

ACCOUNTABILITIES:
Process biological samples including tissues and fluids (Colon, Bile, Urine, CSF and/or Plasma) for enzymatic digestion, sample clean-up, and sample enrichment
Develop high-throughput sample processing approaches utilizing plate-based approaches and robotic instruments such as KingFisher and liquid handlers (eg. Tecan)
Implement 1D and 2D liquid chromatography techniques including reverse phase, reverse phase high pH, ion exchange, size exclusion, and others
Utilize Thermo’s hybrid and tribrid instruments to develop specialized biomarker assays for analytes with low physiological concentrations in complex matrices
Utilize Sciex’s TripleQuad and TripleTOF and Waters’ Xevo with Ion Key platforms for biomarker quantitation
Enrich for PTMs such as phosphorylation, acetylation, glycosylation, ubiquitination, and others using chemical affinity and antibody approaches
Leverage software packages including Skyline, Compound Discoverer, Proteome Discoverer, MaxQuant, Spectronaut and others for biomarker discovery and quantitation
Analyze multi-variate data sets and develop data processing pipelines containing normalization, imputation, and statistical analysis
Perform pathway analysis using IPA, Metacore, and other commercial/ public biological databases
Summarize biomarker data and present findings and recommendations to project teams

MINIMUM EDUCATION/EXPERIENCE:
PhD degree in a scientific discipline with 2+ years experience , or
MS with 8+ years experience, or BS with 10+ years experience
Prior experience with mass spectrometry, HPLC, and nano-LC is required. Familiarity with Thermo and/or AbSciex mass spectrometers for biomarker quantitation is required.
Experience with ligand binding assays is beneficial.
The candidate must be able to analyze data and note significant deviations and maintain detailed, accurate and comprehensible study documentation.
The individual is also expected to be highly organized, a team player, enthusiastic about drug discovery, and possess strong communication skills.
Publications in peer-reviewed scientific journals are beneficial

 Takeda_Job Description_Mass Spectrometry Research Scientisty.pdf 
view posting
Research & Product Scientist
jsilva 2021-01-25

About the job (posted on January 25, 2021):

Adeptrix is an entrepreneurial Life Sciences company based in Beverly MA that develops analytical solutions for pharma, biopharma, academic and clinical customers. Having recently completed the Series A financing round, the company is well positioned to become a major player in the fast-growing, multi-billion dollar bio-analytical consumables market. Adeptrix is currently working on a variety of research and diagnostic assays in the areas of neurology, oncology, epigenetics and virology (COVID-19) based on its proprietary BAMS™ platform technology. To learn more about Adeptrix: https://adeptrix.com/

We are currently accepting applications for a Research & Product Scientist who will provide leadership on further advancement of BAMS™ with the main focus on product and applications development, as well as the internal research and ongoing collaborations with Academia, Biotech and Pharma. This position reports to the company leadership.

Key responsibilities include:
• Manage laboratory personnel to co-ordinate and streamline product development activities
• Design and supervise validation efforts for the product development pipeline
• Oversee collection and analysis of analytical data for internal R&D and external collaborations
• Contribute to writing, editing, and producing abstracts, manuscripts, reports, posters
• Present at professional meetings and conferences
• Provide subject matter expertise and support to business development efforts

Qualifications:
• Minimum of 4 years of research or product development experience in bio-analytical assay development
• Experience with proteomic sample preparation methods and mass spectrometry data analysis
• Natural tendency to be curious, positive and creative
• Creative and analytical; can translate data and information into actionable plans
• Excellent project management and interpersonal skills
• Excellent communicator; able to put together convincing arguments
• Ph.D. or Masters degree with relevant industry experience

Personal Attributes:
• Exceptional communication, interpersonal and analytical skills
• Strong sense of professional accountability and integrity
• Highly motivated; plans for and strives to meet project goals and objectives
• Collaborative approach; functions well in team-based environments
• Commercial mindset
• Eager to grow and advance professionally

Competitive compensation and benefits package will be provided. Adeptrix is an equal opportunity employer and prohibits any discrimination or harassment based on race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

Interested scientists are encouraged to reach out to Jeffrey Silva, Chief Technology Officer, at Adeptrix Corporation (jsilva@adeptrix.com).

 Research and Product Scientist Job Description.pdf 
view posting
Postdoctoral Associate - Proteomics Group/Carr Lab (Open)
hasmik 2021-01-22

Post Doctoral Positions in Proteomics of Disease, Signaling and Complex Biological Systems

The Proteomics Group (Carr Lab) at the Broad Institute of MIT and Harvard is looking for several highly
motivated post-doctoral associates to develop and apply state-of-the art proteomics technology to
address compelling questions in biology, chemistry and clinical medicine. The specific research areas
of immediate interest that this scientist could drive include:
• multiomic and proteogenomic studies of a wide range of cancers
• provide detailed views and understanding of cellular signaling networks related to
protein phosphorylation, ubiquitylation, acetylation and cross-talk
• define the targets of drugs or identifying protein interactors through chemical
proteomics technologies and affinity purification MS
• develop biological understanding of response and resistance to therapy
• improve understanding of immune biology and help develop personalized cancer
immunotherapies
• develop and optimize new, broadly enabling proteomic technologies including targeted,
quantitative MS assay development for proteins and modifications of high biological or
clinical interest
Successful candidates will work in one or more of these areas together with an interdisciplinary team
of clinicians, biologists, computational and proteomics scientists to deeply characterize and
understand the proteomes of tumor-derived material, cells and biofluids.
The Broad Institute is a world-leading non-profit research organization dedicated to realizing the
promise of the post-genomic era for human benefit. Located in Cambridge, MA with strong ties to
MIT, Harvard, and world class Boston hospitals, the Broad Institute brings together scientists of diverse
backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner. The
Broad Institute, and the embedded Proteomics Group (www.broadinstitute.org/proteomics), have an
outstanding track-record in training the next generation of research scientists and in developing and
applying proteomic technologies critical to address important questions in biology and medicine. We
collaborate with top-level researchers throughout the world, and results of these studies and our
technology developments are published in top-tier journals.
Qualifications
Candidates must have:
• an MD or Ph.D. in analytical chemistry, biology, biochemistry, or a closely related field
• excellent scientific productivity, evidenced by high-quality research publications in peer
reviewed journals
• track record of conducting independent and creative research
• excellent verbal and written communication skills

Hands on skills and knowledge in one or more of the following areas will be considered an advantage:
• state-of-the-art mass spectrometry-based proteomics
• expertise in expertise in statistical and/or computational analysis of large-scale proteomic or
genomic data
• analysis of cell signaling pathways/networks
• cell biology/ biochemical methods to understand protein function
• Molecular biology/CRISPR-based genome editing
Interested scientists are encouraged to apply on-line at the Broad Website. Inquiries can also be
addressed to Steve Carr, Director of Proteomics, Broad Institute (scarr@broad.mit.edu) and Namrata
Udeshi, Associate Director of Proteomics (Udeshi@broadinstitute.org).

view posting
Mass Spectrometry Senior Scientist
xcong 2021-01-19

SUMMARY

InterVenn Biosciences is seeking mass spectrometry scientists to join our highly collaborative and supportive mass spectrometry team. Candidates will have substantive experience in the field of mass spectrometry-based proteomics/glycoproteomics, and will be highly motivated and resourceful. Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
Lead projects in analytical method development and optimization. Develop LC-MS based targeted biomarker assay (SRM/MRM) and facilitate method validation activities.
Be responsible for mass spectrometry instrumentation operation, troubleshooting and maintenance.
Train and supervise new analysts in glycoproteomics mass spectrometry workflows.
Manage multiple projects within timelines according to high scientific and ethical standards.
Align and collaborate with project managers, data science team and clinical laboratory personnel across the biomarker assay product portfolio.
Promote a culture of transparency and traceability across all aspects of laboratory operations.

SKILLS AND QUALIFICATION REQUIREMENTS
Ph.D. in biological sciences, chemistry, or analytical chemistry.
Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially triple-quadrupole MS (QQQ).
Extensive experience in targeted mass spectrometry-based proteomics/glycoproteomics.
Extensive knowledge of application of complex sample preparation methodologies for protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies, in particular SRM/MRM methods.
Proven track record of LC-MS based method development and validation for proteomics biomarker assays.
Applied knowledge of/experience with MS software analysis pipelines.
Experience in the pharmaceutical/biotech, diagnostic, or life-science-tools industry is preferred.
Experience in developing computational algorithms proteomics data processing and skills in computational programming languages (e.g. Python) is a plus.
Working experience in regulatory-compliant environments (GxP) and familiarity with regulatory guidelines on bioanalysis (FDA, CLSI etc.) is a plus.
Proven record of being a fast learner, flexible, and mindful team member.
Excellent verbal and written communication skills.

view posting
Senior Research Associate
xcong 2021-01-19

Senior Research Associate
Location: South San Francisco, US
InterVenn Biosciences is seeking a Sr. Research Associate to join our highly collaborative and supportive biomarker discovery team. The successful candidate will be a highly motivated and resourceful individual with a robust track record of experience in the field of mass spectrometry- based proteomics and glycoproteomics, . Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
RESPONSIBILITIES
Conduct experiments for the development of sample preparation and peptide separation methods, glycoproteomic technology evaluation, data analysis and interpretation,and glycoproteomic software evaluation.
Prepare biological samples and run assays on instruments under general guidance.
Document experimental work, analyze data, document and present results.
Prepare written methods and SOPs.
Perform mass spectrometry instrumentation operation, troubleshooting and maintenance.
Manage multiple projects within timelines according to high scientific and ethical standards.
Align and collaborate with project managers, computational biologists and software development project leads across the biomarker discovery project portfolio.
Promote a culture of transparency and traceability across all aspects of laboratory operations.

QUALIFICATIONS
BS or MS in life sciences, chemistry or related fields with 4 or more years of industry or equivalent postgraduate experience is required.
Extensive knowledge and application of complex sample preparation methodologies as applied to protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies including label-free analyses (DIA, PRM/SRM) methods.
Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially high resolution mass spectrometers (Orbitrap or qTOF)
Applied knowledge with MS software analysis pipelines
Demonstrated ability to plan and execute research experiments.
Proven record of being a fast learner, flexible, excellent communicator and mindful team member.
Excellent verbal and written communication skills.

view posting
Researcher 5 in Quantitative Proteomics
ztflaten 2021-01-19

Job description:

This is an exciting growth opportunity that focuses on large-scale quantitative proteomics applications in the Li Lab at the University of Minnesota’s Medical School and the Graduate Neuroscience Program. Our expertise and research has been focused on applying cutting edge quantitative proteomics to identify novel mechanisms and biomarkers for precision and personalized treatment of neurodegenerative diseases. The individual will be scientifically responsible for aspects of research planning, method development, sample preparation, data acquisition and biostatistics and bioinformatics. Responsibilities also include effectively communicating project progress, teaching and mentoring lab staff and graduate student, large-scale data analyses using biostatistics and bioinformatics, preparing presentations, and participating in grant writing and scientific publications in high impact journals.

Responsibilities:

Conduct investigations or experiments in an assigned area to aid in the solution of a research problem.
Set up and operate equipment used in collecting research data.
Calculate and analyze data.
Select and review literature relating to the assigned area.
Actively participate in research efforts by exploring new possible approaches to problems and discuss possible approaches to problems with supervisor.
Write routine summary reports on results of work and confer with supervisor on interpretation of results and avenues of investigation.
Write manuscripts as author and/or co-author for publication

Required Qualifications:

Masters degree (chemistry, biochemistry or related discipline) with at least one year of experience
Significant background in proteomics
A clear record of publications
Proficiency in bioinformatics approaches including protein quantification, statistical analyses, and pathway analysis
Outstanding communication skills

Preferred Qualifications:

PhD (chemistry, biochemistry or related discipline)
Programming experience
Direct experience with data-independent acquisition

Lab Website: https://sites.google.com/umn.edu/the-danni-li-lab/home

Apply here: https://hr.myu.umn.edu/psc/hrprd/EMPLOYEE/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&SiteId=1&FOCUS=Applicant&JobOpeningId=338758&PostingSeq=1&

view posting
Postdoctoral and Research Assistant Positions in Signal Transduction Quantitative Proteomics (Stem Cell induced-Neurons, Protein Homeostasis, Ubiquitin Intact-mass)
alban ordureau 2021-01-19

Applications are invited for various positions ranging from Research Assistant to Postdoctoral Researcher levels to work in the laboratory of Alban Ordureau in the Cell Biology Program at Memorial Sloan Kettering Cancer Center (MSKCC) in New York. Sloan Kettering Institute at MSKCC provides an exceptionally supportive, collaborative, and comprehensive training and research environment.

We have broad interests in kinases, ubiquitin ligases, and overall protein homeostasis (including autophagy). For further details, please see our website: https://www.mskcc.org/research/ski/labs/alban-ordureau

The successful applicants will deploy a state-of-the-art blend of quantitative proteomics methodologies (TMT, PRM, AHA-methodologies (degradome and translatome), ubiquitin intact-mass and top-down). They will gain experience in understanding signal transduction pathways linked to cellular functions and how they are linked to disease. Proteomics is central to our research, and for this, the lab maintains an Eclipse-ETD/UVPD Orbitrap mass spectrometer.

Applicants with experience in mass spectrometry/analytical chemistry and quantitative proteomic analysis expertise are encouraged to apply. Experience in nanoLC-MS/MS and Orbitrap-based mass spectrometers is preferable, but not necessary, and training can be provided. Experience in proteomics sample preparation (e.g., protein extraction, HPLC separation), mass spectrometry technical development is preferred. Some knowledge or desire to learn Python, R, and the ability to write and develop scripts and modify/implement open-source or published code is desirable. Enthused applicants eager to participate and gain experience in undertaking biological studies to generate samples and validate data would be advantageous, and training can be provided.

Interested candidates should send a cover letter and CV to Dr. Ordureau (ordureau.lab@gmail.com)

view posting
Scientist, Quantitative Proteomics - Denali Therapeutics, South San Francisco, Ca
auger 2020-12-17

https://www.denalitherapeutics.com/job?id=2545559

Help us #defeatdegeneration and join a growing proteomics team at Denali! We are looking for a highly motivated scientist to help craft quantitative proteomic assays.

The Opportunity

Denali Therapeutics is seeking a Scientist in the Proteomics group focused on mass spectrometry based assays for preclinical and clinical studies supporting therapeutic discovery and development. Working in close collaboration with colleagues in Therapeutic Discovery, Translational Sciences, Development Sciences, and Clinical Development, the candidate will help to build qualitative and quantitative multiplexed peptide assays. This will include working closely with pathway and project scientists to identify targets of interest, build in silico models to identify proper analytes, and build optimized assays to measure the aforementioned analytes in a robust manner. The candidate will interact with scientists across the Company to lead discussions around implementation of quantitative proteomics in support of ongoing research and development projects. The candidate must have excellent communication skills and work well in a highly collaborative team environment.

Responsibilities

Interact with pathway teams to collate and build highly multiplexed qualitative and quantitative peptide LCMS assays to elucidate significant changes in in vitro and in vivo models
Build upon existing targeted assays to improve coverage of relevant biomarkers for clinical and nonclinical samples
Leverage internal and external resources to provide high impact pathway data in collaboration with other -omic platforms
Create synergies between multiple -omic datasets and assays to better understand complex biological questions
Requirements

The successful candidate will have a PhD with 0-3 or BS/MS degree with 5-7 years industry experience developing quantitative proteomic assays for pharmacodynamic endpoints in complex matrices.
Familiarity with proteomics raw data processing, interpretation, and visualization
Familiarity with multiple vendor instrument software as well as the Skyline, Panorama, and Labkey platforms
Ability to create in silico models of peptides for targeted assays
Experience with LCMS method development and qualification
Understanding of proteomic best lab practices for sample handling and preparation
Ability to deliver complex results to teams of diverse scientific backgrounds
Ability to work effectively and collaboratively on cross-functional projects teams
Excellent oral, presentation, and written communication skills

view posting
Biotechnology Associate 2, Yale University
ad request 2020-11-23

Yale University offers exciting opportunities for achievement and growth in New Haven, Connecticut. Conveniently located between Boston and New York, New Haven is the creative capital of Connecticut with cultural resources that include three major museums, a critically-acclaimed repertory theater, state-of-the-art concert hall, and world-renowned schools of Architecture, Art, Drama, and Music.

General Purpose:
The MS & Proteomics Resource at Yale has an opening for a M&P level mass spectrometrist with hands on expertise in mass spectrometry and proteomics. The successful candidate will work in a resource laboratory along-side other Biotechnology Associates dedicated to helping a multitude of investigators use MS analyses to advance their proteomics research. The Resource’s mission is to provide investigators of all disciplines (chemical, biological, clinical, etc.) with access to the most advanced mass spectrometry based biotechnologies through efficient and cost-effective proteomics and small molecule services. These technologies are developed and implemented with a broad spectrum of mass spectrometry based techniques for protein/peptide/small molecule chemistries to separate, characterize, profile, and quantify analytes from complex biological samples. The Resource is superbly equipped for this purpose with 5 state-of-the-art MS systems that are utilized for a wide range of biotechnologies.

Required Education and Experience:
Master’s Degree in chemistry, biology, biochemistry, or other related discipline and three years of experience or an equivalent combination of experience and education.

Qualifications:
• Thorough understanding of mass spectrometry.
• Demonstrated knowledge of quantitative proteomics, protein chemistry and proteomics sample handling.
• Well-developed written and oral communication skills..
• Ability to work with and lead multiple projects.
• Working knowledge of major licensed proteomics software.
• Preferred Education and Experience: PhD level in Analytical Chemistry, Biochemistry.

Application: For more information and immediate consideration, please apply online at https://bit.ly/YaleCareers-63101BR. Please be sure to reference this website when applying for this position.

We invite you to discover the excitement, diversity, rewards and excellence of a career at Yale University. One of the country's great workplaces, Yale University offers exciting opportunities for meaningful accomplishment and true growth. Our benefits package is among the best anywhere, with a wide variety of insurance choices, liberal paid time off, fantastic family and educational benefits, a variety of retirement benefits, extensive recreational facilities, and much more.

Yale University considers applicants for employment without regard to and does not discriminate on the basis of an individual’s sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression.

https://your.yale.edu/careers

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Postdoctoral fellow in iPSC, proteomics, and cardiovascular research
edward lau 2020-10-21

Research Opportunity:
Interested in applying your Skyline and mass spec experience to human induced pluripotent stem cell research? We are looking for a postdoctoral fellow to join our team at the University of Colorado School of Medicine. We are interested in examining protein homeostasis and cellular communication using large-scale sequencing, targeted mass spectrometry, and related technologies. Some of our prior work includes methods to quantify protein turnover (https://pubmed.ncbi.nlm.nih.gov/29317621/) and identify protein alternative isoforms (https://pubmed.ncbi.nlm.nih.gov/31825849/). We are now developing companion strategies that are applicable to questions in cell biology and cardiovascular research. Please visit our website at https://laulab.net for details.

Minimum Qualifications:
Ph.D. or equivalent in biochemistry, cell biology, or related scientific fields from an accredited institution.
Minimum of 3 years of active research experience in the life sciences in an academic environment.

Preferred Qualifications:
Prior experience with experiments and data analysis related to next-generation sequencing and/or mass spectrometry approaches.
Prior experience with cell culture models including human induced pluripotent stem cell models as applied toward basic biomedical research.

Application:
Please apply here: https://cu.taleo.net/careersection/2/jobdetail.ftl?job=19172&lang=en
Include a cover letter, CV, and contact info of 3 references.

Salary and Benefits:
Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services. Funding for this position is guaranteed for one year. Continuation of employment thereafter is subject to annual performance review and mutual interest.

Diversity and Equity:
Please click here for information on disability accommodations: http://www.ucdenver.edu/about/departments/HR/jobs/Pages/JobsatCUDenver.aspx
The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

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Postdoctoral Fellowship in Multi-Omics and Machine learning
jmeyer 2020-10-17

The Meyer lab in the Biochemistry Department at the Medical College of Wisconsin is seeking a postdoctoral scholar with experience or interest in mass spectrometry, proteomics, metabolomics, machine learning, bioinformatics, or related areas.

The long-term goal of the Meyer lab is to predict molecular and phenotypic behavior of biology using computational models trained with large-scale omics data. Ongoing projects relate to drug discovery, basic understanding of metabolism, and personalized patient diagnosis. New technology we develop is motivated by the need for cures and diagnostics for neurological diseases and cancer.

The successful candidate will have exclusive access to a new Orbitrap Exploris 240 mass spectrometer with FAIMS Pro.

Competitive candidates will have experience in at least one of the following areas:

  1. data analysis with python and/or R
  2. mammalian tissue culture
  3. bacterial/yeast culture
  4. sample preparation for mass spectrometry
  5. experience operating liquid chromatography mass spectrometry (LC-MS) instruments,
  6. machine learning with scikit-learn (sklearn), keras/tensorflow, pytorch, fastai
  7. website building and maintenance

Please check out our website for more information about previous publications and ongoing projects:
www.jessemeyerlab.com

Interested candidates please apply here:
https://careers.peopleclick.com/careerscp/client_medcollegewi/external_staff/gateway.do?functionName=viewFromLink&jobPostId=16743&localeCode=en-us

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Senior Scientist, Proteomics Mass Spectrometry (Protein Sciences) - Merck Research Laboratories - SSF, CA
daniela.tomazela 2020-09-24

Our Research Laboratories is seeking to recruit an experienced mass spectrometry scientist with broad experience in Proteomics applications to join the Protein Sciences Department in South San Francisco, CA.

The position will be hands-on at the bench and will report to the mass spectrometry group leader.

Responsibilities:
Design and perform proteomics-based experiments, including phospho-proteomics, labeled and label-free differential protein expression, and targeted protein quantification.
Sample preparation for proteomics analysis including protein extraction, immunoprecipitation, proteolytic digestion, and sample clean-up prior to MS analysis.
Perform analytical routines for Tandem liquid chromatography mass spectrometry (LCMSMS) systems maintenance, including calibration, system suitability, and troubleshooting.
Strong communication & interpersonal skills.

Education Minimum Requirement:
PhD in Biochemistry, Cell Biology, Analytical Chemistry or a related field, with a minimum of 3 years relevant postdoctoral or pharmaceutical/biotechnology experience.

Required Experience and Skills:
Knowledge and direct experience with state - of - the - art technologies and methods for mass spectrometry-based proteomics, including Thermo Orbitrap mass spectrometers.
Proficiency in quantitative proteomics techniques SILAC, Tandem Mass Tag (TMT), label-free quantification approaches and peptide fragmentation methods.
Proficiency in using Proteome Discoverer, Peaks, Genedata, MaxQuant, Skyline, and other DB search engine tools.

Preferred Experience and Skills:
Biologics characterization using mass spectrometric methods (PTMs/glycosylation, intact and subunit mass analysis).
Understanding and working knowledge of various analytical methods for protein characterization such as SEC, IEX, RP – HPLC, CE-SDS.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …
Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.
IMPACT.
INSPIRE.

NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement​
OFCCP EEO Supplement
OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
Yes

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:
1

Link to the position:
https://msd.wd5.myworkdayjobs.com/SearchJobs/job/USA---California---South-San-Francisco---Grand-Ave/Senior-Scientist--Proteomics-Mass-Spectrometry--Protein-Sciences-_R74512

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Biogen Biomarkers - Quantitative Proteomics position
omar mabrouk 2020-07-08

Associate Scientist II/III – Fluid Biomarker Assay Development
*Job Description
The Biomarkers group (Section of Clinical Sciences) is seeking a creative and collaborative lab-based scientist engaged in targeted proteomics for the detection of proteins and metabolites in different biological matrices (including plasma, serum, CSF, urine, tissues) to support early clinical stage programs. The successful candidate will be capable of multitasking and effective planning to consistently meet deadlines.
*Responsibilities:
• Targeted protein biomarker assay development using state of the art liquid-chromatography-mass spectrometry (LC-MS) platforms including nano-LC, orbitrap (Q-Exactive, Q-Exactive +, Q-Exactive HF/HFX, Fusion) and UPLC-QQQ MS (AB Sciex)
 Sample preparation (tissues and cell lysates) for protein quantification
 Biotinylation and various bead-antibody conjugation techniques
 Identification and selection of antibodies for immunoprecipitation prior to LC-MS analysis
 Identification of novel techniques and strategies to enhance assay sensitivity
 Fit for purpose qualification of protein and small molecule LC-MS assays
 LC-MS instrumentation troubleshooting
• Point of contact with Contract Research Organizations
 Work with CRO partners to oversee biomarker assay implementation including assay interpretation
• Timely recording keeping and data entry into Electronic Lab Notebook
• Prepare, review, and deliver scientific presentations for internal/external use
*Qualifications

  1. Proven experience with LC-MS instrumentation is required with experience in targeted and global proteomic profiling.
  2. Preference will be given to candidates with hands on experience in developing and qualifying high resolution (Orbitrap) LC-MS assays, including immunoprecipitation LC-MS for the detection of proteins in biological samples
  3. Expertise using Skyline and familiarity with Thermo Xcalibur, Proteome Discoverer, AB Sciex Analyst
  4. Excellent assay troubleshooting skills
  5. Familiarity with neuroscience, including knowledge of neurodegenerative diseases (AD, PD, ALS) is considered a plus but not required
  6. Experience in or willingness to learn classic immunoassay based assays (ELISA)
  7. Demonstrated track record of providing support activities for multiple research projects
  8. Solid work ethic and demonstrated record of productivity such as participating in peer reviewed publications or scientific poster presentations
    *Education
    • BS with >3 years experience or MS with >1 year experience in relevant scientific area

contact me directly at omar.mabrouk@biogen.com if you may be interested

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Immatics Biotechnologies GmbH - Scientist Immunopeptidomics/ Proteomics (all genders welcome)
Christoph S 2020-06-23

http://immatics.com/career-details/scientist-immunopeptidomics-proteomics-all-genders-welcome.html

Scientist Immunopeptidomics/ Proteomics (all genders welcome)
to support our team in the research and development of innovative immunotherapeutic products. You will work in Tuebingen (Germany) in an interdisciplinary environment with colleagues from all research and preclinical/ clinical development departments. Your analytical reasoning and action-oriented style as well as your organization and communication skills will contribute to the team’s success.

The job profile is focused on the characterization and validation of novel HLA presented targets, which will involve but is not limited to the following tasks:
Characterization of HLA presented peptides using Immatics’ proprietary absolute quantitation technology (AbsQuantTM) to identify and validate the best targets for clinical development
Contribution to the elucidation of the biological mechanisms of novel cryptic targets using (targeted) proteomics analysis together with various Omics datasets integrated in Immatics’ XPRESIDENT® target discovery and validation platform
Coordination and project management of target characterization activities involving stakeholders from different departments and disciplines
Development of new strategies and methodologies for target characterization using a diverse set of protein chemistry and mass spectrometry techniques

Your profile
You hold a PhD degree in Life Sciences, Biochemistry, Biotechnology, Pharmacy or have been comparably educated and proven your scientific excellence and your ability to account for complex projects, preferentially with a track record in proteomics or immunopeptidomics. You are familiar with mass spectrometry data analysis and ideally have already gathered experience with targeted methodologies (such as SRM, MRM or PRM) and data independent acquisition. You show a high motivation to translate your scientific findings into clinical development and application. Preferably, you also have previous experience in large-scale data analysis and have already worked with relational databases. You take careful processing and documentation of your results for granted. Your scientific excellence, extraordinary analytical competence and communication skills enable you to successfully contribute to projects as part of a team and to present your work internally or to external partners from the pharmaceutical and biotech industry.

We expect a high degree of independent working, analytical reasoning and excellent communication skills in English. You embrace rapidly changing requirements with an open mind and show a high degree of flexibility in an environment which is marked by a constant striving for excellence. Your motivation is driven by your passion for innovation and science. You approach tasks in a structured, reliable and foresighted manner, combined with an elevated level of individual responsibility, enthusiasm and strong social skills.

What we offer
We are a committed and inspired team and cherish the collegial, highly motivated and family-friendly atmosphere within Immatics. Our culture allows for a high level of originality, independent thinking and initiative. We believe in supporting our employees’ professional and social skills: We enable them to join conferences and trainings as well as to enjoy our Immatics benefits – e.g. job bike, job ticket, Health Programs, childcare benefits, relocation allowance, Company summer and winter events.

If you’re interested in working for Immatics, please apply online and provide your application documents along with the relevant credentials and certificates. Mrs Annemarie Selbenbacher will answer initial questions at +49 89 125 03 98 33 (landline number Germany). Coredi Recruiting GmbH (Mrs Annemarie Selbenbacher) advises Immatics on this job posting.

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Postdoctoral and Associate Positions in Signal Transduction Proteomics
benmajor 2020-01-28

Postdoctoral and research associate positions are available in the laboratory of Dr. Ben Major at Washington University in St. Louis, School of Medicine. We use protein mass spectrometry, functional genomics and chemical screens to study signal transduction in cancer. In addition to broad interests in kinases and ubiquitin ligases, our research focuses on the WNT/b-catenin pathway and the KEAP1/NRF2 oxidative stress response pathway. Mass spectrometry is central to our research and for this the lab maintains an Eclipse-ETD Orbitrap mass spectrometer. The Major laboratory recently moved from the University of North Carolina at Chapel Hill to Washington University in St. Louis. The new lab space is fully renovated and houses new instrumentation for cancer research, cell biology and multi-OMIC screening. The Department of Cell Biology and Physiology, Otolaryngology and the Siteman Comprehensive Cancer Center provide an exceptionally supportive, collaborative and comprehensive training and research environment.

For further details please see our website: http://majorlab.wustl.edu/research.php

Postdocs and Research Associates will identify, develop and drive independent research projects that broadly relate to the following research areas:

  1. KEAP1/NRF2 oxidative stress response pathway in lung cancer, head and neck cancer and esophageal cancer. Topics include: pathway mechanics, ubiquitylation, protein-protein interaction and proximity networks, phospho-proteomics, functional genomic screening, drug discovery, mouse models and clinical trials. Structural biology of cancer-derived mutations in KEAP1. Proteogenomics and informatics of KEAP1/NRF2 signaling in clinical samples.

  2. WNT signaling pathway in pancreas and lung cancer. Basic pathway mechanics of the destruction complex, signalosome and enhanceosome. Time-resolved protein-proximity networks and phospho-proteomics. Proteogenomics and informatic correlations in cancer.

  3. Understudied kinases and ubiquitin ligases altered in human disease. Protein-protein interaction and proximity networks. Crispr-A and Crispr-I genetic screens. ORF screens. Phospho-proteomics. Kinase enrichment mass spectrometry. E3 substrate identification.

Prior experience, achievements and letters of recommendation that clearly articulate scientific devotion, drive and curiosity will benefit the applicant. A record of accomplishment of leading projects to completion and publication in peer-reviewed journals is required.

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Interested candidates should send a cover letter and CV to Dr. Major (bmajor@wustl.edu)

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Post-doctoral opportunity in proteomics and immunotherapy at UCSF
apwiita 2019-10-23

The laboratory of Arun Wiita at the University of California, San Francisco is currently recruiting post-docs to help us advance our mission of discovering new targets and developing new immunotherapies for hematologic malignancies (see brief description of related work at https://wiitalab.ucsf.edu/developing-novel-immunotherapies-profiling-cancer-cell-surface). In particular, we are interested in finding candidates with experience in redox proteomics, disulfide proteomics, and/or cross-linking mass spectrometry to enhance our discovery of novel cancer immunotherapy targets and therapeutics. Experience in mass spectrometry-based proteomics is required, and prior experience in immunology, cell biology, and/or protein biochemistry would be assets.

Our group is located in beautiful San Francisco, California. UCSF is one of the premier academic medical centers in the world, excelling in both basic science and clinical research. We are a multidisciplinary research group and our interests span from the basic to translational realms across a number of conditions, as well as new technology development combining chemical-based enrichment and quantitative proteomics.
We offer competitive salary in line with cost-of-living in the Bay Area. We are fortunate to have numerous sources of funding including the NIH New Innovator Award, an NCI R01, and additional federal and private grants to support our work. We are also fortunate to have extensive collaborations with other world-leading scientists across UCSF, as well as access to world-class core facilities to accelerate discoveries in biomedical research. In addition, all mentorship and project design within our group is customized for the scholar's career goals, whether entering academia or industry.

Well-qualified applicants should send a CV, cover letter, and contact information for two references to arun.wiita@ucsf.edu.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

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Post-doctoral research position in functional cancer proteomics
kentsisresearchgroup 2019-09-30

Functional Cancer Proteomics

We are a group of biochemists, biologists and physicians in the Molecular Pharmacology Program at the Sloan Kettering Institute in New York City, USA. We carry out research in cancer biology, and our current work is focused on the phenomenon of cellular plasticity, as it relates both to the fundamental mechanisms of cancer pathogenesis and emerging rational therapies.

In particular, we are studying the biology of refractory leukemias and solid tumors, and we are interested in understanding the principles of disorganization of their genomes and proteomes, and determining the molecular mechanisms of response and adaptation of tumor cells to targeted therapies.

To answer these questions, we are developing new approaches, based on quantitative mass spectrometry and functional proteomics, to decipher the mechanisms of cancer cell signaling and develop new therapeutics.

Forward Proteomic Screens for Cancer Therapeutics and Macromolecular Delivery. Using recently developed methods for quantitative proteomics and peptide barcoding (Egloff et al, Nature Methods 2019, PMID: 31113958), we’ve developed a new platform for high-throughput design and screening of macromolecular cell penetration and delivery reagents. This is a transformative technology that enables the generation of new classes of drugs to modulate specific protein-protein interactions, which we’ve recently applied for targeted leukemia therapy (Ramaswamy et al, Nature Communications 2018, PMID 29317678). Current efforts are focused on applying this technology for protein engineering and development of new peptide conjugates for cancer and gene therapy.

Quantitative Cell Proteomics Atlas (http://qcpa.mskcc.org). Using developed methods for ultra-sensitive quantitative proteomics (Cifani & Kentsis, MCP 2017, PMID 28821601), we’ve developed an atlas of targeted mass spectrometry assays to profile biochemical signaling at the pathway scale in normal and cancer cells. Current efforts are focused on developing high-throughput and genome-scale methods. This work aims to define systems-level mechanisms of aberrant signaling in cancer cells, as well as fundamental cell biological processes of signaling adaptation, feedback and integration.

If you are a recent PhD graduate with interest in the above areas and experience with nanoscale liquid chromatography, electrospray ionization, high-resolution mass spectrometry or protein engineering and chemistry, please contact Alex Kentsis at http://alexkentsis.net/ or kentsisresearchgroup+application@gmail.com

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