The Research & Development Division Global BioAnalytical (BA) group at Merck within the Preclinical Development department, (PCD), is seeking students for a 6 month Co-op experience. The Global BA group at our company provides quantitative analysis of biologically derived samples for all our company's discovery and development programs.

Learning opportunities for the prospective Co-op are:

• Involvement in the development and execution of protein/peptide quantitative proteomic assays by LC-MS/MS for therapeutic biologic products.
• Gaining hands-on experience in using automation platforms, mass spectrometers, UPLC or UHPLC, immunoprecipitation (IP), solid phase extraction (SPE).
• Hands-on exposure to laboratory work in the form of bioanalysis experimentation utilizing different platforms.

In addition to laboratory skills, the Co-ops will have the opportunity to be engaged in scientific discussion and interpretation of data. The Co-op student will have an opportunity to present their research results in both oral and written formats.

We are seeking Co-op candidates at all levels with strong academic performance, communication skills, teamwork, and the ability to work in a cross-collaborative environment.

Location: West Point, PA

This is a full-time Co-op position. Housing subsidy is not available as part of this program and must be funded 100% by the student.

Required Experience and Skills:

• Candidates must be currently enrolled undergraduate senior student pursuing a bachelor’s degree OR a currently enrolled graduate student pursuing a master’s or PhD Chemistry, Biochemistry, Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Biology, Immunology, Molecular Biology, Pharmaceutical Sciences, or related field
• Candidates must be available to work full-time for up to (24) consecutive weeks beginning in May or June of 2023
• Candidates must have completed at least (2) years of studies toward bachelor’s degree by June 2023

Additional Experience and Skills:

• Candidates should have basic laboratory skills to carry out biochemical techniques for sample preparation, such as, basic pipetting, dilution techniques, ligand binding assays (ELISA, etc.)
• Candidates should have hands on experience in sample preparation and biological techniques such as protein, peptide, preparation for mass spectrometry analysis as well as cell culture, gel electrophoresis, protein digestion and western blotting. LC MS protein analysis or proteomics experience is a plus
• Candidates should have basic knowledge of general chemistry, organic chemistry, and protein chemistry
• Candidates should have basic understanding of pharmacokinetics and immunogenicity
• Candidates should have the ability to follow procedures and thoroughly document experiments
• Candidates should be highly motivated, self-starter and significant interest in scientific research
• Candidates should have strong interpersonal, communication, problem solving, and collaboration skills
• Candidates should have strong time management to allow parallel pursuit of multiple objectives

Please apply at this link -
https://jobs.merck.com/us/en/job/R227014/2023-Global-Bioanalytical-Co-op

or send me an email (with resume/CV) at shivangi.awasthi@merck.com to learn more.

Post-Doctoral Research Associate - Food Allergen Proteomics
https://employment.unl.edu/postings/84330

The Department of Food Science and Technology at the University of Nebraska-Lincoln (UNL) Institute of Agriculture and Natural Resources (IANR) is seeking applications for a highly motivated and enthusiastic post-doctoral research associate. This 12-month (calendar year), postdoc researcher appointment will plan, conduct, and supervise research on food allergen proteomics. In particular, the research will be focused on conducting protein mass spectrometry experiments to identify, detect, quantify, and characterize food allergens. The apportionment is 100% research. This position will be located in Lincoln, Nebraska.

The individual will be expected to conduct research both independently and as part of a team. Duties will also include collaborative supervision and management of multiple, shared high-resolution mass spectrometers. Contribution to the supervision of graduate and undergraduate students is also anticipated.

Preparation and publication of manuscripts in peer-reviewed journals or other appropriate outlets is expected. The individual may also have the opportunity to make presentations at regional, national, or international scientific meetings. In addition, the individual may be asked to contribute to the preparation of grant proposals and progress reports related to the research projects.

Recognizing that diversity enhances creativity, innovation, impact, and a sense of belonging, the Institute of Agriculture and Natural Resources (IANR) and the Department of Food Science and Technology are committed to creating learning, research, Extension programming, and work environments that are inclusive of all forms of diversity. Consistent with the University’s N2025 Strategic Plan, every person and every interaction are treated as important to our collective well-being and our ability to deliver on our mission.

Required Qualifications
• Ph.D. in Food Science, Biochemistry, Biology, Chemistry, Bioinformatics, Plant Science, or a related field.

Preferred Qualifications
• Experience with proteomics and protein mass spectrometry, including targeted proteomics method development.
• Experience with protein purification techniques.
• Familiarity with informatics tools for proteomics (for example, Mascot, Skyline, Progenesis, and instrument vendor software).

Review of applications will begin April 17, 2023 and will continue until the position is filled or the search is closed. To view details of the position and create an application, go to https://employment.unl.edu, requisition F_230023. Click “Apply for this Job” and complete the information form. Attach the following documents:

1. A letter of interest that describes your qualifications for the job and anticipated contributions.
2. Your curriculum vitae.
3. Contact information for three professional references.

As an EO/AA employer, the University of Nebraska considers qualified applicants for employment without regard to race, color, ethnicity, national origin, sex, pregnancy, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, marital status, and/or political affiliation. See https://www.unl.edu/equity/notice-nondiscrimination.

Job Description

Reporting to the Metabolomics Platform Manager, the Research Support Specialist will focus on the Metabolomics Platform at the Proteomics Resource Center (PRC). Responsibilities include sample preparation, maintaining and operating LC-MS/MS equipment and analyzing metabolomic and lipidomic projects in close collaboration with colleagues and researchers from a wide variety of University laboratories, as well as method development, implementation of untargeted workflows and related data analysis. Specifically, the Research Support Specialist will be expected to: consult with Metabolomics Platform Manager to identify project goals, experimental design and deadlines; interact with team members in support of overall Center operations; comply with lab safety guidelines; track samples and submit billing and purchasing information; maintain lab records; generate detailed technical documents and sample operating procedures; maintain laboratory appearance and monitoring chemical inventory and supplies; manage and expand compound libraries; maintain and operate LC-MS (Q-Exactive Plus and Orbitrap IQ-X) and related equipment with a focus on high quality data generation; prepare samples from a variety of biological matrices, using various sample processing techniques. The Research Support Specialist will also develop and implement metabolomics/lipidomics-related methodology; process, analyze and interpret data using open source and vendor software; prepare detailed reports for investigators; and interact with and advise investigators regarding study design and implementation. The targeted salary is $70,000 to $90,000.

Job Requirements

Master's degree (with 3+ years of related work experience) or Ph.D. (with emphasis in analytical chemistry/mass spectrometry) is required. Must have in-depth experience with liquid chromatography coupled to mass spectrometry-based small molecule analysis (preferably LC-MS), including method development, as well as experience with high resolution mass spectrometers (preferably Orbitrap MS) including operation, calibration, tuning, cleaning, and other maintenance. Must have a strong understanding of metabolomics and/or lipidomics workflows and have expert competency in one or more of the following: Quantitative Metabolomics Workflows; Untargeted Metabolomics Workflows; and Untargeted Lipdomics Workflows. Candidate should be experienced processing HRMS data with vendor and/or open-source software, as well as sample preparation of biological and synthetic samples using a variety of sample processing techniques. Candidate is expected to have excellent communication (oral and written English) and interpersonal skills, as well as strong organizational and multitasking skills, with the ability to work independently as well as part of a team. Candidate must be able to keep accurate and detailed records in a lab notebook and LIMS system. Must have strong analytical and wet lab skills, and the ability to maintain and expand knowledge of mass spectrometry techniques through self-education, dialog with other experts, reading literature, and attending conferences and courses as necessary. Practical experience with bioinformatics and statistical analysis is preferred.

https://recruit.rockefeller.edu/OA_HTML/OA.jsp?page=/oracle/apps/irc/candidateSelfService/webui/VisVacDispPG&OAHP=IRC_EXT_SITE_VISITOR_APPL&OASF=IRC_VIS_VAC_DISPLAY&akRegionApplicationId=821&transactionid=1041844002&retainAM=N&addBreadCrumb=RP&p_svid=28736&p_spid=1224190&oapc=9&oas=6n-R1NFT42vXFL1uUBKp-Q

Apply through the posted link. If you have any questions, you can contact me at halwaseem@rockefeller.edu

Apply now! https://talus-bioscience-inc.breezy.hr/

Talus Bioscience is seeking highly motivated summer interns to join our team! Internships are PAID and available in the areas of research & development, drug discovery, proteomics, and data science. These internships provide opportunities to own and participate in challenging and impactful business-critical projects at a thriving biotech start-up!

Internships are approximately 3-months (summer) in duration and the roles are performed on-site at our Seattle, WA laboratory under the supervision of PhD scientists. Relocation assistance benefits are not available for this job posting. Interns will participate in all lab meetings, team meetings, and the company summer retreat, as well as Talus social and team-building events. All positions require excellent communication and interpersonal skills, and successful candidates will complement our culture and align with our core values. At the end of the internship, interns will present their project to the entire company.

Group: Technology Development

Internship Description: Talus Bio is seeking a summer intern to help develop high-throughput proteomics approaches for drug discovery. The intern will automate sample preparation approaches using Talus’ robotic instrumentation and will have the opportunity to test and implement cutting-edge mass spectrometry acquisition strategies for rapid sample analysis.

https://uwhires.admin.washington.edu/ENG/Candidates/default.cfm?szCategory=jobprofile&szOrderID=208636

The MacCoss Lab at the University of Washington, Genome Sciences is seeking a Research Scientist will conduct laboratory research focusing on the discovery of novel peptide adducts associated with exposure to low-dose ionizing radiation using high-throughput quantitative mass spectrometry. This position will require expertise in biochemical sample preparation and meticulous pipetting skills and the ability to perform research and take responsibility for assuring quality, cost effectiveness, and timeliness for large projects. The Research Scientist will work under immediate supervision to meet project deadlines and complete assigned tasks by implementing well-established protocols and evaluating and developing new protocols. Weekly meetings are held to discuss project status.

Dimensions and Impact to the University
This position will work in a prominent mass spectrometry laboratory whose work impacts other researchers worldwide. The research conducted will be reflected in even greater funding opportunities and enhancement of the reputation of the University as a biomedical research powerhouse.

RESPONSIBILITIES:
• Processing and preparation of proteomics samples in a mass spectrometry lab (60%)
o Preparation of chemical solutions.
o Perform high-throughput proteomic sample preparation protocols using KingFisher robot
o Perform in-solution and in-gel proteomic sample lysis and digestions.
• Develop and apply proteomics analyses (20%)
o Use nano-flow liquid chromatography systems and mass spectrometers to analyze peptides.
o Perform routine assessment of mass spectrometry data quality using lab software.
o Analyze data using lab software (Linux and Windows)
o Troubleshoot instrumentation errors and malfunctions.
• Lab maintenance and research support (20%)
o Work with sample manager tracking system to log metadata, sample receipt, and workflow data.
o Develop and maintain precise laboratory protocols and records.
o Present data to collaborators and scientific community.
o Assist and collaborate with other members of the lab on related projects.
o Perform other tasks as needed.

MINIMUM REQUIREMENTS:
Bachelor’s degree in Biology, Biochemistry, Chemistry, or other related Life Sciences field and 3 months research or laboratory experience.
• Working knowledge of molecular biology, biochemistry, and/or chemistry.
• Excellent technical skills at the bench.
• Excellent recording keeping.
• Well-developed analytical and problem-solving skills.
• Excellent written, verbal, and interpersonal communication skills.
• Demonstrated commitment to valuing diversity and contributing to an inclusive working and learning environment.
• Must be highly organized with a strong attention to detail.
• Open to receiving direction and to asking for assistance when needed.
• Ability to work both independently and collaboratively.

Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.

Desired Qualifications
• Experience with automated sample transfer and purification systems, specifically, Thermo KingFisher instruments.
• Laboratory experience especially in a mass spectrometry laboratory, whether in a professional or academic setting.
• Working knowledge of proteomic sample preparation methods.

Apply here: https://uwhires.admin.washington.edu/ENG/Candidates/default.cfm?szCategory=jobprofile&szOrderID=208636

An exciting Staff Scientist position has been created for an experienced researcher to join Prof. Andrew Emili’s laboratory at the Knight Cancer Institute Center at Oregon Health & Science University in Portland, OR. We are seeking an experienced researcher to join our growing team in a full-time role, who will work independently and as a collaborative project co-leader, to establish and support our precision mass spectrometry platform.

Contact information: Please contact (send Resume/CV) Professor Andrew Emili: emili@ohsu.edu

Position:
As an Staff Scientist, you will support cutting-edge mass spectrometry-focused functional proteomics research at Prof. Emili’s Collaboratory for Network Systems Biology (CNSB). Major new project initiatives involve interrogation of primary patient specimens, tissue specimens from animal models of disease, and engineered cell culture systems, to characterize the macromolecules and biological pathways altered in disease states, as well as the mechanisms of action of bioactive compounds.

The primary role for the Staff Scientist candidate will be to support serve as the principal proteomic mass spectrometry support expert for the group. This role will involve the operation, maintenance and support of high-performance LC/MS instrumentation, and participation as lead scientist on select projects throughout their lifespan including providing significant input on experimental study design, control inclusion and placement, data acquisition strategies and, critically, the analysis, mining and interpretation of datasets.

Additional roles for the candidate will involve providing support in sample preparation, method development, instrument optimization, and tracking of instrument use, samples, datasets, methods (experimental and analytic) over collective studies.

The candidate will be required to explore and apply new MS proteomic capabilities as they emerge, and will need to scale analytic platforms and algorithms for highly scaled collaborative studies.

The candidate will independently design, execute and interpret proteomic method development studies critical to the evolution of our workflows to support advanced sample interrogation.

The candidate, an exceptional self–starter, should be inquisitive and highly motivated, and able to operate effectively with internal team members and actively solicit input from expert external consultants and collaborators.

The candidate will on occasion oversee more junior analysts and experimental researchers and train them on appropriate methods and approaches to build wider team expertise.

Qualifications
• Doctoral degree in relevant field and 3+ years of relevant post-doctoral work experience
• >3 years research experience in proteomics/analytical chemistry or closely related discipline
• Practical understanding/experience with, shotgun mode mass spectrometry analysis of protein/peptide mixtures.
• Experience with high performance (Orbitrap) nano-LC/MS instrumentation (operation, maintenance)
• Understanding proteomic method development and best lab practices for sample handling and analysis
• Strong analytical and practical skills in protein sample preparation
• Experience and operational knowledge of high throughput setups and proteomics workflows
• Experience with quantitative LC/MS (e.g. isotope-tagging) and PTM analysis for discovery proteomics
• Proven ability to generate high quality / high quantity mass spectrometry data
• Familiarity with data processing, interpretation, and visualization
• Excellent communication, analytical and organizational skills: both written and verbal
• Ability to work independently and as part of a team while being collaborative in resolving problems

Preferred experience
• Degree in biochemistry, molecular biology, biomedical engineering, analytical chemistry and/or mass spectrometry
• 4+ years hands-on LC-MS experience
• Computational skill with latest versions of proteomic software such as MaxQuant.
• Experience with R, MATLAB, or python and general computational abilities
• Ability to prioritize multiple tasks at one time.
• Intermediate skills with MS Office (Excel, Outlook, Word, PowerPoint), statistical tools and programing languages.

Contact information: Please contact (send Resume/CV) Professor Andrew Emili: emili@ohsu.edu

The Proteomics Core at Northwestern offers cutting edge mass spectrometry methods to identify and characterize proteins and their roles in human health and disease. Our award-winning core team of 10 staff partners closely with academic, medical, and industrial researchers to advance biomedical research and translation. The facility offers multiple types of experiments from simple protein identification to protein quantitation (both relative and absolute) using both bottom-up proteomics and intact top-down proteomics analyses that enable detection of post-translational modifications. We specialize in untargeted quantitative peptide proteomics, targeted quantitative peptide proteomics, epiproteomic histone modification panel, and phosphoproteomics. The Proteomics Core leverages the expertise of its parent research center, Northwestern | Proteomics, in technology development and computational analysis to stay at the forefront of proteomics analyses.

A Core Specialist performs the required standard operating procedures of the Core Research Facility. This includes the execution of research activities associated with established protocols and procedures; modifying them as needed. Operates or guides Core user in utilizing the facility's specialized equipment and services in support of user needs. Ensures the smooth flow and quality of daily work within the lab and ensures compliance in regard to University, sponsor, and federal rules and regulations.

Plans, conducts, and evaluates experiments and assays of low-to-moderate complexities.
Demonstrates an understanding of protocols and guiding principles, and applies the protocols to experiments.
Calculates, records, compiles, and reports data.
Analyzes and interprets data.
Engages in problem-solving, relative to daily lab activities.
Maintains instrumentation and equipment used in services provided by the Core Facility.
Maintains and performs basic equipment repairs, in compliance with manufacturer and University guidelines.
Ensures compliance with all University, sponsor and federal rules and regulations.

Minimum Qualifications:
Successful completion of a full 4-year course of study in an accredited college or university leading to a bachelor's or higher degree; OR appropriate combination of education and experience1 year of technical or other relevant experience required.
2 years of technical or other relevant experience required.

If you would like to be a part of a team committed to service excellence, innovation, and outreach, we’d love to hear from you!

More information can be found at https://careers.northwestern.edu/psp/hr857prd_er/EMPLOYEE/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&FOCUS=Applicant&SiteId=1&JobOpeningId=45892&PostingSeq=1

Apply through the posted link. If you have any questions, you can contact me at renu.goel@northwestern.edu

An exciting opportunity has been created, effective November 1, for an experienced researcher to join the Prof. Andrew Emili’s Network Systems Biology laboratory, within the Knight Cancer Institute Center at Oregon Health & Science University in Portland, OR.

We are seeking a Senior Research Associate to join our growing team in a full-time role, who will work both independently and as a collaborative project co-leader, to establish and support our precision mass spectrometry (LC/MS) platform.

We are looking for a technically highly experienced, energetic, and engaging researcher interested in developing and applying innovative proteomics technologies to solve complex biological problems while working in working in a stimulating, fast-paced, and highly collaborative research environment.

As a lead technical member of the Emili Laboratory, the candidate will work with a multi-disciplinary research team of basic scientists, molecular biologists, analytical chemists, and computational biologists.

Primary responsibilities will be to establish, operate and maintain powerful new LC/MS instrument systems and to perform qualitative and quantitative high-throughput proteomics studies, and to engage with collaborating scientists. The position involves include working closely with diverse project scientists, processing and analyzing samples using optimizing proteomic workflows, and generating and interpreting complex proteomics data. The candidate must have exceptional experience operating and maintain high performance LC/MS instrumentation, and in generating and analyzing high-throughput proteomics data, as well as excellent communication skills and experience working in a highly collaborative team environment.

Duties include but are not limited to:
• Experimental design and laboratory execution of biochemical and mass spectrometry-based assays including proteomics data generation, processing, visualization, and interpretation. Routine usage and maintenance of high-performance LC/MS systems, including the operation of Thermo/Orbitrap family of mass spectrometers with UHPLC separation for high-throughput quantitative proteomics analyses. Day-to-day operation and support of LC-MS systems in the lab. Protein isolation from mammalian cells and peptide preparation and isotopic labeling for quantitative mass spectrometry. Help to develop, improve and implement new proteomics methods and workflows in the group

Required Qualifications
• PhD in relevant field AND 1 year of relevant experience OR Master's Degree in relevant field AND 5 years of relevant experience OR Bachelor's Degree in relevant field AND 9 years of relevant experience
• Proven ability to generate high quality mass spectrometry data
• Experience working with high performance nano-LC/MS instrumentation, ideally in operation, troubleshooting and maintenance of Orbitrap systems/software.
• Experience with proteomic method development, LC/MS maintenance, and troubleshooting
• Familiarity with raw data processing, interpretation, and visualization
• Understanding proteomic best lab practices for sample handling and analysis
• Experience and operational knowledge of high throughput setups and proteomics workflows
• Experience with quantitative LC/MS (e.g. isotope-tagging) and PTM analysis for discovery proteomics
• Experience with R, MATLAB, or python and general computational abilities
• Strong analytical and practical skills in protein sample preparation

Preferred Qualifications
• Degree in biochemistry, molecular biology, biomedical engineering, analytical chemistry and/or mass spectrometry
• 5+ years of research experience
• 4+ years hands-on LC-MS experience

Contact information:
Please contact Professor Emili: emili@ohsu.edu (send Resume/CV)

Ideally, also apply online. Please be sure to upload a Cover Letter and Resume/CV to:
https://externalcareers-ohsu.icims.com/jobs/19529/senior-research-associate/job?mode=view&mobile=false&width=759&height=500&bga=true&needsRedirect=false&jan1offset=-480&jun1offset=-420

Food Allergy Research and Resource Program (https://farrp.unl.edu)
Department of Food Science and Technology
University of Nebraska-Lincoln

Food Allergen Proteomics Research Scientist
https://employment.unl.edu/postings/81530

POSITION DESCRIPTION:
Conduct research in collaboration with faculty principal investigators (PIs) on a broad range of food allergen proteomics projects, with a primary focus on protein mass spectrometry (MS) applications. Research activities are expected to include discovery proteomics experiments for food allergen protein characterization, development and evaluation of targeted, quantitative MS methods, purification and evaluation of food proteins, and assessment of samples by immunoassay (ELISA, Western blotting, etc.). Research responsibilities include designing experiments, preparing samples, and conducting laboratory analysis, performing proteomics and statistical data analysis, and writing research reports and summaries.

Operate, supervise, and conduct routine maintenance on high-resolution LC-MS/MS instrument. Generate and monitor instrument performance data and serve as primary manager of coordination with instrument vendor service engineers. Develop and implement standardized and automated protocols for food allergen MS methods and data analysis for internal and external use.

Act as direct contact person with industrial clients (outside funding sources) and research collaborators, in collaboration with project PIs. Participate in research communication through conference presentations, primary manuscript drafting for individually led projects, and co-author contributions on collaborative projects.

Oversee all aspects of laboratory management in collaboration with PIs, including safety monitoring and training, mentoring of graduate and undergraduate students (e.g., as a resource for experimental design planning and statistical analysis assistance). Assist students and workers in the development of mass spectrometry protocols needed for their experiments. Maintain laboratory compliance with safety requirements and SOPs.

The University of Nebraska-Lincoln seeks to attract and retain a high performing and diverse workforce in which employees’ differences are respected and valued to better meet the varying needs of the diverse populations we serve. The university fosters a diverse and inclusive work environment that promotes collaboration so that all individuals are able to participate and contribute to their full potential. As an EO/AA employer, qualified applicants are considered for employment without regard to race, color, ethnicity, national origin, sex, pregnancy, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, marital status, and/or political affiliation. See: http://www.unl.edu/equity/notice-nondiscrimination.

MINIMUM REQUIRED QUALIFICATIONS
Master’s degree plus two years of relevant experience or PhD in Chemistry, Biochemistry, Food Science or related field. Relevant experience should show both basic and technical science including experience with mass spectrometry. Project management and/or supervisory experience required. Prioritization, organizational, communication and facilitation skills essential. Record-keeping and computer skills necessary. Must have knowledge of compliance and safety regulations and demonstrated ability to teach others.

PREFERRED QUALIFICATIONS:
Proteomics (protein mass spectrometry), protein purification, immunoassay (ELISA, Western blotting), and other protein chemistry experience (e.g., SDS-PAGE) is preferred.

APPLICATION REVIEW: 10/17/2022
TO APPLY: https://employment.unl.edu/postings/81530

INTRODUCTION
We are looking for a motivated and ambitious Postdoctoral fellow with extensive bioanalytical experience for studying Alzheimer pathology in human brain tissue using stable isotope labelling and mass spectrometry. We seek to understand the mechanisms by which Alzheimer pathology develops, which is critical for developing new treatment strategies and biomarkers. This is a two-year, NIH-funded fellowship.

SUBJECT AREA
Neurochemistry, Analytical Chemistry, Neurodegenerative Disease

SPECIFIC SUBJECT DESCRIPTION
A pathological hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptide into extracellular plaques and tau into intracellular tangles in the brain. New antibody therapies targeting those proteins give exciting but also ambiguous clinical results for treatment of AD which relates largely to the fact that it is still not fully resolved where and when AD pathology emerges in the brain. Hence, there is a great need for a detailed understanding of early AD pathology as well as new biomarkers that can be measured in cerebral spinal fluid (CSF) and blood that reflect early pathology in the brain and facilitate an early and accurate diagnosis and prognosis of AD.

DESCRIPTION
As part of this research, you will drive and be involved in a clinical projects utilizing SILK-mass spectrometry-based analysis of protein dynamics in AD pathology in brain tissue, specifically, the rate of deposition of amyloid-beta and other potential proteins and lipids in pathological aggregates in the brain. The main analytical methods to be used include mass spectrometry imaging (MSI), immunohistochemistry (IHC), immunoprecipitation (IP), fluorescence microscopy and ex-situ mass spectrometry of proteins (proteomics). Please note that some on the work will be performed in conjunction with our Co-Investigator, Assoc. Prof. Jorg Hanrieder, in Gothenburg, Sweden. Travel stipend will be provided for this period.

ELIGIBILITY
To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject e.g. biology, chemistry, biomedicine, pharmacy; or MD, PhD with neuropathology fellowship training.

ASSESSMENT
Candidates will be assessed based on documented scientific experience with focus on method development and knowledge with regard to mass spectrometry of biological samples as demonstrated by publications in international, peer-reviewed journals. Previous experience in mass spectrometry imaging or alternatively, tissue imaging, immunoassays for neurochemical biomarker development for brain pathologies is a particular merit.
Ability to independently process data and write scientific publications is essential, as is the ability to be flexible and able to work independently. During assessment, account will be taken with respect to personal ability and qualifications.

CONTACT: Assoc. Prof. Katherine Schwetye, MD, PhD

Address:
Campus Box 8118
660 S. Euclid Ave.
St. Louis, MO 63110

Dept. Psychiatry and Neurochemistry
University of Gothenburg
Mölndal Hospital House V3
SE 43180 Mölndal, Sweden

Homepage: www.neurochem.se

E-mail: schwetyk@wustl.edu
jh@gu.se

Key Literature:

Michno et al 2021 Science Advances
https://www.science.org/doi/10.1126/sciadv.abg4855

Michno et al 2019 J Biol Chem
https://www.jbc.org/article/S0021-9258(20)36610-2/fulltext

JOB DESCRIPTION
The Discovery Proteomics group at our South San Francisco campus is tasked with developing and
implementing proteomic characterization technologies in support of Amgen’s early discovery pipeline
In this vital role you will you will conduct statistical analysis, data ingestion, and computational pipeline development for internal and external mass spectrometry-based and other type of proteomics data to support biomarker discovery, target validation, experimental design, and mechanism‐of‐action studies. You will work closely with other lab-based scientists in the Discovery Proteomics group, genomics, and software engineers in the Research Informatics team to support multi-omics
data integration.

ROLE RESPONSIBILITIES
Enable Amgen’s preclinical pipeline through delivery of innovative technologies and technical expertise.
Implementation of data analysis, management, and visualization strategies for the complex proteomics and posttranslational data generated by mass spectrometry and other technologies.
Develop and establish computational solutions for differential protein expression analysis, protein turnover rate estimation, and protein-protein interaction identification.
Work across genomic and proteomic platforms, and potentially other ‘omic’ platforms, for data integration and mining, applying available external resources where appropriate.

PREFERRED QUALIFICATIONS:
Doctorate degree, Master’s degree plus 4 years of relevant experience, Bachelor’s degree plus 6 years of relevant experience.
Proficiency in Python/R/SQL/Java and familiarity with analytic techniques/packages necessary for statistical analysis, data processing, data visualization, and machining learning
Good practice in coding project management and reproducible data analysis.
Solid understanding in the Unix/Linux and cloud computing (AWS) environment.
Experiences in analyzing large scale protein interactions, protein turnover, and/or posttranslational modification studies.
Knowledge of proteomics data processing pipeline such as Proteome Discoverer, Spectronaunt, Skyline, MaxQuant, DIANN, MSstats, or OpenMS.
Strong background in biology or chemistry, especially as it pertains to human disease in the fields of Immunology, Oncology, Inflammation, and Cardiometabolic Disease.
Basic understanding in genomics and transcriptomics technologies and data properties.

FOR MORE DETAILS AND APPLY THE POSITON:
http://adtrk.tw/tp/rj6-vaM5-y-K

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We are uniquely structured with opportunities for all scientists to contribute to both established programs as well as ongoing early target selection, screens and validation. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Job Summary:
The successful candidate will have extensive hands-on experience and expertise with mass-spectrometry instrumentation and MS-based proteomics applications are required, including quantitative strategies like isotopic and isobaric labeling, as well as label-free techniques (e.g. DIA, PRM/SRM). Strong working knowledge of biochemistry and analytical chemistry are desired; familiarity with small-molecule pharmacology is a plus. The successful candidate will join a small group of Proteomics scientists working to develop and operate a cutting-edge chemoproteomic screening platform for the discovery and development of novel drug candidates and targets.

Education and Experience requirements:

• PhD (or equivalent experience) in mass-spectrometry based proteomics, analytical chemistry, chemical biology, or related discipline
• Extensive hands-on experience with Thermo Orbitrap mass spectrometers and associated software
• Demonstrated ability to apply and troubleshoot complex proteomic techniques in a biological context
• Experience with ancillary techniques is highly desirable (cell culture, molecular biology, immunoprecipitation/protein isolation, PTM enrichment, bioinformatics, etc)

Required Key Attributes:

• Candidates must have strong communication skills and an ability to present results to large teams
• Candidates must have effective troubleshooting and problem-solving skills.
• Candidates must be an effective team player, strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines.

Please apply directly to hr@vividion.com, or using the link below
https://vividiontherapeutics.applytojob.com/apply/xmUMTktVHr/Scientist-Proteomics?referrer=20220623234325C0MQUQS5LWMRZHXV

Biogen is looking to grow its Clinical LC-MS biomarker capabilities. Currently looking for an individual with strong LC-MS skills, in particular with the Orbitrap line. We use QE+, QE HFX, Exploris 480, Fusion. We mainly work with nanoLC, including Dionex RSLC, EasySpray and more recently the Evosep One platform. We primarily do targeted measurements (PRM).
Of course we are strong supporters of Skyline (everyone should be). This role is for a technical expert, ideally with experience doing immunoenrichments (manual with dynabeads or using Agilent Bravo) prior to LC-MS. This person would also get exposure to clinical development project teams and get lots of experience to grow their career. Contact me directly to learn more: omar.mabrouk@biogen.com

The Tow Center for Developmental Oncology at MSKCC is seeking a highly motivated scientist with experience in proteomics and biochemistry. The Senior Research Scientist will be part of the Molecular Therapeutics Initiative, dedicated to the development of improved models of childhood cancers and mechanism-based translational science, with the aim to enable improved therapies for patients. As Senior Research Scientist you will participate in the execution of biochemical and molecular studies supporting the Tow Center and collaborating investigators. You will have a central role in the proteomic analysis of tumor samples using advanced analytical techniques, including mass spectrometry proteomics and single-cell protein and nucleic acid profiling. Under guidance, you will establish SOPs, develop analytical methods, and optimize experimental protocols. You will be part of a collaborative effort in an ambitious project and are therefore expected to be organized, flexible, and an excellent team player. This role is an opportunity to join a highly dynamic and interdisciplinary team with access to state-of-the-art technologies and the prospective of implementing innovative research and discovery tools in order to advance cancer science and treatments for children and adults with refractory cancers.

You are:
• An experienced biochemist with a strong background in proteomics and molecular biology
• Proficient with analytical chemistry, biochemistry and molecular biology
• Proficient with proteomics sample preparation, nanoscale liquid chromatography, nanoelectrospray ionization, and high-resolution mass spectrometry, such as Thermo Orbitrap or Bruker, Sciex, or Waters TOF mass spectrometers
• Eager to learn and respond to challenges
• Highly organized
• Able to multitask and work both independently and in teams
• Capable to adapt to change and evolving circumstances
• An excellent communicator, able to effectively address different audiences

You will:
• Work closely with MSK colleagues to carry out experimental efforts that will include comprehensive proteomic analysis of tumor samples
• Collaborate with MSK core facilities personnel to process and analyze patient specimens
• Operate and maintain high-end analytical instruments
• Present experimental results in written and oral form

You need:
• Ph.D. in chemistry, biochemistry, or biology
• At least three-five years of experience in laboratory research
• Direct experience with mass spectrometry or proteomics
• Experience with cancer biology and other advanced analytical techniques is preferred

To apply, please send one-page letter of interest explaining your past research, current interests, and how your past work has prepared you to succeed and enable our mission, along with your current CV/resume to devonc@mskcc.org.
MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision

Senior Application Scientist (Proteomics/Translational Research)
Location San Jose, California, US Job ID: 196964BR

https://jobs.thermofisher.com/global/en/job/196964BR/Senior-Marketing-Manager-Proteomics-Translational-Research

Interested job seekers can reach out to me for any follow up questions: Justin Chang - justin.chang@thermofisher.com

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them.

How you will make an impact:
We have an exciting opportunity for a highly motivated Application Scientist to join the Vertical Marketing group in the Proteomics department at Thermo Fisher Scientific. The candidate will have a leading role in developing new mass spectrometry-based tools and workflows for the translational proteomics market working within the mass spectrometry and chromatography business and in collaboration with other departments at Thermo Fisher Scientific.
The candidate will be part of a larger team improving and developing market leading instrumentation, software and consumables products and supporting the development efforts through from the application perspective. Critical to the role is the regular interaction with leading scientist in the field of proteomics and the assessment of market needs through VOC, sales and the broader marketing organization. The application scientist also provides internal and external training as well as customer support. This role liaises with product, application marketing peers, the marketing communications team for creation of marketing and sales collateral to support programs and drive campaigns.

What you will do:
• Day-to-day operation and support of LC-MS systems in the lab
• Design and execute experiments that translate instrument performance capabilities into scientifically meaningful data and results to demonstrate product value.
• Develop strategic application plans, generate laboratory applications data, create exemplary data examples, and perform product technology evaluations to support R&D and field sales.
• Perform market research, capture customer input (VOC) and emerging trends in the protein biomarker and translational markets, develop and maintain current competitive marketing information for review and response.
• Develop and publish application notes, generate and deliver application-related material for internal and external trainings.
• Ensure the above information is communicated to product marketing, sales, demo centers and R&E groups.
• Offer application support to Key Collaborators and customers when appropriate;
• Manage relationships with outside collaborators.
• Ability to travel 20 – 30%,

How you will get here:

Education:
• MS degree in science (chemistry, biology, or related discipline) with minimal 8 years of industrial experience or equivalent.
• PhD degree in Biochemistry, Chemical Biology, Structural Biology or a related discipline and experience in mass spectrometry-based proteomics, preferred

Experience:
• Experience in operation, troubleshooting and maintenance of LCMS instrumentation, preferably Orbitrap instrumentation including Thermo Scientific hybrid, Thermo Scientific Tribrid Orbitrap mass spectrometers and HPLC/nanoUHPLC systems.
• Experience and operational knowledge of high throughput setups including liquid handlers and proteomics factories is desired, but not required.

Knowledge, Skills, Abilities:
• Position may require Covid-19 vaccination, including a booster and/or routine testing, per client discretion. As a requirement to be onsite at Thermo Fisher Scientific this position requires vaccination status disclosure upon employment.
• Strong analytical and practical skills in protein or nucleic acid sample preparation, protein data analysis and interpretation.
• Ability to pick up new technologies quickly and ultimately troubleshoot independently
• Excellent communication skills in oral and written English

Our global team of more than 100,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.

ROLE SUMMARY

A Postdoctoral Research Fellow position is available in the Mass Spectrometry Technology group in Drug Safety R&D Andover, MA for a highly motivated and innovative Ph.D. graduate. The candidate will utilize the entire suite of cutting-edge mass spectrometry technologies to elucidate changes in proteome phosphorylation in response to drug treatment. The newly established approaches will lead to the implementation of highly-plexed phospho-peptide assays for relevant signaling pathways across different therapeutic modalities. This offers a platform compatible with the use of chemical probes for target engagement and spatial resolution proteomics techniques. This role is within the state-of-the-art mass spectrometry lab in Global Discovery, Investigative and Translational Sciences (G-DITS) organization and brings multidisciplinary opportunities across in Drug Safety R&D and Pfizer. The expectation is that this work will lead to publications in top-tier journals, enable the candidate to gain a broader knowledge in drug development and toxicology discipline, and set the foundation for a career in industry or academia. This position requires a strong background in biochemistry, hands-on experience in mass spectrometry-based proteomics and demonstrated leadership in emerging technologies and innovation.

ROLE RESPONSIBILITIES

The successful candidate will be responsible for the development of targeted (PRM, SureQuant) and unbiased mass spectrometry to affinity enrich and elucidate peptide phosphorylation.
Ability to implement highly-plexed assays for selected signaling pathways using hiRes MS.
Deliver kinase activity profiling platform compatible with affinity-/activity-based approaches and spatial resolution techniques such as phosphoproteome analysis from FFPE sections isolated by laser capture microdissection.
Demonstrate the utility of the developed methodologies by their application for hypothesis generation and testing of the mechanism of toxicities.
Participate in all phases of mass spectrometry laboratory operations including technology evaluations, development of sample preparation and separation methods, maintenance and troubleshooting of chromatography and mass spectrometers.
Apply analytical mindset, strong problem-solving, and trouble-shooting skills to enable technology and scientific advancements.
Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g., responsible for electronic notebook record-keeping, and raw data storage.
Publications in peer-reviewed scientific journals and external/internal presentations.

QUALIFICATIONS

Basic Qualifications

Qualified applicants must hold a Ph.D. in Analytical Sciences, Biochemistry, or closely related fields with 0-2 years of postdoctoral experience.
Proficient with protein biochemistry, expertise in biological sample handling, and application of complex sample preparation methodologies applied to protein mass spectrometry.
Expertise in hiRes MS, nanoLC and relevant software packages for data analysis.
Strong written and oral communication skills, and interpersonal skills for collaboration.
Well organized, self-motivated, ability to multitask and with attention to detail.
Strong scientific curiosity and interest in drug development and technology innovation.
Record of peer-reviewed publications.
Preferred Qualifications

Understanding of enrichment strategies using IMAC, TiO2, click-chemistry.
Strong motivation for emerging technologies for single-cell proteomics.
Familiar with laser capture microdissection.

OTHER JOB DETAILS

Eligible for Relocation Assistance

Must have Work Authorization in the US

INTERESTED APPLICANTS PLEASE APPLY AT: https://pfizer.wd1.myworkdayjobs.com/PfizerCareers/job/United-States---Massachusetts---Andover/Postdoctoral-Research-Fellow--Drug-Safety-R-D_4846950-3

Pfizer Contact: Mireia Fernandez Ocana- Mireia.FernandezOcana@pfizer.com

POSTDOCTORAL FELLOW IN MASS SPECTROMETRY OF ALZHEIMER PATHOLOGY

INTRODUCTION
We are looking for a motivated and ambitious Postdoctoral fellow with extensive bioanalytical experience for studying Alzheimer pathology in human brain tissue using stable isotope labelling and mass spectrometry. We seek to understand the mechanisms by which Alzheimer pathology develops, which is critical for developing new treatment strategies and biomarkers. This is a two-year, NIH-funded fellowship.

SUBJECT AREA
Neurochemistry, Analytical Chemistry, Neurodegenerative Disease

SPECIFIC SUBJECT DESCRIPTION
A pathological hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptide into extracellular plaques and tau into intracellular tangles in the brain. New antibody therapies targeting those proteins give exciting but also ambiguous clinical results for treatment of AD which relates largely to the fact that it is still not fully resolved where and when AD pathology emerges in the brain. Hence, there is a great need for a detailed understanding of early AD pathology as well as new biomarkers that can be measured in cerebral spinal fluid (CSF) and blood that reflect early pathology in the brain and facilitate an early and accurate diagnosis and prognosis of AD.

DESCRIPTION
As part of this research, you will drive and be involved in a clinical projects utilizing SILK-mass spectrometry-based analysis of protein dynamics in AD pathology in brain tissue, specifically, the rate of deposition of amyloid-beta and other potential proteins and lipids in pathological aggregates in the brain. The main analytical methods to be used include mass spectrometry imaging (MSI), immunohistochemistry (IHC), immunoprecipitation (IP), fluorescence microscopy and ex-situ mass spectrometry of proteins (proteomics). Please note that some on the work will be performed in conjunction with our Co-Investigator, Assoc. Prof. Jorg Hanrieder, in Gothenburg, Sweden. Travel stipend will be provided for this period.

ELIGIBILITY
To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject e.g. biology, chemistry, biomedicine, pharmacy; MD or equivalent; or MD, PhD with neuropathology fellowship training.

ASSESSMENT
Candidates will be assessed based on documented scientific experience with focus on method development and knowledge with regard to mass spectrometry of biological samples as demonstrated by publications in international, peer-reviewed journals. Previous experience in mass spectrometry imaging or alternatively, tissue imaging, immunoassays for neurochemical biomarker development for brain pathologies is a particular merit.
Ability to independently process data and write scientific publications is essential, as is the ability to be flexible and able to work independently. During assessment, account will be taken with respect to personal ability and qualifications.

CONTACT: Assoc. Prof. Katherine Schwetye, MD, PhD

Address:
Pathology & Immunology
Washington University School of Medicine
Campus Box 8118
660 S. Euclid Ave.
St. Louis, MO 63110

Dept. Psychiatry and Neurochemistry
University of Gothenburg
Mölndal Hospital House V3
SE 43180 Mölndal, Sweden

Homepage: www.neurochem.se

E-mail: schwetyk@wustl.edu
jh@gu.se

Key Literature:

Michno et al 2021 Science Advances
https://www.science.org/doi/10.1126/sciadv.abg4855

Michno et al 2019 J Biol Chem
https://www.jbc.org/article/S0021-9258(20)36610-2/fulltext

The structural biology and native mass spectrometry teams at Genentech are looking to recruit a joint contract research scientist (PhD level) for a 1-year term (with potential to extend) to work on a high impact project that aims to enrich the information gained from protein structure studies. The project will use complementary technologies across ion mobility, mass spectrometry, and imaging. We're hoping to find someone with experience in native MS or cryoEM, native protein preparation, hardware development, data analysis, and programming; candidates who have experience in some, but not all, of these areas are encouraged to apply, given that they are interested in learning and developing new skills. The ideal candidate will be able to lead their research projects independently and also collaborate with scientists in cross-disciplines. There will be opportunities for publication and dissemination of results. The position is competitively paid and includes benefits. It is a lab-based position located in SSF, CA at Genentech, Inc.

Please reach out directly to hecht.elizabeth@gene.com with the subject line: "Skyline Posting: Research Scientist Position"

Position Summary
Dr. Randall Bateman’s lab investigates the causes and future diagnosis and treatments of Alzheimer’s
disease utilizing a wide variety of assays and techniques from basic applications, such as quantitative
measurement of stable-isotope labeled peptides to clinical translational studies in diagnostic and
therapeutic biomarkers for AD. This position assists with the technical aspects of studies and experiments
including running experiments, completing data analysis, planning projects, designs protocols, maintaining
documentation, and completing general maintenance and organizational duties to ensure smooth
operation across the lab.

Primary Duties & Responsibilities
Assists in developing and conducting research projects, including experiment design,
experiment execution, data analysis and documentation of experiment results.
Performs data entry and maintains data files on research.
Complies with established safety procedures and maintains required documentation on
laboratory and specimen conditions. 
May assist with grant preparation and reporting.
Performs complex statistical analysis of data collected and writes interpretative reports. 
Verifies the correctness of the data submitted and makes recommendations based on these
analyses.
Solves practical problems relating to difficulties with equipment or test subjects.  Suggests
technical or procedural improvements in testing methods.

Preferred Qualifications
Degree in biological science or chemistry.  
Experience with analytical chemistry or GLP. 
Experience with immunoprecipitation and automated bench work.
Experience with mass spectrometry is strongly preferred.
Critical thinking, analytical, reasoning and problem-solving skills.
High precision and tight Quality Control of all bench experiments
Ability to organize and prioritize tasks.
Good scientific writing and oral communication skills.
Detail-oriented.
Ability to maintain complete and organized records/reports. 
Able to work independently yet collaboratively in a team environment.
Ability to analyze and interpret statistical data and to communicate data in a clear, concise
manner. 
Computer literacy, including the ability to use a variety of software packages to analyze data.

Required Qualifications
Master’s degree with four years of experience in research lab operations or an equivalent combination of
education and experience equaling nine years.

Salary Range
$44,700.00 - $81,200.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University.
Individual rates within the range will be determined by factors including one's qualifications and
performance, equity with others in the department, market rates for positions within the same grade and
department budget.

Apply at:
https://wustl.wd1.myworkdayjobs.com/External/job/Washington-University-Medical-Campus/Staff-
Scientist---Neurology_JR64024

Email Cindy Hodge at hernkece@wustl.edu for more information

GENERAL SUMMARY:

A position is open for a full-time laboratory senior scientist focused on protoemics at the MGH Cancer Center in the laboratory of Liron Bar-Peled. The laboratory studies the cellular response to altered metabolic states in multiple cancer models. Specific studies relate to discovering druggable vulnerabilities in genetically defined cancers and elucidating the mechanisms of reactive oxygen species in cancer growth using cutting edge chemical proteomic technologies. To learn more about our research visit: barpeledlab.org.
The candidate will supervise a major expansion of cysteine druggability mapping in patient samples, overseeing the implementation of this technology by maintaining and operating advanced proteomics instruments and corresponding sample analysis. These duties include operation of LC-MS/MS systems, sample preparation, proteomic data collection and analaysis and accurate recording of procedures and results, developing the project, supervising trainees, preparing figures for publications ordering necessary reagents to conduct experiments and participation in joint upkeep of the lab.

Dr. Bar-Peled seeks exceptionally motivated candidates who enjoy conducting research and involving themselves in the dynamic and intellectual environment of the laboratory. She or he will have the opportunity to become fully involved with all the steps of research being completed in our laboratory, often working directly with Dr. Bar-Peled, which will lead to numerous publications. Investigators in our laboratory will present at regular laboratory meetings. The experience gained in the lab will be very helpful for pursuing a career as a researcher or physician.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

The primary techniques required for this position include:
• Extensive experience operating LC-MS/MS proteomic instruments
• TMT labeling and proteomic sample preparation
• Supervises and oversees multiple projects in the lab
• Prepares manuscripts
• Independent researcher
• Performs base-level procedures as assigned (i.e. – pipetting, tissue culture, in vitro assays, etc.)
• Conducts mammalian tissue culture experiments
• Maintains laboratory notebook
• Understands and applies basic scientific techniques
• Conducts analysis of results
• Supports the research of other lab members
• Assists with organizing materials for publication or presentation
• Maintains and orders supplies
• Works in an efficient manner
• Has a high capacity for problem solving
Other techniques may be required to further expand on experimental findings.

SKILLS & COMPETENCIES REQUIRED:

Doctoral degree with a preference in biology, molecular biology, chemistry, or biochemistry and at least 5 years lab experience as a postdoctoral researcher with proteomics expertise. Candidates with a strong computational background are also encouraged to apply. The ideal candidate will be detail-oriented, organized, and able to work independently as well as part of a team in a fast-paced evolving environment. Excellent communication and organizational skills are necessary.

To apply, contact Dr. Liron Bar-Peled lbar-peled@mgh.harvard.edu
To learn more about our research visit: barpeledlab.org.

The Hoofnagle lab has an outstanding opportunity for a Research Scientist/Engineer 3. The person in this role will perform routine laboratory procedures and support research and development of analytical chemistry techniques to quantify proteins and small molecules in complex mixtures, including urine, serum, plasma, cell culture, blood spots, cerebral spinal fluid, and frozen and preserved tissues. One of the overarching goals of the Hoofnagle lab is development of reference method procedures for proteins in complex mixtures to serve as the gold standard for patient care and clinical research. This person will design and develop novel quantitative assays and perform routine testing that can be used to support clinical research studies. It is expected that these fundamental studies will lay the foundation for high-quality clinical assays in the future.

Responsibilities:
• Develop, validate, and implement new LC-MS assays to quantify proteins and small molecules from typical clinical chemistry sample types to expand understanding of the pathophysiology of different disease states.
• Characterize antibody and affinity reagents using a variety of biochemical techniques (e.g. SDS-PAGE, SE-HPLC, N-glycan profiling, peptide mapping, etc.).
• Independently perform a variety of laboratory techniques (e.g. affinity purification, tryptic digestion, solid-phase-extraction, HPLC-MS, ELISA, etc.).
• Perform established assays using targeted proteomics and metabolomics technologies for the sensitive and specific quantification of proteins and small molecules.
• Manage projects of moderate size and scope; initiate new projects, identify long- and short-term project goals, and design & prioritize experiments to determine feasibility of set objectives.
• Communicate with outside scientists in academia and industry to develop collaborative projects.
• Contribute, analyze, and present research data using summary graphs for publication and grant submission; present and update research progress at lab meeting or joined group settings.
• Optimize protocols and troubleshoot experiments as necessary to generate relevant data. Continuously evaluate existing methods with an eye toward improving data quality, reducing costs, and/or improving turn-around-time.
• Monitor assignments and projects to ensure they are completed within specified time frame; accommodate schedule changes to cooperatively accomplished required daily work.
• Perform work accurately and precisely; recognize, correct, and document errors when they occur.
• Maintain complete, accurate, legible records. Author, review, and revise SOPs and manuscripts for publication.
• Provide ongoing feedback and updates to supervisor/project coordinator and actively solicit input on overcoming roadblocks and impediments to success.
• Train new employees and guest technicians in experimental procedures and assays, instrument maintenance, laboratory safety, and general lab procedures.
• Perform routine instrument maintenance as well as troubleshooting; serve as point-of-contact with service engineers.
• Coordinate sample receiving/shipments with collaborators; assist with sample tracking, inventory maintenance, data entry, and database updating.
• Prepare and verify reagents; monitor and order supplies.
• Perform other duties as assigned.

Requirements:
Master’s degree in Life Sciences (including chemistry, biophysics, biochemistry, etc.) and 5+ years of working experience. Previous experience with mass spectrometry is required.
Must be able to communicate effectively in English, both verbally and in writing.

Desired:
PhD degree in Life Sciences (including chemistry, biophysics, biochemistry, etc.) and 3+ years of relevant experience. The ideal candidate with have demonstrated the ability to think and work independently. They will have strong organizational skills and a keen attention to detail, be able to clearly express oneself both verbally and in writing, and have the capacity to carefully analyze the data they generate. It is also highly desirable that the applicant be comfortable working in a team environment, be able to manage their own workload effectively, be careful and fastidious, and have strong computer skills with a working knowledge of general MS Office applications.

Specific experience with the following techniques is highly desired:
• Proteomics, metabolomics, peptide mapping, and/or quantitative LC-MS assay development.
• Quality control, standard operating procedures, and method validation.
• Excellent writing skills as evidenced by peer-reviewed publications and participation in constructing funding applications.

To apply, please visit this link:
https://uwhires.admin.washington.edu/eng/candidates/default.cfm?szCategory=jobprofile&szOrderID=197136&szCandidateID=0&szSearchWords=Laboratory OR Medicine&szReturnToSearch=1

Hiring manager:
Michelle Emrick emrick@uw.edu

The Hoofnagle Lab has an outstanding opportunity for a Research Scientist/Engineer 1. The person in this role will perform routine laboratory procedures and support research and development of analytical chemistry techniques to quantify proteins and small molecules in complex mixtures, including urine, serum, plasma, cell culture, blood spots, and frozen and preserved tissues. One of the overarching goals of the Hoofnagle Lab is development of reference method procedures for proteins in complex mixtures to serve as the gold standard for patient care and clinical research. This individual will work with clinical technologists and research scientists to design and develop novel clinical laboratory tests and perform routine testing in support of clinical research studies.

Responsibilities:
• Independently perform a variety of laboratory techniques (e.g. affinity purification, tryptic digestion, solid-phase-extraction, HPLC-MS, ELISA, etc.).
• Perform established assays using targeted proteomics and metabolomics technologies for the sensitive and specific quantification of proteins and small molecules.
• Analyze experimental data with various software and analysis tools.
• Contribute, analyze, and present research data using summary graphs for publication and grant submission, present and update research progress at lab meeting or joined group settings.
• Optimize protocols and troubleshoot experiments that are necessary to generate relevant data and improve data quality.
• Perform work accurately, precisely, and recognize & corrects & documents errors when they occur.
• Monitor assignments and projects to ensure they are completed within specified time frame; accommodate schedule changes to cooperatively accomplish required daily work.
• Maintain complete, accurate, legible records. Create SOPs, thoroughly document any modifications.
• Provide ongoing feedback and updates to supervisor/project coordinator and actively solicit input on overcoming roadblocks and impediments to success.
• Assist with instrument maintenance and troubleshooting.
• Assist with sample tracking, inventory maintenance, data entry, and database updating.
• Prepare and verify reagents; monitor and order supplies.
• Perform other duties as assigned.

Requirements:
Bachelor’s degree in Life Sciences (including chemistry, biophysics, biochemistry, etc.) AND previous experience working in a laboratory setting.
Must be able to communicate effectively in English, both verbally and in writing.

Desired:
The ideal candidate with have demonstrated the ability to think and work independently. They will have strong organizational skills and a keen attention to detail, be able to clearly express oneself both verbally and in writing, and have the capacity to carefully analyze the data they generate. It is also highly desirable that the applicant be comfortable working in a team environment, be able to manage their own workload effectively, be careful and fastidious, and have strong computer skills with a working knowledge of general MS Office applications. Working knowledge of mass spectrometry and liquid chromatography would be very valuable.

To apply, please visit this link:
https://uwhires.admin.washington.edu/eng/candidates/default.cfm?szCategory=jobprofile&szOrderID=204265&szCandidateID=0&szSearchWords=&szReturnToSearch=1

Michelle Emrick: emrick@uw.edu

Job Description

We are looking for an Associate Scientist to join the Mass Spectrometry group in the Protein Therapeutics department at Gilead Sciences. The successful candidate will be responsible for the analytical characterization of proteins and biologics by mass spectrometry.

The successful candidate is expected to conduct independent lab work and collaborate with other scientists and project teams. He or she should be able to think critically and troubleshoot complex scientific and technical issues while contributing to a team-work oriented environment to advance research projects. He or she should possess excellent protein mass spectrometry skills, knowledge of molecular biology techniques, and experience with software packages necessary for data analysis and reporting.

Functions and Responsibilities

• Characterize protein therapeutics by intact protein and subunit analysis mass spectrometry.
• Perform experiments to identify and characterize post translational modifications by peptide mapping mass spectrometry.
• Develop workflows and strategies to improve analysis and throughput.
• Calibrate and perform routine maintenance on LC/MS equipment.
• Document findings in electronic notebooks and lab protocols.
• Participate and present data at team meetings.

Knowledge, Experience and Skills

• Must have hands on experience with intact mass spectrometry and molecular characterization of protein therapeutics.
• Experience with molecular biology techniques such as SDS-PAGE, western blotting, HPLC, protein fractionation, and immunoprecipitation. (a plus)
• Experience in sample preparation for glycoprotein, antibody subunit and peptide mapping workflows.
• Experience operating and analyzing data from Agilent TOF/qTOF mass spectrometers is desirable. Knowledge of other mass spectrometry platforms is a plus.
• Experience maintaining and troubleshooting HPLCs and mass spectrometers (a plus)
• Experience with Protein Metrics Byos, MassHunter and Skyline. Experience with other mass spectrometry software packages is a plus. Proficient with Microsoft Office applications.
• Ability to multi-task in an extremely dynamic environment while providing high-quality and detailed analytical support in a professional, pleasant, and tactful manner is a necessity.
• Strong communication & interpersonal skills are essential for success in this collaborative role.
• Minimum relevant industrial experience: Bachelor’s degree with 7+ years of experience or Master’s degree with 5+ years of experience. Job title will be commensurate with experience.

To apply, please visit this link:
https://gilead.wd1.myworkdayjobs.com/gileadcareers/job/United-States---California---Foster-City/Associate-Scientist--Mass-Spectrometry_R0025701-1

We are looking to hire a talented and motivated scientist for our metabolomics/lipidomics platform, within the proteomics resource center, at Rockefeller University. Position is available ASAP.

The Rockefeller University, located at the Upper East Side of Manhattan, is a world-renowned center for research and graduate education in the biomedical sciences. We seek an enthusiastic and diligent colleague to join the Proteomics Resource Center (http://proteomics.rockefeller.edu/). The position is focused on small molecule applications of analytical chemistry and mass spectrometry. The position is an excellent opportunity to apply mass spectrometry-based analytical chemistry to exciting projects, spanning a wide range of sample and project types.

Responsibilities

Maintaining and operating high-flow LC-MS/MS (Q-Exactive Plus), GCMS (Agilent Intuvo) and related equipment
Managing compound library
Interacting with and advising investigators with regard to experiments
Interacting with other Center staff in support of overall Center operations
Developing and implementing metabolomics related protocols in the Center
Processing, analyzing, and interpreting data and reporting findings to investigators and the Director of the Proteomics Resource Center
Generating standard operating procedures
Tracking and submitting billing and purchasing information
Monitoring and maintaining laboratory appearance

Who you are

Bachelor’s degree in science and a minimum of 2 years of related experience; Master’s degree or Ph.D. preferred
Strong analytical and practical skills in sample preparation, LC-MS, GCMS, and data analysis and interpretation
Excellent communication skills in oral and written English
Ability to work independently as well as part of a team, and flexibility to interact with a diverse group of researchers
In-depth experience with liquid chromatography mass spectrometry based small molecule analysis
Hands-on experience with mass spectrometry, preferably Orbitrap type instruments, in-depth knowledge of instrument operation and maintenance, data interpretation, and knowledge of background literature
Practical experience with informatics is desirable
Ability to maintain and expand knowledge of mass spectrometry techniques through self-education, dialog with other experts, reading literature, and attending conferences and courses as necessary

About the Proteomics Resource Center (PRC)

Scientists at the PRC work and collaborate on a wide variety of projects with Rockefeller investigators as well as with scientists from not-for-profit institutions. Projects range from analysis of small molecules and metabolites to PTM analysis of thousands of proteins.

Examples of projects include nucleoside and amino acid quantitation, TCA cycle intermediates, analysis of secreted mosquito peptides, and quantitative profiling of exosomes. The PRC operates in a detail-oriented style and addresses projects individually; this allows the scientists of the Center to engage with many researchers and tackle a broad range of research areas. A Research Support Specialist at the PRC will be able to address biological projects using both metabolomics and proteomics mass spectrometry based strategies. The position is ideal for a scientist with hands-on LC-MS/MS and GCMS experience who has or wishes to gain additional experience in a very exciting and high-impact scientific environment.

To apply to this job, please email your resume and cover letter to halwaseem@rockefeller.edu

Job Description:
We are looking for an experienced scientist to join the Mass Spectrometry group in the Protein Therapeutics department. The successful candidate will be responsible for mass spectrometry characterization of biologics, development of sample preparation workflows, acquisition and analysis of proteomics datasets, and other drug discovery-related projects.

The successful candidate is expected to conduct independent lab work and collaborate with other scientists and project teams. He or she should be able to think critically and troubleshoot complex scientific and technical issues while contributing to a team-work oriented environment to advance research projects. He or she should possess excellent protein mass spectrometry skills, knowledge of molecular biology techniques, and experience with software packages necessary for data analysis.

Functions and Responsibilities:

• Design and conduct experiments to characterize protein therapeutics.
• Perform proteomics experiments to characterize biological samples, protein relative quantitation, post-translational modifications and protein-protein interactions.
• Develop workflows and strategies to improve analysis and throughput.
• Participate and present data at team meetings.
• Maintain knowledge of advancements in the field.

Knowledge, Experience and Skills:

• Hands on experience with intact mass spectrometry and molecular characterization of protein therapeutics is highly desirable.
• Experience with quantitative proteomics methods such as TMT-tagging or SILAC.
• Experience operating and analyzing data from ThermoFisher Orbitrap and Agilent TOF/qTOF mass spectrometers is highly desirable. Knowledge of other mass spectrometry platforms is a plus.
• Experience with Proteome Discoverer, Protein Metrics Byos, MassHunter, Skyline and other mass spectrometry software packages.
• Experience maintaining and troubleshooting HPLC and mass spectrometers.
• Understanding of molecular biology techniques such as western blotting, immunoprecipitation, fractionation and biofluid processing methods a plus.
• Ability to multi-task in an extremely dynamic environment while providing high-quality analytical support in a professional, pleasant, and tactful manner is a necessity.
• Strong communication & interpersonal skills are essential for success in this collaborative role.
• Minimum relevant industrial experience: Bachelor’s degree with 8+ years of experience, Master’s degree with 6+ years of experience or Doctorate degree. Job title will be commensurate with experience.

Please click to following link to apply. Thank you!
https://gilead.yello.co/jobs/twgCkoSC_Q4BKwj_GxSq7g/job_boards/v42vD4vKxb3AkKvV93YsrQ

Food Allergy Research and Resource Program (https://farrp.unl.edu/)
Department of Food Science and Technology
University of Nebraska-Lincoln

Food Allergen Proteomics Research Laboratory Manager
https://employment.unl.edu/hr/postings/77072

Position Description:
Oversee all aspects of laboratory management in collaboration with faculty principal investigators (PIs), including mentoring of graduate and undergraduate students, including safety monitoring and training, experimental design planning, and statistical analysis assistance. Operate and conduct routine maintenance on high-resolution LC-MS/MS instrument and serve as primary manager of coordination with instrument vendor service engineers. Develop and implement standardized and automated protocols for food allergen MS methods and data analysis for internal and external use. Order all materials and supplies, assist students and workers in the development of mass spectrometry protocols needed for their experiments. Maintain laboratory compliance with safety requirements and develop SOP’s. Act as direct contact person with industrial clients (outside funding sources) and research collaborators, in collaboration with project PIs. In addition, conduct research in collaboration with principal investigators on food allergen proteomics, including development and evaluation of quantitative mass spectrometry (MS) methods, characterization and purification of food proteins, and assessment of samples by immunoassay (ELISA, Western blotting, etc.). Research activities include designing experiments, preparing samples and conducting analysis, performing proteomics data analysis, and writing research reports and summaries. Participate in research communication through conference presentations and manuscript drafting.

The University of Nebraska-Lincoln seeks to attract and retain a high performing and diverse workforce in which employees’ differences are respected and valued to better meet the varying needs of the diverse populations we serve. The university fosters a diverse and inclusive work environment that promotes collaboration so that all individuals are able to participate and contribute to their full potential. As an EO/AA employer, qualified applicants are considered for employment without regard to race, color, ethnicity, national origin, sex, pregnancy, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, marital status, and/or political affiliation. See: http://www.unl.edu/equity/notice-nondiscrimination.

Required:
Bachelor’s degree in Chemistry, Biochemistry, Food Science or related field, plus four years relevant laboratory experience utilizing both basic and technical science including experience with mass spectrometry. Project management and/or supervisory experience required. Prioritization, organizational, communication and facilitation skills essential. Record-keeping and computer skills necessary. Must have knowledge of compliance and safety regulations and demonstrated ability to teach others.

Application review: 02/21/2022
To Apply: https://employment.unl.edu/hr/postings/77072

Research Associate II / Senior Research Associate, Mass Spectrometry/Proteomics
Vividion Therapeutics
San Diego CA

Job Summary:

Vividion Therapeutics is seeking a highly motivated Research Associate to help support the operation of our cutting-edge proteomics platforms. The successful candidate will have extensive hands-on experience with mass spectrometry and HPLC instrumentation and, will be responsible for operation and routine maintenance of several Orbitrap based instruments. As a member of our dynamic proteomics team, the successful candidate will have the opportunity to utilize quantitative mass spectrometry to support our target-discovery and lead-optimization efforts. As such, this individual will directly contribute to the ongoing development of our pipeline.

Experience and education requirements:

• BS with 4+ years or MS with 2+ years of experience in mass spectrometry
• Extensive experience operating and maintaining a mass spectrometer.
• Familiarity with common proteomics acquisition and analysis techniques like PRM, SRM, DIA, SILAC, etc. is desirable.
• Experience with quantitative analysis of mass spectrometry data is a plus.
• Outstanding problem-solving, organization and time management skills.
• Be an effective team player and strong individual contributor, self-driven, flexible, pragmatic, and able to handle multiple tasks and deliver high quality results under tight timelines.

https://vividiontherapeutics.applytojob.com/apply/Xs5jPUocQw/Research-Associate-IISenior-Research-Associate-Mass-SpectrometryProteomics

Position Summary
Dr. Randall Bateman’s lab investigates the causes and future diagnosis and treatments of Alzheimer’s disease utilizing a wide variety of assays and techniques from basic applications, such as quantitative measurement of stable-isotope labeled peptides to clinical translational studies in diagnostic and therapeutic biomarkers for AD. This position assists with the technical aspects of studies and experiments including running experiments, completing data analysis, planning projects, designs protocols, maintaining documentation, and completing general maintenance and organizational duties to ensure smooth operation across the lab.

Job Description

Primary Duties & Responsibilities

Assists in developing and conducting research projects, including experiment design, experiment execution, data analysis and documentation of experiment results.
Performs data entry and maintains data files on research.
Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions. 
May assist with grant preparation and reporting.
Performs complex statistical analysis of data collected and writes interpretative reports.  Verifies the correctness of the data submitted and makes recommendations based on these analyses.
Solves practical problems relating to difficulties with equipment or test subjects.  Suggests technical or procedural improvements in testing methods.

Preferred Qualifications

Degree in biological science or chemistry.  
Experience with analytical chemistry or GLP.  
Experience with immunoprecipitation and automated bench work. 
Experience with mass spectrometry is strongly preferred.
Critical thinking, analytical, reasoning and problem-solving skills.
High precision and tight Quality Control of all bench experiments
Ability to organize and prioritize tasks.
Good scientific writing and oral communication skills.
Detail-oriented.
Ability to maintain complete and organized records/reports. 
Able to work independently yet collaboratively in a team environment.
Ability to analyze and interpret statistical data and to communicate data in a clear, concise manner. 
Computer literacy, including the ability to use a variety of software packages to analyze data.

Required Qualifications

Master’s degree with four years of experience in research lab operations or an equivalent combination of education and experience equaling nine years.
APPLY HERE: https://wustl.wd1.myworkdayjobs.com/en-US/External/job/Washington-University-Medical-Campus/Staff-Scientist---Neurology_JR64024

Contact: Cynthia Hodge, Research Lab Manager, hernkec@wustl.edu

Scientist/Senior Scientist, Proteomics
at Flagship Pioneering, Inc.
Cambridge, MA USA
Position Summary:

FL69 is seeking a highly motivated and team-oriented candidate for a (Senior) Scientist, Proteomics. This individual will be responsible for the discovery and analysis of non-canonical proteins in large-scale proteomic datasets. The ideal candidate has a strong scientific foundation in proteomics and a demonstrated ability to develop tailored immuno- or biochemical enrichment methods. The candidate will be able to develop semi- or fully automated workflows for large-scale proteomics sample preparation and LC-MS analysis. The candidate will work closely with genomics scientists, computational biologists, and a functional genomics team to identify novel targets involved in disease and bring them to preclinical models.

Key Responsibilities:

Develop proteomics sample preparation workflows for global or targeted proteomics studies from varied biological samples, such as cultured cells, tissues, and biofluids
Capable of developing novel immune or biochemical enrichment strategies for target proteins
Design proteomics experiments and conduct biomarker discovery for therapeutics and diagnosis studies
Conduct proteomics data analysis using commercial and/or open-source software
Experiences on automation of proteomics sample preparation and high throughput LC-MS analysis are preferred
Manage proteomics projects and collaborate with CROs
Work closely with molecular and cell biologists to collaboratively iterate on experiments
Minimum Qualifications:

PhD in proteomics, biochemistry, analytical chemistry or related field
2+ years of industrial (or post-doc) experiences on method development of large-scale proteomics studies
In-depth understanding of LC-MS technologies for discovery or targeted proteomics
Hands-on skills in proteomic sample preparation of varied biological samples
Demonstrated expertise in conducting DDA, DIA, and PRM based proteomics studies
Demonstrated experience in maintaining and operating nanoLC and mass spectrometer
Ability to work as a collaborative team-member
Excellent oral and written communication and presentation skills
Preferred Qualifications:

Experience in proteomic analysis of biofluids (plasma, urine, or CSF) is a plus
Experience in cell-culture and tissue sample handling is a plus
Familiarity with top-down proteomics is a plus
Broad understanding of proteomics database search, quantitative analysis, visualization, and interpretation, using commercial and/or open-source software, such as MaxQuant, Skyline, PEAKS, DIA-NN
Experiences in MHC immune-peptidomics or proteogenomics are preferred
Experiences in affinity enrichment, IP/co-IP, or proximity labeling based interactome are preferred
Hands-on experiences with HPLC separation, such as RPLC, IEX, SEC are preferred
Computational skill such as bioinformatics, statistics, or programing skill by R/Python is a plus

https://boards.greenhouse.io/flagshippioneeringinc/jobs/5290158002?gh_jid=5290158002

Apply here:
https://careers.idexx.com/us/en/job/J-022502/Principal-Scientist-LCMS-Biomarker-Discovery-Team-Leader

The LCMS group within the R&D Discovery and Technology Futures group is looking for a creative and energetic Discovery Team Lead to join our organization. The successful candidate will join a team of experienced scientists at the BS/MS and PhD levels to lead multiomic biomarker discovery projects. We are looking for a highly motivated individual who has strong wet-bench and data analysis skills and a deep understanding of LCMS instrumentation and software. Additionally, the successful candidate must be a proven technical leader with a demonstrated track record for delivering on challenging biomarker discovery projects.

What you can expect:

Lead a growing dynamic LCMS Discovery team consisting of PhD scientists to Lab Associates to develop novel and robust multiomic biomarker platforms.

Use cutting edge instrumentation and analysis software to dig deep into the world of proteomics, glycobiology, metabolites, post-translational modifications and lipidomics across blood, urine, tissues (including FFPE sections), and fecal samples.

Interface with other teams within the R&D Discovery and Technology Futures group to align on project priorities and schedules to ensure that the goals of the organization are met.

Drive experimental design for large biomarker experiments and optimize sample preparation protocols for expanding reach of discovery programs.

Develop top down workflows with immunoaffinity capture for characterization of proteins of interest.

Prepares materials, performs experiments, analyzes data, and reaches conclusions.

Present data and strategy to IDEXX leadership.

Communicate and clearly present results to a broad audience within R&D, including IDEXX senior leadership.

Maintain an active knowledge of developments in the field and industry through seminars and conferences.

What you need to succeed:

PhD in scientific or related discipline with at least 3-5 years of post-doctoral biomarker discovery experience. Experience in academia qualifies but industry experience is preferred.

Background in Biochemistry or Chemistry with a deep understanding of LCMS instrumentation and data analysis software.

Demonstrated ability to work with wide variety of sample types, including plasma/serum proteomic experience.

Experience with Thermo Scientific Orbitrap mass spectrometers is ideal.

Experience with proteomic software tools and developing ad hoc data processing workflows.

Incorporating AI and Machine Learning into the biomarker discovery workflow.

Excellent communication and organizational skills.

Demonstrated ability to critically evaluate techniques and deliver results.

Demonstrated ability to effectively manage a team of scientists, collaborate effectively in an interdisciplinary program, and overcome barriers to produce successful outcomes on challenging technical projects.

Why IDEXX

We’re proud of the work we do, because our work matters. An innovation leader in every industry we serve, we follow our Purpose and Guiding Principles to help pet owners worldwide keep their companion animals healthy and happy, to ensure safe drinking water for billions, and to help farmers protect livestock and poultry from diseases. We have customers in over 175 countries and a global workforce of over 9,000 talented people.

So, what does that mean for you? We enrich the livelihoods of our employees with a positive and respectful work culture that embraces challenges and encourages learning and discovery.   At IDEXX, you will be supported by competitive compensation, incentives, and benefits while enjoying purposeful work that drives improvement.

Let’s pursue what matters together.

IDEXX values a diverse workforce and workplace and strongly encourages women, people of color, LGBT individuals, people with disabilities, members of ethnic minorities, foreign-born residents, and veterans to apply.

IDEXX is an equal opportunity employer. Applicants will not be discriminated against because of race, color, creed, sex, sexual orientation, gender identity or expression, age, religion, national origin, citizenship status, disability, ancestry, marital status, veteran status, medical condition, or any protected category prohibited by local, state, or federal laws.

The OHSU Proteomics Shared Resource (PSR) facility was established to make state-of-the-art mass spectrometry-based protein analysis capabilities available to the biomedical research community at OHSU. The PSR provides services to both internal and external clients outside OHSU, including supporting ophthalmological and cancer research by members of the Casey Eye and Knight Cancer Institutes.

PSR has an immediate opening for a full-time Research Associate (RA). OHSU provides a comprehensive compensation package including salary, and benefits such as PTO, medical/dental/vision and 401(k) plan etc.

Responsibilities

Prepare samples for proteomics analysis by LC/MS using standard operating procedures

Develop and test new methodologies of sample preparation

Document experimental work, analyze data, and present results

Prepare and maintain standard operating procedures (SOPs)

Operate mass spectrometry instrumentation, perform troubleshooting and maintenance

Manage multiple projects within timelines assigned maintaining high scientific and ethical standards

Assist in the preparation of manuscripts and grant applications

Work collaboratively with team members

Other duties as assigned to support the PSR.

Qualifications:
•Minimum: Bachelor’s degree in life sciences, analytical chemistry or related field with major courses in the field of research and 5 years of relevant experience

•Preferred: MS or PhD in Analytical Chemistry or closely aligned field

•Extensive knowledge of complex proteomics sample preparation methods as applied to protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies including label-free analyses (DIA, PRM/SRM) and labeled (TMT) methods

•Prior experience in operation of LC/MS systems preferably Thermo Orbitraps

•In-depth understanding of both hardware and software of nanoflow LC-MS

•Proficiency in LC-MS related software and data analysis

•Highly motivated, a team player, a quick learner, and a problem solver

•Excellent oral and written communication skills

•Eligibility to work in the United States

To apply

Please send a cover letter, resume with the publication list, and contact information for three references, to https://externalcareers-ohsu.icims.com/jobs/9664/research-associate/job?hub=6&mobile=false&width=1252&height=500&bga=true&needsRedirect=false&jan1offset=-480&jun1offset=-420

Location: Halifax, Canada

Employer: Dalhousie University

Duration: 2 Years

Salary: $CDN50, 000 – 60, 000

Description

The candidate will join a team of scientists, engineers and clinicians from across Canada that are developing innovative approaches toward the manufacturing, characterization, and de-risking of innovative next generation chimeric antigen receptor T-cell (CAR-T) therapies for cancer treatment. The candidate will develop novel immunometabolomic methods using high-resolution tandem mass spectrometry, combined with advanced analysis of both CAR-T laboratory samples and samples from patients enrolled in CAR-T clinical trials to identify unique biomarkers relevant to CAR-T potency and efficacy?
Research to be conducted by the candidate will provide a unique training experience at the interface between biology, analytical chemistry, and clinical research. The successful candidate will join a group of experts in proteomics, metabolomics and cell signalling.
Metabolomics to advance CAR-T therapy. Cell therapies are an emerging modality; one that comes with additional levels of complexity as they are viable cellular systems. Advancement of this potentially revolutionary treatment modality would be accelerated by the development of innovative techniques to efficiently characterize the CAR-T systems. Molecular complexity is magnified significantly with cell therapies; therefore, adaptation and innovation of analytical methodologies is required to begin to address critical questions around the interplay between metabolism and potency. The successful candidate will develop quantitative immunometabolomic methods to push boundaries of sensitivity, throughput, and dynamic range to allow identification of potential biomarkers relevant to CAR-T potency and favorable host metabolic & microbiome phenotype.
Requirements
The successful candidate should have or be nearing completion of a PhD in Analytical Chemistry, Biochemistry, or related field and have published papers in relevant journals as primary author. Experience in liquid chromatography-mass spectrometry based metabolomics and/or proteomics is required. Experience in the use of complex bioinformatics tools for ‘omics data analysis is preferred. The successful candidate will be expected to work within a network of internal and external collaborators, engage stakeholders and display the potential to become a recognized leader in the field. Preference will be given to Canadian citizens.

Please submit Cover letter and CV to:

Dev.Pinto@nrc-cnrc.gc.ca and cc: Alejandro.Cohen@Dal.Ca and jim.fawcett@dal.ca

The Translational Geroproteomics Unit (TGU) is seeking diverse, highly motivated, and enthusiastic postdoctoral fellows to tackle important questions in aging biology using proteomic approaches. This is a full-time and fully funded primary research fellowship for individuals interested in leveraging mass spectrometry-based proteomics to have a translational impact on age-related diseases linked to hallmarks of aging such as cellular senescence and loss of proteostasis. Postdoctoral fellows will be mentored by Dr. Nathan Basisty, and will have access to a highly interactive, resourceful, and dynamic scientific environment with state-of-the-art instrumentation and ample opportunities for training and career development.

The NIH and the TGU are dedicated to building a diverse community in its training and employment programs and are committed to creating and maintaining an environment that is welcoming, safe, accessible, and uplifting to ALL individuals. We encourage and welcome applications from individuals from underrepresented backgrounds.

Potential projects: We are looking for postdocs interested in working on various projects, including but not limited to:

• Discovery and validation of ‘proteoform’ (modified proteins and protein isoforms) biomarkers of aging and their relationship with the rate of aging, the development of age-related diseases as well as physical and cognitive disability in human cohort studies such as the BLSA, GESTALT, and InCHIANTI.
• Targeting and quantifying senescent cells and dissecting the functions of heterogeneous senescent cell populations via their surfaceomes (cell surface proteomes)
• Mass spectrometry method development, particularly the development and application of workflows involving data independent acquisition (DIA/SWATH), PTM identification/quantification, and/or protein turnover analysis.

Postdocs are encouraged to independently develop and drive the direction of research projects, as well as establish new research directions.

Training and career development: Fellows will have access to hands-on training in multiple technologies and scientific techniques including mass spectrometry-based proteomics on several high-end instruments, analytical chemistry, cell culture, and mouse work. The NIA offers multiple career development opportunities for postdocs, including opportunities to apply for internal funding through the FARE (Fellows Award for Research Excellence) program, Nathan Shock travel awards, Interlaboratory Funding Proposals, Postdoctoral Fellowship Funding Awards, and the Independent Research Scholar (IRS) Program.

Postdocs are highly encouraged to attend conferences and scientific workshops for career development. Training also includes active participation in weekly multidisciplinary lab meetings, weekly Longitudinal Studies Section (LSS) Meetings, and professional development and research methods courses offered through the NIH Office of Intramural Training and Education (OITE). Fellows are also encouraged to take advantage of the NIH interest groups, particularly the Proteomics Interest Group and the NIA Molecular Biology Interest Group.

Postdocs will also have the opportunity to collaborate on projects with the Baltimore Longitudinal Study of Aging (BLSA), the longest running human aging study in the U.S., as well as other human cohorts (GESTALT, InCHIANTI).

Qualifications: The successful candidate must have a PhD, MD, or equivalent doctoral degree. We are looking for candidates with background and/or a strong interest in one or more of the following areas: mass spectrometry-based proteomics, characterization of PTMs, cell culture, or related fields who are passionate and self-motivated in research. Candidates with prior experience developing and performing mass spectrometry workflows, coding with R or Python, and experience with human or mouse aging models are especially encouraged to apply.

How to Apply: Please email a (i) CV, (ii) cover letter detailing research interest, experience, and career goals, and (iii) three references to Nathan Basisty, PhD at nathan.basisty@nih.gov.

Employer Name: National Institute on Aging (NIA)

Position Location: Baltimore, MD

Application Deadline: September 31, 2021, or until filled.

Job Description

The Integrative Omics group within the Biological Sciences Division at Pacific Northwest National Laboratory is seeking an outstanding Post-Doctoral candidate to join our multi-disciplinary team focusing on mass spectrometry (MS)-based proteomics analyses. The research areas include the development of quantitative methodologies for precise protein and posttranslational modification measurements, and corresponding large-scale applications in biofluids, cell, or tissue specimens towards clinical and translational research in cancer. The Integrative Omics group also presents a diverse array of opportunities ranging from analytical biochemistry, MS instrumentation, multi-omics measurements, single cell proteomics, bioinformatics, and biomedical applications. The preferred candidate would have a Ph.D. degree in analytical chemistry, biochemistry, chemistry, clinical chemistry, or closely related fields. Although not required, hands-on experience in mass spectrometry, proteomics, LC separations, posttranslational modifications, and data analysis will be considered as a plus. Efforts will include methods development, sample preparation and separation methods for enhancing reproducibility and sensitivity, and applications of specific candidate verifications in different sample types. The successful candidate will be expected to work effectively with an interdisciplinary team of researchers, be self-motivated, and have excellent verbal and written communication skills. The successful candidate will assist, and possibly lead, in the preparation and presentation of papers, posters, reports, etc. Additionally, he/she will use project management systems at PNNL, maintain an accurate laboratory notebook, adhere to Environmental Safety and Health (ES&H) Operations, and follow security requirements as well as directorate/group policies.

Strong organization and communication skills are needed to work efficiently in a team environment and to effectively demonstrate project success.

This is a full-time, limited term employment position. The duration of this appointment is two years, with the option of extending the appointment for up to three years.

Minimum Qualifications

Candidates must have received a PhD within the past five years (60 months) or within the next 8 months from an accredited college or university.

Preferred Qualifications

Ph.D. in Biochemistry, Analytical Chemistry, Chemistry, or a closely related field is required.

Equal Employment Opportunity

Battelle Memorial Institute (BMI) at Pacific Northwest National Laboratory (PNNL) is an Affirmative Action/Equal Opportunity Employer and supports diversity in the workplace. All employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital or family status, sexual orientation, gender identity, or genetic information. All BMI staff must be able to demonstrate the legal right to work in the United States. BMI is an E-Verify employer. Learn more at jobs.pnnl.gov.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request via https://jobs.pnnl.gov/help.stm

Please be aware that the Department of Energy (DOE) prohibits DOE employees and contractors from having any affiliation with the foreign government of a country DOE has identified as a “country of risk” without explicit approval by DOE and Battelle. If you are offered a position at PNNL and currently have any affiliation with the government of one of these countries you will be required to disclose this information and recuse yourself of that affiliation or receive approval from DOE and Battelle prior to your first day of employment.

To learn more or to apply visit, https://pnnl.jobs/richland-wa/post-doctorate-ra-quantitative-proteomics-cancer-biomarkers-and-other-applications-of-proteomics/F4B959FA259345A79B892C9F873FCFA4/job/

The Department of Medicine, Translational Proteomics, Prof. Johannes Graumann, has an immediate opening for the permanent position of an Scientist Mass Spectrometry (m/f/d) to fill.

The position is full-time with salary and benefits commensurate with a public service position in the state Hesse, Germany (TV-H E 13, 100 %).

Your tasks include scientific services in research and teaching, in particular the development of methods for mass spectrometry-based proteomic analysis, for single-cell proteomics and proteomic characterization of post-translational modifications as well as the application of the methods in independent research projects and their scientific publication. Further application and project specific adaptation of the methods in the context of the Core Facility Translational Proteomics as well as contributions to teaching the fundamentals of mass spectrometry.

The university expects from its employees the willingness and capability to acquire and apply skills necessary for further assignments.
Requirements include a university degree (diploma, master or comparable) as well as a PhD in a bioanalytical field and several years of experimental experience in the field of mass spectrometry-based proteomics (supported by scientific publications). Further expected are familiarity with working in scientific environments, fluency in English (written and spoken, both) as well as experience in teaching the basics of mass spectrometry.

For questions regarding the position, please contact Johannes Graumann at johannes.graumann@uni-marburg.de.
We support women and strongly encourage them to apply. In areas where women are underrepresented, female applicants will be preferred in case of equal qualifications. Applicants with children are welcome – Philipps-University is certified as a family-friendly university. Sharing a full-time position (§ 8 Abs. 2 S. 1 HGlG) as well as a reduction of working time is possible. Applicants with a disability as described in SGB IX (§ 2 Abs. 2, 3) will be preferred
in case of equal qualifications. Application and interview costs can not be refunded. Please send your application until July 23rd 2021 as a single PDF file and mentioning the reference number fb20-0128-wm-2021 to translational.proteomics@uni-marburg.de.

In conjunction with the Research Unit FOR2509 “The Concert of Dolichol-Based Glycosylation:
From Molecules to Disease Models”, the Core Facility for Mass Spectrometry and Proteomics at the Center for Molecular Biology of the University of Heidelberg (ZMBH) has an opening for

A Research Scientist (m/f/d)
Fulltime position, starting date: immediately

During the first funding period of the project “Production of the dolichol N-glycan precursor:
Monitoring of this pathway by quantitative mass spectrometry” a sensitive MRM assay was established to monitor glycosyltransfreases in the ER, responsible for N-glycosylation, O-mannosylation and C-mannosylation. With this method at hand the PhD scientist now will work on the biochemical characterization of these pathways. In addition, there is a tight collaboration with a clinical group which allows studies of these pathways in diseased states.

Information about the MRM assay can be found here:
(https://www.biorxiv.org/content/10.1101/2020.09.15.291732v1)

Your ideal qualifications

• Expert knowledge in nanoUPLC-MS
• Experience in various quantitative proteomics techniques
• Proficiency in data analysis including database searches and software for quantitative proteomics, especially Skyline
• Hands-on experience in preparation of biological samples
• Team working abilities and aptitude in guiding technical assistants
• Excellent written and spoken English language skills, German will be an advantage

The position is advertised until December 2023. Prolongation is not possible. Payment will be according to German TV-L13 (full-time).
The University of Heidelberg is an equal opportunity employer and encourages applications from qualified female candidates. A kindergarten service is available. Handicapped applicants will be given preference in the case of equal qualifications.

Contact: Dr. T. Ruppert (+49 6221 546895)

Application Deadline: Evaluation will begin two weeks after the announcement and will continue until the positions are filled.

Please submit your applications online to t.ruppert@zmbh.uni-heidelberg.de

Summary:

The Tulane University Proteomics Core is seeking a Mass spectrometry research technician. This is a full time position that will involve sample preparation, routine cell culture, mass spectrometry operation, data reporting, routine instrument and lab maintenance, supply ordering and making general lab chemicals. Facility instruments include a mixture of LCMS/MS instruments.

Required Knowledge, Skills, and Abilities:

-A thorough understanding of how Mass Spectrometry works, basic chemistry and biology
-Routine cell culture, protein extraction
-A thorough understanding of the quantitative criteria involved in selecting analytical methods (e.g., precision, accuracy/bias, sensitivity, detection and quantification limits, sensitivity, and dynamic range) and their corresponding figures of merit
-Demonstrated knowledge of LC-MS/MS
-Demonstrated knowledge of mass spectral libraries
-Ability to perform routine maintenance and troubleshooting
-Strong verbal and written communication skills
-Good mathematical skills and experience performing calculations in Excel

Required Education and/or Experience:

Bachelor’s degree and one year of basic laboratory research experience.

Preferred Qualifications:

Familiarity and prior experience running Mass Spectrometry instruments will be viewed favorably.

Compensation Information:

This position is assigned to pay grade T2.23. Tulane offers a variety of options to enhance your health and well-being so that you may enjoy more out of life now and in the future. Learn more about Life at Tulane as well as our Benefits and Pay. See our Candidate Resources to learn more about our hiring process and what to expect.

How to Apply:

Apply on the Tulane University website at this link:
https://selfservice.tulane.edu/OA_HTML/OA.jsp?OAFunc=IRC_VIS_VAC_DISPLAY&p_svid=21062&p_spid=268599

This position will close on the date it is filled.

Tulane University is an EOE/M/F/Vet/Disabled employer with a strong commitment to diversity and inclusion. Applications by members of all underrepresented groups are encouraged.

The MacCoss lab has been a pioneer in the development and application of quantitative proteomics methods. We are currently seeking a motivated post-doc candidate with experience in performing drug and/or genetic perturbations, followed by the phenotypic characterization of those perturbations using omics methods. This project will be performed in collaboration with a major pharmaceutical company.

The successful candidate will be part of an interdisciplinary team of mass spectrometrists, bioinformatics experts, biochemists, and software developers. Requirements:
• The candidate should have a Ph.D. in biochemistry, cell biology, biology, or related discipline.
• A strong background in cell culture, experience in protein biochemistry, and running complex experiments.
• Exposure to mass-spectrometry based proteomics is a major plus.
• Excellent writing and presentation skills.
• Must have the ability to analyze complex Omic datasets using python, R, or similar.
• Ability to learn quickly, problem solve, and work independently.

Desired skills:
• Experience preparing protein samples for analysis by mass spectrometry.
• Familiarity with ThermoFisher instrumentation.
• Expertise in the use of Skyline software for quantitative analysis of mass spectrometry data.
• Familiarity with data-independent acquisition mass spectrometry data.

The University of Washington, Department of Genome Sciences provides a vibrant research environment. The MacCoss lab is well equipped and features an interdisciplinary research team with a strength in proteomics method development with collaborations related to neurodegenerative diseases, basic biology of aging, diabetes, clinical assay development, drug response characterization, etc...

Interested individuals may contact Mike MacCoss via (positions@maccosslab.org) for more information.

A position is available in Genentech's Discovery Proteomics group, within the department of Microchemistry, Proteomics, Lipidomics and NGS. This individual will serve as a data scientist to develop novel tools for the analysis of Proteomics, Lipidomics and high-throughput Protein Array datasets. The position will work closely with our computational team as well as bench scientists in the department to understand their technology and deliver the best possible working software prototypes. Demonstrated communication, prioritization, organization skills, as well as the ability to be flexible and responsive in a fast-paced environment are abilities that are highly desired.

Responsibilities:

• Contribute to the development of software modules that support the analysis and visual representation of internal datasets and embedding them in configurable computational workflows
• Development of a relational database to store analyzed datasets along with their annotations
• Assist in running routine tasks through computational workflows and communicating the outcomes to internal stakeholders

Requirements: Strong candidates for this position will meet most of the following requirements,

• MS or PhD in bioinformatics or related disciplines is required.
• Skilled at converting experimental data and biological meta data from a variety of input formats into a relational database (i.e. MySQL) and performing complex queries.
• High level of programming proficiency with R and Python and good understanding of command line tools in a Linux environment.
• Demonstrated experience with software development in a team setting and good coding practices
• Experience with workflow engines, web frameworks and data visualization tools would be considered a tremendous plus

Location: South San Francisco, CA. But the remote work is an option.

Contact: Encouraged to apply here: https://evotecgroup.wd3.myworkdayjobs.com/Evotec_Career_Site/job/South-San-Francisco/BioInformatics-Associate-I_REQ-02710
or Please contact choi.meena@gene.com (Meena Choi). Please write "Skyline bioinformatics associate position inquiry" in the subject line.

The MacDonald lab conducts multi-omic analyses of synaptic protein networks in human postmortem brain tissue and model systems to address questions in psychiatric disease. Potential projects involve the development and validation of novel approaches to interrogate synaptic proteomes in human postmortem brain tissue; high throughput sample preparation of human postmortem brain tissue for protein and PTM quantitation (LFQ, TMT, DIA) on an Orbitrap Eclipse; integration of proteomic datasets with other -omics data and intermediate phenotypes (e.g. SNP array, WGS, RNAseq, spine density, and spine size); and investigation of promising targets in model systems (primary neuronal culture, iPSC, mice). These projects are currently funded by multiple R01s and T32 support is available for qualified candidates. The Department of Psychiatry at the University of Pittsburgh has an unparalleled track record of supporting early career scientists as they transition to independence in academia, industry, or government positions.

Research Opportunities - Neurology - Job ID 51155
Washington University in St. Louis - Department of Neurology - Medical School Campus
This position is full-time and works approximately 40 hours per week.

Essential Functions: There is a research opportunity in the laboratory of Dr. Randall Bateman investigating the causes, future diagnosis and treatments of Alzheimer’s disease utilizing a wide variety of assays and techniques from basic applications, such as quantitative measurement of stable-isotope labeled peptides to clinical translational studies in diagnostic and therapeutic biomarkers for Alzheimer’s disease. Work in the lab includes running experiments and assays, preparing reagents and samples at the bench and using automated equipment, preparing samples for mass spectrometry analysis. For more information about the Bateman Lab, please visit: https://neuro.wustl.edu/labs/bateman_r/.

Required Qualifications: Bachelor’s degree. Candidates with additional education and experience are encouraged to apply.

Preferred Qualifications:
Degree in biological science or chemistry is strongly preferred.
Experience with analytical chemistry OR GLP is strongly preferred.
Experience with immunoprecipitation, automated bench work and proven bench lab skills.
Experience with developing laboratory Standard Operating Procedures and working in a GxP regulated environment.
Ability to maintain complete and organized records/reports.
Working knowledge of computer software and general lab equipment.

For further information or to apply, go to:
https://jobs.wustl.edu/psc/APPLHRMS/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&REL_ACTION=Yes&SiteId=1&HRS_JO_PST_TYPE=E&HRS_JOB_OPENING_ID=51155&HRS_JO_PST_SEQ=1

Description

Uniquely positioned to enhance quality of life in aging, at Alkahest, we are pioneering science that is rapidly being translated to the clinic. Our approaches utilize in vivo, in vitro, proteomic, and molecular techniques to identify new therapeutics and apply them to patients.

We are seeking a highly motivated, resourceful, and detail-oriented scientist to join our collaborative and supportive mass spectrometry-based proteomics team. This position will be key in advancing our mass spectrometry platform as we establish and implement new enabling technologies to discover, characterize and validate biomarker and therapeutic target candidate proteins in complex biological samples. This position provides a unique opportunity to shape next generation MS efforts at Alkahest by integrating state-of-the-art approaches for sample preparation, data acquisition and data analysis with a focus on plasma proteomics.

Our ideal candidate will be an enthusiastic self-starter with a positive attitude, excellent organizational and interpersonal skills, and the ability to learn, develop, and implement MS methodology efficiently. The researcher will be responsible for designing and executing MS proteomics studies to analyze clinical and research samples on Thermo Orbitrap instruments, and actively contribute to MS data analysis. He/she will have opportunities to learn and develop state-of-the-art MS proteomics techniques, drive the implementation of high-throughput sample preparation methods, and utilize them to facilitate the development of novel therapeutics for aging diseases. The role requires dedication to drive science, flexibility, and efficient interaction with a team of scientists and research associates to advance multiple projects in parallel.

Responsibilities
Specific responsibilities include, but are not limited to:
Conduct mass spectrometry-based proteomics studies with an emphasis on development of LC-MS based targeted assays
Develop new and improve upon existing procedures for sample preparation for LC-MS/MS analysis, including automation of high-throughput proteomic sample preparation methods, such as chemical labeling, and in-gel and in-solution proteolytic digestion protocols
Research, identify, explore and implement novel approaches for plasma proteomics
Support discovery proteomics efforts using DIA, TMT, and label-free proteomics approaches
Align and collaborate with group members and in vitro and in vivo research teams across Alkahest to support and advance research goals
Work with human clinical samples
Operate, troubleshoot, and maintain MS instrumentation

Requirements
PhD (or MS plus extensive experience) in a relevant chemical, biochemical, or biological discipline
Experience in method development and optimization for targeted proteomics
Extensive hands-on experience with Orbitrap MS platforms and liquid chromatography systems and proteomics sample preparation methods
Proficiency in mass spectrometry analysis software packages
Experience with top-down MS methods for intact protein analysis is a plus
Collaborative team spirit and the ability to self-motivate and work independently
Excellent interpersonal, verbal and written communication skills
Comfortable working in a multi-tasked, fast-paced startup environment

Please apply at the link below:
https://www.alkahest.com/careers-culture/join-us/?p=job%2FopMLefwU

A position is available in Genentech's Discovery Proteomics group, within the department of Microchemistry, Proteomics, Lipidomics and NGS. This individual will serve as a technical lead and be responsible for carrying out experimental research aimed at understanding the role of proteins and post-translational modifications in human disease. An important focus of the lab is to study how membrane protein interactomes and their downstream signaling modulate cellular function, utilizing established cultures, primary cell lines as well as complex cellular models. Advances in proteomics, especially mass spectrometry, have revolutionized the study of cellular proteins and motivated in depth molecular characterization of normal human physiology and disease biology. The Discovery Proteomics group develops and implements protein analytical methods to differentiate between dynamic biological states by characterizing the abundance, dynamics and interactions of proteins. The researcher will also have the opportunity to utilize and further implement state-of-the-art technologies for the discovery and characterization of receptor-ligand interactions. As is true across Genentech, research in the group is fast paced and highly collaborative, drawing on the expertise of some of the world's leading experts in biochemistry, cell biology and disease indications.

Requirements: This position requires an MS plus at least 3 years of relevant analytical sciences work or academic research experience or PhD in Chemistry, Biochemistry, or related field with experience in analytical sciences. The ideal candidate should have experience in protein biochemistry and cell biology techniques. Interest and hands-on experience in membrane protein biology and receptor-ligand interactions (biophysics, biochemistry, signaling) are preferred. Past experience with proteomics sample preparation (i.e. proteolytic digestion, solid phase extraction, immunoprecipitation) and operation of an Orbitrap mass spectrometer are preferred, but not essential for success in this role. Computational skills and ‘big data’ experience are highly desirable, including working knowledge of python, R or related tools. Strong communication & interpersonal skills are essential for success in this collaborative role.

Location: South San Francisco, CA. This is a lab based position and remote work is not an option.

Contact: Interested scientists are encouraged to apply here: https://www.indeed.com/jobs?q=Evotec&l=South San Francisco%2C CA&vjk=6e0b0378bf315a4b
or Please contact choi.meena@gene.com (Meena Choi). Please write "Skyline DP-SSR position inquiry" in the subject line.

LAB RESEARCH ANALYST II , Duke University School of Medicine
Duke Proteomics and Metabolomics Core Facility
Durham, North Carolina

Position Description:
Seeking a self-starting scientist with good problem-solving skills and strengths in quantitative analysis, particularly by LC-MS/MS. Job duties will be to work in a fast-paced, team-based environment to conduct a variety of complex and independent investigations addressing physical, chemical, and other research laboratory experiments to obtain and interpret data for research projects at Duke, specifically addressing metabolomics and proteomics in cancer, neurodegenerative diseases, and infectious diseases. Scientific integrity, curiosity, and determination are key qualities of a successful candidate.

In particular, under the guidance of the Director or Assistant Director, the Lab Analyst II will conduct a variety of complex laboratory procedures and specialized laboratory techniques for the analysis of endogenous metabolites, drug molecules, peptides and proteins in the Proteomics and Metabolomics Core Facility for the School of Medicine. Note that both SOP-driven and independent analyses will be required, and proven analytical thinking and problem-solving skills are critical. The ability to effectively work in a multidisciplinary team environment and move easily from one task to another is essential.

Position requires a bachelor’s degree in Chemistry, Biology, or related field and a minimum of 4 years experience. Master’s degree or Ph.D. can substitute for appropriate years’ experience.

Tasks may include:

1. 40% - Preparation of biological samples for metabolomic, proteomic, and pharmacokinetic analyses.

2. 40% - Quantification of metabolites using triple quadrupole mass spectrometry, and contribution to the development of new LC-MS/MS assays. Validation of figures of merit for quantitative LC-MS/MS assay.

3. 10% - Protein identification and quantitation using nanoscale capillary liquid chromatography and analytical scale liquid chromatography coupled with either high resolution, accurate mass tandem mass spectrometers (LC/MS/MS) or triple quadrupole mass spectrometers operated in MRM mode.

4. 5% - Contribution to written reports and publications of results in collaboration with investigators inside and outside of Duke. Review journals, abstracts and scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.

5. 5% - Presentation of their ongoing work at group meetings, and critical evaluation of new approaches for metabolomics and proteomics presented in the literature or by others.

Interested applicants can find more information and apply for the position at the link below:
https://careers.duke.edu/job/Durham-LAB-RESEARCH-ANALYST-II-NC-27710/713080600/?locale=en_US

Interested individuals may contact Will Thompson (will.thompson at duke.edu) for more information, however applications must be processed through the Duke Careers web site.

AbSci is a growth stage synthetic biology company located in a new, state-of-the art laboratory in downtown Vancouver, WA, just across the river from Portland, OR. AbSci is a global leader and innovator of revolutionary biomanufacturing technologies, designing and programming cells for next-generation biopharmaceuticals. Our Protein Printing™ technology results in dramatic reductions in the cost of producing biologics, acceleration of drug discovery timelines, and enables the production of previously difficult or impossible-to-produce molecules. Our technology is a new paradigm in protein production, as it increases discovery throughput, accelerates development, reduces manufacturing costs, and increases plant capacity for the biopharmaceutical industry.

Job Description:
We are currently seeking a self-motivated, passionate, and accomplished Scientist to join our Analytical Development team. Using your strong attention to detail, you will play a significant role in analytical method development and characterization of therapeutic proteins expressed using SoluPro™, AbSci’s proprietary E. coli expression platform. You will utilize your successful background in the development and analytical characterization of complex biologics by LC-MS and proteomics approaches while exploring new and innovative technologies. This position will utilize your interpersonal and strong written and verbal communication skills for multi-disciplinary collaboration with the other teams within AbSci, including Molecular Sciences, Fermentation, Purification, and Bioinformatics. You bring a passion for scientific innovation, excellent technical skills, and you execute your responsibilities with high attention to detail. You work with a sense of urgency, and thrive in a team dynamic in a high-performance culture.

Responsibilities:
Develop and execute laboratory tasks to support the development and optimization of various mass spectrometry-based methods for the characterization of complex biotherapeutics by LC-MS, including intact mass, disulfide mapping (including PTMs), and targeted mass spectrometry (PRM/MRM)
Perform multi-step sample preparations including enzymatic digestion (solution and in-gel), reduction/alkylation, buffer exchange, deglycosylation, sample concentration, etc.
Method development and optimization for transfer to non-mass spectrometry, stand-alone LC-UV-based techniques for analyses of protein biologics
Operation, maintenance, and installation of LC-MS instrumentation
Write and review formal reports, including method SOPs, reports, and other technical documents
Evaluate data for trends indicative of product performance, method performance, and/or analyst performance and present internally to team members and senior management
Oversee routine instrument operation and maintenance
Lead, mentor, and inspire junior team members
Evaluate new technologies and platforms
Support internal technical teams, including R&D, fermentation and purification process development teams
Maintain accurate documentation of all work in laboratory notebooks

Qualifications:
PhD in Analytical Chemistry, Biochemistry, or related scientific disciplines
Experience in protein engineering, expression, purification, and biochemical characterization (e.g. antibodies, cytokines, and antigens).
Hands-on knowledge of protein analytics and characterization by LC-MS, including intact mass, disulfide mapping, PTMs, and targeted mass spectrometry (MRM/SRM)
Hands-on experience with SDS-PAGE, Western blot, and capillary electrophoresis
Experience in the operation, maintenance, and troubleshooting of associated instrumentation
Strong capabilities in experimental design, execution and data interpretation
Ability to communicate with colleagues and business partners who do not share candidate’s core area of expertise is required
Huge plus (but not required):
Post-doctoral and/or industry experience preferred; 2+ years industry experience is a plus
Experience with Sciex and Thermo MS and Agilent LCs is preferred
Experience with proteomics is preferred
Experience in LC-MS sample preparation for implementation on automated liquid handlers is preferred
Experience with JMP or comparable statistical software packages is preferred
Proficiency in Python or R is a plus
Experience with ELISA, BLI, and SPR is a plus
Experience working with CMO’s and CRO’s for methods transfer, method optimization, and data and report review is a plus
Knowledge of cGLP/cGMP, FDA, EMA, ICH guidance and industry standards for analytical development and characterization of proteins is a plus

We seek candidates with a passion for building a creative company culture that is collaborative, multidisciplinary, and committed to making a transformative impact on our industry. To be successful in this role, we look for passion in technology innovation, adept technical skills, and excitement about working in a dynamic startup environment. A demonstrable track record of success in functioning as part of a project team is essential.

Apply here:
https://grnh.se/ed9d1f623us

The Durham Lab at the University of Florida is currently recruiting a laboratory Research Technician. The start date is flexible, but ideally the successful candidate would begin between April 2021 and June 2021. Research in the Durham Lab (https://www.durham-lab.com) focuses on the molecular ecology and chemistry of environmental microbes. Current projects include exploration of metabolite exchange in marine phytoplankton-bacterial interactions and terrestrial moss-cyanobacterial interactions. The technician will be primarily responsible for processing and analyzing microbial and plant samples using liquid chromatography-mass spectrometry (LC-MS)-metabolomics techniques. In particular, the technician will analyze samples using high-resolution LC-MS system(s) located in the UF’s Interdisciplinary Center for Biotechnology Research (www.biotech.ufl.edu) mass spectrometry core facility. Other responsibilities may include microbial cell culture, administration of the lab (e.g., lab safety, chemical inventory, ordering supplies), and LC-MS data analysis. This is a one-year term position with the potential for renewal. We will consider candidates who seek part-time or full-time work, with a minimum commitment of 20 hours per week.

Fundamental requirements and qualifications include the following:
• A Bachelor’s degree in Chemistry or related field
• Demonstrated knowledge of chromatography and/or mass spectrometry methods
• Strong work ethic and independence
• Excellent communication and teamwork skills
• Excellent English writing and speaking ability
• Ability to manage multiple projects
• Excellent organizational skills and attention to detail

Additional, preferred qualifications include the following:
• A Master’s degree or work experience in environmental or analytical chemistry or related field
• Demonstrated scientific writing skills (preferably through publication record)
• Data analysis experience (R or Python)

Tulane University: School of Medicine: Basic Science Departments: Biochemistry & Molecular Biology
Location
New Orleans, LA
Open Date
Jan 19, 2021

Description
The Postdoctoral Fellow for the Department of Biochemistry and Molecular Biology will be responsible for developing mass spectrometry-based new technologies and approaches to detect and measure biomarkers associated with cancer and infectious disease, and to employ these methods to analyze samples from animal models of human disease and human subjects to test and validate their performance.

We are a multi-disciplinary team across biology, chemistry and bioinformatics. You will join a team that focuses on developing non-invasive approaches for early disease diagnosis and disease prognosis, the use of advanced mass spectrometry approaches for proteomics and protein/peptide characterization, and analysis of extracellular vesicles as biomarkers in the progression of cancer and infectious disease.

Qualifications

1. Recent Ph.D. in in protein mass spectrometry, proteomics or related field, with demonstrated skills in analytical chemistry, MALDI, LC-MS/MS
2. Research experience in nano/micro scale liquid chromatography, electrospray ionization, high resolution mass spectrometry, protein biochemistry, top-down and bottom-up proteomics including project design, sample preparation and data analysis, PTM identification.

Equal Employment Opportunity Statement
Tulane University is an Equal Employment Opportunity/Affirmative Action institution committed to excellence through diversity. Tulane University will not discriminate based upon race, ethnicity, color, sex, religion, national origin, age, disability, genetic information, sexual orientation, gender identity or expression, pregnancy, marital status, military or veteran status, or any other status or classification protected by federal, state, or local law. All eligible candidates are encouraged to apply.

Application link: https://apply.interfolio.com/83136

The National High Magnetic Field Laboratory (NHMFL) is searching for a postdoctoral fellow to assist the Ion Cyclotron Resonance (ICR) Program instrumentation group. The ideal candidate for this postdoctoral position will be a scientist with experience in the field of mass spectrometry with a record of significant scholarly activity. Experience in mass spectrometry applications and/or software development for mass spectrometry data analysis is desired.

The postdoctoral fellow will work with the FT-ICR Facility permanent staff to implement a novel data-independent analysis pipeline for the flagship 21 Tesla FT-ICR MS and help develop downstream software to analyze the data in collaboration with the MacCoss Laboratory at the University of Washington. The candidate will collaborate with NHMFL and MacCoss laboratory staff. Travel funds have been allocated for an extended learning/collaboration opportunity to perform research at the University of Washington within the MacCoss Laboratory. Candidates are expected to have a Ph.D. in a relevant field.

The NHMFL is the world’s premier magnet laboratory with state-of-the-art high magnetic field facilities (up to 21T in superconducting magnets, 36T in resistive DC magnets, 45T in hybrid DC magnets, and 100T in pulsed magnets) for research in physics, materials science, engineering, chemistry geochemistry, biochemistry, and biology.

Interested candidates can apply to Florida State University at https://jobs.fsu.edu and reference Job Requisition #48464. Please attach your curriculum vitae, cover letter describing your research experience, and names and contact information of at least three references. For additional information, please contact Ms. Bettina Roberson, National High Magnetic Field Laboratory, Florida State University, 1800 E. Paul Dirac Drive, Tallahassee, FL 32310-2740, 850-644-0855. Additional information may be attached and emailed to roberson@magnet.fsu.edu. The NHMFL is operated for the National Science Foundation by a collaboration of institutions comprising Florida State University, the University of Florida, and Los Alamos National Laboratory. The Florida State University is an Equal Opportunity, Affirmative Action employer, committed to diversity in hiring, and a Public Records Agency.
If you have any questions, or want to check directly about the position, please do not hesitate to contact Chad Weisbrod at weisbrod@magnet.fsu.edu or Mike MacCoss at maccoss@uw.edu for further information.

Who we are:
Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.
Position description:
Calico is seeking an experienced Senior Research Associate/Scientist to join the mass spectrometry proteomics group. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. We are looking for someone with detailed knowledge of proteomics and biochemistry techniques, and with demonstrated hands-on application. This is a hands-on bench position, focused on sample preparation, instrument maintenance, troubleshooting and data analysis. The successful candidate will work with a large numbers of samples for collaborative projects, optimize and develop methods as well as be responsible for smaller research projects. The Proteomics group collaborates with multiple labs within Calico, and as such is involved in many areas of research from oncology to immunology, as well as technology and assay development.
Responsibilities:
• Prepare samples from tissues, cells, and biofluids.
• Optimize and develop new sample preparation methods
• Maintain and troubleshoot instruments including HPLCs, mass spectrometers and other bioanalytical equipment.
• Analyze data to share will collaborators
Position requirements:
• Recent PhD graduates are encouraged to apply. Or thesis-based MS in biochemistry or related discipline required, plus 5 years of research experience in an academic or industry.
• Experience in method development for HPLC and/or mass spectrometers
• Experience in maintaining and troubleshooting HPLCs and mass spectrometers
• Experience in sample preparation for proteomics (e.g. isobaric labels)
• Experience in proteomics data analysis and basic coding (e.g. R, Matlab, Python)
• Detail-oriented and organized
• Strong teamwork and communication skills
• Self-motivated with a “can-do” attitude is required for success
• Flexible, able to respond quickly to shifting priorities and able to multitask
• Demonstrated ability to design, execute and draw conclusions from scientific projects

Nice to have:
• Experience maintaining Thermo mass spectrometers (e.g. Eclipse/Lumos) and HPLC
• Experience in automation and liquid handling platforms
• Experience in affinity/immunoprecipitation of proteins and post translational modification
• Experience in native fractionation FPLC/HPLC.

Link to apply: https://www.linkedin.com/jobs/view/2384574356/?capColoOverride=true

At EpiQMAx, we offer a service to pharmaceutical companies and research institutes, based on mass spectrometry, for the measurement of epigenetic and post-translational modifications on histones and other proteins. An essential challenge in our domain is the discovery and identification of markers associated with a disease or a biological condition.

We are looking for an AI developer/engineer, whose role will be to use classical ML algorithms as well as develop CNN models for the discrimination of distinctive proteins and PTMs associated with a condition. As input data, she/he will count with matrix-like files and images.

Candidate requirements: Master Sc. or Ph.D. title in Computer Science or Statistics/Data Analysis, Bioinformatics or alike. Good to very good knowledge of ML/AI models, architectures, and model training. Good to vast expertise on image classification and object recognition.

Apply by sending your CV and a cover letter to info@epiqmax.de

More information about the position can be found on our careers site: https://epiqmax.com/career

This key position in our platform biology group will develop and perform mass spectrometry (MS) assays in support of proteomics applications for our therapeutic areas. The candidate will be expected to work with key stakeholders and under direction of senior members of the group to perform analyses to support our understanding of the mechanism of action, cell-based activity and biophysical properties of our small molecule protein degraders. This position reports to Principal Research Investigator, under the supervision of Senior Research Scientist in the Platform Biology department and will be located at our headquarters in New Haven, CT.
Qualifications
• Extensive hands-on experience with Orbitrap MS platforms
• Experience with liquid chromatography systems (nanoLC experience is preferred)
• Proficiency in MS acquisition methods such as data-dependent acquisition (DDA), data-independent acquisition (DIA), parallel reaction monitoring (PRM), etc.
• Experience with labeled MS quantitation methods such as TMT and iTRAQ
• Hands-on experience with MS proteomics sample preparation methods including BCA quantitation, tryptic digestion, peptide desalting, phosphopeptide enrichment, peptide labeling
• Experience with targeted MS protein quantitation using heavy isotope labeled standards
• Experience with top-down MS methods for intact protein analysis
• Proficiency in mass spectrometry analysis software packages including Proteome Discoverer, Scaffold, and Skyline.
• Ability to trouble-shoot and problem-solve independently while under general supervision by the project leader
• Ability to organize and work on multiple projects simultaneously
• Excellent data handling and recording skills as well as oral and written communication skills is required.

Play here: https://jobs.lever.co/impossiblefoods/401f5851-7291-4294-afec-704d7f8ad2b5

Impossible Foods is addressing the most catastrophic threats facing humanity: climate change and biodiversity collapse. A global transition to a plant-based food system will turn back the clock on atmospheric CO2 levels, restore natural ecosystems and reverse meltdown in wildlife biomass.

The easiest -- if not only -- way to make our civilization sustainable is to eliminate livestock, the most dangerous technology on Earth. But humans won’t give up meat. So we need to make meat better -- more delicious and more nutritious, without animals as the underlying production technology. That means that making meat sustainably is the most important and urgent problem for the global scientific community.

Impossible Foods' mission is to completely replace the use of animals as a food-production technology by offering consumers everything they currently value about animal products -- and making products that are vastly superior to their animal analogues.

To do this, we are taking a revolutionary scientific and market-based approach. We are inventing efficient, sustainable ways to transform ingredients from plants into meat, fish and dairy foods that deliver all the pleasures and nutritional benefits consumers demand, without the destructive environmental or public health impact.

Our world-class R&D team has been building the know-how and technology platform to produce meat, fish and dairy foods from plants. Impossible Foods is experiencing rapid growth and is resolutely committed to leading all aspects of the plant-based food revolution—from discovery to commercial production. The only thing that will separate Impossible Foods from success and failure is our ability to recruit more world-class experts.

Want to join? Check out the job opening and requirements below:

We are inviting an experienced researcher with broad knowledge of proteomics and mass spectrometry to join the Discovery Team at Impossible Foods at Redwood City, CA. We are looking for a top-tier scientist to design and perform high-throughput proteomics experiments, and to develop in-house protein analysis platforms. Alongside your R&D team members you will collaboratively tackle some of the hardest challenges at the frontier of food science and biotechnology.

You Will:

• Use your knowledge in analytical chemistry and biology to design and perform high-throughput quantitative proteomics experiments.
• Develop new analytical methods for mass spectrometry-based protein analysis, including but not limited to bottom-up proteomics, top-down proteomics, targeted proteomics, PTM characterization, peptide mapping, intact protein MS, native MS.
• Collaborate with other researchers on the projects in different fields including microbiology, downstream processing, materials and texture, nutrition, food science, legal and regulation.
• Performing MS data processing and statistical analysis with various software packages.

You Have:

• Ph. D./M. S., or equivalent, in chemistry, biology, or related fields.
• Strong oral and written communications skills.
• Abilities to work efficiently with diverse and dynamic teams.
• A self-motivated personality and an “can-do” attitude are required for success.
• Good hands-on abilities. Good observer and recorder.
• Avid data analyst.
• Extensive hands-on experience on proteomics sample preparation, including but not limited to: sample homogenization, protein extraction, proteolytic digestion, peptide fractionation.
• Extensive experience and knowledge on using LC-MS systems, preferably Thermo Orbitrap series instruments.
• Experiences in data processing with programming languages such as Python or R are strongly preferred, especially on pipeline & workflow development and web frameworks.

Impossible Foods Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

SUMMARY

InterVenn Biosciences is seeking mass spectrometry scientists to join our highly collaborative and supportive mass spectrometry team. Candidates will have substantive experience in the field of mass spectrometry-based proteomics/glycoproteomics, and will be highly motivated and resourceful. Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
● Lead projects in analytical method development and optimization. Develop LC-MS based targeted biomarker assay (SRM/MRM) and facilitate method validation activities.
● Be responsible for mass spectrometry instrumentation operation, troubleshooting and maintenance.
● Train and supervise new analysts in glycoproteomics mass spectrometry workflows.
● Manage multiple projects within timelines according to high scientific and ethical standards.
● Align and collaborate with project managers, data science team and clinical laboratory personnel across the biomarker assay product portfolio.
● Promote a culture of transparency and traceability across all aspects of laboratory operations.

SKILLS AND QUALIFICATION REQUIREMENTS
● Ph.D. in biological sciences, chemistry, or analytical chemistry.
● Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially triple-quadrupole MS (QQQ).
● Extensive experience in targeted mass spectrometry-based proteomics/glycoproteomics.
● Extensive knowledge of application of complex sample preparation methodologies for protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies, in particular SRM/MRM methods.
● Proven track record of LC-MS based method development and validation for proteomics biomarker assays.
● Applied knowledge of/experience with MS software analysis pipelines.
● Experience in the pharmaceutical/biotech, diagnostic, or life-science-tools industry is preferred.
● Experience in developing computational algorithms proteomics data processing and skills in computational programming languages (e.g. Python) is a plus.
● Working experience in regulatory-compliant environments (GxP) and familiarity with regulatory guidelines on bioanalysis (FDA, CLSI etc.) is a plus.
● Proven record of being a fast learner, flexible, and mindful team member.
● Excellent verbal and written communication skills.

The laboratory for Functional and Translational Proteomics, led by Prof. Oliver Schilling, is part of the Institute for Surgical Pathology, at the University Medical Center Freiburg, Germany. We are soliciting applications for a postdoctoral researcher to join our friendly and open-minded team of about 15 scientists with backgrounds in biology, chemistry, medicine, pharmacy and bioinformatics.

The project enables the unique opportunity to shape the next generation of translational proteomics by integrating state of the art approaches for sample preparation, data acquisition and data analysis to unravel proteomic characteristics of diverse solid tumors.

Selected tasks include:

• Improvement of existing and development of new methods, especially for shotgun proteomics to allow additional analysis such as regulatory modifications and proteogenomics
• Establishing targeted proteomic assays
• Contribute to the supervision and maintenance of our diverse mass spectrometers
• Active collaboration with medical doctors and life scientists on local, national and international level

We offer

• Full-time postdoctoral position (TV-L E13, 100%) for initially two years (extension possible); starting date is flexible but early in 2021 is preferred
• Highly translational projects with clinical relevance in a productive and friendly work environment with international and industry collaborations
• Well funded and equipped lab
• Ample opportunities for scientific publishing, conference presentations, grant applications and student supervision
• Plenty opportunities for scientific and professional development

Required qualifications include a PhD in a life sciences discipline (e.g. biology, molecular medicine,
chemistry, pharmacy); strong scientific background and experience in mass spectrometry based
proteomics including sample preparation, LC-MS/MS instrument handling and ideally also data
analysis. Experience with cell culture techniques, protein biochemistry, molecular biology, and / or
microscopy is an asset. We also ask for a proactive and cooperative work attitude with excellent
problem-solving and organizational skills, very good communication skills in English (written and
spoken), and an interest in supervising (PhD) students.

For further inquiries please contact
oliver.schilling@uniklinik-freiburg.de

To apply, please send CV, motivation letter and contact details of two references to melanie.foell@uniklinik-freiburg.de.

Please find further information in the attachment.

Greetings!

My lab at Vanderbilt University in Nashville, TN, USA is looking for a biochemistry-minded research scientist, research associate or postdoctoral fellow interested in applying mass spectrometry-based approaches to protein structural biology. We recently published the first full-length integrated structural model of a monomeric nuclear receptor. The model of this transcription factor bound to a DNA oligo was derived largely from mass spectrometry-based data:

https://www.cell.com/structure/fulltext/S0969-2126(20)30166-0

The target protein is the nuclear receptor LRH-1 (NR5A2), a ligand activated transcription factor and target for antidiabetic drug design. The above paper establishes the unperturbed ground state structure. Your project will be to determine how known small molecule ligands, drugs, hormones, peptides and DNA sequences regulate this structure.

The techniques we applied to determine the above structure included BS3 chemical crosslinking, benzophenone artificial amino acid crosslinking, engineered disulphide crosslinking and hydrogen-deuterium exchange (HDX). We used these techniques as amino acid proximity sensors in this multi-domain protein target to model how the individual domains interact with each other. For more details please visit my lab site:

http://www.blindlab.org

Although scientist-level candidates should have extensive proteomic data analysis, protein expression, purification and characterization experience, postdoc or research associates need only basic protein biochemistry skills, an eagerness to learn and a strong sense of scientific bravery.

Send your CV to the PI (Ray Blind) at ray.blind@vanderbilt.edu, soon-to-be PhD graduates are specifically encouraged to apply.

West Point, Pennsylvania, United States of America Job Type : Full time

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Merck Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

What You'll Be Doing:

You'll be helping us build metabolomics capabilities for improving drug metabolism and pharmacokinetics. You will join a dynamic bioanalytical group, also work closely with drug absorption, distribution, metabolism and excretion (ADME) experts and big data modeling scientists in PPDM to study the roles of endogenous molecules (including metabolites, lipids and peptides) in our drug discovery models. The goal is to develop novel predictive approaches based on the flux of endogenous molecules to enable early detection of drug-drug interactions and drug clearance pathways.

Responsibilities include but are not limited to:
Interact frequently with key collaborators and solicit input from bioanalytical and ADME experts to shape study plans. This includes but not limited to:
Design in vitro and in vivo studies on preclinical species using probe drugs to generate hypotheses driven samples.
Generate metabolomics data. Analyze samples using state of the art LC/MS instruments and coordinate with other capability groups within our company or CROs.
Metabolomic data analysis and model building to link endogenous molecules changes responding to probe drugs.
Drive novel hypotheses based on data; conduct new experiments to progress continuously and achieve predictability.
Prepare manuscripts for novel findings

What You Need:
Candidates must currently hold a PhD OR receive a PhD by fall of 2021.
A record of establishments in advancing metabolomics workflow and applications including analytical platform development and biological sample analysis
Excellent big data processing, visualization (including graphical model) skills with proficiency of metabolomics bioinformatic software packages including pathway analysis
Excellent verbal and written communication skills; ability to excel in a team-interactive environment.
Proven record of innovation with publications in peer-reviewed journals and presentations in leading scientific conferences (ASMS, Metabolomics, etc.).

It's Great If You Have:
Experiences working with endogenous molecules flux for enzymatic systems
Ability to create novel data visualization methods when existing software doesn’t suffice.
Proven understanding of drug metabolism and pharmacokinetics of xenobiotics

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.
IMPACT.
INSPIRE.

mrlpostdoc
US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement​
OFCCP EEO Supplement
OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:
1
Requisition ID:R91315

Apply at: https://jobs.merck.com/us/en/job/R91315/Postdoctoral-Research-Fellow-Pharmacokinetics-and-Metabolomics

Apply Here: https://takeda.wd3.myworkdayjobs.com/External/job/San-Diego-CA/Scientist-II--DMPK_R0026102-1

OBJECTIVES:
Develop targeted biomarker assays for target engagement and pathway modulation biomarkers using mass spectrometry approaches
Quantify peptides, proteins, post-translational modifications, lipids, and metabolites to inform go- no-go decisions on assets and targets
Support discovery proteomics efforts using DIA, TMT, and label-free proteomics approaches
Lead scientific advances in specialized sample processing techniques, nano-LCMS, and software packages related to biomarker analyses

ACCOUNTABILITIES:
Process biological samples including tissues and fluids (Colon, Bile, Urine, CSF and/or Plasma) for enzymatic digestion, sample clean-up, and sample enrichment
Develop high-throughput sample processing approaches utilizing plate-based approaches and robotic instruments such as KingFisher and liquid handlers (eg. Tecan)
Implement 1D and 2D liquid chromatography techniques including reverse phase, reverse phase high pH, ion exchange, size exclusion, and others
Utilize Thermo’s hybrid and tribrid instruments to develop specialized biomarker assays for analytes with low physiological concentrations in complex matrices
Utilize Sciex’s TripleQuad and TripleTOF and Waters’ Xevo with Ion Key platforms for biomarker quantitation
Enrich for PTMs such as phosphorylation, acetylation, glycosylation, ubiquitination, and others using chemical affinity and antibody approaches
Leverage software packages including Skyline, Compound Discoverer, Proteome Discoverer, MaxQuant, Spectronaut and others for biomarker discovery and quantitation
Analyze multi-variate data sets and develop data processing pipelines containing normalization, imputation, and statistical analysis
Perform pathway analysis using IPA, Metacore, and other commercial/ public biological databases
Summarize biomarker data and present findings and recommendations to project teams

MINIMUM EDUCATION/EXPERIENCE:
PhD degree in a scientific discipline with 2+ years experience , or
MS with 8+ years experience, or BS with 10+ years experience
Prior experience with mass spectrometry, HPLC, and nano-LC is required. Familiarity with Thermo and/or AbSciex mass spectrometers for biomarker quantitation is required.
Experience with ligand binding assays is beneficial.
The candidate must be able to analyze data and note significant deviations and maintain detailed, accurate and comprehensible study documentation.
The individual is also expected to be highly organized, a team player, enthusiastic about drug discovery, and possess strong communication skills.
Publications in peer-reviewed scientific journals are beneficial

About the job (posted on January 25, 2021):

Adeptrix is an entrepreneurial Life Sciences company based in Beverly MA that develops analytical solutions for pharma, biopharma, academic and clinical customers. Having recently completed the Series A financing round, the company is well positioned to become a major player in the fast-growing, multi-billion dollar bio-analytical consumables market. Adeptrix is currently working on a variety of research and diagnostic assays in the areas of neurology, oncology, epigenetics and virology (COVID-19) based on its proprietary BAMS™ platform technology. To learn more about Adeptrix: https://adeptrix.com/

We are currently accepting applications for a Research & Product Scientist who will provide leadership on further advancement of BAMS™ with the main focus on product and applications development, as well as the internal research and ongoing collaborations with Academia, Biotech and Pharma. This position reports to the company leadership.

Key responsibilities include:
• Manage laboratory personnel to co-ordinate and streamline product development activities
• Design and supervise validation efforts for the product development pipeline
• Oversee collection and analysis of analytical data for internal R&D and external collaborations
• Contribute to writing, editing, and producing abstracts, manuscripts, reports, posters
• Present at professional meetings and conferences
• Provide subject matter expertise and support to business development efforts

Qualifications:
• Minimum of 4 years of research or product development experience in bio-analytical assay development
• Experience with proteomic sample preparation methods and mass spectrometry data analysis
• Natural tendency to be curious, positive and creative
• Creative and analytical; can translate data and information into actionable plans
• Excellent project management and interpersonal skills
• Excellent communicator; able to put together convincing arguments
• Ph.D. or Masters degree with relevant industry experience

Personal Attributes:
• Exceptional communication, interpersonal and analytical skills
• Strong sense of professional accountability and integrity
• Highly motivated; plans for and strives to meet project goals and objectives
• Collaborative approach; functions well in team-based environments
• Commercial mindset
• Eager to grow and advance professionally

Competitive compensation and benefits package will be provided. Adeptrix is an equal opportunity employer and prohibits any discrimination or harassment based on race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

Interested scientists are encouraged to reach out to Jeffrey Silva, Chief Technology Officer, at Adeptrix Corporation (jsilva@adeptrix.com).

Post Doctoral Positions in Proteomics of Disease, Signaling and Complex Biological Systems

The Proteomics Group (Carr Lab) at the Broad Institute of MIT and Harvard is looking for several highly
motivated post-doctoral associates to develop and apply state-of-the art proteomics technology to
address compelling questions in biology, chemistry and clinical medicine. The specific research areas
of immediate interest that this scientist could drive include:
• multiomic and proteogenomic studies of a wide range of cancers
• provide detailed views and understanding of cellular signaling networks related to
protein phosphorylation, ubiquitylation, acetylation and cross-talk
• define the targets of drugs or identifying protein interactors through chemical
proteomics technologies and affinity purification MS
• develop biological understanding of response and resistance to therapy
• improve understanding of immune biology and help develop personalized cancer
immunotherapies
• develop and optimize new, broadly enabling proteomic technologies including targeted,
quantitative MS assay development for proteins and modifications of high biological or
clinical interest
Successful candidates will work in one or more of these areas together with an interdisciplinary team
of clinicians, biologists, computational and proteomics scientists to deeply characterize and
understand the proteomes of tumor-derived material, cells and biofluids.
The Broad Institute is a world-leading non-profit research organization dedicated to realizing the
promise of the post-genomic era for human benefit. Located in Cambridge, MA with strong ties to
MIT, Harvard, and world class Boston hospitals, the Broad Institute brings together scientists of diverse
backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner. The
Broad Institute, and the embedded Proteomics Group (www.broadinstitute.org/proteomics), have an
outstanding track-record in training the next generation of research scientists and in developing and
applying proteomic technologies critical to address important questions in biology and medicine. We
collaborate with top-level researchers throughout the world, and results of these studies and our
technology developments are published in top-tier journals.
Qualifications
Candidates must have:
• an MD or Ph.D. in analytical chemistry, biology, biochemistry, or a closely related field
• excellent scientific productivity, evidenced by high-quality research publications in peer
reviewed journals
• track record of conducting independent and creative research
• excellent verbal and written communication skills

Hands on skills and knowledge in one or more of the following areas will be considered an advantage:
• state-of-the-art mass spectrometry-based proteomics
• expertise in expertise in statistical and/or computational analysis of large-scale proteomic or
genomic data
• analysis of cell signaling pathways/networks
• cell biology/ biochemical methods to understand protein function
• Molecular biology/CRISPR-based genome editing
Interested scientists are encouraged to apply on-line at the Broad Website. Inquiries can also be
addressed to Steve Carr, Director of Proteomics, Broad Institute (scarr@broad.mit.edu) and Namrata
Udeshi, Associate Director of Proteomics (Udeshi@broadinstitute.org).

SUMMARY

InterVenn Biosciences is seeking mass spectrometry scientists to join our highly collaborative and supportive mass spectrometry team. Candidates will have substantive experience in the field of mass spectrometry-based proteomics/glycoproteomics, and will be highly motivated and resourceful. Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
Lead projects in analytical method development and optimization. Develop LC-MS based targeted biomarker assay (SRM/MRM) and facilitate method validation activities.
Be responsible for mass spectrometry instrumentation operation, troubleshooting and maintenance.
Train and supervise new analysts in glycoproteomics mass spectrometry workflows.
Manage multiple projects within timelines according to high scientific and ethical standards.
Align and collaborate with project managers, data science team and clinical laboratory personnel across the biomarker assay product portfolio.
Promote a culture of transparency and traceability across all aspects of laboratory operations.

SKILLS AND QUALIFICATION REQUIREMENTS
Ph.D. in biological sciences, chemistry, or analytical chemistry.
Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially triple-quadrupole MS (QQQ).
Extensive experience in targeted mass spectrometry-based proteomics/glycoproteomics.
Extensive knowledge of application of complex sample preparation methodologies for protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies, in particular SRM/MRM methods.
Proven track record of LC-MS based method development and validation for proteomics biomarker assays.
Applied knowledge of/experience with MS software analysis pipelines.
Experience in the pharmaceutical/biotech, diagnostic, or life-science-tools industry is preferred.
Experience in developing computational algorithms proteomics data processing and skills in computational programming languages (e.g. Python) is a plus.
Working experience in regulatory-compliant environments (GxP) and familiarity with regulatory guidelines on bioanalysis (FDA, CLSI etc.) is a plus.
Proven record of being a fast learner, flexible, and mindful team member.
Excellent verbal and written communication skills.

Senior Research Associate
Location: South San Francisco, US
InterVenn Biosciences is seeking a Sr. Research Associate to join our highly collaborative and supportive biomarker discovery team. The successful candidate will be a highly motivated and resourceful individual with a robust track record of experience in the field of mass spectrometry- based proteomics and glycoproteomics, . Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
RESPONSIBILITIES
Conduct experiments for the development of sample preparation and peptide separation methods, glycoproteomic technology evaluation, data analysis and interpretation,and glycoproteomic software evaluation.
Prepare biological samples and run assays on instruments under general guidance.
Document experimental work, analyze data, document and present results.
Prepare written methods and SOPs.
Perform mass spectrometry instrumentation operation, troubleshooting and maintenance.
Manage multiple projects within timelines according to high scientific and ethical standards.
Align and collaborate with project managers, computational biologists and software development project leads across the biomarker discovery project portfolio.
Promote a culture of transparency and traceability across all aspects of laboratory operations.

QUALIFICATIONS
BS or MS in life sciences, chemistry or related fields with 4 or more years of industry or equivalent postgraduate experience is required.
Extensive knowledge and application of complex sample preparation methodologies as applied to protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies including label-free analyses (DIA, PRM/SRM) methods.
Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially high resolution mass spectrometers (Orbitrap or qTOF)
Applied knowledge with MS software analysis pipelines
Demonstrated ability to plan and execute research experiments.
Proven record of being a fast learner, flexible, excellent communicator and mindful team member.
Excellent verbal and written communication skills.

Job description:

This is an exciting growth opportunity that focuses on large-scale quantitative proteomics applications in the Li Lab at the University of Minnesota’s Medical School and the Graduate Neuroscience Program. Our expertise and research has been focused on applying cutting edge quantitative proteomics to identify novel mechanisms and biomarkers for precision and personalized treatment of neurodegenerative diseases. The individual will be scientifically responsible for aspects of research planning, method development, sample preparation, data acquisition and biostatistics and bioinformatics. Responsibilities also include effectively communicating project progress, teaching and mentoring lab staff and graduate student, large-scale data analyses using biostatistics and bioinformatics, preparing presentations, and participating in grant writing and scientific publications in high impact journals.

Responsibilities:

Conduct investigations or experiments in an assigned area to aid in the solution of a research problem.
Set up and operate equipment used in collecting research data.
Calculate and analyze data.
Select and review literature relating to the assigned area.
Actively participate in research efforts by exploring new possible approaches to problems and discuss possible approaches to problems with supervisor.
Write routine summary reports on results of work and confer with supervisor on interpretation of results and avenues of investigation.
Write manuscripts as author and/or co-author for publication

Required Qualifications:

Masters degree (chemistry, biochemistry or related discipline) with at least one year of experience
Significant background in proteomics
A clear record of publications
Proficiency in bioinformatics approaches including protein quantification, statistical analyses, and pathway analysis
Outstanding communication skills

Preferred Qualifications:

PhD (chemistry, biochemistry or related discipline)
Programming experience
Direct experience with data-independent acquisition

Lab Website: https://sites.google.com/umn.edu/the-danni-li-lab/home

Apply here: https://hr.myu.umn.edu/psc/hrprd/EMPLOYEE/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&SiteId=1&FOCUS=Applicant&JobOpeningId=338758&PostingSeq=1&

Applications are invited for various positions ranging from Research Assistant to Postdoctoral Researcher levels to work in the laboratory of Alban Ordureau in the Cell Biology Program at Memorial Sloan Kettering Cancer Center (MSKCC) in New York. Sloan Kettering Institute at MSKCC provides an exceptionally supportive, collaborative, and comprehensive training and research environment.

We have broad interests in kinases, ubiquitin ligases, and overall protein homeostasis (including autophagy). For further details, please see our website: https://www.mskcc.org/research/ski/labs/alban-ordureau

The successful applicants will deploy a state-of-the-art blend of quantitative proteomics methodologies (TMT, PRM, AHA-methodologies (degradome and translatome), ubiquitin intact-mass and top-down). They will gain experience in understanding signal transduction pathways linked to cellular functions and how they are linked to disease. Proteomics is central to our research, and for this, the lab maintains an Eclipse-ETD/UVPD Orbitrap mass spectrometer.

Applicants with experience in mass spectrometry/analytical chemistry and quantitative proteomic analysis expertise are encouraged to apply. Experience in nanoLC-MS/MS and Orbitrap-based mass spectrometers is preferable, but not necessary, and training can be provided. Experience in proteomics sample preparation (e.g., protein extraction, HPLC separation), mass spectrometry technical development is preferred. Some knowledge or desire to learn Python, R, and the ability to write and develop scripts and modify/implement open-source or published code is desirable. Enthused applicants eager to participate and gain experience in undertaking biological studies to generate samples and validate data would be advantageous, and training can be provided.

Interested candidates should send a cover letter and CV to Dr. Ordureau (ordureau.lab@gmail.com)

Yale University offers exciting opportunities for achievement and growth in New Haven, Connecticut. Conveniently located between Boston and New York, New Haven is the creative capital of Connecticut with cultural resources that include three major museums, a critically-acclaimed repertory theater, state-of-the-art concert hall, and world-renowned schools of Architecture, Art, Drama, and Music.

General Purpose:
The MS & Proteomics Resource at Yale has an opening for a M&P level mass spectrometrist with hands on expertise in mass spectrometry and proteomics. The successful candidate will work in a resource laboratory along-side other Biotechnology Associates dedicated to helping a multitude of investigators use MS analyses to advance their proteomics research. The Resource’s mission is to provide investigators of all disciplines (chemical, biological, clinical, etc.) with access to the most advanced mass spectrometry based biotechnologies through efficient and cost-effective proteomics and small molecule services. These technologies are developed and implemented with a broad spectrum of mass spectrometry based techniques for protein/peptide/small molecule chemistries to separate, characterize, profile, and quantify analytes from complex biological samples. The Resource is superbly equipped for this purpose with 5 state-of-the-art MS systems that are utilized for a wide range of biotechnologies.

Required Education and Experience:
Master’s Degree in chemistry, biology, biochemistry, or other related discipline and three years of experience or an equivalent combination of experience and education.

Qualifications:
• Thorough understanding of mass spectrometry.
• Demonstrated knowledge of quantitative proteomics, protein chemistry and proteomics sample handling.
• Well-developed written and oral communication skills..
• Ability to work with and lead multiple projects.
• Working knowledge of major licensed proteomics software.
• Preferred Education and Experience: PhD level in Analytical Chemistry, Biochemistry.

Application: For more information and immediate consideration, please apply online at https://bit.ly/YaleCareers-63101BR. Please be sure to reference this website when applying for this position.

We invite you to discover the excitement, diversity, rewards and excellence of a career at Yale University. One of the country's great workplaces, Yale University offers exciting opportunities for meaningful accomplishment and true growth. Our benefits package is among the best anywhere, with a wide variety of insurance choices, liberal paid time off, fantastic family and educational benefits, a variety of retirement benefits, extensive recreational facilities, and much more.

Yale University considers applicants for employment without regard to and does not discriminate on the basis of an individual’s sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression.

https://your.yale.edu/careers

Research Opportunity:
Interested in applying your Skyline and mass spec experience to human induced pluripotent stem cell research? We are looking for a postdoctoral fellow to join our team at the University of Colorado School of Medicine. We are interested in examining protein homeostasis and cellular communication using large-scale sequencing, targeted mass spectrometry, and related technologies. Some of our prior work includes methods to quantify protein turnover (https://pubmed.ncbi.nlm.nih.gov/29317621/) and identify protein alternative isoforms (https://pubmed.ncbi.nlm.nih.gov/31825849/). We are now developing companion strategies that are applicable to questions in cell biology and cardiovascular research. Please visit our website at https://laulab.net for details.

Minimum Qualifications:
Ph.D. or equivalent in biochemistry, cell biology, or related scientific fields from an accredited institution.
Minimum of 3 years of active research experience in the life sciences in an academic environment.

Preferred Qualifications:
Prior experience with experiments and data analysis related to next-generation sequencing and/or mass spectrometry approaches.
Prior experience with cell culture models including human induced pluripotent stem cell models as applied toward basic biomedical research.

Application:
Please apply here: https://cu.taleo.net/careersection/2/jobdetail.ftl?job=19172&lang=en
Include a cover letter, CV, and contact info of 3 references.

Salary and Benefits:
Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services. Funding for this position is guaranteed for one year. Continuation of employment thereafter is subject to annual performance review and mutual interest.

Diversity and Equity:
Please click here for information on disability accommodations: http://www.ucdenver.edu/about/departments/HR/jobs/Pages/JobsatCUDenver.aspx
The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

The Meyer lab in the Biochemistry Department at the Medical College of Wisconsin is seeking a postdoctoral scholar with experience or interest in mass spectrometry, proteomics, metabolomics, machine learning, bioinformatics, or related areas.

The long-term goal of the Meyer lab is to predict molecular and phenotypic behavior of biology using computational models trained with large-scale omics data. Ongoing projects relate to drug discovery, basic understanding of metabolism, and personalized patient diagnosis. New technology we develop is motivated by the need for cures and diagnostics for neurological diseases and cancer.

The successful candidate will have exclusive access to a new Orbitrap Exploris 240 mass spectrometer with FAIMS Pro.

Competitive candidates will have experience in at least one of the following areas:

1. data analysis with python and/or R
2. mammalian tissue culture
3. bacterial/yeast culture
4. sample preparation for mass spectrometry
5. experience operating liquid chromatography mass spectrometry (LC-MS) instruments,
6. machine learning with scikit-learn (sklearn), keras/tensorflow, pytorch, fastai
7. website building and maintenance

Please check out our website for more information about previous publications and ongoing projects:
www.jessemeyerlab.com

Interested candidates please apply here:
https://careers.peopleclick.com/careerscp/client_medcollegewi/external_staff/gateway.do?functionName=viewFromLink&jobPostId=16743&localeCode=en-us

Our Research Laboratories is seeking to recruit an experienced mass spectrometry scientist with broad experience in Proteomics applications to join the Protein Sciences Department in South San Francisco, CA.

The position will be hands-on at the bench and will report to the mass spectrometry group leader.

Responsibilities:
Design and perform proteomics-based experiments, including phospho-proteomics, labeled and label-free differential protein expression, and targeted protein quantification.
Sample preparation for proteomics analysis including protein extraction, immunoprecipitation, proteolytic digestion, and sample clean-up prior to MS analysis.
Perform analytical routines for Tandem liquid chromatography mass spectrometry (LCMSMS) systems maintenance, including calibration, system suitability, and troubleshooting.
Strong communication & interpersonal skills.

Education Minimum Requirement:
PhD in Biochemistry, Cell Biology, Analytical Chemistry or a related field, with a minimum of 3 years relevant postdoctoral or pharmaceutical/biotechnology experience.

Required Experience and Skills:
Knowledge and direct experience with state - of - the - art technologies and methods for mass spectrometry-based proteomics, including Thermo Orbitrap mass spectrometers.
Proficiency in quantitative proteomics techniques SILAC, Tandem Mass Tag (TMT), label-free quantification approaches and peptide fragmentation methods.
Proficiency in using Proteome Discoverer, Peaks, Genedata, MaxQuant, Skyline, and other DB search engine tools.

Preferred Experience and Skills:
Biologics characterization using mass spectrometric methods (PTMs/glycosylation, intact and subunit mass analysis).
Understanding and working knowledge of various analytical methods for protein characterization such as SEC, IEX, RP – HPLC, CE-SDS.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …
Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.
IMPACT.
INSPIRE.

NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement​
OFCCP EEO Supplement
OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
Yes

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:
1

Link to the position:
https://msd.wd5.myworkdayjobs.com/SearchJobs/job/USA---California---South-San-Francisco---Grand-Ave/Senior-Scientist--Proteomics-Mass-Spectrometry--Protein-Sciences-_R74512

Associate Scientist II/III – Fluid Biomarker Assay Development
*Job Description
The Biomarkers group (Section of Clinical Sciences) is seeking a creative and collaborative lab-based scientist engaged in targeted proteomics for the detection of proteins and metabolites in different biological matrices (including plasma, serum, CSF, urine, tissues) to support early clinical stage programs. The successful candidate will be capable of multitasking and effective planning to consistently meet deadlines.
*Responsibilities:
• Targeted protein biomarker assay development using state of the art liquid-chromatography-mass spectrometry (LC-MS) platforms including nano-LC, orbitrap (Q-Exactive, Q-Exactive +, Q-Exactive HF/HFX, Fusion) and UPLC-QQQ MS (AB Sciex)
 Sample preparation (tissues and cell lysates) for protein quantification
 Biotinylation and various bead-antibody conjugation techniques
 Identification and selection of antibodies for immunoprecipitation prior to LC-MS analysis
 Identification of novel techniques and strategies to enhance assay sensitivity
 Fit for purpose qualification of protein and small molecule LC-MS assays
 LC-MS instrumentation troubleshooting
• Point of contact with Contract Research Organizations
 Work with CRO partners to oversee biomarker assay implementation including assay interpretation
• Timely recording keeping and data entry into Electronic Lab Notebook
• Prepare, review, and deliver scientific presentations for internal/external use
*Qualifications

1. Proven experience with LC-MS instrumentation is required with experience in targeted and global proteomic profiling.
2. Preference will be given to candidates with hands on experience in developing and qualifying high resolution (Orbitrap) LC-MS assays, including immunoprecipitation LC-MS for the detection of proteins in biological samples
3. Expertise using Skyline and familiarity with Thermo Xcalibur, Proteome Discoverer, AB Sciex Analyst
4. Excellent assay troubleshooting skills
5. Familiarity with neuroscience, including knowledge of neurodegenerative diseases (AD, PD, ALS) is considered a plus but not required
6. Experience in or willingness to learn classic immunoassay based assays (ELISA)
7. Demonstrated track record of providing support activities for multiple research projects
8. Solid work ethic and demonstrated record of productivity such as participating in peer reviewed publications or scientific poster presentations
   *Education
   • BS with >3 years experience or MS with >1 year experience in relevant scientific area

contact me directly at omar.mabrouk@biogen.com if you may be interested

http://immatics.com/career-details/scientist-immunopeptidomics-proteomics-all-genders-welcome.html

Scientist Immunopeptidomics/ Proteomics (all genders welcome)
to support our team in the research and development of innovative immunotherapeutic products. You will work in Tuebingen (Germany) in an interdisciplinary environment with colleagues from all research and preclinical/ clinical development departments. Your analytical reasoning and action-oriented style as well as your organization and communication skills will contribute to the team’s success.

The job profile is focused on the characterization and validation of novel HLA presented targets, which will involve but is not limited to the following tasks:
Characterization of HLA presented peptides using Immatics’ proprietary absolute quantitation technology (AbsQuantTM) to identify and validate the best targets for clinical development
Contribution to the elucidation of the biological mechanisms of novel cryptic targets using (targeted) proteomics analysis together with various Omics datasets integrated in Immatics’ XPRESIDENT® target discovery and validation platform
Coordination and project management of target characterization activities involving stakeholders from different departments and disciplines
Development of new strategies and methodologies for target characterization using a diverse set of protein chemistry and mass spectrometry techniques

Your profile
You hold a PhD degree in Life Sciences, Biochemistry, Biotechnology, Pharmacy or have been comparably educated and proven your scientific excellence and your ability to account for complex projects, preferentially with a track record in proteomics or immunopeptidomics. You are familiar with mass spectrometry data analysis and ideally have already gathered experience with targeted methodologies (such as SRM, MRM or PRM) and data independent acquisition. You show a high motivation to translate your scientific findings into clinical development and application. Preferably, you also have previous experience in large-scale data analysis and have already worked with relational databases. You take careful processing and documentation of your results for granted. Your scientific excellence, extraordinary analytical competence and communication skills enable you to successfully contribute to projects as part of a team and to present your work internally or to external partners from the pharmaceutical and biotech industry.

We expect a high degree of independent working, analytical reasoning and excellent communication skills in English. You embrace rapidly changing requirements with an open mind and show a high degree of flexibility in an environment which is marked by a constant striving for excellence. Your motivation is driven by your passion for innovation and science. You approach tasks in a structured, reliable and foresighted manner, combined with an elevated level of individual responsibility, enthusiasm and strong social skills.

What we offer
We are a committed and inspired team and cherish the collegial, highly motivated and family-friendly atmosphere within Immatics. Our culture allows for a high level of originality, independent thinking and initiative. We believe in supporting our employees’ professional and social skills: We enable them to join conferences and trainings as well as to enjoy our Immatics benefits – e.g. job bike, job ticket, Health Programs, childcare benefits, relocation allowance, Company summer and winter events.

If you’re interested in working for Immatics, please apply online and provide your application documents along with the relevant credentials and certificates. Mrs Annemarie Selbenbacher will answer initial questions at +49 89 125 03 98 33 (landline number Germany). Coredi Recruiting GmbH (Mrs Annemarie Selbenbacher) advises Immatics on this job posting.