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Showing: all postings
Post-doctoral opportunity in proteomics and immunotherapy at UCSF
apwiita 2019-10-23

The laboratory of Arun Wiita at the University of California, San Francisco is currently recruiting post-docs to help us advance our mission of discovering new targets and developing new immunotherapies for hematologic malignancies (see brief description of related work at https://wiitalab.ucsf.edu/developing-novel-immunotherapies-profiling-cancer-cell-surface). In particular, we are interested in finding candidates with experience in redox proteomics, disulfide proteomics, and/or cross-linking mass spectrometry to enhance our discovery of novel cancer immunotherapy targets and therapeutics. Experience in mass spectrometry-based proteomics is required, and prior experience in immunology, cell biology, and/or protein biochemistry would be assets.

Our group is located in beautiful San Francisco, California. UCSF is one of the premier academic medical centers in the world, excelling in both basic science and clinical research. We are a multidisciplinary research group and our interests span from the basic to translational realms across a number of conditions, as well as new technology development combining chemical-based enrichment and quantitative proteomics.
We offer competitive salary in line with cost-of-living in the Bay Area. We are fortunate to have numerous sources of funding including the NIH New Innovator Award, an NCI R01, and additional federal and private grants to support our work. We are also fortunate to have extensive collaborations with other world-leading scientists across UCSF, as well as access to world-class core facilities to accelerate discoveries in biomedical research. In addition, all mentorship and project design within our group is customized for the scholar's career goals, whether entering academia or industry.

Well-qualified applicants should send a CV, cover letter, and contact information for two references to arun.wiita@ucsf.edu.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

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Scientist LCMS (https://www.adimab.com/)
AdimabHR 2019-10-13

Role

Adimab is seeking a skilled biochemist to join our Protein Analytics team. This person will work in a small team setting to support Adimab’s novel antibody discovery, maturation, and production platform.

Responsibilities

-Develop and execute LCMS-related assays to characterize therapeutic antibodies, investigate PTMs, identify epitopes, and survey chemical liabilities
-Critically interpret data, troubleshoot experiments, and communicate the results to internal customers
-Operate and maintain multiple LCs & mass spectrometers
-Other responsibilities include, but are not limited to, characterization of antibody samples using other analytical technologies such as ForteBio kinetics, chromatographic assays, CZE, etc.

Needed upon hire

-M.S. in biochemistry, analytical chemistry or a related field; industry experience preferred
-Strong biochemistry background with an in-depth technical knowledge of MS
-Strong attention to detail
-Ability to proactively identify and troubleshoot problems
-Adaptable and productive in a fast-paced environment
-Communicates effectively and openly with colleagues and supervisors
-Prior experience with epitope mapping, HDX, or nanospray MS is desired
-Familiarity of scripting workflows and analyses is a plus

Come join us!

https://www.adimab.com/

As a profitable privately-held biotech company, we take a long-term view on value creation and make substantial investments in technology development, research, and our people. We proudly promote meritocracy and reward employees who are productive, use their resources wisely, and make meaningful contributions to the team. We offer individually tailored compensation packages comprised of a competitive salary, meaningful equity, a 2:1 401(k) match, and comprehensive health care benefits.

Located in New Hampshire’s beautiful Upper Connecticut River Valley, we are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated in an area that is renowned for its premier skiing, hiking, and biking.

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Post-doctoral research position in functional cancer proteomics
kentsisresearchgroup 2019-09-30

Functional Cancer Proteomics

We are a group of biochemists, biologists and physicians in the Molecular Pharmacology Program at the Sloan Kettering Institute in New York City, USA. We carry out research in cancer biology, and our current work is focused on the phenomenon of cellular plasticity, as it relates both to the fundamental mechanisms of cancer pathogenesis and emerging rational therapies.

In particular, we are studying the biology of refractory leukemias and solid tumors, and we are interested in understanding the principles of disorganization of their genomes and proteomes, and determining the molecular mechanisms of response and adaptation of tumor cells to targeted therapies.

To answer these questions, we are developing new approaches, based on quantitative mass spectrometry and functional proteomics, to decipher the mechanisms of cancer cell signaling and develop new therapeutics.

Forward Proteomic Screens for Cancer Therapeutics and Macromolecular Delivery. Using recently developed methods for quantitative proteomics and peptide barcoding (Egloff et al, Nature Methods 2019, PMID: 31113958), we’ve developed a new platform for high-throughput design and screening of macromolecular cell penetration and delivery reagents. This is a transformative technology that enables the generation of new classes of drugs to modulate specific protein-protein interactions, which we’ve recently applied for targeted leukemia therapy (Ramaswamy et al, Nature Communications 2018, PMID 29317678). Current efforts are focused on applying this technology for protein engineering and development of new peptide conjugates for cancer and gene therapy.

Quantitative Cell Proteomics Atlas (http://qcpa.mskcc.org). Using developed methods for ultra-sensitive quantitative proteomics (Cifani & Kentsis, MCP 2017, PMID 28821601), we’ve developed an atlas of targeted mass spectrometry assays to profile biochemical signaling at the pathway scale in normal and cancer cells. Current efforts are focused on developing high-throughput and genome-scale methods. This work aims to define systems-level mechanisms of aberrant signaling in cancer cells, as well as fundamental cell biological processes of signaling adaptation, feedback and integration.

If you are a recent PhD graduate with interest in the above areas and experience with nanoscale liquid chromatography, electrospray ionization, high-resolution mass spectrometry or protein engineering and chemistry, please contact Alex Kentsis at http://alexkentsis.net/ or kentsisresearchgroup+application@gmail.com

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Postdoc in Targeted Proteomics, Aarhus University, Aarhus
bh 2019-09-29

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a three-year position as Postdoc in the field of Targeted Proteomics as per 1 December 2019 or as soon as possible thereafter. The position is a fixed-term full-time position.

We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work either in the brand new ‘Skou Building’ or similar as we are in the process of modernizing our old facilities. You can read more about the department here (https://biomed.au.dk/en/) and about the faculty here (http://health.au.dk/en/).

About the research project
The position is part of a newly established national research group that investigates the eye disease age-related macular degeneration (AMD). The position is funded by the Velux Foundation. The research work will mainly be to perform LC-MS analyses (targeted proteomics using SRM) and other relevant protein analyses on samples obtained from the other participating laboratories. The samples consist of biological material from patients, research animals and cultured cells.

Your job responsibilities
As Postdoc in Targeted Proteomics your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of:

Independent research of high international quality, including publication.

You will report to Professor Bent Honoré and be supervised by him.

Your competences
The ideal candidate has the following profile:

MSc/PhD in human biology, molecular biology, molecular medicine or similar.
Hands-on experience using liquid chromatography and tandem mass spectrometry (LC-MS/MS) on Thermo Scientific instruments with standard software for instrument control (Xcalibur).
Knowledge concerning preparation of biological samples (e.g., tissue, cells, plasma, serum).
Experience with quantitative analyses of peptides/proteins from biological material using nanoLC and MS-techniques (SRM, MRM on triple quadrupole MS, e.g. TSQ Quantiva).
Ability to pursue and evaluate quantitative analyses and skills to analyze complex data sets using, e.g., Skyline and other types of software for bioinformatics analyses.
Excellent communication and presentation skills. Ability to work as part of a group as well as independently.
Willingness to implement new relevant methods for proteomics analyses of tissue.

For further information please see: http://health.au.dk/om-health/ledige-stillinger/job/postdoc-in-targeted-proteomics/

If you have any questions about the position, please contact Professor Bent Honoré at bh@biomed.au.dk. The application must be submitted via Aarhus University’s recruitment system at the latest on the 10th of October 2019, which can be accessed under the job advertisement on Aarhus University's website.

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Translational Research Scientist (with Proteomic Mass Spec expertise)
nancy.finkel 2019-09-12

#1! That’s the ranking that Fast Company gave Novartis in their 2018 list of ‘The World’s Most Innovative Companies’. The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. We collaborate across scientific and organization boundaries, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs from patients.

We seek a creative and collaborative scientist to join the Exploratory Translational Profiling group in Disease Area X and contribute to advancing novel therapeutics by enabling the discovery and validation of novel biomarkers. In this role, you will focus on discovery and targeted proteomics of clinical samples from well-designed disease cohorts, applying competitive edge mass spectrometry and aptamer/antibody-based approaches.

Your responsibilities will include:

• Developing and employing novel approaches to identify, profile and quantify biomarkers in clinical samples to support translational research across multiple therapeutic areas of unmet medical need, including hepatology, nephrology and benign hematology
• Establishing quantitative mass spectrometry and antibody/aptamer assays for measuring proteins in complex biological matrices (plasma, serum, urine, CSF), including data processing and analyses in support of translation to clinical validation /qualification
• Playing a key role in an interdisciplinary team of translational research/medical scientists, biologist and computational scientists
• Participating in alliances with external partners at top healthcare institutions, with the opportunity to publish your work

EEO Statement
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements
What you will bring to the role:

• BS with +7 years experience or MS with +3 years experience in relevant scientific area.
• Proven experience with instrumentation and techniques in mass spectrometry and nano-HPLC is required with experience in targeted and global proteomic profiling.
• Excellent communication, good organizational skills, capacity to multi-task and the ability to work in a fast-paced, team-oriented environment are essential.

Additional desirable attributes include, but are not limited to:

• Translational research and industry working experience, including the handling of clinical samples and data
• Familiarity with developing quantitative antibody/aptamer-based assays with orthogonal detection methods

Why consider Novartis?

750 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

You can apply using the following link: Job ID 276154BR
https://www.novartis.com/careers/career-search/job-details/276154BR

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