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Showing: all postings
Research Scientist - Mass Spectrometry; Gilead Sciences; Foster City, CA
edward.hsieh1 2022-01-20

Job Description:
We are looking for an experienced scientist to join the Mass Spectrometry group in the Protein Therapeutics department. The successful candidate will be responsible for mass spectrometry characterization of biologics, development of sample preparation workflows, acquisition and analysis of proteomics datasets, and other drug discovery-related projects.

The successful candidate is expected to conduct independent lab work and collaborate with other scientists and project teams. He or she should be able to think critically and troubleshoot complex scientific and technical issues while contributing to a team-work oriented environment to advance research projects. He or she should possess excellent protein mass spectrometry skills, knowledge of molecular biology techniques, and experience with software packages necessary for data analysis.

Functions and Responsibilities:

  • Design and conduct experiments to characterize protein therapeutics.
  • Perform proteomics experiments to characterize biological samples, protein relative quantitation, post-translational modifications and protein-protein interactions.
  • Develop workflows and strategies to improve analysis and throughput.
  • Participate and present data at team meetings.
  • Maintain knowledge of advancements in the field.

Knowledge, Experience and Skills:

  • Hands on experience with intact mass spectrometry and molecular characterization of protein therapeutics is highly desirable.
  • Experience with quantitative proteomics methods such as TMT-tagging or SILAC.
  • Experience operating and analyzing data from ThermoFisher Orbitrap and Agilent TOF/qTOF mass spectrometers is highly desirable. Knowledge of other mass spectrometry platforms is a plus.
  • Experience with Proteome Discoverer, Protein Metrics Byos, MassHunter, Skyline and other mass spectrometry software packages.
  • Experience maintaining and troubleshooting HPLC and mass spectrometers.
  • Understanding of molecular biology techniques such as western blotting, immunoprecipitation, fractionation and biofluid processing methods a plus.
  • Ability to multi-task in an extremely dynamic environment while providing high-quality analytical support in a professional, pleasant, and tactful manner is a necessity.
  • Strong communication & interpersonal skills are essential for success in this collaborative role.
  • Minimum relevant industrial experience: Bachelor’s degree with 8+ years of experience, Master’s degree with 6+ years of experience or Doctorate degree. Job title will be commensurate with experience.

Please click to following link to apply. Thank you!
https://gilead.yello.co/jobs/twgCkoSC_Q4BKwj_GxSq7g/job_boards/v42vD4vKxb3AkKvV93YsrQ

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Research Manager Lab I – Food Allergen Proteomics
Melanie Downs 2022-01-20

Food Allergy Research and Resource Program (https://farrp.unl.edu/)
Department of Food Science and Technology
University of Nebraska-Lincoln

Food Allergen Proteomics Research Laboratory Manager
https://employment.unl.edu/hr/postings/77072

Position Description:
Oversee all aspects of laboratory management in collaboration with faculty principal investigators (PIs), including mentoring of graduate and undergraduate students, including safety monitoring and training, experimental design planning, and statistical analysis assistance. Operate and conduct routine maintenance on high-resolution LC-MS/MS instrument and serve as primary manager of coordination with instrument vendor service engineers. Develop and implement standardized and automated protocols for food allergen MS methods and data analysis for internal and external use. Order all materials and supplies, assist students and workers in the development of mass spectrometry protocols needed for their experiments. Maintain laboratory compliance with safety requirements and develop SOP’s. Act as direct contact person with industrial clients (outside funding sources) and research collaborators, in collaboration with project PIs. In addition, conduct research in collaboration with principal investigators on food allergen proteomics, including development and evaluation of quantitative mass spectrometry (MS) methods, characterization and purification of food proteins, and assessment of samples by immunoassay (ELISA, Western blotting, etc.). Research activities include designing experiments, preparing samples and conducting analysis, performing proteomics data analysis, and writing research reports and summaries. Participate in research communication through conference presentations and manuscript drafting.

The University of Nebraska-Lincoln seeks to attract and retain a high performing and diverse workforce in which employees’ differences are respected and valued to better meet the varying needs of the diverse populations we serve. The university fosters a diverse and inclusive work environment that promotes collaboration so that all individuals are able to participate and contribute to their full potential. As an EO/AA employer, qualified applicants are considered for employment without regard to race, color, ethnicity, national origin, sex, pregnancy, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, marital status, and/or political affiliation. See: http://www.unl.edu/equity/notice-nondiscrimination.

Required:
Bachelor’s degree in Chemistry, Biochemistry, Food Science or related field, plus four years relevant laboratory experience utilizing both basic and technical science including experience with mass spectrometry. Project management and/or supervisory experience required. Prioritization, organizational, communication and facilitation skills essential. Record-keeping and computer skills necessary. Must have knowledge of compliance and safety regulations and demonstrated ability to teach others.

Application review: 02/21/2022
To Apply: https://employment.unl.edu/hr/postings/77072

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Research Associate II / Senior Research Associate, Mass Spectrometry/Proteomics
christiee 2022-01-11

Research Associate II / Senior Research Associate, Mass Spectrometry/Proteomics
Vividion Therapeutics
San Diego CA

Job Summary:

Vividion Therapeutics is seeking a highly motivated Research Associate to help support the operation of our cutting-edge proteomics platforms. The successful candidate will have extensive hands-on experience with mass spectrometry and HPLC instrumentation and, will be responsible for operation and routine maintenance of several Orbitrap based instruments. As a member of our dynamic proteomics team, the successful candidate will have the opportunity to utilize quantitative mass spectrometry to support our target-discovery and lead-optimization efforts. As such, this individual will directly contribute to the ongoing development of our pipeline.

Experience and education requirements:

• BS with 4+ years or MS with 2+ years of experience in mass spectrometry
• Extensive experience operating and maintaining a mass spectrometer.
• Familiarity with common proteomics acquisition and analysis techniques like PRM, SRM, DIA, SILAC, etc. is desirable.
• Experience with quantitative analysis of mass spectrometry data is a plus.
• Outstanding problem-solving, organization and time management skills.
• Be an effective team player and strong individual contributor, self-driven, flexible, pragmatic, and able to handle multiple tasks and deliver high quality results under tight timelines.

https://vividiontherapeutics.applytojob.com/apply/Xs5jPUocQw/Research-Associate-IISenior-Research-Associate-Mass-SpectrometryProteomics

 Proteomics RAII_SRA_2022.01.05 CE.docx 
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Staff Scientist - Neurology
hernkec 2022-01-06

Position Summary
Dr. Randall Bateman’s lab investigates the causes and future diagnosis and treatments of Alzheimer’s disease utilizing a wide variety of assays and techniques from basic applications, such as quantitative measurement of stable-isotope labeled peptides to clinical translational studies in diagnostic and therapeutic biomarkers for AD. This position assists with the technical aspects of studies and experiments including running experiments, completing data analysis, planning projects, designs protocols, maintaining documentation, and completing general maintenance and organizational duties to ensure smooth operation across the lab.

Job Description

Primary Duties & Responsibilities

Assists in developing and conducting research projects, including experiment design, experiment execution, data analysis and documentation of experiment results.
Performs data entry and maintains data files on research.
Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions. 
May assist with grant preparation and reporting.
Performs complex statistical analysis of data collected and writes interpretative reports.  Verifies the correctness of the data submitted and makes recommendations based on these analyses.
Solves practical problems relating to difficulties with equipment or test subjects.  Suggests technical or procedural improvements in testing methods.

Preferred Qualifications

Degree in biological science or chemistry.  
Experience with analytical chemistry or GLP.  
Experience with immunoprecipitation and automated bench work. 
Experience with mass spectrometry is strongly preferred.
Critical thinking, analytical, reasoning and problem-solving skills.
High precision and tight Quality Control of all bench experiments
Ability to organize and prioritize tasks.
Good scientific writing and oral communication skills.
Detail-oriented.
Ability to maintain complete and organized records/reports. 
Able to work independently yet collaboratively in a team environment.
Ability to analyze and interpret statistical data and to communicate data in a clear, concise manner. 
Computer literacy, including the ability to use a variety of software packages to analyze data.

Required Qualifications

Master’s degree with four years of experience in research lab operations or an equivalent combination of education and experience equaling nine years.
APPLY HERE: https://wustl.wd1.myworkdayjobs.com/en-US/External/job/Washington-University-Medical-Campus/Staff-Scientist---Neurology_JR64024

Contact: Cynthia Hodge, Research Lab Manager, hernkec@wustl.edu

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Proteomics Research Assistant for the Tow Center for Developmental Oncology. Memorial Sloan Kettering, New York, NY
casaleg 2021-12-16

The Tow Center for Developmental Oncology at MSKCC is seeking a highly motivated scientist with experience in proteomics and biochemistry. The Research Assistant will be part of the Molecular Therapeutics Initiative, dedicated to the development of improved models of childhood cancers and mechanism-based translational science, with the aim to enable improved therapies for patients. As Research Assistant you will participate in the execution of biochemical and molecular studies supporting the Tow Center and collaborating investigators. You will have a central role in the proteomic analysis of tumor samples using advanced analytical techniques, including mass spectrometry proteomics and single-cell protein and nucleic acid profiling. Under guidance, you will establish SOPs, develop analytical methods, and optimize experimental protocols. You will be part of a collaborative effort in an ambitious project and are therefore expected to be organized, flexible, and an excellent team player. This role is an opportunity to join a highly dynamic and interdisciplinary team with access to state-of-the-art technologies and the prospective of implementing innovative research and discovery tools in order to advance cancer science and treatments for children and adults with refractory cancers.

You are:
• An experienced biochemist with a strong background in proteomics and molecular biology
• Proficient with analytical chemistry, biochemistry and molecular biology
• Proficient with proteomics sample preparation, nanoscale liquid chromatography, nanoelectrospray ionization, and high-resolution mass spectrometry, such as Thermo Orbitrap or Bruker, Sciex, or Waters TOF mass spectrometers
• Eager to learn and respond to challenges
• Highly organized
• Able to multitask and work both independently and in teams
• Capable to adapt to change and evolving circumstances
• An excellent communicator, able to effectively address different audiences

You will:
• Work closely with MSK colleagues to carry out experimental efforts that will include comprehensive proteomic analysis of tumor samples
• Collaborate with MSK core facilities personnel to process and analyze patient specimens
• Operate and maintain high-end analytical instruments
• Present experimental results in written and oral form

You need:
• BA or BS in chemistry, biochemistry, or biology
• At least three-five years of experience in laboratory research
• Direct experience with mass spectrometry or proteomics
• Experience with cancer biology and other advanced analytical techniques is preferred

To apply, please send one-page letter of interest explaining your past research, current interests, and how your past work has prepared you to succeed and enable our mission, along with your current CV/resume via our portal .

Requisition ID 2021-55943

https://externaltalent-mskcc.icims.com/jobs/55943/proteomics-research-assistant-for-the-tow-center-for-developmental-oncology/jobmode=view&mobile=false&width=1251&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240

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Scientist/Senior Scientist, Proteomics at Flagship Pioneering Company
cnicod 2021-10-06

Scientist/Senior Scientist, Proteomics
at Flagship Pioneering, Inc.
Cambridge, MA USA
Position Summary:

FL69 is seeking a highly motivated and team-oriented candidate for a (Senior) Scientist, Proteomics. This individual will be responsible for the discovery and analysis of non-canonical proteins in large-scale proteomic datasets. The ideal candidate has a strong scientific foundation in proteomics and a demonstrated ability to develop tailored immuno- or biochemical enrichment methods. The candidate will be able to develop semi- or fully automated workflows for large-scale proteomics sample preparation and LC-MS analysis. The candidate will work closely with genomics scientists, computational biologists, and a functional genomics team to identify novel targets involved in disease and bring them to preclinical models.

Key Responsibilities:

Develop proteomics sample preparation workflows for global or targeted proteomics studies from varied biological samples, such as cultured cells, tissues, and biofluids
Capable of developing novel immune or biochemical enrichment strategies for target proteins
Design proteomics experiments and conduct biomarker discovery for therapeutics and diagnosis studies
Conduct proteomics data analysis using commercial and/or open-source software
Experiences on automation of proteomics sample preparation and high throughput LC-MS analysis are preferred
Manage proteomics projects and collaborate with CROs
Work closely with molecular and cell biologists to collaboratively iterate on experiments
Minimum Qualifications:

PhD in proteomics, biochemistry, analytical chemistry or related field
2+ years of industrial (or post-doc) experiences on method development of large-scale proteomics studies
In-depth understanding of LC-MS technologies for discovery or targeted proteomics
Hands-on skills in proteomic sample preparation of varied biological samples
Demonstrated expertise in conducting DDA, DIA, and PRM based proteomics studies
Demonstrated experience in maintaining and operating nanoLC and mass spectrometer
Ability to work as a collaborative team-member
Excellent oral and written communication and presentation skills
Preferred Qualifications:

Experience in proteomic analysis of biofluids (plasma, urine, or CSF) is a plus
Experience in cell-culture and tissue sample handling is a plus
Familiarity with top-down proteomics is a plus
Broad understanding of proteomics database search, quantitative analysis, visualization, and interpretation, using commercial and/or open-source software, such as MaxQuant, Skyline, PEAKS, DIA-NN
Experiences in MHC immune-peptidomics or proteogenomics are preferred
Experiences in affinity enrichment, IP/co-IP, or proximity labeling based interactome are preferred
Hands-on experiences with HPLC separation, such as RPLC, IEX, SEC are preferred
Computational skill such as bioinformatics, statistics, or programing skill by R/Python is a plus

https://boards.greenhouse.io/flagshippioneeringinc/jobs/5290158002?gh_jid=5290158002

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Principal Scientist - LCMS Biomarker Discovery Team Leader
idexx_lcms 2021-10-01

Apply here:
https://careers.idexx.com/us/en/job/J-022502/Principal-Scientist-LCMS-Biomarker-Discovery-Team-Leader

The LCMS group within the R&D Discovery and Technology Futures group is looking for a creative and energetic Discovery Team Lead to join our organization. The successful candidate will join a team of experienced scientists at the BS/MS and PhD levels to lead multiomic biomarker discovery projects. We are looking for a highly motivated individual who has strong wet-bench and data analysis skills and a deep understanding of LCMS instrumentation and software. Additionally, the successful candidate must be a proven technical leader with a demonstrated track record for delivering on challenging biomarker discovery projects.

What you can expect:

Lead a growing dynamic LCMS Discovery team consisting of PhD scientists to Lab Associates to develop novel and robust multiomic biomarker platforms.

Use cutting edge instrumentation and analysis software to dig deep into the world of proteomics, glycobiology, metabolites, post-translational modifications and lipidomics across blood, urine, tissues (including FFPE sections), and fecal samples.

Interface with other teams within the R&D Discovery and Technology Futures group to align on project priorities and schedules to ensure that the goals of the organization are met.

Drive experimental design for large biomarker experiments and optimize sample preparation protocols for expanding reach of discovery programs.

Develop top down workflows with immunoaffinity capture for characterization of proteins of interest.

Prepares materials, performs experiments, analyzes data, and reaches conclusions.

Present data and strategy to IDEXX leadership.

Communicate and clearly present results to a broad audience within R&D, including IDEXX senior leadership.

Maintain an active knowledge of developments in the field and industry through seminars and conferences.

What you need to succeed:

PhD in scientific or related discipline with at least 3-5 years of post-doctoral biomarker discovery experience. Experience in academia qualifies but industry experience is preferred.

Background in Biochemistry or Chemistry with a deep understanding of LCMS instrumentation and data analysis software.

Demonstrated ability to work with wide variety of sample types, including plasma/serum proteomic experience.

Experience with Thermo Scientific Orbitrap mass spectrometers is ideal.

Experience with proteomic software tools and developing ad hoc data processing workflows.

Incorporating AI and Machine Learning into the biomarker discovery workflow.

Excellent communication and organizational skills.

Demonstrated ability to critically evaluate techniques and deliver results.

Demonstrated ability to effectively manage a team of scientists, collaborate effectively in an interdisciplinary program, and overcome barriers to produce successful outcomes on challenging technical projects.

Why IDEXX

We’re proud of the work we do, because our work matters. An innovation leader in every industry we serve, we follow our Purpose and Guiding Principles to help pet owners worldwide keep their companion animals healthy and happy, to ensure safe drinking water for billions, and to help farmers protect livestock and poultry from diseases. We have customers in over 175 countries and a global workforce of over 9,000 talented people.

So, what does that mean for you? We enrich the livelihoods of our employees with a positive and respectful work culture that embraces challenges and encourages learning and discovery.   At IDEXX, you will be supported by competitive compensation, incentives, and benefits while enjoying purposeful work that drives improvement.

Let’s pursue what matters together.

IDEXX values a diverse workforce and workplace and strongly encourages women, people of color, LGBT individuals, people with disabilities, members of ethnic minorities, foreign-born residents, and veterans to apply.

IDEXX is an equal opportunity employer. Applicants will not be discriminated against because of race, color, creed, sex, sexual orientation, gender identity or expression, age, religion, national origin, citizenship status, disability, ancestry, marital status, veteran status, medical condition, or any protected category prohibited by local, state, or federal laws.

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Research Associate in Proteomics
Ashok 2021-07-27

The OHSU Proteomics Shared Resource (PSR) facility was established to make state-of-the-art mass spectrometry-based protein analysis capabilities available to the biomedical research community at OHSU. The PSR provides services to both internal and external clients outside OHSU, including supporting ophthalmological and cancer research by members of the Casey Eye and Knight Cancer Institutes.

PSR has an immediate opening for a full-time Research Associate (RA). OHSU provides a comprehensive compensation package including salary, and benefits such as PTO, medical/dental/vision and 401(k) plan etc.

Responsibilities

Prepare samples for proteomics analysis by LC/MS using standard operating procedures

Develop and test new methodologies of sample preparation

Document experimental work, analyze data, and present results

Prepare and maintain standard operating procedures (SOPs)

Operate mass spectrometry instrumentation, perform troubleshooting and maintenance

Manage multiple projects within timelines assigned maintaining high scientific and ethical standards

Assist in the preparation of manuscripts and grant applications

Work collaboratively with team members

Other duties as assigned to support the PSR.

Qualifications:
•Minimum: Bachelor’s degree in life sciences, analytical chemistry or related field with major courses in the field of research and 5 years of relevant experience

•Preferred: MS or PhD in Analytical Chemistry or closely aligned field

•Extensive knowledge of complex proteomics sample preparation methods as applied to protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies including label-free analyses (DIA, PRM/SRM) and labeled (TMT) methods

•Prior experience in operation of LC/MS systems preferably Thermo Orbitraps

•In-depth understanding of both hardware and software of nanoflow LC-MS

•Proficiency in LC-MS related software and data analysis

•Highly motivated, a team player, a quick learner, and a problem solver

•Excellent oral and written communication skills

•Eligibility to work in the United States

To apply

Please send a cover letter, resume with the publication list, and contact information for three references, to https://externalcareers-ohsu.icims.com/jobs/9664/research-associate/job?hub=6&mobile=false&width=1252&height=500&bga=true&needsRedirect=false&jan1offset=-480&jun1offset=-420

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Post Doctoral Fellow
alejandro.cohen 2021-07-19

Location: Halifax, Canada

Employer: Dalhousie University

Duration: 2 Years

Salary: $CDN50, 000 – 60, 000

Description

The candidate will join a team of scientists, engineers and clinicians from across Canada that are developing innovative approaches toward the manufacturing, characterization, and de-risking of innovative next generation chimeric antigen receptor T-cell (CAR-T) therapies for cancer treatment. The candidate will develop novel immunometabolomic methods using high-resolution tandem mass spectrometry, combined with advanced analysis of both CAR-T laboratory samples and samples from patients enrolled in CAR-T clinical trials to identify unique biomarkers relevant to CAR-T potency and efficacy?
Research to be conducted by the candidate will provide a unique training experience at the interface between biology, analytical chemistry, and clinical research. The successful candidate will join a group of experts in proteomics, metabolomics and cell signalling.
Metabolomics to advance CAR-T therapy. Cell therapies are an emerging modality; one that comes with additional levels of complexity as they are viable cellular systems. Advancement of this potentially revolutionary treatment modality would be accelerated by the development of innovative techniques to efficiently characterize the CAR-T systems. Molecular complexity is magnified significantly with cell therapies; therefore, adaptation and innovation of analytical methodologies is required to begin to address critical questions around the interplay between metabolism and potency. The successful candidate will develop quantitative immunometabolomic methods to push boundaries of sensitivity, throughput, and dynamic range to allow identification of potential biomarkers relevant to CAR-T potency and favorable host metabolic & microbiome phenotype.
Requirements
The successful candidate should have or be nearing completion of a PhD in Analytical Chemistry, Biochemistry, or related field and have published papers in relevant journals as primary author. Experience in liquid chromatography-mass spectrometry based metabolomics and/or proteomics is required. Experience in the use of complex bioinformatics tools for ‘omics data analysis is preferred. The successful candidate will be expected to work within a network of internal and external collaborators, engage stakeholders and display the potential to become a recognized leader in the field. Preference will be given to Canadian citizens.

Please submit Cover letter and CV to:

Dev.Pinto@nrc-cnrc.gc.ca and cc: Alejandro.Cohen@Dal.Ca and jim.fawcett@dal.ca

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Postdoctoral Fellow, Proteomics, National Institute on Aging (NIA), NIH
nbasisty23530 2021-07-15

The Translational Geroproteomics Unit (TGU) is seeking diverse, highly motivated, and enthusiastic postdoctoral fellows to tackle important questions in aging biology using proteomic approaches. This is a full-time and fully funded primary research fellowship for individuals interested in leveraging mass spectrometry-based proteomics to have a translational impact on age-related diseases linked to hallmarks of aging such as cellular senescence and loss of proteostasis. Postdoctoral fellows will be mentored by Dr. Nathan Basisty, and will have access to a highly interactive, resourceful, and dynamic scientific environment with state-of-the-art instrumentation and ample opportunities for training and career development.

The NIH and the TGU are dedicated to building a diverse community in its training and employment programs and are committed to creating and maintaining an environment that is welcoming, safe, accessible, and uplifting to ALL individuals. We encourage and welcome applications from individuals from underrepresented backgrounds.

Potential projects: We are looking for postdocs interested in working on various projects, including but not limited to:

  • Discovery and validation of ‘proteoform’ (modified proteins and protein isoforms) biomarkers of aging and their relationship with the rate of aging, the development of age-related diseases as well as physical and cognitive disability in human cohort studies such as the BLSA, GESTALT, and InCHIANTI.
  • Targeting and quantifying senescent cells and dissecting the functions of heterogeneous senescent cell populations via their surfaceomes (cell surface proteomes)
  • Mass spectrometry method development, particularly the development and application of workflows involving data independent acquisition (DIA/SWATH), PTM identification/quantification, and/or protein turnover analysis.

Postdocs are encouraged to independently develop and drive the direction of research projects, as well as establish new research directions.

Training and career development: Fellows will have access to hands-on training in multiple technologies and scientific techniques including mass spectrometry-based proteomics on several high-end instruments, analytical chemistry, cell culture, and mouse work. The NIA offers multiple career development opportunities for postdocs, including opportunities to apply for internal funding through the FARE (Fellows Award for Research Excellence) program, Nathan Shock travel awards, Interlaboratory Funding Proposals, Postdoctoral Fellowship Funding Awards, and the Independent Research Scholar (IRS) Program.

Postdocs are highly encouraged to attend conferences and scientific workshops for career development. Training also includes active participation in weekly multidisciplinary lab meetings, weekly Longitudinal Studies Section (LSS) Meetings, and professional development and research methods courses offered through the NIH Office of Intramural Training and Education (OITE). Fellows are also encouraged to take advantage of the NIH interest groups, particularly the Proteomics Interest Group and the NIA Molecular Biology Interest Group.

Postdocs will also have the opportunity to collaborate on projects with the Baltimore Longitudinal Study of Aging (BLSA), the longest running human aging study in the U.S., as well as other human cohorts (GESTALT, InCHIANTI).

Qualifications: The successful candidate must have a PhD, MD, or equivalent doctoral degree. We are looking for candidates with background and/or a strong interest in one or more of the following areas: mass spectrometry-based proteomics, characterization of PTMs, cell culture, or related fields who are passionate and self-motivated in research. Candidates with prior experience developing and performing mass spectrometry workflows, coding with R or Python, and experience with human or mouse aging models are especially encouraged to apply.

How to Apply: Please email a (i) CV, (ii) cover letter detailing research interest, experience, and career goals, and (iii) three references to Nathan Basisty, PhD at nathan.basisty@nih.gov.

Employer Name: National Institute on Aging (NIA)

Position Location: Baltimore, MD

Application Deadline: September 31, 2021, or until filled.

 2021_TGU_NIA_postdoc_postition.pdf 
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Post Doctorate RA - Quantitative Proteomics, Cancer Biomarkers, and Other Applications of Proteomics
dale walker 2021-07-13

Job Description

The Integrative Omics group within the Biological Sciences Division at Pacific Northwest National Laboratory is seeking an outstanding Post-Doctoral candidate to join our multi-disciplinary team focusing on mass spectrometry (MS)-based proteomics analyses. The research areas include the development of quantitative methodologies for precise protein and posttranslational modification measurements, and corresponding large-scale applications in biofluids, cell, or tissue specimens towards clinical and translational research in cancer. The Integrative Omics group also presents a diverse array of opportunities ranging from analytical biochemistry, MS instrumentation, multi-omics measurements, single cell proteomics, bioinformatics, and biomedical applications. The preferred candidate would have a Ph.D. degree in analytical chemistry, biochemistry, chemistry, clinical chemistry, or closely related fields. Although not required, hands-on experience in mass spectrometry, proteomics, LC separations, posttranslational modifications, and data analysis will be considered as a plus. Efforts will include methods development, sample preparation and separation methods for enhancing reproducibility and sensitivity, and applications of specific candidate verifications in different sample types. The successful candidate will be expected to work effectively with an interdisciplinary team of researchers, be self-motivated, and have excellent verbal and written communication skills. The successful candidate will assist, and possibly lead, in the preparation and presentation of papers, posters, reports, etc. Additionally, he/she will use project management systems at PNNL, maintain an accurate laboratory notebook, adhere to Environmental Safety and Health (ES&H) Operations, and follow security requirements as well as directorate/group policies.

Strong organization and communication skills are needed to work efficiently in a team environment and to effectively demonstrate project success.

This is a full-time, limited term employment position. The duration of this appointment is two years, with the option of extending the appointment for up to three years.

Minimum Qualifications

Candidates must have received a PhD within the past five years (60 months) or within the next 8 months from an accredited college or university.

Preferred Qualifications

Ph.D. in Biochemistry, Analytical Chemistry, Chemistry, or a closely related field is required.

Equal Employment Opportunity

Battelle Memorial Institute (BMI) at Pacific Northwest National Laboratory (PNNL) is an Affirmative Action/Equal Opportunity Employer and supports diversity in the workplace. All employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital or family status, sexual orientation, gender identity, or genetic information. All BMI staff must be able to demonstrate the legal right to work in the United States. BMI is an E-Verify employer. Learn more at jobs.pnnl.gov.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request via https://jobs.pnnl.gov/help.stm

Please be aware that the Department of Energy (DOE) prohibits DOE employees and contractors from having any affiliation with the foreign government of a country DOE has identified as a “country of risk” without explicit approval by DOE and Battelle. If you are offered a position at PNNL and currently have any affiliation with the government of one of these countries you will be required to disclose this information and recuse yourself of that affiliation or receive approval from DOE and Battelle prior to your first day of employment.

To learn more or to apply visit, https://pnnl.jobs/richland-wa/post-doctorate-ra-quantitative-proteomics-cancer-biomarkers-and-other-applications-of-proteomics/F4B959FA259345A79B892C9F873FCFA4/job/

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Scientist Mass Spectrometry (m/f/d) - Permanent Position at Philipps-Universität in Marburg (Germany)
johannes graumann 2021-07-05

The Department of Medicine, Translational Proteomics, Prof. Johannes Graumann, has an immediate opening for the permanent position of an Scientist Mass Spectrometry (m/f/d) to fill.

The position is full-time with salary and benefits commensurate with a public service position in the state Hesse, Germany (TV-H E 13, 100 %).

Your tasks include scientific services in research and teaching, in particular the development of methods for mass spectrometry-based proteomic analysis, for single-cell proteomics and proteomic characterization of post-translational modifications as well as the application of the methods in independent research projects and their scientific publication. Further application and project specific adaptation of the methods in the context of the Core Facility Translational Proteomics as well as contributions to teaching the fundamentals of mass spectrometry.

The university expects from its employees the willingness and capability to acquire and apply skills necessary for further assignments.
Requirements include a university degree (diploma, master or comparable) as well as a PhD in a bioanalytical field and several years of experimental experience in the field of mass spectrometry-based proteomics (supported by scientific publications). Further expected are familiarity with working in scientific environments, fluency in English (written and spoken, both) as well as experience in teaching the basics of mass spectrometry.

For questions regarding the position, please contact Johannes Graumann at johannes.graumann@uni-marburg.de.
We support women and strongly encourage them to apply. In areas where women are underrepresented, female applicants will be preferred in case of equal qualifications. Applicants with children are welcome – Philipps-University is certified as a family-friendly university. Sharing a full-time position (§ 8 Abs. 2 S. 1 HGlG) as well as a reduction of working time is possible. Applicants with a disability as described in SGB IX (§ 2 Abs. 2, 3) will be preferred
in case of equal qualifications. Application and interview costs can not be refunded. Please send your application until July 23rd 2021 as a single PDF file and mentioning the reference number fb20-0128-wm-2021 to translational.proteomics@uni-marburg.de.

 fb20-0128-wm-230721-englisch.pdf 
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Scientist, targeted proteomics, at the ZMBH, University Heidelberg, Germany
t ruppert 2021-06-15

In conjunction with the Research Unit FOR2509 “The Concert of Dolichol-Based Glycosylation:
From Molecules to Disease Models”, the Core Facility for Mass Spectrometry and Proteomics at the Center for Molecular Biology of the University of Heidelberg (ZMBH) has an opening for

A Research Scientist (m/f/d)
Fulltime position, starting date: immediately

During the first funding period of the project “Production of the dolichol N-glycan precursor:
Monitoring of this pathway by quantitative mass spectrometry” a sensitive MRM assay was established to monitor glycosyltransfreases in the ER, responsible for N-glycosylation, O-mannosylation and C-mannosylation. With this method at hand the PhD scientist now will work on the biochemical characterization of these pathways. In addition, there is a tight collaboration with a clinical group which allows studies of these pathways in diseased states.

Information about the MRM assay can be found here:
(https://www.biorxiv.org/content/10.1101/2020.09.15.291732v1)

Your ideal qualifications

  • Expert knowledge in nanoUPLC-MS
  • Experience in various quantitative proteomics techniques
  • Proficiency in data analysis including database searches and software for quantitative proteomics, especially Skyline
  • Hands-on experience in preparation of biological samples
  • Team working abilities and aptitude in guiding technical assistants
  • Excellent written and spoken English language skills, German will be an advantage

The position is advertised until December 2023. Prolongation is not possible. Payment will be according to German TV-L13 (full-time).
The University of Heidelberg is an equal opportunity employer and encourages applications from qualified female candidates. A kindergarten service is available. Handicapped applicants will be given preference in the case of equal qualifications.

Contact: Dr. T. Ruppert (+49 6221 546895)

Application Deadline: Evaluation will begin two weeks after the announcement and will continue until the positions are filled.

Please submit your applications online to t.ruppert@zmbh.uni-heidelberg.de

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Lab Research Technician - Biochemistry - AAU Research Activities
mmuravit 2021-06-07

Summary:

The Tulane University Proteomics Core is seeking a Mass spectrometry research technician. This is a full time position that will involve sample preparation, routine cell culture, mass spectrometry operation, data reporting, routine instrument and lab maintenance, supply ordering and making general lab chemicals. Facility instruments include a mixture of LCMS/MS instruments.

Required Knowledge, Skills, and Abilities:

-A thorough understanding of how Mass Spectrometry works, basic chemistry and biology
-Routine cell culture, protein extraction
-A thorough understanding of the quantitative criteria involved in selecting analytical methods (e.g., precision, accuracy/bias, sensitivity, detection and quantification limits, sensitivity, and dynamic range) and their corresponding figures of merit
-Demonstrated knowledge of LC-MS/MS
-Demonstrated knowledge of mass spectral libraries
-Ability to perform routine maintenance and troubleshooting
-Strong verbal and written communication skills
-Good mathematical skills and experience performing calculations in Excel

Required Education and/or Experience:

Bachelor’s degree and one year of basic laboratory research experience.

Preferred Qualifications:

Familiarity and prior experience running Mass Spectrometry instruments will be viewed favorably.

Compensation Information:

This position is assigned to pay grade T2.23. Tulane offers a variety of options to enhance your health and well-being so that you may enjoy more out of life now and in the future. Learn more about Life at Tulane as well as our Benefits and Pay. See our Candidate Resources to learn more about our hiring process and what to expect.

How to Apply:

Apply on the Tulane University website at this link:
https://selfservice.tulane.edu/OA_HTML/OA.jsp?OAFunc=IRC_VIS_VAC_DISPLAY&p_svid=21062&p_spid=268599

This position will close on the date it is filled.

Tulane University is an EOE/M/F/Vet/Disabled employer with a strong commitment to diversity and inclusion. Applications by members of all underrepresented groups are encouraged.

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Scientist, Analytical Chemistry - Protein Analytics, Emeryville, CA, USA
ana 2021-05-18

Zymergen has an opportunity for a scientist who will be working on protein identification and quantitation using liquid chromatography coupled with high resolution, accurate mass tandem mass spectrometry, triple quadrupole mass spectrometry, and UV detection.

Job Description and Specific Responsibilities

Immediate responsibilities include:

Prepare samples from small and large scale microbial fermentations.
Perform multi-step sample preparations including enzymatic digestion (solution and in-gel), reduction/alkylation, buffer exchange, deglycosylation, sample concentration, etc.
Optimization and development of new sample preparation methods including high throughput sample preparation.
Method development and optimization for transfer to non-mass spectrometry, LC-UV-based techniques.
Operation and maintenance of LC-MS equipment including performance of system suitability tests.
Perform data analysis.
Evaluate new technologies and platforms.
Write and review formal reports, including method SOPs and other technical documents and present findings in technical team meetings and to collaborators.
Lead, mentor, and inspire junior team members.

Qualifications/Experience

The favor candidates with the following profile:

Hands-on experience in protein analytics and characterization (top-down, bottom-up, and targeted proteomics) by LC/MS, including intact mass determination, glycosylation and analysis of other PTMs.
Expertise in sample preparation techniques for protein analysis such as enzymatic hydrolysis including in-gel digestion.
Knowledge of chromatography techniques used for protein characterization (RP, size exclusion).
Proficiency in LC and MS-related software, such as Agilent MassHunter, Skyline, Agilent BioConfirm, Thermo Xcalibur, PEAKS.
Experience with liquid handling and automation systems is a plus.
Experience with small molecule determination and quantification is a plus.
Proven track record of initiative, attention to detail, collaborating and communicating within a team.

link to apply: https://www.zymergen.com/about-us/careers/#scientist-analytical-chemistry-protein-analytics

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MacCoss Lab, University of Washington Department of Genome Sciences, is seeking a Postdoctoral fellow.
Mike MacCoss 2021-04-26

The MacCoss lab has been a pioneer in the development and application of quantitative proteomics methods. We are currently seeking a motivated post-doc candidate with experience in performing drug and/or genetic perturbations, followed by the phenotypic characterization of those perturbations using omics methods. This project will be performed in collaboration with a major pharmaceutical company.

The successful candidate will be part of an interdisciplinary team of mass spectrometrists, bioinformatics experts, biochemists, and software developers. Requirements:
• The candidate should have a Ph.D. in biochemistry, cell biology, biology, or related discipline.
• A strong background in cell culture, experience in protein biochemistry, and running complex experiments.
• Exposure to mass-spectrometry based proteomics is a major plus.
• Excellent writing and presentation skills.
• Must have the ability to analyze complex Omic datasets using python, R, or similar.
• Ability to learn quickly, problem solve, and work independently.

Desired skills:
• Experience preparing protein samples for analysis by mass spectrometry.
• Familiarity with ThermoFisher instrumentation.
• Expertise in the use of Skyline software for quantitative analysis of mass spectrometry data.
• Familiarity with data-independent acquisition mass spectrometry data.

The University of Washington, Department of Genome Sciences provides a vibrant research environment. The MacCoss lab is well equipped and features an interdisciplinary research team with a strength in proteomics method development with collaborations related to neurodegenerative diseases, basic biology of aging, diabetes, clinical assay development, drug response characterization, etc...

Interested individuals may contact Mike MacCoss via (positions@maccosslab.org) for more information.

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Bioinformatics Associate I
choi meena 2021-04-08

A position is available in Genentech's Discovery Proteomics group, within the department of Microchemistry, Proteomics, Lipidomics and NGS. This individual will serve as a data scientist to develop novel tools for the analysis of Proteomics, Lipidomics and high-throughput Protein Array datasets. The position will work closely with our computational team as well as bench scientists in the department to understand their technology and deliver the best possible working software prototypes. Demonstrated communication, prioritization, organization skills, as well as the ability to be flexible and responsive in a fast-paced environment are abilities that are highly desired.

Responsibilities:

  • Contribute to the development of software modules that support the analysis and visual representation of internal datasets and embedding them in configurable computational workflows
  • Development of a relational database to store analyzed datasets along with their annotations
  • Assist in running routine tasks through computational workflows and communicating the outcomes to internal stakeholders

Requirements: Strong candidates for this position will meet most of the following requirements,

  • MS or PhD in bioinformatics or related disciplines is required.
  • Skilled at converting experimental data and biological meta data from a variety of input formats into a relational database (i.e. MySQL) and performing complex queries.
  • High level of programming proficiency with R and Python and good understanding of command line tools in a Linux environment.
  • Demonstrated experience with software development in a team setting and good coding practices
  • Experience with workflow engines, web frameworks and data visualization tools would be considered a tremendous plus

Location: South San Francisco, CA. But the remote work is an option.

Contact: Encouraged to apply here: https://evotecgroup.wd3.myworkdayjobs.com/Evotec_Career_Site/job/South-San-Francisco/BioInformatics-Associate-I_REQ-02710
or Please contact choi.meena@gene.com (Meena Choi). Please write "Skyline bioinformatics associate position inquiry" in the subject line.

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The MacDonald Lab, University of Pittsburgh/Department of Psychiatry, is seeking Postdoctoral Fellows in Neuroproteomics
mlmacdonald 2021-04-08

The MacDonald lab conducts multi-omic analyses of synaptic protein networks in human postmortem brain tissue and model systems to address questions in psychiatric disease. Potential projects involve the development and validation of novel approaches to interrogate synaptic proteomes in human postmortem brain tissue; high throughput sample preparation of human postmortem brain tissue for protein and PTM quantitation (LFQ, TMT, DIA) on an Orbitrap Eclipse; integration of proteomic datasets with other -omics data and intermediate phenotypes (e.g. SNP array, WGS, RNAseq, spine density, and spine size); and investigation of promising targets in model systems (primary neuronal culture, iPSC, mice). These projects are currently funded by multiple R01s and T32 support is available for qualified candidates. The Department of Psychiatry at the University of Pittsburgh has an unparalleled track record of supporting early career scientists as they transition to independence in academia, industry, or government positions.

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Research Opportunities - Randall Bateman Lab - Washington Universitiy in St. Louis
hernkec 2021-03-19

Research Opportunities - Neurology - Job ID 51155
Washington University in St. Louis - Department of Neurology - Medical School Campus
This position is full-time and works approximately 40 hours per week.

Essential Functions: There is a research opportunity in the laboratory of Dr. Randall Bateman investigating the causes, future diagnosis and treatments of Alzheimer’s disease utilizing a wide variety of assays and techniques from basic applications, such as quantitative measurement of stable-isotope labeled peptides to clinical translational studies in diagnostic and therapeutic biomarkers for Alzheimer’s disease. Work in the lab includes running experiments and assays, preparing reagents and samples at the bench and using automated equipment, preparing samples for mass spectrometry analysis. For more information about the Bateman Lab, please visit: https://neuro.wustl.edu/labs/bateman_r/.

Required Qualifications: Bachelor’s degree. Candidates with additional education and experience are encouraged to apply.

Preferred Qualifications:
Degree in biological science or chemistry is strongly preferred.
Experience with analytical chemistry OR GLP is strongly preferred.
Experience with immunoprecipitation, automated bench work and proven bench lab skills.
Experience with developing laboratory Standard Operating Procedures and working in a GxP regulated environment.
Ability to maintain complete and organized records/reports.
Working knowledge of computer software and general lab equipment.

For further information or to apply, go to:
https://jobs.wustl.edu/psc/APPLHRMS/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&REL_ACTION=Yes&SiteId=1&HRS_JO_PST_TYPE=E&HRS_JOB_OPENING_ID=51155&HRS_JO_PST_SEQ=1

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Scientist - MS Proteomics, Alkahest, San Carlos, CA
shreyachand 2021-03-02

Description

Uniquely positioned to enhance quality of life in aging, at Alkahest, we are pioneering science that is rapidly being translated to the clinic. Our approaches utilize in vivo, in vitro, proteomic, and molecular techniques to identify new therapeutics and apply them to patients.

We are seeking a highly motivated, resourceful, and detail-oriented scientist to join our collaborative and supportive mass spectrometry-based proteomics team. This position will be key in advancing our mass spectrometry platform as we establish and implement new enabling technologies to discover, characterize and validate biomarker and therapeutic target candidate proteins in complex biological samples. This position provides a unique opportunity to shape next generation MS efforts at Alkahest by integrating state-of-the-art approaches for sample preparation, data acquisition and data analysis with a focus on plasma proteomics.

Our ideal candidate will be an enthusiastic self-starter with a positive attitude, excellent organizational and interpersonal skills, and the ability to learn, develop, and implement MS methodology efficiently. The researcher will be responsible for designing and executing MS proteomics studies to analyze clinical and research samples on Thermo Orbitrap instruments, and actively contribute to MS data analysis. He/she will have opportunities to learn and develop state-of-the-art MS proteomics techniques, drive the implementation of high-throughput sample preparation methods, and utilize them to facilitate the development of novel therapeutics for aging diseases. The role requires dedication to drive science, flexibility, and efficient interaction with a team of scientists and research associates to advance multiple projects in parallel.

Responsibilities
Specific responsibilities include, but are not limited to:
Conduct mass spectrometry-based proteomics studies with an emphasis on development of LC-MS based targeted assays
Develop new and improve upon existing procedures for sample preparation for LC-MS/MS analysis, including automation of high-throughput proteomic sample preparation methods, such as chemical labeling, and in-gel and in-solution proteolytic digestion protocols
Research, identify, explore and implement novel approaches for plasma proteomics
Support discovery proteomics efforts using DIA, TMT, and label-free proteomics approaches
Align and collaborate with group members and in vitro and in vivo research teams across Alkahest to support and advance research goals
Work with human clinical samples
Operate, troubleshoot, and maintain MS instrumentation

Requirements
PhD (or MS plus extensive experience) in a relevant chemical, biochemical, or biological discipline
Experience in method development and optimization for targeted proteomics
Extensive hands-on experience with Orbitrap MS platforms and liquid chromatography systems and proteomics sample preparation methods
Proficiency in mass spectrometry analysis software packages
Experience with top-down MS methods for intact protein analysis is a plus
Collaborative team spirit and the ability to self-motivate and work independently
Excellent interpersonal, verbal and written communication skills
Comfortable working in a multi-tasked, fast-paced startup environment

Please apply at the link below:
https://www.alkahest.com/careers-culture/join-us/?p=job%2FopMLefwU

view posting
Senior Scientific Researcher, Genentech, Inc. (South San Francisco, CA)
choi meena 2021-03-02

A position is available in Genentech's Discovery Proteomics group, within the department of Microchemistry, Proteomics, Lipidomics and NGS. This individual will serve as a technical lead and be responsible for carrying out experimental research aimed at understanding the role of proteins and post-translational modifications in human disease. An important focus of the lab is to study how membrane protein interactomes and their downstream signaling modulate cellular function, utilizing established cultures, primary cell lines as well as complex cellular models. Advances in proteomics, especially mass spectrometry, have revolutionized the study of cellular proteins and motivated in depth molecular characterization of normal human physiology and disease biology. The Discovery Proteomics group develops and implements protein analytical methods to differentiate between dynamic biological states by characterizing the abundance, dynamics and interactions of proteins. The researcher will also have the opportunity to utilize and further implement state-of-the-art technologies for the discovery and characterization of receptor-ligand interactions. As is true across Genentech, research in the group is fast paced and highly collaborative, drawing on the expertise of some of the world's leading experts in biochemistry, cell biology and disease indications.

Requirements: This position requires an MS plus at least 3 years of relevant analytical sciences work or academic research experience or PhD in Chemistry, Biochemistry, or related field with experience in analytical sciences. The ideal candidate should have experience in protein biochemistry and cell biology techniques. Interest and hands-on experience in membrane protein biology and receptor-ligand interactions (biophysics, biochemistry, signaling) are preferred. Past experience with proteomics sample preparation (i.e. proteolytic digestion, solid phase extraction, immunoprecipitation) and operation of an Orbitrap mass spectrometer are preferred, but not essential for success in this role. Computational skills and ‘big data’ experience are highly desirable, including working knowledge of python, R or related tools. Strong communication & interpersonal skills are essential for success in this collaborative role.

Location: South San Francisco, CA. This is a lab based position and remote work is not an option.

Contact: Interested scientists are encouraged to apply here: https://www.indeed.com/jobs?q=Evotec&l=South San Francisco%2C CA&vjk=6e0b0378bf315a4b
or Please contact choi.meena@gene.com (Meena Choi). Please write "Skyline DP-SSR position inquiry" in the subject line.

view posting
Lab Research Analyst II, Duke Proteomics and Metabolomics Core Facility
Will Thompson 2021-02-22

LAB RESEARCH ANALYST II , Duke University School of Medicine
Duke Proteomics and Metabolomics Core Facility
Durham, North Carolina

Position Description:
Seeking a self-starting scientist with good problem-solving skills and strengths in quantitative analysis, particularly by LC-MS/MS. Job duties will be to work in a fast-paced, team-based environment to conduct a variety of complex and independent investigations addressing physical, chemical, and other research laboratory experiments to obtain and interpret data for research projects at Duke, specifically addressing metabolomics and proteomics in cancer, neurodegenerative diseases, and infectious diseases. Scientific integrity, curiosity, and determination are key qualities of a successful candidate.

In particular, under the guidance of the Director or Assistant Director, the Lab Analyst II will conduct a variety of complex laboratory procedures and specialized laboratory techniques for the analysis of endogenous metabolites, drug molecules, peptides and proteins in the Proteomics and Metabolomics Core Facility for the School of Medicine. Note that both SOP-driven and independent analyses will be required, and proven analytical thinking and problem-solving skills are critical. The ability to effectively work in a multidisciplinary team environment and move easily from one task to another is essential.

Position requires a bachelor’s degree in Chemistry, Biology, or related field and a minimum of 4 years experience. Master’s degree or Ph.D. can substitute for appropriate years’ experience.

Tasks may include:

  1. 40% - Preparation of biological samples for metabolomic, proteomic, and pharmacokinetic analyses.

  2. 40% - Quantification of metabolites using triple quadrupole mass spectrometry, and contribution to the development of new LC-MS/MS assays. Validation of figures of merit for quantitative LC-MS/MS assay.

  3. 10% - Protein identification and quantitation using nanoscale capillary liquid chromatography and analytical scale liquid chromatography coupled with either high resolution, accurate mass tandem mass spectrometers (LC/MS/MS) or triple quadrupole mass spectrometers operated in MRM mode.

  4. 5% - Contribution to written reports and publications of results in collaboration with investigators inside and outside of Duke. Review journals, abstracts and scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.

  5. 5% - Presentation of their ongoing work at group meetings, and critical evaluation of new approaches for metabolomics and proteomics presented in the literature or by others.

Interested applicants can find more information and apply for the position at the link below:
https://careers.duke.edu/job/Durham-LAB-RESEARCH-ANALYST-II-NC-27710/713080600/?locale=en_US

Interested individuals may contact Will Thompson (will.thompson at duke.edu) for more information, however applications must be processed through the Duke Careers web site.

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Scientist/Senior Scientist, Analytical Development (Mass Spectrometry)
echan 2021-02-17

AbSci is a growth stage synthetic biology company located in a new, state-of-the art laboratory in downtown Vancouver, WA, just across the river from Portland, OR. AbSci is a global leader and innovator of revolutionary biomanufacturing technologies, designing and programming cells for next-generation biopharmaceuticals. Our Protein Printing™ technology results in dramatic reductions in the cost of producing biologics, acceleration of drug discovery timelines, and enables the production of previously difficult or impossible-to-produce molecules. Our technology is a new paradigm in protein production, as it increases discovery throughput, accelerates development, reduces manufacturing costs, and increases plant capacity for the biopharmaceutical industry.

Job Description:
We are currently seeking a self-motivated, passionate, and accomplished Scientist to join our Analytical Development team. Using your strong attention to detail, you will play a significant role in analytical method development and characterization of therapeutic proteins expressed using SoluPro™, AbSci’s proprietary E. coli expression platform. You will utilize your successful background in the development and analytical characterization of complex biologics by LC-MS and proteomics approaches while exploring new and innovative technologies. This position will utilize your interpersonal and strong written and verbal communication skills for multi-disciplinary collaboration with the other teams within AbSci, including Molecular Sciences, Fermentation, Purification, and Bioinformatics. You bring a passion for scientific innovation, excellent technical skills, and you execute your responsibilities with high attention to detail. You work with a sense of urgency, and thrive in a team dynamic in a high-performance culture.

Responsibilities:
Develop and execute laboratory tasks to support the development and optimization of various mass spectrometry-based methods for the characterization of complex biotherapeutics by LC-MS, including intact mass, disulfide mapping (including PTMs), and targeted mass spectrometry (PRM/MRM)
Perform multi-step sample preparations including enzymatic digestion (solution and in-gel), reduction/alkylation, buffer exchange, deglycosylation, sample concentration, etc.
Method development and optimization for transfer to non-mass spectrometry, stand-alone LC-UV-based techniques for analyses of protein biologics
Operation, maintenance, and installation of LC-MS instrumentation
Write and review formal reports, including method SOPs, reports, and other technical documents
Evaluate data for trends indicative of product performance, method performance, and/or analyst performance and present internally to team members and senior management
Oversee routine instrument operation and maintenance
Lead, mentor, and inspire junior team members
Evaluate new technologies and platforms
Support internal technical teams, including R&D, fermentation and purification process development teams
Maintain accurate documentation of all work in laboratory notebooks

Qualifications:
PhD in Analytical Chemistry, Biochemistry, or related scientific disciplines
Experience in protein engineering, expression, purification, and biochemical characterization (e.g. antibodies, cytokines, and antigens).
Hands-on knowledge of protein analytics and characterization by LC-MS, including intact mass, disulfide mapping, PTMs, and targeted mass spectrometry (MRM/SRM)
Hands-on experience with SDS-PAGE, Western blot, and capillary electrophoresis
Experience in the operation, maintenance, and troubleshooting of associated instrumentation
Strong capabilities in experimental design, execution and data interpretation
Ability to communicate with colleagues and business partners who do not share candidate’s core area of expertise is required
Huge plus (but not required):
Post-doctoral and/or industry experience preferred; 2+ years industry experience is a plus
Experience with Sciex and Thermo MS and Agilent LCs is preferred
Experience with proteomics is preferred
Experience in LC-MS sample preparation for implementation on automated liquid handlers is preferred
Experience with JMP or comparable statistical software packages is preferred
Proficiency in Python or R is a plus
Experience with ELISA, BLI, and SPR is a plus
Experience working with CMO’s and CRO’s for methods transfer, method optimization, and data and report review is a plus
Knowledge of cGLP/cGMP, FDA, EMA, ICH guidance and industry standards for analytical development and characterization of proteins is a plus

We seek candidates with a passion for building a creative company culture that is collaborative, multidisciplinary, and committed to making a transformative impact on our industry. To be successful in this role, we look for passion in technology innovation, adept technical skills, and excitement about working in a dynamic startup environment. A demonstrable track record of success in functioning as part of a project team is essential.

Apply here:
https://grnh.se/ed9d1f623us

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Marine Metabolomics Research Technician, University of Florida
bryndandurham 2021-02-13

The Durham Lab at the University of Florida is currently recruiting a laboratory Research Technician. The start date is flexible, but ideally the successful candidate would begin between April 2021 and June 2021. Research in the Durham Lab (https://www.durham-lab.com) focuses on the molecular ecology and chemistry of environmental microbes. Current projects include exploration of metabolite exchange in marine phytoplankton-bacterial interactions and terrestrial moss-cyanobacterial interactions. The technician will be primarily responsible for processing and analyzing microbial and plant samples using liquid chromatography-mass spectrometry (LC-MS)-metabolomics techniques. In particular, the technician will analyze samples using high-resolution LC-MS system(s) located in the UF’s Interdisciplinary Center for Biotechnology Research (www.biotech.ufl.edu) mass spectrometry core facility. Other responsibilities may include microbial cell culture, administration of the lab (e.g., lab safety, chemical inventory, ordering supplies), and LC-MS data analysis. This is a one-year term position with the potential for renewal. We will consider candidates who seek part-time or full-time work, with a minimum commitment of 20 hours per week.

Fundamental requirements and qualifications include the following:
• A Bachelor’s degree in Chemistry or related field
• Demonstrated knowledge of chromatography and/or mass spectrometry methods
• Strong work ethic and independence
• Excellent communication and teamwork skills
• Excellent English writing and speaking ability
• Ability to manage multiple projects
• Excellent organizational skills and attention to detail

Additional, preferred qualifications include the following:
• A Master’s degree or work experience in environmental or analytical chemistry or related field
• Demonstrated scientific writing skills (preferably through publication record)
• Data analysis experience (R or Python)

 Technician_Job_Posting.docx.pdf 
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Postdoctoral Fellow
pandafj 2021-02-10

Tulane University: School of Medicine: Basic Science Departments: Biochemistry & Molecular Biology
Location
New Orleans, LA
Open Date
Jan 19, 2021

Description
The Postdoctoral Fellow for the Department of Biochemistry and Molecular Biology will be responsible for developing mass spectrometry-based new technologies and approaches to detect and measure biomarkers associated with cancer and infectious disease, and to employ these methods to analyze samples from animal models of human disease and human subjects to test and validate their performance.

We are a multi-disciplinary team across biology, chemistry and bioinformatics. You will join a team that focuses on developing non-invasive approaches for early disease diagnosis and disease prognosis, the use of advanced mass spectrometry approaches for proteomics and protein/peptide characterization, and analysis of extracellular vesicles as biomarkers in the progression of cancer and infectious disease.

Qualifications

  1. Recent Ph.D. in in protein mass spectrometry, proteomics or related field, with demonstrated skills in analytical chemistry, MALDI, LC-MS/MS
  2. Research experience in nano/micro scale liquid chromatography, electrospray ionization, high resolution mass spectrometry, protein biochemistry, top-down and bottom-up proteomics including project design, sample preparation and data analysis, PTM identification.

Equal Employment Opportunity Statement
Tulane University is an Equal Employment Opportunity/Affirmative Action institution committed to excellence through diversity. Tulane University will not discriminate based upon race, ethnicity, color, sex, religion, national origin, age, disability, genetic information, sexual orientation, gender identity or expression, pregnancy, marital status, military or veteran status, or any other status or classification protected by federal, state, or local law. All eligible candidates are encouraged to apply.

Application link: https://apply.interfolio.com/83136

 Apply - Interfolio.pdf 
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Post-doctoral fellowship in data independent acquisition method development using 21 Tesla FT-ICR MS
Mike MacCoss 2021-02-10

The National High Magnetic Field Laboratory (NHMFL) is searching for a postdoctoral fellow to assist the Ion Cyclotron Resonance (ICR) Program instrumentation group. The ideal candidate for this postdoctoral position will be a scientist with experience in the field of mass spectrometry with a record of significant scholarly activity. Experience in mass spectrometry applications and/or software development for mass spectrometry data analysis is desired.

The postdoctoral fellow will work with the FT-ICR Facility permanent staff to implement a novel data-independent analysis pipeline for the flagship 21 Tesla FT-ICR MS and help develop downstream software to analyze the data in collaboration with the MacCoss Laboratory at the University of Washington. The candidate will collaborate with NHMFL and MacCoss laboratory staff. Travel funds have been allocated for an extended learning/collaboration opportunity to perform research at the University of Washington within the MacCoss Laboratory. Candidates are expected to have a Ph.D. in a relevant field.

The NHMFL is the world’s premier magnet laboratory with state-of-the-art high magnetic field facilities (up to 21T in superconducting magnets, 36T in resistive DC magnets, 45T in hybrid DC magnets, and 100T in pulsed magnets) for research in physics, materials science, engineering, chemistry geochemistry, biochemistry, and biology.

Interested candidates can apply to Florida State University at https://jobs.fsu.edu and reference Job Requisition #48464. Please attach your curriculum vitae, cover letter describing your research experience, and names and contact information of at least three references. For additional information, please contact Ms. Bettina Roberson, National High Magnetic Field Laboratory, Florida State University, 1800 E. Paul Dirac Drive, Tallahassee, FL 32310-2740, 850-644-0855. Additional information may be attached and emailed to roberson@magnet.fsu.edu. The NHMFL is operated for the National Science Foundation by a collaboration of institutions comprising Florida State University, the University of Florida, and Los Alamos National Laboratory. The Florida State University is an Equal Opportunity, Affirmative Action employer, committed to diversity in hiring, and a Public Records Agency.
If you have any questions, or want to check directly about the position, please do not hesitate to contact Chad Weisbrod at weisbrod@magnet.fsu.edu or Mike MacCoss at maccoss@uw.edu for further information.

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Scientist/Senior Research Associate
fiona 2021-02-08

Who we are:
Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.
Position description:
Calico is seeking an experienced Senior Research Associate/Scientist to join the mass spectrometry proteomics group. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. We are looking for someone with detailed knowledge of proteomics and biochemistry techniques, and with demonstrated hands-on application. This is a hands-on bench position, focused on sample preparation, instrument maintenance, troubleshooting and data analysis. The successful candidate will work with a large numbers of samples for collaborative projects, optimize and develop methods as well as be responsible for smaller research projects. The Proteomics group collaborates with multiple labs within Calico, and as such is involved in many areas of research from oncology to immunology, as well as technology and assay development.
Responsibilities:
• Prepare samples from tissues, cells, and biofluids.
• Optimize and develop new sample preparation methods
• Maintain and troubleshoot instruments including HPLCs, mass spectrometers and other bioanalytical equipment.
• Analyze data to share will collaborators
Position requirements:
• Recent PhD graduates are encouraged to apply. Or thesis-based MS in biochemistry or related discipline required, plus 5 years of research experience in an academic or industry.
• Experience in method development for HPLC and/or mass spectrometers
• Experience in maintaining and troubleshooting HPLCs and mass spectrometers
• Experience in sample preparation for proteomics (e.g. isobaric labels)
• Experience in proteomics data analysis and basic coding (e.g. R, Matlab, Python)
• Detail-oriented and organized
• Strong teamwork and communication skills
• Self-motivated with a “can-do” attitude is required for success
• Flexible, able to respond quickly to shifting priorities and able to multitask
• Demonstrated ability to design, execute and draw conclusions from scientific projects

Nice to have:
• Experience maintaining Thermo mass spectrometers (e.g. Eclipse/Lumos) and HPLC
• Experience in automation and liquid handling platforms
• Experience in affinity/immunoprecipitation of proteins and post translational modification
• Experience in native fractionation FPLC/HPLC.

Link to apply: https://www.linkedin.com/jobs/view/2384574356/?capColoOverride=true

 Scientist_SRA_Contractor_JD.pdf 
view posting
AI software engineer/developer at EpiQMAx GmbH
solis 2021-02-06

At EpiQMAx, we offer a service to pharmaceutical companies and research institutes, based on mass spectrometry, for the measurement of epigenetic and post-translational modifications on histones and other proteins. An essential challenge in our domain is the discovery and identification of markers associated with a disease or a biological condition.

We are looking for an AI developer/engineer, whose role will be to use classical ML algorithms as well as develop CNN models for the discrimination of distinctive proteins and PTMs associated with a condition. As input data, she/he will count with matrix-like files and images.

Candidate requirements: Master Sc. or Ph.D. title in Computer Science or Statistics/Data Analysis, Bioinformatics or alike. Good to very good knowledge of ML/AI models, architectures, and model training. Good to vast expertise on image classification and object recognition.

Apply by sending your CV and a cover letter to info@epiqmax.de

More information about the position can be found on our careers site: https://epiqmax.com/career

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Senior Associate Scientist, Platform Biology
kelli nolan 2021-02-05

This key position in our platform biology group will develop and perform mass spectrometry (MS) assays in support of proteomics applications for our therapeutic areas. The candidate will be expected to work with key stakeholders and under direction of senior members of the group to perform analyses to support our understanding of the mechanism of action, cell-based activity and biophysical properties of our small molecule protein degraders. This position reports to Principal Research Investigator, under the supervision of Senior Research Scientist in the Platform Biology department and will be located at our headquarters in New Haven, CT.
Qualifications
• Extensive hands-on experience with Orbitrap MS platforms
• Experience with liquid chromatography systems (nanoLC experience is preferred)
• Proficiency in MS acquisition methods such as data-dependent acquisition (DDA), data-independent acquisition (DIA), parallel reaction monitoring (PRM), etc.
• Experience with labeled MS quantitation methods such as TMT and iTRAQ
• Hands-on experience with MS proteomics sample preparation methods including BCA quantitation, tryptic digestion, peptide desalting, phosphopeptide enrichment, peptide labeling
• Experience with targeted MS protein quantitation using heavy isotope labeled standards
• Experience with top-down MS methods for intact protein analysis
• Proficiency in mass spectrometry analysis software packages including Proteome Discoverer, Scaffold, and Skyline.
• Ability to trouble-shoot and problem-solve independently while under general supervision by the project leader
• Ability to organize and work on multiple projects simultaneously
• Excellent data handling and recording skills as well as oral and written communication skills is required.

 Arvinas Senior Associate Scientist Platform Biology Proteomics-Final-2.docx 
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Senior Research Associate on Proteomics - Impossible Foods, Redwood City, CA
Yiming Chen 2021-02-04

Play here: https://jobs.lever.co/impossiblefoods/401f5851-7291-4294-afec-704d7f8ad2b5

Impossible Foods is addressing the most catastrophic threats facing humanity: climate change and biodiversity collapse. A global transition to a plant-based food system will turn back the clock on atmospheric CO2 levels, restore natural ecosystems and reverse meltdown in wildlife biomass.

The easiest -- if not only -- way to make our civilization sustainable is to eliminate livestock, the most dangerous technology on Earth. But humans won’t give up meat. So we need to make meat better -- more delicious and more nutritious, without animals as the underlying production technology. That means that making meat sustainably is the most important and urgent problem for the global scientific community.

Impossible Foods' mission is to completely replace the use of animals as a food-production technology by offering consumers everything they currently value about animal products -- and making products that are vastly superior to their animal analogues.

To do this, we are taking a revolutionary scientific and market-based approach. We are inventing efficient, sustainable ways to transform ingredients from plants into meat, fish and dairy foods that deliver all the pleasures and nutritional benefits consumers demand, without the destructive environmental or public health impact.

Our world-class R&D team has been building the know-how and technology platform to produce meat, fish and dairy foods from plants. Impossible Foods is experiencing rapid growth and is resolutely committed to leading all aspects of the plant-based food revolution—from discovery to commercial production. The only thing that will separate Impossible Foods from success and failure is our ability to recruit more world-class experts.

Want to join? Check out the job opening and requirements below:

We are inviting an experienced researcher with broad knowledge of proteomics and mass spectrometry to join the Discovery Team at Impossible Foods at Redwood City, CA. We are looking for a top-tier scientist to design and perform high-throughput proteomics experiments, and to develop in-house protein analysis platforms. Alongside your R&D team members you will collaboratively tackle some of the hardest challenges at the frontier of food science and biotechnology.

You Will:

  • Use your knowledge in analytical chemistry and biology to design and perform high-throughput quantitative proteomics experiments.
  • Develop new analytical methods for mass spectrometry-based protein analysis, including but not limited to bottom-up proteomics, top-down proteomics, targeted proteomics, PTM characterization, peptide mapping, intact protein MS, native MS.
  • Collaborate with other researchers on the projects in different fields including microbiology, downstream processing, materials and texture, nutrition, food science, legal and regulation.
  • Performing MS data processing and statistical analysis with various software packages.

You Have:

  • Ph. D./M. S., or equivalent, in chemistry, biology, or related fields.
  • Strong oral and written communications skills.
  • Abilities to work efficiently with diverse and dynamic teams.
  • A self-motivated personality and an “can-do” attitude are required for success.
  • Good hands-on abilities. Good observer and recorder.
  • Avid data analyst.
  • Extensive hands-on experience on proteomics sample preparation, including but not limited to: sample homogenization, protein extraction, proteolytic digestion, peptide fractionation.
  • Extensive experience and knowledge on using LC-MS systems, preferably Thermo Orbitrap series instruments.
  • Experiences in data processing with programming languages such as Python or R are strongly preferred, especially on pipeline & workflow development and web frameworks.

Impossible Foods Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

view posting
Mass Spectrometry Senior Scientist- InterVenn Biosciences
xcong 2021-02-04

SUMMARY

InterVenn Biosciences is seeking mass spectrometry scientists to join our highly collaborative and supportive mass spectrometry team. Candidates will have substantive experience in the field of mass spectrometry-based proteomics/glycoproteomics, and will be highly motivated and resourceful. Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
● Lead projects in analytical method development and optimization. Develop LC-MS based targeted biomarker assay (SRM/MRM) and facilitate method validation activities.
● Be responsible for mass spectrometry instrumentation operation, troubleshooting and maintenance.
● Train and supervise new analysts in glycoproteomics mass spectrometry workflows.
● Manage multiple projects within timelines according to high scientific and ethical standards.
● Align and collaborate with project managers, data science team and clinical laboratory personnel across the biomarker assay product portfolio.
● Promote a culture of transparency and traceability across all aspects of laboratory operations.

SKILLS AND QUALIFICATION REQUIREMENTS
● Ph.D. in biological sciences, chemistry, or analytical chemistry.
● Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially triple-quadrupole MS (QQQ).
● Extensive experience in targeted mass spectrometry-based proteomics/glycoproteomics.
● Extensive knowledge of application of complex sample preparation methodologies for protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies, in particular SRM/MRM methods.
● Proven track record of LC-MS based method development and validation for proteomics biomarker assays.
● Applied knowledge of/experience with MS software analysis pipelines.
● Experience in the pharmaceutical/biotech, diagnostic, or life-science-tools industry is preferred.
● Experience in developing computational algorithms proteomics data processing and skills in computational programming languages (e.g. Python) is a plus.
● Working experience in regulatory-compliant environments (GxP) and familiarity with regulatory guidelines on bioanalysis (FDA, CLSI etc.) is a plus.
● Proven record of being a fast learner, flexible, and mindful team member.
● Excellent verbal and written communication skills.

view posting
Postdoctoral position in translational proteomics in Freiburg, Germany
mcfoell 2021-02-04

The laboratory for Functional and Translational Proteomics, led by Prof. Oliver Schilling, is part of the Institute for Surgical Pathology, at the University Medical Center Freiburg, Germany. We are soliciting applications for a postdoctoral researcher to join our friendly and open-minded team of about 15 scientists with backgrounds in biology, chemistry, medicine, pharmacy and bioinformatics.

The project enables the unique opportunity to shape the next generation of translational proteomics by integrating state of the art approaches for sample preparation, data acquisition and data analysis to unravel proteomic characteristics of diverse solid tumors.

Selected tasks include:

  • Improvement of existing and development of new methods, especially for shotgun proteomics to allow additional analysis such as regulatory modifications and proteogenomics
  • Establishing targeted proteomic assays
  • Contribute to the supervision and maintenance of our diverse mass spectrometers
  • Active collaboration with medical doctors and life scientists on local, national and international level

We offer

  • Full-time postdoctoral position (TV-L E13, 100%) for initially two years (extension possible); starting date is flexible but early in 2021 is preferred
  • Highly translational projects with clinical relevance in a productive and friendly work environment with international and industry collaborations
  • Well funded and equipped lab
  • Ample opportunities for scientific publishing, conference presentations, grant applications and student supervision
  • Plenty opportunities for scientific and professional development

Required qualifications include a PhD in a life sciences discipline (e.g. biology, molecular medicine,
chemistry, pharmacy); strong scientific background and experience in mass spectrometry based
proteomics including sample preparation, LC-MS/MS instrument handling and ideally also data
analysis. Experience with cell culture techniques, protein biochemistry, molecular biology, and / or
microscopy is an asset. We also ask for a proactive and cooperative work attitude with excellent
problem-solving and organizational skills, very good communication skills in English (written and
spoken), and an interest in supervising (PhD) students.

For further inquiries please contact
oliver.schilling@uniklinik-freiburg.de

To apply, please send CV, motivation letter and contact details of two references to melanie.foell@uniklinik-freiburg.de.

Please find further information in the attachment.

 postdoc_Schilling_lab.pdf 
view posting
Protein Structural Mass Spectrometry Position
ray blind 2021-02-04

Greetings!

My lab at Vanderbilt University in Nashville, TN, USA is looking for a biochemistry-minded research scientist, research associate or postdoctoral fellow interested in applying mass spectrometry-based approaches to protein structural biology. We recently published the first full-length integrated structural model of a monomeric nuclear receptor. The model of this transcription factor bound to a DNA oligo was derived largely from mass spectrometry-based data:

https://www.cell.com/structure/fulltext/S0969-2126(20)30166-0

The target protein is the nuclear receptor LRH-1 (NR5A2), a ligand activated transcription factor and target for antidiabetic drug design. The above paper establishes the unperturbed ground state structure. Your project will be to determine how known small molecule ligands, drugs, hormones, peptides and DNA sequences regulate this structure.

The techniques we applied to determine the above structure included BS3 chemical crosslinking, benzophenone artificial amino acid crosslinking, engineered disulphide crosslinking and hydrogen-deuterium exchange (HDX). We used these techniques as amino acid proximity sensors in this multi-domain protein target to model how the individual domains interact with each other. For more details please visit my lab site:

http://www.blindlab.org

Although scientist-level candidates should have extensive proteomic data analysis, protein expression, purification and characterization experience, postdoc or research associates need only basic protein biochemistry skills, an eagerness to learn and a strong sense of scientific bravery.

Send your CV to the PI (Ray Blind) at ray.blind@vanderbilt.edu, soon-to-be PhD graduates are specifically encouraged to apply.

view posting
Postdoctoral Research Fellow – Pharmacokinetics and Metabolomics: Merck Research Laboratories: West Point, PA
shivangi awasthi15418 2021-02-04

West Point, Pennsylvania, United States of America Job Type : Full time

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Merck Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

What You'll Be Doing:

You'll be helping us build metabolomics capabilities for improving drug metabolism and pharmacokinetics. You will join a dynamic bioanalytical group, also work closely with drug absorption, distribution, metabolism and excretion (ADME) experts and big data modeling scientists in PPDM to study the roles of endogenous molecules (including metabolites, lipids and peptides) in our drug discovery models. The goal is to develop novel predictive approaches based on the flux of endogenous molecules to enable early detection of drug-drug interactions and drug clearance pathways.

Responsibilities include but are not limited to:
Interact frequently with key collaborators and solicit input from bioanalytical and ADME experts to shape study plans. This includes but not limited to:
Design in vitro and in vivo studies on preclinical species using probe drugs to generate hypotheses driven samples.
Generate metabolomics data. Analyze samples using state of the art LC/MS instruments and coordinate with other capability groups within our company or CROs.
Metabolomic data analysis and model building to link endogenous molecules changes responding to probe drugs.
Drive novel hypotheses based on data; conduct new experiments to progress continuously and achieve predictability.
Prepare manuscripts for novel findings

What You Need:
Candidates must currently hold a PhD OR receive a PhD by fall of 2021.
A record of establishments in advancing metabolomics workflow and applications including analytical platform development and biological sample analysis
Excellent big data processing, visualization (including graphical model) skills with proficiency of metabolomics bioinformatic software packages including pathway analysis
Excellent verbal and written communication skills; ability to excel in a team-interactive environment.
Proven record of innovation with publications in peer-reviewed journals and presentations in leading scientific conferences (ASMS, Metabolomics, etc.).

It's Great If You Have:
Experiences working with endogenous molecules flux for enzymatic systems
Ability to create novel data visualization methods when existing software doesn’t suffice.
Proven understanding of drug metabolism and pharmacokinetics of xenobiotics

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.
IMPACT.
INSPIRE.

mrlpostdoc
US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement​
OFCCP EEO Supplement
OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:
1
Requisition ID:R91315

Apply at: https://jobs.merck.com/us/en/job/R91315/Postdoctoral-Research-Fellow-Pharmacokinetics-and-Metabolomics

view posting
Scientist II: Mass Spectrometry Proteomics
faizanzubair2 2021-01-29

Apply Here: https://takeda.wd3.myworkdayjobs.com/External/job/San-Diego-CA/Scientist-II--DMPK_R0026102-1

OBJECTIVES:
Develop targeted biomarker assays for target engagement and pathway modulation biomarkers using mass spectrometry approaches
Quantify peptides, proteins, post-translational modifications, lipids, and metabolites to inform go- no-go decisions on assets and targets
Support discovery proteomics efforts using DIA, TMT, and label-free proteomics approaches
Lead scientific advances in specialized sample processing techniques, nano-LCMS, and software packages related to biomarker analyses

ACCOUNTABILITIES:
Process biological samples including tissues and fluids (Colon, Bile, Urine, CSF and/or Plasma) for enzymatic digestion, sample clean-up, and sample enrichment
Develop high-throughput sample processing approaches utilizing plate-based approaches and robotic instruments such as KingFisher and liquid handlers (eg. Tecan)
Implement 1D and 2D liquid chromatography techniques including reverse phase, reverse phase high pH, ion exchange, size exclusion, and others
Utilize Thermo’s hybrid and tribrid instruments to develop specialized biomarker assays for analytes with low physiological concentrations in complex matrices
Utilize Sciex’s TripleQuad and TripleTOF and Waters’ Xevo with Ion Key platforms for biomarker quantitation
Enrich for PTMs such as phosphorylation, acetylation, glycosylation, ubiquitination, and others using chemical affinity and antibody approaches
Leverage software packages including Skyline, Compound Discoverer, Proteome Discoverer, MaxQuant, Spectronaut and others for biomarker discovery and quantitation
Analyze multi-variate data sets and develop data processing pipelines containing normalization, imputation, and statistical analysis
Perform pathway analysis using IPA, Metacore, and other commercial/ public biological databases
Summarize biomarker data and present findings and recommendations to project teams

MINIMUM EDUCATION/EXPERIENCE:
PhD degree in a scientific discipline with 2+ years experience , or
MS with 8+ years experience, or BS with 10+ years experience
Prior experience with mass spectrometry, HPLC, and nano-LC is required. Familiarity with Thermo and/or AbSciex mass spectrometers for biomarker quantitation is required.
Experience with ligand binding assays is beneficial.
The candidate must be able to analyze data and note significant deviations and maintain detailed, accurate and comprehensible study documentation.
The individual is also expected to be highly organized, a team player, enthusiastic about drug discovery, and possess strong communication skills.
Publications in peer-reviewed scientific journals are beneficial

 Takeda_Job Description_Mass Spectrometry Research Scientisty.pdf 
view posting
Research & Product Scientist
jsilva 2021-01-25

About the job (posted on January 25, 2021):

Adeptrix is an entrepreneurial Life Sciences company based in Beverly MA that develops analytical solutions for pharma, biopharma, academic and clinical customers. Having recently completed the Series A financing round, the company is well positioned to become a major player in the fast-growing, multi-billion dollar bio-analytical consumables market. Adeptrix is currently working on a variety of research and diagnostic assays in the areas of neurology, oncology, epigenetics and virology (COVID-19) based on its proprietary BAMS™ platform technology. To learn more about Adeptrix: https://adeptrix.com/

We are currently accepting applications for a Research & Product Scientist who will provide leadership on further advancement of BAMS™ with the main focus on product and applications development, as well as the internal research and ongoing collaborations with Academia, Biotech and Pharma. This position reports to the company leadership.

Key responsibilities include:
• Manage laboratory personnel to co-ordinate and streamline product development activities
• Design and supervise validation efforts for the product development pipeline
• Oversee collection and analysis of analytical data for internal R&D and external collaborations
• Contribute to writing, editing, and producing abstracts, manuscripts, reports, posters
• Present at professional meetings and conferences
• Provide subject matter expertise and support to business development efforts

Qualifications:
• Minimum of 4 years of research or product development experience in bio-analytical assay development
• Experience with proteomic sample preparation methods and mass spectrometry data analysis
• Natural tendency to be curious, positive and creative
• Creative and analytical; can translate data and information into actionable plans
• Excellent project management and interpersonal skills
• Excellent communicator; able to put together convincing arguments
• Ph.D. or Masters degree with relevant industry experience

Personal Attributes:
• Exceptional communication, interpersonal and analytical skills
• Strong sense of professional accountability and integrity
• Highly motivated; plans for and strives to meet project goals and objectives
• Collaborative approach; functions well in team-based environments
• Commercial mindset
• Eager to grow and advance professionally

Competitive compensation and benefits package will be provided. Adeptrix is an equal opportunity employer and prohibits any discrimination or harassment based on race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

Interested scientists are encouraged to reach out to Jeffrey Silva, Chief Technology Officer, at Adeptrix Corporation (jsilva@adeptrix.com).

 Research and Product Scientist Job Description.pdf 
view posting
Postdoctoral Associate - Proteomics Group/Carr Lab (Open)
hasmik 2021-01-22

Post Doctoral Positions in Proteomics of Disease, Signaling and Complex Biological Systems

The Proteomics Group (Carr Lab) at the Broad Institute of MIT and Harvard is looking for several highly
motivated post-doctoral associates to develop and apply state-of-the art proteomics technology to
address compelling questions in biology, chemistry and clinical medicine. The specific research areas
of immediate interest that this scientist could drive include:
• multiomic and proteogenomic studies of a wide range of cancers
• provide detailed views and understanding of cellular signaling networks related to
protein phosphorylation, ubiquitylation, acetylation and cross-talk
• define the targets of drugs or identifying protein interactors through chemical
proteomics technologies and affinity purification MS
• develop biological understanding of response and resistance to therapy
• improve understanding of immune biology and help develop personalized cancer
immunotherapies
• develop and optimize new, broadly enabling proteomic technologies including targeted,
quantitative MS assay development for proteins and modifications of high biological or
clinical interest
Successful candidates will work in one or more of these areas together with an interdisciplinary team
of clinicians, biologists, computational and proteomics scientists to deeply characterize and
understand the proteomes of tumor-derived material, cells and biofluids.
The Broad Institute is a world-leading non-profit research organization dedicated to realizing the
promise of the post-genomic era for human benefit. Located in Cambridge, MA with strong ties to
MIT, Harvard, and world class Boston hospitals, the Broad Institute brings together scientists of diverse
backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner. The
Broad Institute, and the embedded Proteomics Group (www.broadinstitute.org/proteomics), have an
outstanding track-record in training the next generation of research scientists and in developing and
applying proteomic technologies critical to address important questions in biology and medicine. We
collaborate with top-level researchers throughout the world, and results of these studies and our
technology developments are published in top-tier journals.
Qualifications
Candidates must have:
• an MD or Ph.D. in analytical chemistry, biology, biochemistry, or a closely related field
• excellent scientific productivity, evidenced by high-quality research publications in peer
reviewed journals
• track record of conducting independent and creative research
• excellent verbal and written communication skills

Hands on skills and knowledge in one or more of the following areas will be considered an advantage:
• state-of-the-art mass spectrometry-based proteomics
• expertise in expertise in statistical and/or computational analysis of large-scale proteomic or
genomic data
• analysis of cell signaling pathways/networks
• cell biology/ biochemical methods to understand protein function
• Molecular biology/CRISPR-based genome editing
Interested scientists are encouraged to apply on-line at the Broad Website. Inquiries can also be
addressed to Steve Carr, Director of Proteomics, Broad Institute (scarr@broad.mit.edu) and Namrata
Udeshi, Associate Director of Proteomics (Udeshi@broadinstitute.org).

view posting
Mass Spectrometry Senior Scientist
xcong 2021-01-19

SUMMARY

InterVenn Biosciences is seeking mass spectrometry scientists to join our highly collaborative and supportive mass spectrometry team. Candidates will have substantive experience in the field of mass spectrometry-based proteomics/glycoproteomics, and will be highly motivated and resourceful. Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
Lead projects in analytical method development and optimization. Develop LC-MS based targeted biomarker assay (SRM/MRM) and facilitate method validation activities.
Be responsible for mass spectrometry instrumentation operation, troubleshooting and maintenance.
Train and supervise new analysts in glycoproteomics mass spectrometry workflows.
Manage multiple projects within timelines according to high scientific and ethical standards.
Align and collaborate with project managers, data science team and clinical laboratory personnel across the biomarker assay product portfolio.
Promote a culture of transparency and traceability across all aspects of laboratory operations.

SKILLS AND QUALIFICATION REQUIREMENTS
Ph.D. in biological sciences, chemistry, or analytical chemistry.
Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially triple-quadrupole MS (QQQ).
Extensive experience in targeted mass spectrometry-based proteomics/glycoproteomics.
Extensive knowledge of application of complex sample preparation methodologies for protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies, in particular SRM/MRM methods.
Proven track record of LC-MS based method development and validation for proteomics biomarker assays.
Applied knowledge of/experience with MS software analysis pipelines.
Experience in the pharmaceutical/biotech, diagnostic, or life-science-tools industry is preferred.
Experience in developing computational algorithms proteomics data processing and skills in computational programming languages (e.g. Python) is a plus.
Working experience in regulatory-compliant environments (GxP) and familiarity with regulatory guidelines on bioanalysis (FDA, CLSI etc.) is a plus.
Proven record of being a fast learner, flexible, and mindful team member.
Excellent verbal and written communication skills.

view posting
Senior Research Associate
xcong 2021-01-19

Senior Research Associate
Location: South San Francisco, US
InterVenn Biosciences is seeking a Sr. Research Associate to join our highly collaborative and supportive biomarker discovery team. The successful candidate will be a highly motivated and resourceful individual with a robust track record of experience in the field of mass spectrometry- based proteomics and glycoproteomics, . Their work will enable qualitative and quantitative epi-proteomics workflow development for innovative biomarker discovery.
RESPONSIBILITIES
Conduct experiments for the development of sample preparation and peptide separation methods, glycoproteomic technology evaluation, data analysis and interpretation,and glycoproteomic software evaluation.
Prepare biological samples and run assays on instruments under general guidance.
Document experimental work, analyze data, document and present results.
Prepare written methods and SOPs.
Perform mass spectrometry instrumentation operation, troubleshooting and maintenance.
Manage multiple projects within timelines according to high scientific and ethical standards.
Align and collaborate with project managers, computational biologists and software development project leads across the biomarker discovery project portfolio.
Promote a culture of transparency and traceability across all aspects of laboratory operations.

QUALIFICATIONS
BS or MS in life sciences, chemistry or related fields with 4 or more years of industry or equivalent postgraduate experience is required.
Extensive knowledge and application of complex sample preparation methodologies as applied to protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies including label-free analyses (DIA, PRM/SRM) methods.
Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially high resolution mass spectrometers (Orbitrap or qTOF)
Applied knowledge with MS software analysis pipelines
Demonstrated ability to plan and execute research experiments.
Proven record of being a fast learner, flexible, excellent communicator and mindful team member.
Excellent verbal and written communication skills.

view posting
Researcher 5 in Quantitative Proteomics
ztflaten 2021-01-19

Job description:

This is an exciting growth opportunity that focuses on large-scale quantitative proteomics applications in the Li Lab at the University of Minnesota’s Medical School and the Graduate Neuroscience Program. Our expertise and research has been focused on applying cutting edge quantitative proteomics to identify novel mechanisms and biomarkers for precision and personalized treatment of neurodegenerative diseases. The individual will be scientifically responsible for aspects of research planning, method development, sample preparation, data acquisition and biostatistics and bioinformatics. Responsibilities also include effectively communicating project progress, teaching and mentoring lab staff and graduate student, large-scale data analyses using biostatistics and bioinformatics, preparing presentations, and participating in grant writing and scientific publications in high impact journals.

Responsibilities:

Conduct investigations or experiments in an assigned area to aid in the solution of a research problem.
Set up and operate equipment used in collecting research data.
Calculate and analyze data.
Select and review literature relating to the assigned area.
Actively participate in research efforts by exploring new possible approaches to problems and discuss possible approaches to problems with supervisor.
Write routine summary reports on results of work and confer with supervisor on interpretation of results and avenues of investigation.
Write manuscripts as author and/or co-author for publication

Required Qualifications:

Masters degree (chemistry, biochemistry or related discipline) with at least one year of experience
Significant background in proteomics
A clear record of publications
Proficiency in bioinformatics approaches including protein quantification, statistical analyses, and pathway analysis
Outstanding communication skills

Preferred Qualifications:

PhD (chemistry, biochemistry or related discipline)
Programming experience
Direct experience with data-independent acquisition

Lab Website: https://sites.google.com/umn.edu/the-danni-li-lab/home

Apply here: https://hr.myu.umn.edu/psc/hrprd/EMPLOYEE/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&SiteId=1&FOCUS=Applicant&JobOpeningId=338758&PostingSeq=1&

view posting
Postdoctoral and Research Assistant Positions in Signal Transduction Quantitative Proteomics (Stem Cell induced-Neurons, Protein Homeostasis, Ubiquitin Intact-mass)
alban ordureau 2021-01-19

Applications are invited for various positions ranging from Research Assistant to Postdoctoral Researcher levels to work in the laboratory of Alban Ordureau in the Cell Biology Program at Memorial Sloan Kettering Cancer Center (MSKCC) in New York. Sloan Kettering Institute at MSKCC provides an exceptionally supportive, collaborative, and comprehensive training and research environment.

We have broad interests in kinases, ubiquitin ligases, and overall protein homeostasis (including autophagy). For further details, please see our website: https://www.mskcc.org/research/ski/labs/alban-ordureau

The successful applicants will deploy a state-of-the-art blend of quantitative proteomics methodologies (TMT, PRM, AHA-methodologies (degradome and translatome), ubiquitin intact-mass and top-down). They will gain experience in understanding signal transduction pathways linked to cellular functions and how they are linked to disease. Proteomics is central to our research, and for this, the lab maintains an Eclipse-ETD/UVPD Orbitrap mass spectrometer.

Applicants with experience in mass spectrometry/analytical chemistry and quantitative proteomic analysis expertise are encouraged to apply. Experience in nanoLC-MS/MS and Orbitrap-based mass spectrometers is preferable, but not necessary, and training can be provided. Experience in proteomics sample preparation (e.g., protein extraction, HPLC separation), mass spectrometry technical development is preferred. Some knowledge or desire to learn Python, R, and the ability to write and develop scripts and modify/implement open-source or published code is desirable. Enthused applicants eager to participate and gain experience in undertaking biological studies to generate samples and validate data would be advantageous, and training can be provided.

Interested candidates should send a cover letter and CV to Dr. Ordureau (ordureau.lab@gmail.com)

view posting
Biotechnology Associate 2, Yale University
ad request 2020-11-23

Yale University offers exciting opportunities for achievement and growth in New Haven, Connecticut. Conveniently located between Boston and New York, New Haven is the creative capital of Connecticut with cultural resources that include three major museums, a critically-acclaimed repertory theater, state-of-the-art concert hall, and world-renowned schools of Architecture, Art, Drama, and Music.

General Purpose:
The MS & Proteomics Resource at Yale has an opening for a M&P level mass spectrometrist with hands on expertise in mass spectrometry and proteomics. The successful candidate will work in a resource laboratory along-side other Biotechnology Associates dedicated to helping a multitude of investigators use MS analyses to advance their proteomics research. The Resource’s mission is to provide investigators of all disciplines (chemical, biological, clinical, etc.) with access to the most advanced mass spectrometry based biotechnologies through efficient and cost-effective proteomics and small molecule services. These technologies are developed and implemented with a broad spectrum of mass spectrometry based techniques for protein/peptide/small molecule chemistries to separate, characterize, profile, and quantify analytes from complex biological samples. The Resource is superbly equipped for this purpose with 5 state-of-the-art MS systems that are utilized for a wide range of biotechnologies.

Required Education and Experience:
Master’s Degree in chemistry, biology, biochemistry, or other related discipline and three years of experience or an equivalent combination of experience and education.

Qualifications:
• Thorough understanding of mass spectrometry.
• Demonstrated knowledge of quantitative proteomics, protein chemistry and proteomics sample handling.
• Well-developed written and oral communication skills..
• Ability to work with and lead multiple projects.
• Working knowledge of major licensed proteomics software.
• Preferred Education and Experience: PhD level in Analytical Chemistry, Biochemistry.

Application: For more information and immediate consideration, please apply online at https://bit.ly/YaleCareers-63101BR. Please be sure to reference this website when applying for this position.

We invite you to discover the excitement, diversity, rewards and excellence of a career at Yale University. One of the country's great workplaces, Yale University offers exciting opportunities for meaningful accomplishment and true growth. Our benefits package is among the best anywhere, with a wide variety of insurance choices, liberal paid time off, fantastic family and educational benefits, a variety of retirement benefits, extensive recreational facilities, and much more.

Yale University considers applicants for employment without regard to and does not discriminate on the basis of an individual’s sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression.

https://your.yale.edu/careers

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Postdoctoral fellow in iPSC, proteomics, and cardiovascular research
edward lau 2020-10-21

Research Opportunity:
Interested in applying your Skyline and mass spec experience to human induced pluripotent stem cell research? We are looking for a postdoctoral fellow to join our team at the University of Colorado School of Medicine. We are interested in examining protein homeostasis and cellular communication using large-scale sequencing, targeted mass spectrometry, and related technologies. Some of our prior work includes methods to quantify protein turnover (https://pubmed.ncbi.nlm.nih.gov/29317621/) and identify protein alternative isoforms (https://pubmed.ncbi.nlm.nih.gov/31825849/). We are now developing companion strategies that are applicable to questions in cell biology and cardiovascular research. Please visit our website at https://laulab.net for details.

Minimum Qualifications:
Ph.D. or equivalent in biochemistry, cell biology, or related scientific fields from an accredited institution.
Minimum of 3 years of active research experience in the life sciences in an academic environment.

Preferred Qualifications:
Prior experience with experiments and data analysis related to next-generation sequencing and/or mass spectrometry approaches.
Prior experience with cell culture models including human induced pluripotent stem cell models as applied toward basic biomedical research.

Application:
Please apply here: https://cu.taleo.net/careersection/2/jobdetail.ftl?job=19172&lang=en
Include a cover letter, CV, and contact info of 3 references.

Salary and Benefits:
Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services. Funding for this position is guaranteed for one year. Continuation of employment thereafter is subject to annual performance review and mutual interest.

Diversity and Equity:
Please click here for information on disability accommodations: http://www.ucdenver.edu/about/departments/HR/jobs/Pages/JobsatCUDenver.aspx
The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

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Postdoctoral Fellowship in Multi-Omics and Machine learning
jmeyer 2020-10-17

The Meyer lab in the Biochemistry Department at the Medical College of Wisconsin is seeking a postdoctoral scholar with experience or interest in mass spectrometry, proteomics, metabolomics, machine learning, bioinformatics, or related areas.

The long-term goal of the Meyer lab is to predict molecular and phenotypic behavior of biology using computational models trained with large-scale omics data. Ongoing projects relate to drug discovery, basic understanding of metabolism, and personalized patient diagnosis. New technology we develop is motivated by the need for cures and diagnostics for neurological diseases and cancer.

The successful candidate will have exclusive access to a new Orbitrap Exploris 240 mass spectrometer with FAIMS Pro.

Competitive candidates will have experience in at least one of the following areas:

  1. data analysis with python and/or R
  2. mammalian tissue culture
  3. bacterial/yeast culture
  4. sample preparation for mass spectrometry
  5. experience operating liquid chromatography mass spectrometry (LC-MS) instruments,
  6. machine learning with scikit-learn (sklearn), keras/tensorflow, pytorch, fastai
  7. website building and maintenance

Please check out our website for more information about previous publications and ongoing projects:
www.jessemeyerlab.com

Interested candidates please apply here:
https://careers.peopleclick.com/careerscp/client_medcollegewi/external_staff/gateway.do?functionName=viewFromLink&jobPostId=16743&localeCode=en-us

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Senior Scientist, Proteomics Mass Spectrometry (Protein Sciences) - Merck Research Laboratories - SSF, CA
daniela.tomazela 2020-09-24

Our Research Laboratories is seeking to recruit an experienced mass spectrometry scientist with broad experience in Proteomics applications to join the Protein Sciences Department in South San Francisco, CA.

The position will be hands-on at the bench and will report to the mass spectrometry group leader.

Responsibilities:
Design and perform proteomics-based experiments, including phospho-proteomics, labeled and label-free differential protein expression, and targeted protein quantification.
Sample preparation for proteomics analysis including protein extraction, immunoprecipitation, proteolytic digestion, and sample clean-up prior to MS analysis.
Perform analytical routines for Tandem liquid chromatography mass spectrometry (LCMSMS) systems maintenance, including calibration, system suitability, and troubleshooting.
Strong communication & interpersonal skills.

Education Minimum Requirement:
PhD in Biochemistry, Cell Biology, Analytical Chemistry or a related field, with a minimum of 3 years relevant postdoctoral or pharmaceutical/biotechnology experience.

Required Experience and Skills:
Knowledge and direct experience with state - of - the - art technologies and methods for mass spectrometry-based proteomics, including Thermo Orbitrap mass spectrometers.
Proficiency in quantitative proteomics techniques SILAC, Tandem Mass Tag (TMT), label-free quantification approaches and peptide fragmentation methods.
Proficiency in using Proteome Discoverer, Peaks, Genedata, MaxQuant, Skyline, and other DB search engine tools.

Preferred Experience and Skills:
Biologics characterization using mass spectrometric methods (PTMs/glycosylation, intact and subunit mass analysis).
Understanding and working knowledge of various analytical methods for protein characterization such as SEC, IEX, RP – HPLC, CE-SDS.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …
Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.
IMPACT.
INSPIRE.

NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement​
OFCCP EEO Supplement
OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
Yes

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:
1

Link to the position:
https://msd.wd5.myworkdayjobs.com/SearchJobs/job/USA---California---South-San-Francisco---Grand-Ave/Senior-Scientist--Proteomics-Mass-Spectrometry--Protein-Sciences-_R74512

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Biogen Biomarkers - Quantitative Proteomics position
omar mabrouk 2020-07-08

Associate Scientist II/III – Fluid Biomarker Assay Development
*Job Description
The Biomarkers group (Section of Clinical Sciences) is seeking a creative and collaborative lab-based scientist engaged in targeted proteomics for the detection of proteins and metabolites in different biological matrices (including plasma, serum, CSF, urine, tissues) to support early clinical stage programs. The successful candidate will be capable of multitasking and effective planning to consistently meet deadlines.
*Responsibilities:
• Targeted protein biomarker assay development using state of the art liquid-chromatography-mass spectrometry (LC-MS) platforms including nano-LC, orbitrap (Q-Exactive, Q-Exactive +, Q-Exactive HF/HFX, Fusion) and UPLC-QQQ MS (AB Sciex)
 Sample preparation (tissues and cell lysates) for protein quantification
 Biotinylation and various bead-antibody conjugation techniques
 Identification and selection of antibodies for immunoprecipitation prior to LC-MS analysis
 Identification of novel techniques and strategies to enhance assay sensitivity
 Fit for purpose qualification of protein and small molecule LC-MS assays
 LC-MS instrumentation troubleshooting
• Point of contact with Contract Research Organizations
 Work with CRO partners to oversee biomarker assay implementation including assay interpretation
• Timely recording keeping and data entry into Electronic Lab Notebook
• Prepare, review, and deliver scientific presentations for internal/external use
*Qualifications

  1. Proven experience with LC-MS instrumentation is required with experience in targeted and global proteomic profiling.
  2. Preference will be given to candidates with hands on experience in developing and qualifying high resolution (Orbitrap) LC-MS assays, including immunoprecipitation LC-MS for the detection of proteins in biological samples
  3. Expertise using Skyline and familiarity with Thermo Xcalibur, Proteome Discoverer, AB Sciex Analyst
  4. Excellent assay troubleshooting skills
  5. Familiarity with neuroscience, including knowledge of neurodegenerative diseases (AD, PD, ALS) is considered a plus but not required
  6. Experience in or willingness to learn classic immunoassay based assays (ELISA)
  7. Demonstrated track record of providing support activities for multiple research projects
  8. Solid work ethic and demonstrated record of productivity such as participating in peer reviewed publications or scientific poster presentations
    *Education
    • BS with >3 years experience or MS with >1 year experience in relevant scientific area

contact me directly at omar.mabrouk@biogen.com if you may be interested

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Immatics Biotechnologies GmbH - Scientist Immunopeptidomics/ Proteomics (all genders welcome)
Christoph S 2020-06-23

http://immatics.com/career-details/scientist-immunopeptidomics-proteomics-all-genders-welcome.html

Scientist Immunopeptidomics/ Proteomics (all genders welcome)
to support our team in the research and development of innovative immunotherapeutic products. You will work in Tuebingen (Germany) in an interdisciplinary environment with colleagues from all research and preclinical/ clinical development departments. Your analytical reasoning and action-oriented style as well as your organization and communication skills will contribute to the team’s success.

The job profile is focused on the characterization and validation of novel HLA presented targets, which will involve but is not limited to the following tasks:
Characterization of HLA presented peptides using Immatics’ proprietary absolute quantitation technology (AbsQuantTM) to identify and validate the best targets for clinical development
Contribution to the elucidation of the biological mechanisms of novel cryptic targets using (targeted) proteomics analysis together with various Omics datasets integrated in Immatics’ XPRESIDENT® target discovery and validation platform
Coordination and project management of target characterization activities involving stakeholders from different departments and disciplines
Development of new strategies and methodologies for target characterization using a diverse set of protein chemistry and mass spectrometry techniques

Your profile
You hold a PhD degree in Life Sciences, Biochemistry, Biotechnology, Pharmacy or have been comparably educated and proven your scientific excellence and your ability to account for complex projects, preferentially with a track record in proteomics or immunopeptidomics. You are familiar with mass spectrometry data analysis and ideally have already gathered experience with targeted methodologies (such as SRM, MRM or PRM) and data independent acquisition. You show a high motivation to translate your scientific findings into clinical development and application. Preferably, you also have previous experience in large-scale data analysis and have already worked with relational databases. You take careful processing and documentation of your results for granted. Your scientific excellence, extraordinary analytical competence and communication skills enable you to successfully contribute to projects as part of a team and to present your work internally or to external partners from the pharmaceutical and biotech industry.

We expect a high degree of independent working, analytical reasoning and excellent communication skills in English. You embrace rapidly changing requirements with an open mind and show a high degree of flexibility in an environment which is marked by a constant striving for excellence. Your motivation is driven by your passion for innovation and science. You approach tasks in a structured, reliable and foresighted manner, combined with an elevated level of individual responsibility, enthusiasm and strong social skills.

What we offer
We are a committed and inspired team and cherish the collegial, highly motivated and family-friendly atmosphere within Immatics. Our culture allows for a high level of originality, independent thinking and initiative. We believe in supporting our employees’ professional and social skills: We enable them to join conferences and trainings as well as to enjoy our Immatics benefits – e.g. job bike, job ticket, Health Programs, childcare benefits, relocation allowance, Company summer and winter events.

If you’re interested in working for Immatics, please apply online and provide your application documents along with the relevant credentials and certificates. Mrs Annemarie Selbenbacher will answer initial questions at +49 89 125 03 98 33 (landline number Germany). Coredi Recruiting GmbH (Mrs Annemarie Selbenbacher) advises Immatics on this job posting.

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