It looks like there are two separate errors in the text file that you attached:
[12/16/2022 9:56:59 AM] ERROR: Failure attempting to write the file D:\EXPLORIS_DATA\Sys\16dez22_QC_iRT_template_Exploris.skyd
[12/16/2022 9:56:59 AM] The process cannot access the file because it is being used by another process.
and the other error is:
[12/16/2022 9:57:02 AM] ERROR: Message: pwiz.Skyline.Model.Results.ChromCacheBuildException: Failed importing results file 'D:\EXPLORIS_DATA\Sys_PRM_Exploris_raws\13dez22_Sys_PRM_scheduled_50cm_110min_2.raw'.
[12/16/2022 9:57:02 AM] [RawFileImpl::ctor()] Corrupt RAW file D:\EXPLORIS_DATA\Sys_PRM_Exploris_raws\13dez22_Sys_PRM_scheduled_50cm_110min_2.raw ---> System.Exception: [RawFileImpl::ctor()] Corrupt RAW file D:\EXPLORIS_DATA\Sys_PRM_Exploris_raws\13dez22_Sys_PRM_scheduled_50cm_110min_2.raw
I am not sure what might be causing the first error. If you had another instance of Skyline running and were looking at the same Skyline document, then that could certainly cause the error. That error does not have anything to do with the contents of "16dez22_QC_iRT_template_Exploris.skyd", it is just saying that some other program is looking at that file when Skyline is trying to change it. Sometimes the problem is that Skyline itself is looking at it, and forgot to close the file before trying to change it.
The other error sounds like there is a problem with "13dez22_Sys_PRM_scheduled_50cm_110min_2.raw". Do you want to send that file to us? We might be able to figure out what is wrong with it, or it might be the file really is corrupted and there is nothing we can do.
Files which are less than 50MB can be attached to this support request. You can upload larger files here: