The answer to the second question: "Could I view spectrum by skyline and pick the strongest product ion to quantitation with skyline?" is Yes.
Skyline provides two possible ranking values in its reports:
Transitions.Library Rank - ranking based on intensity of a spectrum in a spectral library
TransitionResults.Peak Rank - ranking based on imported data
You should consult the tutorial on the Skyline Live Reports to understand how to use them with the Document Grid:
The other important property for what you mention is:
Once you understand these and how to use the Document Grid, it is relatively straightforward to create a report that includes them, filter by a ranking and turn off the Transitions.Quantitative property for all transitions with the rankings you do not want included in your quantification.
Thanks for your interest in Skyline.