Note, however, that LFQ is often used in the field as a synonym for MS1 chromatogram extraction from DDA data, because it was one of the earliest methods for doing "label-free quantification" (as opposed to SILAQ, ITRAQ or TMT which are label based technologies for DDA).
The answer to that question, is also, yes, you can do label free quantification with DDA data in Skyline, but you will want to start more specifically with the MS1 filtering tutorial:
https://skyline.ms/tutorial_ms1_filtering.url
And the DDA Search tutorial:
https://skyline.ms/tutorial_dda_search.url
If you were not thinking DDA, then Nick's more general answer still applies.
--Brendan