Failure attempting to modify the Skyline document with SWATH spectral library search data | Chinmaya k | 2021-08-25 21:02 | |||||||||||||||
Hello, I am trying to search SWATH data against a Prosit-generated spectral library. However, when I tried to reintegrate the peaks using a mProphet model, the Skyline is not able to reintegrate the all peaks with a decoy trained mProphet model. What could be the reason for this failure? Can you please help me to resolve the issue? Please find the below error message for your reference. --------------------------- Skyline --------------------------- Failure attempting to modify the document. Unexpected document change during operation. --------------------------- OK More Info --------------------------- System.IO.InvalidDataException: Unexpected document change during operation. at pwiz.Skyline.Menus.RefineMenu.<>c__DisplayClass5_1.<ShowReintegrateDialog>b__0(SrmDocument doc) in C:\proj\skyline_21_1_x64\pwiz_tools\Skyline\Menus\RefineMenu.cs:line 76 at pwiz.Skyline.SkylineWindow.ModifyDocumentInner(Func`2 act, Action onModifying, Action onModified, String description, Func`2 logFunc, AuditLogEntry& resultEntry) in C:\proj\skyline_21_1_x64\pwiz_tools\Skyline\Skyline.cs:line 786 at pwiz.Skyline.SkylineWindow.ModifyDocumentOrThrow(String description, IUndoState undoState, Func`2 act, Action onModifying, Action onModified, Func`2 logFunc) in C:\proj\skyline_21_1_x64\pwiz_tools\Skyline\Skyline.cs:line 755 at pwiz.Skyline.SkylineWindow.ModifyDocument(String description, IUndoState undoState, Func`2 act, Action onModifying, Action onModified, Func`2 logFunc) in C:\proj\skyline_21_1_x64\pwiz_tools\Skyline\Skyline.cs:line 732 --------------------------- Thank you, Chinmaya |
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