Hi Dietmar,
Great idea. We certainly have a lot of great material to cover. We are just getting started.

Some of the tools have specific annotations they look for, which get installed into Skyline with the tools (e.g. MSstats BioReplicate & Condition, QuaSAR Concentration). They also frequently have documentation available on the tool details page in the Tool Store web pages.

In general, sample annotations can be created through the Settings > Annotations menu item. When you add your annotation, be sure to check the box that indicates it applies to "Replicates". Then you can set the annotation through the Document Grid or Results Grid. The Existing and Quantitative Experiments tutorial covers this on page 33:

https://skyline.gs.washington.edu/labkey/_webdav/home/software/Skyline/%40files/tutorials/ExistingQuant-1_4.pdf#page=33

I am working on another tutorial now that prepares a grouped study data set for analysis with MSstats, which may also be of interest when it is posted sometime in November.

Thanks for your interest in using Skyline in your research and for your enthusiasm for the webinars.

--Brendan