Issue 831: Change or add an option for MS/MS spectrum graph dotp value in mirror plot with Prosit

issues
Status:open
Assigned To:ritach
Type:Defect
Area:Skyline
Priority:3
Milestone:21.2
Opened:2021-07-29 by Brendan MacLean
Changed:2021-07-29 by Brendan MacLean
Resolved:
Resolution:
Closed:
2021-07-29 Brendan MacLean
Title»Change or add an option for MS/MS spectrum graph dotp value in mirror plot with Prosit
Assigned To»ritach
Type»Defect
Area»Skyline
Priority»3
Milestone»21.2
From a user and instructor of Skyline:

"When you correlate two spectrums with the mirror option in Skyline a dotp is calculated, does it take into account the unfragmented precursor peak? I ask this question because I have noticed that PROSIT and other prediction tools (like pdeep3) do not include the unfragmented precursor intensity in the prediction and I guess this affects negatively in the dotp value. Am I right? I attach you some examples in a word document."

She also referenced this paper as a useful source:
https://pubmed.ncbi.nlm.nih.gov/33970638/

Whe should either fix what we do for dotp in this case, or add an option, if we feel what we are currently doing has some utility.
 
 correlated-spectrum.docx