Hello,

I'm currently using Skyline 23.1.0.268 (64-bit) on a MassLynx PC (v4.2 SCN1007, Windows 10) and I would like to perform a CE optimization.

I followed the instructions in your method development guide (https://skyline.ms/_webdav/home/software/Skyline/%40files/tutorials/SmallMoleculeMethodDevCEOpt-23_1.pdf), but I'm getting an error when exporting the method (see below).

Can you help me out with this issue?

Thanks in advance and best regards,

Gioele


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Skyline
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An error occurred attempting to export.
Error generating Quanpedia databank

Command-line: Method\Waters\BuildWatersMethod -w 9.3 -m "D:\Project\MP-80318.PRO\Skyline\VerifyETemplateGV.exp" "D:\Project\MP-80318.PRO\Skyline\CE Optimization\moh5awvf.4hm\transitions.txt"
Working directory: D:\Project\MP-80318.PRO\Skyline\CE Optimization
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OK More Info
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System.IO.IOException: Error generating Quanpedia databank

Command-line: Method\Waters\BuildWatersMethod -w 9.3 -m "D:\Project\MP-80318.PRO\Skyline\VerifyETemplateGV.exp" "D:\Project\MP-80318.PRO\Skyline\CE Optimization\moh5awvf.4hm\transitions.txt"
Working directory: D:\Project\MP-80318.PRO\Skyline\CE Optimization ---> System.IO.IOException: Error generating Quanpedia databank

Command-line: Method\Waters\BuildWatersMethod -w 9.3 -m "D:\Project\MP-80318.PRO\Skyline\VerifyETemplateGV.exp" "D:\Project\MP-80318.PRO\Skyline\CE Optimization\moh5awvf.4hm\transitions.txt"
Working directory: D:\Project\MP-80318.PRO\Skyline\CE Optimization
   at pwiz.Common.SystemUtil.ProcessRunner.Run(ProcessStartInfo psi, String stdin, IProgressMonitor progress, IProgressStatus& status, TextWriter writer, ProcessPriorityClass priorityClass, Boolean forceTempfilesCleanup, Func`3 outputAndExitCodeAreGoodFunc, Boolean updateProgressPercentage) in C:\proj\skyline_23_1\pwiz_tools\Shared\Common\SystemUtil\ProcessRunner.cs:line 181
   at pwiz.Skyline.Util.Extensions.UtilProcess.RunProcess(ProcessStartInfo psi, String stdin, String messagePrefix, IProgressMonitor progress, IProgressStatus& status) in C:\proj\skyline_23_1\pwiz_tools\Skyline\Util\Extensions\UtilProcess.cs:line 45
   at pwiz.Skyline.Model.MethodExporter.ExportMethod(String exeName, List`1 argv, String fileName, String templateName, Dictionary`2 dictTranLists, IProgressMonitor progressMonitor) in C:\proj\skyline_23_1\pwiz_tools\Skyline\Model\Export.cs:line 4731
   at pwiz.Skyline.Model.WatersMethodExporter.ExportMethod(String fileName, String templateName, IProgressMonitor progressMonitor) in C:\proj\skyline_23_1\pwiz_tools\Skyline\Model\Export.cs:line 4523
   at pwiz.Skyline.Controls.LongWaitDlg.RunWork(Action`1 performWork) in C:\proj\skyline_23_1\pwiz_tools\Skyline\Controls\LongWaitDlg.cs:line 254
   --- End of inner exception stack trace ---
   at pwiz.Skyline.Util.Helpers.WrapAndThrowException(Exception x) in C:\proj\skyline_23_1\pwiz_tools\Skyline\Util\Util.cs:line 1922
   at pwiz.Skyline.Controls.LongWaitDlg.PerformWork(Control parent, Int32 delayMillis, Action`1 performWork) in C:\proj\skyline_23_1\pwiz_tools\Skyline\Controls\LongWaitDlg.cs:line 202
   at pwiz.Skyline.Controls.LongWaitDlg.PerformWork(Control parent, Int32 delayMillis, Action`1 performWork) in C:\proj\skyline_23_1\pwiz_tools\Skyline\Controls\LongWaitDlg.cs:line 140
   at pwiz.Skyline.FileUI.ExportDlgProperties.PerformLongExport(Action`1 performExport) in C:\proj\skyline_23_1\pwiz_tools\Skyline\FileUI\ExportMethodDlg.cs:line 2313
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