Hello to the Skyline team!

I have greatly enjoyed using y'alls software but have been getting hung up on an little issue involving my figures of merit. In some of my quantitative experiments (for small molecules) I have been unable to get consistent LOD values utilizing the 'blank plus 3* SD'. Although I have a handful of blanks within these runs, I believe my issue is due to the fact that there are no peaks within the blanks of my given RT window. I have used the bilinear regression to utilize the turning point as my LOD which I have greatly enjoyed but would like to be able to calculate my LOD with both approaches.

I am looking for some guidance as to how to have some numerical value for my blank signal (peak area?) that would allow me to get usable SD's.

I apologize if this question has been answered already and I greatly appreciate your help.

Thanks:)