Fail to save skyline file

Fail to save skyline file nicolas hartel  2023-04-07 10:30

Hi Skyline team,

I am just trying to save an "imported DDA results" experiment but I get hit with this message upon trying to "save" or "save as",
"Failed writing to C:\my_folder\experiment.sku"

Additional text is in the attached screenshot but here is the first line of the "more info"
System.Reflection.TargetInvocationException ---> pwiz.Skyline.Util.AssumptionException
at pwiz.Skyline.Util.Assume.Fail(String error) in C:\proj\skyline_22_2\pwiz_tools\Skyline\Util\Util.cs:line 2080

Nick Hartel

Nick Shulman responded:  2023-04-07 10:52
Someone in the our lab ran into this bug a few months ago. Unfortunately, it is impossible to save the document once you have gotten in this state.

This bug happens if you use the protein grouping feature in Skyline and there are some proteins that Skyline is able to fetch information for from the uniprot website, as well as at least one protein that Skyline cannot fetch information for. (Basically, some of the proteins in your fasta file had names that were recognized and some that did not).

We have fixed this bug in Skyline-daily, but this bug has not been fixed in Skyline 22.2.
Sorry about this bug. I will ask around and see whether we can release an updated version of Skyline 22.2.
-- Nick