IM-TOF data will not import into newest release

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IM-TOF data will not import into newest release Allison Stewart  2021-11-02
 

I am unable to import IM-TOF data in the updated version of Skyline-daily. The message I receive is as follows:

At 8:39 AM:
Failed importing results file 'C:\Users\akstewar\Desktop\BA FMT 2021\01Nov2021 BA Cal Curve\01Nov2021 BA Cal Curve\Cal_1.d'.
[MassHunterData::hasIonMobilityData()] Could not load file or assembly 'BaseDataAccess, Version=10.0.1.10035, Culture=neutral, PublicKeyToken=null' or one of its dependencies. The system cannot find the file specified.
pwiz.Skyline.Model.Results.ChromCacheBuildException: Failed importing results file 'C:\Users\akstewar\Desktop\BA FMT 2021\01Nov2021 BA Cal Curve\01Nov2021 BA Cal Curve\Cal_1.d'.
[MassHunterData::hasIonMobilityData()] Could not load file or assembly 'BaseDataAccess, Version=10.0.1.10035, Culture=neutral, PublicKeyToken=null' or one of its dependencies. The system cannot find the file specified. ---> System.Exception: [MassHunterData::hasIonMobilityData()] Could not load file or assembly 'BaseDataAccess, Version=10.0.1.10035, Culture=neutral, PublicKeyToken=null' or one of its dependencies. The system cannot find the file specified.
at pwiz.CLI.msdata.ReaderList.read(String filename, MSData result, Int32 runIndex, ReaderConfig config)
at pwiz.ProteowizardWrapper.MsDataFileImpl..ctor(String path, Int32 sampleIndex, LockMassParameters lockmassParameters, Boolean simAsSpectra, Boolean srmAsSpectra, Boolean acceptZeroLengthSpectra, Boolean requireVendorCentroidedMS1, Boolean requireVendorCentroidedMS2, Boolean ignoreZeroIntensityPoints, Int32 preferOnlyMsLevel, Boolean combineIonMobilitySpectra, Boolean trimNativeId) in C:\proj\pwiz_x64\pwiz_tools\Shared\ProteowizardWrapper\MsDataFileImpl.cs:line 197
at pwiz.Skyline.Model.Results.MsDataFilePath.OpenMsDataFile(Boolean simAsSpectra, Boolean preferOnlyMs1, Boolean centroidMs1, Boolean centroidMs2, Boolean ignoreZeroIntensityPoints) in C:\proj\pwiz_x64\pwiz_tools\Skyline\Model\Results\MsDataFilePath.cs:line 291
at pwiz.Skyline.Model.Results.ChromCacheBuilder.BuildCache() in C:\proj\pwiz_x64\pwiz_tools\Skyline\Model\Results\ChromCacheBuilder.cs:line 188
--- End of inner exception stack trace ---

 
 
Nick Shulman responded:  2021-11-02
I believe that sort of error means that some important files have been deleted from your Skyline installation.

I would recommend that you uninstall Skyline and then install it again from the Skyline website.
-- Nick
 
Brendan MacLean responded:  2021-11-02
You can also follow these instructions to avoid losing settings across a clean reinstallation:

https://skyline.ms/install_recover.url
 
Nick Shulman responded:  2021-11-04
Thank you for reporting this issue.
The latest Skyline-Daily installer that we made is missing several of the files that are needed for Agilent.
We will try to fix this soon (probably less than a week).

I believe the Skyline-Daily Administrator Installer does not have this problem, so you might have a better outcome if you use that until we are able to fix the regular Skyline-Daily installer:
https://skyline.ms/wiki/home/software/Skyline/daily/page.view?name=install-administrator-64

-- Nick