Hi Brian,
thank you for getting back to me regarding this. I would see it in the way that instruments would provide you with an estimated equation to calculate RF lens values automatically (as they also do for CEs) based on m/z and tuning results. However this is, as always, an estimation. Accordingly to our Thermo application scientist contact, RF lens tuning could potentially improve signal intensity of individual analytes. However, I agree that this logic applies to many parameters, like declustering potential etc., which are not tunable via Skyline as of now. I was just encouraged to ask as I discovered the aforementioned issue 505.
Roman