For certain samples I run, I have extremely long tailing. This is not due to a contaminating peak. Typically I include the whole peak from baseline to baseline (Skyline usually finds this and I don't often need to manually adjust peaks), but in some samples when the tailing takes a very long time to come to baseline this ends up seemingly increasing the noise in the sample. Does Skyline have integrator options like a threshold setting than can be adjusted which is computed from the 2nd derivative which approaches zero as the tail becomes horizontal?
Attached is a photo of such a troublesome sample showing the 3 precursors, but if you look at individual transitions, the same tailing trend is evident across the board.