Let me just suggest you have a look at the Hi-Res Metabolomics tutorial (all with MS1):
And the paper on targeting small molecules with Skyline, which has an experiment using only MS1:
While the LipidCreator software can greatly help in getting the necessary chemical formulas for lipids into the Skyline Targets list, it is not necessary, and Skyline can target any molecule by chemical formula, extracting a single XIC or multiple for the isotope envelope of the mulecule in MS1, just as it has done for peptides since 2011 or so for peptides.
Hope this information is helpful. We encourage you to learn more and use these features.