semi-automated removal of 'interfered' transitions?

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semi-automated removal of 'interfered' transitions? Jason Held  2019-09-04
 

Hi,

I've got a very large DIA analysis, used mProphet for peak picking, and am wondering if Skyline has any additional features I'm not aware of that help for (semi?)-automated removal of interfered or bad performing transitions such as the y10 in LPDGNGIELCR highlighted in your large scale DIA tutorial.

Cheers,
Jason

 
 
Brendan MacLean responded:  2019-09-04

Hi Jason,
Nothing quite yet. Though, it is an area of interest.

Your best option right now would be to have a look at AvantGardeDIA in the Skyline Tool Store.

https://skyline.ms/skyts/home/software/Skyline/tools/details.view?name=AvantGardeDIA

https://www.biorxiv.org/content/10.1101/565523v1

Hope this helps.

--Brendan

 
Jason Held responded:  2019-09-04

Interesting. Thanks Brendan.
Jason