Variable modification

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Variable modification dawn dufield  2019-08-05 14:39
 

How do you add a modification that you do not know which AA it goes on. For example a ribosylation that I know adds a certain MW, but fall off in the MS so doesn't change the fragments? or how do you look for a modification that can be on any AA's without creating it on all possible combinations.. Can you generate a list of the possible MRM's?

T

 
 
Brendan MacLean responded:  2019-08-05 23:10

All possible through Edit > Modify Peptide and neutral losses.

There is a webinar on peptide modifications that may help.

https://skyline.ms/webinar10.url