Hi Guys,

We have set up a template for small molecule C13 incorporation into metabolites, using previous versions of Skyline.
When opened with Skyline 4.1 64 bit, the isotopolog order is altered, and this could cause problems with our end users and their manipulation of peak areas of the different species.(see attached PDF)

I might add that we depend heavily on skyline for our targeted metabolomics and proteomics and really appreciate the effort put into the program by your team. I can send relevant Skyline files if the need arises.