Hi Chris,
One of the most important features of the Skyline 4.1 release is the change to small molecule handling which brings the internal model into line with that already in use for peptides (neutral molecule with adducts, similar to neutral peptide with charge+modifications). It's perhaps subtle from the user perspective, but programmatically it's now much easier to extend small molecule support to things like spectral libraries (done) and, yes, iRT (not done, but now possible).
So, look for small molecule support in iRT, optimzation libraries, IMS libraries, and others in upcoming Skyline-Daily releases. I don't have a schedule to offer for that yet. But now that it can happen, it will.
Cheers
Brian |