Storing DP values (Declustering Potential) within Skyline

Storing DP values (Declustering Potential) within Skyline kathrin lauter4951  2016-02-23 08:26
Hi Brendan!

I am using Skyline and I am really appreciating this software!

As I am doing Optimisation of the CE and DP values for the peptides i am analysing, I was happy to see that there is the possibilty to store optimized CE values in a database which makes life much easier.

Now I would like to know if it is/will be possible to also store optimized DP values. In the "optimization library" I just see the opportunity to store CE values or Compensation Voltage...

Thanks, Kathrin
Brendan MacLean responded:  2016-02-23 08:36
Hi Kathrin,
The general consensus seems to be the DP optimization is not worth the effort. On collaborator even had an ASMS poster on this several years ago. I don't think it would be that hard for us to enable, but doing this work may not be a good use of your time. Have you verified that you are getting important benefit from DP optimization?

We chose not to include it in the optimization libraries, because we didn't know anyone who felt this was important and didn't want to imply further that it is.

Please let us know what you think, and maybe provide some evidence of its utility to you.

Thanks for your feedback.

chi nguyen responded:  2023-03-17 12:32
Hello Skyline team,
I was just wondering if you have revisited this issue and reconsider having declustering potential option implemented in the optimization library? That would be great.

Brendan MacLean responded:  2023-03-22 05:07
Not yet. Most recently in this area, we have been focusing on CE optimization for TOF instruments.

Next time we work on expanding the optimization library support, we will definitely consider your vote in favor of including DP.

Thanks for your feedback.