Skyline provides a great interface for the development and analysis of your MRM assays.
Best way to find out is to try it yourself! Just a few statements about it: it's really user-friendly; you get started easily; the tutorials clearly explain the various possibilities; MRM assays can be prepared for different mass spectrometers; the various (graphical) representations to visually inspect your results are great and you have multiple options to manually adjust settings; the support for questions and problems is really fast and helpful!

Karin Wolters Ph.D
Department of Analytical Chemistry
University of Groningen
The Netherlands