Does Skyline support multi-channel analysis (e.g. DAD channel)? For small molecule identification and quant

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Does Skyline support multi-channel analysis (e.g. DAD channel)? For small molecule identification and quant dvik29536  2023-03-29 02:43
 

Hi,

I used Skyline quite a lot in the past for target peptide quantification, and loved the software (so a heartfelt thanks to the team!)

I am starting a new project, which is a small molecule project, and I want to use Skyline if possible. However, our lab setup for small molecule quant is based on three LC channels (MS1, DAD/UV and a Chemiluminescent Nitrogen Detector).

Is it possible to use Skyline for this type of multi-channel analysis?

When I last used Skyline, the Small Molecule features were gaining traction, but where still early dev. and I can see how much has happened since then! I have searched the documentation but so far without result.

thanks,
Daniel

 
 
Brian Pratt responded:  2023-03-29 08:50

Hi Daniel,

I believe Skyline can display those traces (if not, we'd want to hear about that) but they're not used for any computational analysis as far as I know.

Brian Pratt