Crash when importing Raw file

Crash when importing Raw file berjan been 24727  2021-07-01

When importing certain files from our Xevo G2-XS QToF Skyline crashes.
It crashes directly, without displaying an error, just a windows popup that the program has stopped working. The files open in MassLynx without problem.
The samples are system suitability checks for small molecule work. Skyline is updated to the latest version.

What kind of information would you need more to help with this?

Nick Shulman responded:  2021-07-01
Can you send us one of your raw files that is having problems? You can zip up the .raw folder and upload it here:

It would be interesting to check whether this problem also happens with ProteoWizard SeeMS.exe or MSConvert.exe.

If you think this might be a Skyline-specific problem, then you should also send us your Skyline document.
In Skyline you can use the menu item:
File > Share
to create a .zip file containing your Skyline document.

-- Nick
berjan been 24727 responded:  2021-07-02
I've uploaded the files and will try to use the other programs today.
Nick Shulman responded:  2021-07-02
Thank you for sending us those files.

The error is happening when Skyline is trying to get centroided spectra. You can work around this problem in Skyline by going to:
Settings > Transition Settings > Full Scan
and change "Precursor Mass Analyzer" to something else (anything other than "Centroided").

I will ask around and try to find out if someone can fix this bug.

-- Nick
berjan been 24727 responded:  2021-07-05
Thanks Nick.

Changing the Precursor Mass Analyzer did fix it.