citrulline rmoulder  2019-08-07

Dear Skyline team,

I would like to add citrulline as a post translational modification. Should I define the post translational modification by composition, or can I add a new amino acid. At present, as a work round, I have assigned the heavy synthetic citrulline containing peptide as deamidated.

Thank you in advance for your recommendations.

Best regards

Robert Moulder
Turku Bioscience Centre

Nick Shulman responded:  2019-08-07
There is no way to add new amino acids to Skyline.

Therefore your idea to treat citrulline as a modification of some other amino acid sounds like the right thing to do.
-- Nick