Sebastien Gallien Ph.D., works as a Scientist at Thermo Fisher Scientific. He received his Ph.D. in analytical chemistry from the University of Strasbourg, France, at the Bioorganic Mass Spectrometry Laboratory in 2009. In 2010, he joined the Luxembourg Clinical Proteomics Center to work with Prof. Bruno Domon as a post-doctoral fellow and then a staff scientist. His research was focused on technology and methodology developments for targeted quantitative proteomics with emphasis on clinical applications. In 2016, he joined the Precision Medicine Science Center at Thermo, where he focuses developments to improve proteomics analytical workflows, with a focus on targeted analyses that lead to clinically actionable targeted protein panels.

Towards Turnkey Targeted Proteomics Solutions Using SureQuant Internal Standard Triggered Acquisition on Orbitrap Mass Spectrometers

An extension of HR-PRM, called SureQuant method, has recently been introduced to progress targeted proteomics. This method, implemented in the native instrument control software of Orbitrap instruments, uses spiked-in internal standards to dynamically control the acquisition process and maximize its productivity. Its ability to deliver high-density, ultra-sensitive measurements in large-scale experiments has benefited to a variety of applications (including signaling pathway monitoring, global plasma profiling, or host cell protein monitoring during biopharmaceuticals development. Read More Read Less

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