Version 1.0.4344
Uploaded Jun 2, 2024
The PRM Conductor is designed to help bridge the gap between discovery and targeted MSn experiments by automating several tasks related to choosing and scheduling high-quality precursors. PRM Conductor labels transitions as “good” or “bad” with a set of common-sense metrics like area, signal-to-background, and shape correlation, and then filters precursors by requiring a certain number of “good” precursors. Then PRM Conductor allows to schedule precursors in an assay and visualize the effect of instrumental parameters on the instrument acquisition rate. Finally, PRM Conductor can export precursor and transitions lists, Skyline analysis templates, and directly create method files for the Thermo Fisher Scientific Stellar MS, including support for the Adaptive RT algorithm which enables scheduled time windows of < 1 minute. Support is included for targeted tandem mass tag experiments, absolute quantitation with heavy standards, and MS3 analysis.