Inspired by this exchange:
https://skyline.ms/announcements/home/support/thread.view?rowId=62846
wherein a new user hasn't grasped the fundamental purpose of Skyline and is trying to open a mass spec file rather than importing it atop a targets list.
Nick kindly points them at the tutorials and gives a brief explanation of how Skyline needs targets before it can extract chromatograms. I might add that if the user simply wants to inspect the data, they can download SeeMS.