Issue 827: X! Tandem point mutations not understood by BlibBuild

issues
Status:open
Assigned To:Kaipo
Type:Defect
Area:BiblioSpec
Priority:2
Milestone:21.2
Opened:2021-07-28 by Brendan MacLean
Changed:2021-07-28 by Brendan MacLean
Resolved:
Resolution:
Closed:
2021-07-28 Brendan MacLean
Title»X! Tandem point mutations not understood by BlibBuild
Assigned To»Kaipo
Type»Defect
Area»BiblioSpec
Priority»2
Milestone»21.2
This was reported on the support board:

https://skyline.ms/announcements/home/support/thread.view?rowId=52111

The key XML element that BlibBuild is failing to make sense of is:

<aa type="S" at="24" modified="44.00846" pm="M" />

As an initial fix, I think we need to just change the peptide to replace the S at 24 to M.

A more complete fix would preserve the point mutation information somehow in a way that would allow Skyline to make a correct protein assignment based on the original peptide sequence.