Issue 687: Implement support for charged losses where Skyline currently has only neutral losses

Status:resolved
Assigned To:Brendan MacLean
Type:Todo
Area:Skyline
Priority:2
Milestone:19.2
Opened:2019-10-08 by Brendan MacLean
Changed:2019-12-03 by Nick Shulman
Resolved:2019-12-03 by Nick Shulman
Resolution:Fixed
Closed:
2019-10-08 Brendan MacLean
Title»Implement support for charged losses where Skyline currently has only neutral losses
Assigned ToGuest»Nick Shulman
Type»Todo
Area»Skyline
Priority»2
Milestone»19.2
Researchers doing glycoproteomics using Skyline have a need to define charged losses from specific modifications, the way we currently allow neutral losses from structural modifications on peptides.

Here is a relevant support request:
https://skyline.ms/announcements/home/support/thread.view?rowId=41072

It has also been requested that we support some existing lists of glycan structure modifications found in human samples. e.g.

https://assets.thermofisher.com/TFS-Assets/CMD/manuals/man-xcali-97974-biopharma-finder-user-manxcali97974-en.pdf#page=559

It seems like we are likely to want to define charged losses from these structures, though it is not yet immediately obvious from the above list how we would get that information.

2019-12-03 Nick Shulman
resolve as Fixed
Statusopen»resolved
Assigned ToNick Shulman»Brendan MacLean
Charged losses were implemented on November 5, 2019:
https://github.com/ProteoWizard/pwiz/pull/692