|Title||»||Add filter exclusion for peptide duplication|
|Assigned To||»||Brendan MacLean|
The ability to filter peptides in the settings by whether or not they are "unique" to a background proteome has been requested. Unfortunately, this feature probably requires a better definition of uniqueness than is possible with the current background proteome implementation. We would need to introduce the concept of source genes for each protein in order to avoid letting multiple isoforms for the same gene cause peptide exclusion, and even an inability to find uniquely identifying peptides for a FASTA sequence with a very similar isoform.
Once we can produce source gene information for each FASTA sequence, this would be a very useful feature to add to Skyline.