|Title||»||Add ability to specify a list of peptide sequences to BlibBuild|
In a meeting with Jake Jaffe, here in Cambridge, he suggested that it would be great to be able to build more targeted libraries from within Skyline. He has potentially hundreds of msms.txt files from MaxQuant from which he would like to accumulate library data for a know set of target peptides, without necessarily building the entire library for all peptides found in these searches.
To achieve this, we would need to adapt BlibBuild to support passing in a list of target peptide sequences (either bare sequences or in modified format should both be supported), and then BlibBuild would simply ignore all spectra matching other peptides.
You can sort of get this in Skyline today, if you first build the complete library and then add it to a Skyline document that contains just the peptides of interest, and use that to perform a File > Share - Minimal operation. But we'd like to be able to get their directly in the library build step.