--------------------------- Skyline --------------------------- Failure opening C:\Users\sophi\Downloads\1_MQ.mzML. The file you are trying to open ("C:\Users\sophi\Downloads\1_MQ.mzML") does not appear to be a Skyline document. Skyline documents normally have a ".sky" or ".sky.zip" filename extension and are in XML format. --------------------------- OK More Info --------------------------- Skyline (64-bit) 25.1.0.237 (519d29babc) System.IO.IOException: The file you are trying to open ("C:\Users\sophi\Downloads\1_MQ.mzML") does not appear to be a Skyline document. Skyline documents normally have a ".sky" or ".sky.zip" filename extension and are in XML format. ---> System.Reflection.TargetInvocationException: There is an error in XML document (2, 2). ---> System.InvalidOperationException: There is an error in XML document (2, 2). ---> System.InvalidOperationException: was not expected. at Microsoft.Xml.Serialization.GeneratedAssembly.XmlSerializationReaderSrmDocument.Read1_srm_settings() --- End of inner exception stack trace --- at System.Xml.Serialization.XmlSerializer.Deserialize(XmlReader xmlReader, String encodingStyle, XmlDeserializationEvents events) at pwiz.Skyline.SkylineWindow.<>c__DisplayClass771_0.b__0(IProgressMonitor progressMonitor) in C:\proj\skyline_25_1\pwiz_tools\Skyline\SkylineFiles.cs:line 325 at pwiz.Skyline.Controls.LongWaitDlg.RunWork(Action`1 performWork) in C:\proj\skyline_25_1\pwiz_tools\Skyline\Controls\LongWaitDlg.cs:line 254 --- End of inner exception stack trace --- at pwiz.Skyline.Util.Helpers.WrapAndThrowException(Exception x) in C:\proj\skyline_25_1\pwiz_tools\Skyline\Util\Util.cs:line 1926 at pwiz.Skyline.Controls.LongWaitDlg.PerformWork(Control parent, Int32 delayMillis, Action`1 performWork) in C:\proj\skyline_25_1\pwiz_tools\Skyline\Controls\LongWaitDlg.cs:line 202 at pwiz.Skyline.Controls.LongWaitDlg.PerformWork(Control parent, Int32 delayMillis, Action`1 performWork) in C:\proj\skyline_25_1\pwiz_tools\Skyline\Controls\LongWaitDlg.cs:line 140 at pwiz.Skyline.SkylineWindow.OpenFile(String path, FormEx parentWindow) in C:\proj\skyline_25_1\pwiz_tools\Skyline\SkylineFiles.cs:line 341 --- End of inner exception stack trace --- ---------------------------