Dear MacCoss lab, It seems the problem with Bruker files (for Solarix 12T FT-ICR) happen again with the new version of Skyline. The error is: "Failed importing results file 'C:\Data\2022\Proteomics\20220714-LCpepmap\BSA_1uM_AutoMSMS_Acc-0p3s_000001.d'. unknown compressor id: 6bb2e64a-27a0-4575-a66a-4e312c8b9ad7 pwiz.Skyline.Model.Results.ChromCacheBuildException: Failed importing results file 'C:\Data\2022\Proteomics\20220714-LCpepmap\BSA_1uM_AutoMSMS_Acc-0p3s_000001.d'. unknown compressor id: 6bb2e64a-27a0-4575-a66a-4e312c8b9ad7 ---> System.Exception: unknown compressor id: 6bb2e64a-27a0-4575-a66a-4e312c8b9ad7 at pwiz.CLI.msdata.ReaderList.read(String filename, MSData result, Int32 runIndex, ReaderConfig config) at pwiz.ProteowizardWrapper.MsDataFileImpl..ctor(String path, Int32 sampleIndex, LockMassParameters lockmassParameters, Boolean simAsSpectra, Boolean srmAsSpectra, Boolean acceptZeroLengthSpectra, Boolean requireVendorCentroidedMS1, Boolean requireVendorCentroidedMS2, Boolean ignoreZeroIntensityPoints, Int32 preferOnlyMsLevel, Boolean combineIonMobilitySpectra, Boolean trimNativeId) in C:\proj\skyline_21_2\pwiz_tools\Shared\ProteowizardWrapper\MsDataFileImpl.cs:line 197 at pwiz.Skyline.Model.Results.MsDataFilePath.OpenMsDataFile(Boolean simAsSpectra, Boolean preferOnlyMs1, Boolean centroidMs1, Boolean centroidMs2, Boolean ignoreZeroIntensityPoints) in C:\proj\skyline_21_2\pwiz_tools\Skyline\Model\Results\MsDataFilePath.cs:line 291 at pwiz.Skyline.Model.Results.ChromCacheBuilder.BuildCache() in C:\proj\skyline_21_2\pwiz_tools\Skyline\Model\Results\ChromCacheBuilder.cs:line 188 --- End of inner exception stack trace --- " I attached the file I am used below. Could you please take a look when you have time? Thank you very much! All the best, Hung