I don't think so. Many changes to the settings are not yet possible. We have generally been assuming people start with a template which has most of their desired settings in place and then maybe only vary a few key parameters.
Can you describe a bit more what you are trying to achieve?
Obviously, not everything is possible through the Skyline command-line interface, and it would be cost-prohibitive for us to implement everything. So, we need to add things as they get requested with interesting use cases.