I am running Windows 7.
I had an old version of Skyline that may not have been uninstalled properly. It still appeared in the control panel list of installed programs, but there were no program files that I could find. There was copy of the old program in my user's Installed Programs directory. I removed it. Unfortunately, I didn't make note of what version it was, but I think it was 2.1. The last time I installed it was back in 2014.

I get the following error when I try to install 4.1, either the normal version, or the stand-alone one.

When I run 'setup.exe', I see a dialog with the title 'Cannot start Application'. The text reads 'Application cannot be started. Contact the application vendor.' There is a 'Details...' button.

The following text is displayed when I click it.
PLATFORM VERSION INFO
    Windows             : 6.1.7601.65536 (Win32NT)
    Common Language Runtime     : 4.0.30319.42000
    System.Deployment.dll         : 4.7.2558.0 built by: NET471REL1
    clr.dll             : 4.7.2563.0 built by: NET471REL1
    dfdll.dll             : 4.7.2558.0 built by: NET471REL1
    dfshim.dll             : 4.0.41209.0 (Main.041209-0000)

SOURCES
    Deployment url            : file:///C:/Users/mmarx.AGILENT/Documents/Skyline-64_4_1_0_11796/Skyline-64_4_1_0_11796/Skyline.application

ERROR SUMMARY
    Below is a summary of the errors, details of these errors are listed later in the log.
    * Activation of C:\Users\mmarx.AGILENT\Documents\Skyline-64_4_1_0_11796\Skyline-64_4_1_0_11796\Skyline.application resulted in exception. Following failure messages were detected:
        + The system cannot find the file specified. (Exception from HRESULT: 0x80070002)

COMPONENT STORE TRANSACTION FAILURE SUMMARY
    No transaction error was detected.

WARNINGS
    There were no warnings during this operation.

OPERATION PROGRESS STATUS
    * [3/21/2018 5:46:21 PM] : Activation of C:\Users\mmarx.AGILENT\Documents\Skyline-64_4_1_0_11796\Skyline-64_4_1_0_11796\Skyline.application has started.

ERROR DETAILS
    Following errors were detected during this operation.
    * [3/21/2018 5:46:21 PM] System.IO.FileNotFoundException
        - The system cannot find the file specified. (Exception from HRESULT: 0x80070002)
        - Source: System.Deployment
        - Stack trace:
            at System.Deployment.Internal.Isolation.IsolationInterop.GetUserStore(UInt32 Flags, IntPtr hToken, Guid& riid)
            at System.Deployment.Internal.Isolation.IsolationInterop.GetUserStore()
            at System.Deployment.Application.ComponentStore..ctor(ComponentStoreType storeType, SubscriptionStore subStore)
            at System.Deployment.Application.SubscriptionStore..ctor(String deployPath, String tempPath, ComponentStoreType storeType)
            at System.Deployment.Application.SubscriptionStore.get_CurrentUser()
            at System.Deployment.Application.ApplicationActivator.UninstallApplicationAndRedirectActivation(Boolean& isShortCut, Uri& deploymentProviderUri, String textualSubId, Uri activationUri)
            at System.Deployment.Application.ApplicationActivator.CleanApplicationReInstall(Boolean isShortcut, Uri deploymentUri, Uri activationUri, BrowserSettings browserSettings, String textualSubId, String errorPageUrl, String deploymentProviderUrlFromExtension, String shortcutFilePath)
            at System.Deployment.Application.ApplicationActivator.PerformDeploymentActivationWithRetry(Uri activationUri, Boolean isShortcut, String textualSubId, String deploymentProviderUrlFromExtension, BrowserSettings browserSettings, String& errorPageUrl)
            at System.Deployment.Application.ApplicationActivator.ActivateDeploymentWorker(Object state)

COMPONENT STORE TRANSACTION DETAILS
    No transaction information is available.