Hi Elden,
This seems to indicate a dependency issue with "pwiz_data_cli.dll", which is our ProteoWizard data reader DLL, providing all access to raw mass spec data.

I just did my first clean installation of this version onto a new system and had no issues testing data import.

I suppose your case may also indicate some interaction with ion mobility and/or small molecules, which I have not hit yet.

Can you upload your document to the following link?

http://skyline.ms/files.url

This will allow me to more easily check whether I can open it.

If I can, then we can begin to look at why you appear to be missing a dependency of pwiz_data_cli.dll, while I appear to be able to use it without issues.

--Brendan

Hi Brenden,

I just uploaded two docs that I could not open with the new version. One is a small molecule doc but the other is a normal peptide doc.

thanks for your help,

Elden

Hmm... It sees that I cannot save a new document either (see below). Maybe I need to perform a fresh install?

Failed writing to C:\Users\Decs\test.sky
could not load file or assembly 'pwiz_data_cli.dll' or one of its dependencies. The specified module could not be found

yes, I am here. Via remote desktop?