Dear Skyline Users,

I have just released Skyline 3.1.0.7312, the most recent update to the Skyline public release.

First, in updating to this release there are two things you should be aware of:

1. This release no longer supports Windows XP (nearly 1 year after Microsoft stopped supporting it).
2. Upgrading requires that you go to the Skyline web page and install again manually. (NO AUTOMATIC UPGRADE)

PLEASE UPGRADE!! And you will get the following improvements:

• Integrated Group Comparison support (see images below). Get started with:
  • View > Group Comparisons > Add
  • Settings > Document Settings - Group Comparisons tab
  • Tutorial coming soon...
• Support for custom ions / small molecule targeted MS
  • Use Edit > Insert > Transitions - Small molecules to start a Skyline small molecule document
  • Watch Skyline Tutorial Webinar #4 - Preview of Small Molecule Support
• Cloud chromatogram extraction from full-scan data with Chorus
  • Consult the Chorus Cloud Chromatogram Extraction tip to get started.
• New wizards for importing peptide searches with PRM and DIA data sets
• Direct filtering of Document Grid views
• Support for iRT scores in chromatogram libraries from Panorama
• Faster start-up and file open and save progress
• Fully enforced light-heavy ion matching and Find form support for "Mismatched transitions"
• Improved optimization library support
• First draft translations for Chinese and Japanese

If you experience trouble upgrading to this version, please check the following page before requesting support:

Recovering From a Broken Installation

Thanks for using Skyline in your research.

Brendan MacLean
Skyline Principal Developer