Location: Halifax, Canada

Employer: Dalhousie University

Duration: 2 Years

Salary: $CDN50, 000 – 60, 000

Description

The candidate will join a team of scientists, engineers and clinicians from across Canada that are developing innovative approaches toward the manufacturing, characterization, and de-risking of innovative next generation chimeric antigen receptor T-cell (CAR-T) therapies for cancer treatment. The candidate will develop novel immunometabolomic methods using high-resolution tandem mass spectrometry, combined with advanced analysis of both CAR-T laboratory samples and samples from patients enrolled in CAR-T clinical trials to identify unique biomarkers relevant to CAR-T potency and efficacy?
Research to be conducted by the candidate will provide a unique training experience at the interface between biology, analytical chemistry, and clinical research. The successful candidate will join a group of experts in proteomics, metabolomics and cell signalling.
Metabolomics to advance CAR-T therapy. Cell therapies are an emerging modality; one that comes with additional levels of complexity as they are viable cellular systems. Advancement of this potentially revolutionary treatment modality would be accelerated by the development of innovative techniques to efficiently characterize the CAR-T systems. Molecular complexity is magnified significantly with cell therapies; therefore, adaptation and innovation of analytical methodologies is required to begin to address critical questions around the interplay between metabolism and potency. The successful candidate will develop quantitative immunometabolomic methods to push boundaries of sensitivity, throughput, and dynamic range to allow identification of potential biomarkers relevant to CAR-T potency and favorable host metabolic & microbiome phenotype.
Requirements
The successful candidate should have or be nearing completion of a PhD in Analytical Chemistry, Biochemistry, or related field and have published papers in relevant journals as primary author. Experience in liquid chromatography-mass spectrometry based metabolomics and/or proteomics is required. Experience in the use of complex bioinformatics tools for ‘omics data analysis is preferred. The successful candidate will be expected to work within a network of internal and external collaborators, engage stakeholders and display the potential to become a recognized leader in the field. Preference will be given to Canadian citizens.

Please submit Cover letter and CV to:

Dev.Pinto@nrc-cnrc.gc.ca and cc: Alejandro.Cohen@Dal.Ca and jim.fawcett@dal.ca