Senior Scientific Researcher, Genentech, Inc. (South San Francisco, CA) choi meena  2021-03-02

A position is available in Genentech's Discovery Proteomics group, within the department of Microchemistry, Proteomics, Lipidomics and NGS. This individual will serve as a technical lead and be responsible for carrying out experimental research aimed at understanding the role of proteins and post-translational modifications in human disease. An important focus of the lab is to study how membrane protein interactomes and their downstream signaling modulate cellular function, utilizing established cultures, primary cell lines as well as complex cellular models. Advances in proteomics, especially mass spectrometry, have revolutionized the study of cellular proteins and motivated in depth molecular characterization of normal human physiology and disease biology. The Discovery Proteomics group develops and implements protein analytical methods to differentiate between dynamic biological states by characterizing the abundance, dynamics and interactions of proteins. The researcher will also have the opportunity to utilize and further implement state-of-the-art technologies for the discovery and characterization of receptor-ligand interactions. As is true across Genentech, research in the group is fast paced and highly collaborative, drawing on the expertise of some of the world's leading experts in biochemistry, cell biology and disease indications.

Requirements: This position requires an MS plus at least 3 years of relevant analytical sciences work or academic research experience or PhD in Chemistry, Biochemistry, or related field with experience in analytical sciences. The ideal candidate should have experience in protein biochemistry and cell biology techniques. Interest and hands-on experience in membrane protein biology and receptor-ligand interactions (biophysics, biochemistry, signaling) are preferred. Past experience with proteomics sample preparation (i.e. proteolytic digestion, solid phase extraction, immunoprecipitation) and operation of an Orbitrap mass spectrometer are preferred, but not essential for success in this role. Computational skills and ‘big data’ experience are highly desirable, including working knowledge of python, R or related tools. Strong communication & interpersonal skills are essential for success in this collaborative role.

Location: South San Francisco, CA. This is a lab based position and remote work is not an option.

Contact: Interested scientists are encouraged to apply here: San Francisco%2C CA&vjk=6e0b0378bf315a4b
or Please contact (Meena Choi). Please write "Skyline DP-SSR position inquiry" in the subject line.