Lab Research Analyst II, Duke Proteomics and Metabolomics Core Facility

Lab Research Analyst II, Duke Proteomics and Metabolomics Core Facility Will Thompson  2021-02-22

LAB RESEARCH ANALYST II , Duke University School of Medicine
Duke Proteomics and Metabolomics Core Facility
Durham, North Carolina

Position Description:
Seeking a self-starting scientist with good problem-solving skills and strengths in quantitative analysis, particularly by LC-MS/MS. Job duties will be to work in a fast-paced, team-based environment to conduct a variety of complex and independent investigations addressing physical, chemical, and other research laboratory experiments to obtain and interpret data for research projects at Duke, specifically addressing metabolomics and proteomics in cancer, neurodegenerative diseases, and infectious diseases. Scientific integrity, curiosity, and determination are key qualities of a successful candidate.

In particular, under the guidance of the Director or Assistant Director, the Lab Analyst II will conduct a variety of complex laboratory procedures and specialized laboratory techniques for the analysis of endogenous metabolites, drug molecules, peptides and proteins in the Proteomics and Metabolomics Core Facility for the School of Medicine. Note that both SOP-driven and independent analyses will be required, and proven analytical thinking and problem-solving skills are critical. The ability to effectively work in a multidisciplinary team environment and move easily from one task to another is essential.

Position requires a bachelor’s degree in Chemistry, Biology, or related field and a minimum of 4 years experience. Master’s degree or Ph.D. can substitute for appropriate years’ experience.

Tasks may include:

  1. 40% - Preparation of biological samples for metabolomic, proteomic, and pharmacokinetic analyses.

  2. 40% - Quantification of metabolites using triple quadrupole mass spectrometry, and contribution to the development of new LC-MS/MS assays. Validation of figures of merit for quantitative LC-MS/MS assay.

  3. 10% - Protein identification and quantitation using nanoscale capillary liquid chromatography and analytical scale liquid chromatography coupled with either high resolution, accurate mass tandem mass spectrometers (LC/MS/MS) or triple quadrupole mass spectrometers operated in MRM mode.

  4. 5% - Contribution to written reports and publications of results in collaboration with investigators inside and outside of Duke. Review journals, abstracts and scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.

  5. 5% - Presentation of their ongoing work at group meetings, and critical evaluation of new approaches for metabolomics and proteomics presented in the literature or by others.

Interested applicants can find more information and apply for the position at the link below:

Interested individuals may contact Will Thompson (will.thompson at for more information, however applications must be processed through the Duke Careers web site.