Post Doctoral Positions in Proteomics of Disease, Signaling and Complex Biological Systems

The Proteomics Group (Carr Lab) at the Broad Institute of MIT and Harvard is looking for several highly
motivated post-doctoral associates to develop and apply state-of-the art proteomics technology to
address compelling questions in biology, chemistry and clinical medicine. The specific research areas
of immediate interest that this scientist could drive include:
• multiomic and proteogenomic studies of a wide range of cancers
• provide detailed views and understanding of cellular signaling networks related to
protein phosphorylation, ubiquitylation, acetylation and cross-talk
• define the targets of drugs or identifying protein interactors through chemical
proteomics technologies and affinity purification MS
• develop biological understanding of response and resistance to therapy
• improve understanding of immune biology and help develop personalized cancer
immunotherapies
• develop and optimize new, broadly enabling proteomic technologies including targeted,
quantitative MS assay development for proteins and modifications of high biological or
clinical interest
Successful candidates will work in one or more of these areas together with an interdisciplinary team
of clinicians, biologists, computational and proteomics scientists to deeply characterize and
understand the proteomes of tumor-derived material, cells and biofluids.
The Broad Institute is a world-leading non-profit research organization dedicated to realizing the
promise of the post-genomic era for human benefit. Located in Cambridge, MA with strong ties to
MIT, Harvard, and world class Boston hospitals, the Broad Institute brings together scientists of diverse
backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner. The
Broad Institute, and the embedded Proteomics Group (www.broadinstitute.org/proteomics), have an
outstanding track-record in training the next generation of research scientists and in developing and
applying proteomic technologies critical to address important questions in biology and medicine. We
collaborate with top-level researchers throughout the world, and results of these studies and our
technology developments are published in top-tier journals.
Qualifications
Candidates must have:
• an MD or Ph.D. in analytical chemistry, biology, biochemistry, or a closely related field
• excellent scientific productivity, evidenced by high-quality research publications in peer
reviewed journals
• track record of conducting independent and creative research
• excellent verbal and written communication skills

Hands on skills and knowledge in one or more of the following areas will be considered an advantage:
• state-of-the-art mass spectrometry-based proteomics
• expertise in expertise in statistical and/or computational analysis of large-scale proteomic or
genomic data
• analysis of cell signaling pathways/networks
• cell biology/ biochemical methods to understand protein function
• Molecular biology/CRISPR-based genome editing
Interested scientists are encouraged to apply on-line at the Broad Website. Inquiries can also be
addressed to Steve Carr, Director of Proteomics, Broad Institute (scarr@broad.mit.edu) and Namrata
Udeshi, Associate Director of Proteomics (Udeshi@broadinstitute.org).