Senior Scientist, Proteomics Mass Spectrometry (Protein Sciences) - Merck Research Laboratories - SSF, CA

Senior Scientist, Proteomics Mass Spectrometry (Protein Sciences) - Merck Research Laboratories - SSF, CA daniela.tomazela  2020-09-24

Our Research Laboratories is seeking to recruit an experienced mass spectrometry scientist with broad experience in Proteomics applications to join the Protein Sciences Department in South San Francisco, CA.

The position will be hands-on at the bench and will report to the mass spectrometry group leader.

Design and perform proteomics-based experiments, including phospho-proteomics, labeled and label-free differential protein expression, and targeted protein quantification.
Sample preparation for proteomics analysis including protein extraction, immunoprecipitation, proteolytic digestion, and sample clean-up prior to MS analysis.
Perform analytical routines for Tandem liquid chromatography mass spectrometry (LCMSMS) systems maintenance, including calibration, system suitability, and troubleshooting.
Strong communication & interpersonal skills.

Education Minimum Requirement:
PhD in Biochemistry, Cell Biology, Analytical Chemistry or a related field, with a minimum of 3 years relevant postdoctoral or pharmaceutical/biotechnology experience.

Required Experience and Skills:
Knowledge and direct experience with state - of - the - art technologies and methods for mass spectrometry-based proteomics, including Thermo Orbitrap mass spectrometers.
Proficiency in quantitative proteomics techniques SILAC, Tandem Mass Tag (TMT), label-free quantification approaches and peptide fragmentation methods.
Proficiency in using Proteome Discoverer, Peaks, Genedata, MaxQuant, Skyline, and other DB search engine tools.

Preferred Experience and Skills:
Biologics characterization using mass spectrometric methods (PTMs/glycosylation, intact and subunit mass analysis).
Understanding and working knowledge of various analytical methods for protein characterization such as SEC, IEX, RP – HPLC, CE-SDS.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …
Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement​
OFCCP EEO Supplement
OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:


VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:


Valid Driving License:

Hazardous Material(s):

Number of Openings:

Link to the position: