Postdoctoral and research associate positions are available in the laboratory of Dr. Ben Major at Washington University in St. Louis, School of Medicine. We use protein mass spectrometry, functional genomics and chemical screens to study signal transduction in cancer. In addition to broad interests in kinases and ubiquitin ligases, our research focuses on the WNT/b-catenin pathway and the KEAP1/NRF2 oxidative stress response pathway. Mass spectrometry is central to our research and for this the lab maintains an Eclipse-ETD Orbitrap mass spectrometer. The Major laboratory recently moved from the University of North Carolina at Chapel Hill to Washington University in St. Louis. The new lab space is fully renovated and houses new instrumentation for cancer research, cell biology and multi-OMIC screening. The Department of Cell Biology and Physiology, Otolaryngology and the Siteman Comprehensive Cancer Center provide an exceptionally supportive, collaborative and comprehensive training and research environment.

For further details please see our website: http://majorlab.wustl.edu/research.php

Postdocs and Research Associates will identify, develop and drive independent research projects that broadly relate to the following research areas:

1. KEAP1/NRF2 oxidative stress response pathway in lung cancer, head and neck cancer and esophageal cancer. Topics include: pathway mechanics, ubiquitylation, protein-protein interaction and proximity networks, phospho-proteomics, functional genomic screening, drug discovery, mouse models and clinical trials. Structural biology of cancer-derived mutations in KEAP1. Proteogenomics and informatics of KEAP1/NRF2 signaling in clinical samples.

2. WNT signaling pathway in pancreas and lung cancer. Basic pathway mechanics of the destruction complex, signalosome and enhanceosome. Time-resolved protein-proximity networks and phospho-proteomics. Proteogenomics and informatic correlations in cancer.

3. Understudied kinases and ubiquitin ligases altered in human disease. Protein-protein interaction and proximity networks. Crispr-A and Crispr-I genetic screens. ORF screens. Phospho-proteomics. Kinase enrichment mass spectrometry. E3 substrate identification.

Prior experience, achievements and letters of recommendation that clearly articulate scientific devotion, drive and curiosity will benefit the applicant. A record of accomplishment of leading projects to completion and publication in peer-reviewed journals is required.

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Interested candidates should send a cover letter and CV to Dr. Major (bmajor@wustl.edu)