Hi Skyline Team,
I have been getting myself familiar with skyline by doing the tutorials and when I was working on the Targeted Method Refinement Tutorial I got stuck. Whenever I need to import results I end up getting a Corrupt RAW file error. I have tried it with both with Method Refinement supplemental and if I skip that I get the same error when I try to import in the "Scheduling for Efficient Acquisition" step.
I am running skyline 64-bit 22.2 on Windows 11 using Parallels on a 2020 MacBook Air.
I have tried to access the file from a few different ways;
*direct by clicking on the tutorial inside the skyline app,
*downloading it from the website,
*using the hyperlink in the PDF that opens when you start the app (https://skyline.ms/_webdav/home/software/Skyline/%40files/tutorials/MethodRefine-20_1.pdf)
It has also persisted through restarting skyline and using a completely fresh .sky file.
Error message:
At 3:13 PM:
Failed importing results file '\Mac\Home\Downloads\MethodRefineSupplement\MethodRefineSupplement\worm_0001.RAW'.
[RawFileImpl::ctor()] Corrupt RAW file \Mac\Home\Downloads\MethodRefineSupplement\MethodRefineSupplement\worm_0001.RAW
pwiz.Skyline.Model.Results.ChromCacheBuildException: Failed importing results file '\Mac\Home\Downloads\MethodRefineSupplement\MethodRefineSupplement\worm_0001.RAW'.
[RawFileImpl::ctor()] Corrupt RAW file \Mac\Home\Downloads\MethodRefineSupplement\MethodRefineSupplement\worm_0001.RAW ---> System.Exception: [RawFileImpl::ctor()] Corrupt RAW file \Mac\Home\Downloads\MethodRefineSupplement\MethodRefineSupplement\worm_0001.RAW
at pwiz.CLI.msdata.ReaderList.read(String filename, MSData result, Int32 runIndex, ReaderConfig config)
at pwiz.ProteowizardWrapper.MsDataFileImpl..ctor(String path, Int32 sampleIndex, LockMassParameters lockmassParameters, Boolean simAsSpectra, Boolean srmAsSpectra, Boolean acceptZeroLengthSpectra, Boolean requireVendorCentroidedMS1, Boolean requireVendorCentroidedMS2, Boolean ignoreZeroIntensityPoints, Int32 preferOnlyMsLevel, Boolean combineIonMobilitySpectra, Boolean trimNativeId) in C:\proj\skyline_22_2\pwiz_tools\Shared\ProteowizardWrapper\MsDataFileImpl.cs:line 197
at pwiz.Skyline.Model.Results.MsDataFilePath.OpenMsDataFile(Boolean simAsSpectra, Boolean preferOnlyMs1, Boolean centroidMs1, Boolean centroidMs2, Boolean ignoreZeroIntensityPoints) in C:\proj\skyline_22_2\pwiz_tools\Skyline\Model\Results\MsDataFilePath.cs:line 291
at pwiz.Skyline.Model.Results.ChromCacheBuilder.BuildCache() in C:\proj\skyline_22_2\pwiz_tools\Skyline\Model\Results\ChromCacheBuilder.cs:line 199
--- End of inner exception stack trace ---
Many Thanks,
Soren