Nothing that simple. A lot of people are using spectral libraries from DDA data as a starting point, and Skyline makes it easy to limit your peptide selection to only what is available in a spectral library. There are some predictive tools that try to achieve this, and one (PREGO) can be found in the Skyline Tool Store, but we have not been super impressed with their performance compared with an empirical assessment.
I guess I would recommend starting with the Targeted Method Editing tutorial, if you have not already, and follow that with the Targeted Method Refinement tutorial to get a sense for how this problem can be approached in Skyline.
--Brendan