Dear Skyline Users,

We hope you are enjoying ASMS and thanks again for making the user group meeting this year such a special one.

I have just released the second patch to Skyline 20.1 with the following improvements over the initial release:

• Fixes to Prosit integration handling of heavy labeled peptides
  • Fixed failure to annotate fragment ions in heavy labeled Prosit predicted spectra
  • Fixed failure to match m/z values between heavy labeled library spectra and Prosit mirror plot spectra
• Fixed BiblioSpec's mzML -> MSFragger -> PeptideProphet pipeline (broken by previous fix to timsTOF/MGF -> MSFragger -> PeptideProphet)
• Fixed error handling for SkylineCmd.exe, especially when installed from a network downloaded ZIP file
• Fixed formatting of calculated concentration of CalibrationForm so that it displays the units and four decimal places.
• Fixed wrong version of Agilent MethodCreator.dll for SRM method export.
• Fixed validation errors in Edit Irt Calculator form when switching standards using the dropdown list.
• Updated tutorial images and links in the Start form.

We expect this to be the last patch to Skyline 20.1, which we really think was a major release for us and worth the upgrade, if you are still using an earlier release. As explained at the Skyline User Group Meeting last week, we are making an effort to update all of our tutorials to this release.

UPGRADE!!

Skyline should ask you to update the next time you restart or use Help > Check for Updates.

Enjoy.

--Brendan